ZA931647B - Therapeutic nucleosides - Google Patents
Therapeutic nucleosidesInfo
- Publication number
- ZA931647B ZA931647B ZA931647A ZA931647A ZA931647B ZA 931647 B ZA931647 B ZA 931647B ZA 931647 A ZA931647 A ZA 931647A ZA 931647 A ZA931647 A ZA 931647A ZA 931647 B ZA931647 B ZA 931647B
- Authority
- ZA
- South Africa
- Prior art keywords
- substituted
- benzimidazole base
- therapeutic nucleosides
- hepatitis
- halogen
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 title 1
- 125000003835 nucleoside group Chemical group 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000701022 Cytomegalovirus Species 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 229940127073 nucleoside analogue Drugs 0.000 abstract 1
- 241001529453 unidentified herpesvirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929205071A GB9205071D0 (en) | 1992-03-09 | 1992-03-09 | Therapeutic nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA931647B true ZA931647B (en) | 1994-09-08 |
Family
ID=10711750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA931647A ZA931647B (en) | 1992-03-09 | 1993-03-08 | Therapeutic nucleosides |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5534535A (xx) |
| EP (1) | EP0630368B1 (xx) |
| JP (1) | JP3450854B2 (xx) |
| KR (2) | KR950700887A (xx) |
| AT (1) | ATE170846T1 (xx) |
| AU (1) | AU672597B2 (xx) |
| CA (1) | CA2131693A1 (xx) |
| CZ (1) | CZ209494A3 (xx) |
| DE (1) | DE69320945T2 (xx) |
| DK (1) | DK0630368T3 (xx) |
| ES (1) | ES2123048T3 (xx) |
| FI (1) | FI944134A (xx) |
| GB (1) | GB9205071D0 (xx) |
| HU (1) | HUT68445A (xx) |
| IL (1) | IL104976A (xx) |
| NZ (1) | NZ249554A (xx) |
| RU (1) | RU2141952C1 (xx) |
| TW (1) | TW366339B (xx) |
| WO (1) | WO1993018009A1 (xx) |
| ZA (1) | ZA931647B (xx) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9205071D0 (en) * | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
| GB9413724D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Therapeutic nucleosides |
| AU3692895A (en) * | 1994-09-09 | 1996-03-27 | Regents Of The University Of Michigan, The | Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring |
| US5811073A (en) * | 1995-06-19 | 1998-09-22 | President And Fellows Of Harvard College | Method for radioisotopic detection and localization of inflammation in a host |
| US5912356A (en) * | 1995-09-11 | 1999-06-15 | Glaxo Wellcome Inc. | Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring |
| GB9600142D0 (en) * | 1996-01-05 | 1996-03-06 | Wellcome Found | Chemical compounds |
| GB9600143D0 (en) | 1996-01-05 | 1996-03-06 | Wellcome Found | Therapeutic compounds |
| AU6221998A (en) | 1997-02-13 | 1998-09-08 | Glaxo Group Limited | Benzimidazole derivatives |
| SK285229B6 (sk) * | 1997-05-13 | 2006-09-07 | Lonza Ag | Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu |
| ATE246700T1 (de) | 1997-06-10 | 2003-08-15 | Glaxo Group Ltd | Benzimidazolderivate |
| US6455506B1 (en) | 1997-07-30 | 2002-09-24 | Smithkline Beecham Corporation | Lyxofuranosyl benzimidazoles as antiviral agents |
| US6514979B1 (en) | 1999-03-03 | 2003-02-04 | University Of Maryland Biotechnology Institute | Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor |
| GB0008939D0 (en) | 2000-04-11 | 2000-05-31 | Glaxo Group Ltd | Process for preparing substituted benzimidazole compounds |
| JP2003532643A (ja) | 2000-04-13 | 2003-11-05 | フアーマセツト・リミテツド | 肝炎ウイルス感染症を治療するための３’−または２’−ヒドロキシメチル置換ヌクレオシド誘導体 |
| TW200831081A (en) | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
| ES2655028T3 (es) | 2007-08-02 | 2018-02-16 | Millennium Pharmaceuticals, Inc. | Proceso para la síntesis de inhibidores de enzima de activación de E1 |
| ME02198B (me) | 2008-04-28 | 2016-02-20 | Kyorin Seiyaku Kk | Derivati ciklopentilakrilamida |
| US11499722B2 (en) * | 2020-04-30 | 2022-11-15 | Bsh Home Appliances Corporation | Household cooking appliance having an oven door with an interior camera |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4996308A (en) * | 1988-03-25 | 1991-02-26 | Merrell Dow Pharmaceuticals Inc. | Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group |
| ZA894534B (en) * | 1988-06-20 | 1990-03-28 | Merrell Dow Pharma | Novel neplanocin derivatives |
| GB8826205D0 (en) * | 1988-11-09 | 1988-12-14 | Wellcome Found | Heterocyclic compounds |
| GB8926417D0 (en) * | 1989-11-22 | 1990-01-10 | Wellcome Found | Heterocyclic compounds |
| MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
| US5248672A (en) * | 1990-11-01 | 1993-09-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazole nucleosides as antiviral agents |
| GB9205071D0 (en) * | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
-
1992
- 1992-03-09 GB GB929205071A patent/GB9205071D0/en active Pending
-
1993
- 1993-03-08 ES ES93905536T patent/ES2123048T3/es not_active Expired - Lifetime
- 1993-03-08 AU AU36432/93A patent/AU672597B2/en not_active Ceased
- 1993-03-08 NZ NZ249554A patent/NZ249554A/en unknown
- 1993-03-08 RU RU94043771A patent/RU2141952C1/ru active
- 1993-03-08 AT AT93905536T patent/ATE170846T1/de not_active IP Right Cessation
- 1993-03-08 DK DK93905536T patent/DK0630368T3/da active
- 1993-03-08 JP JP51547193A patent/JP3450854B2/ja not_active Expired - Fee Related
- 1993-03-08 ZA ZA931647A patent/ZA931647B/xx unknown
- 1993-03-08 WO PCT/GB1993/000479 patent/WO1993018009A1/en active IP Right Grant
- 1993-03-08 EP EP93905536A patent/EP0630368B1/en not_active Expired - Lifetime
- 1993-03-08 CA CA002131693A patent/CA2131693A1/en not_active Abandoned
- 1993-03-08 IL IL10497693A patent/IL104976A/en not_active IP Right Cessation
- 1993-03-08 DE DE69320945T patent/DE69320945T2/de not_active Expired - Fee Related
- 1993-03-08 CZ CZ942094A patent/CZ209494A3/cs unknown
- 1993-03-08 HU HU9402582A patent/HUT68445A/hu unknown
- 1993-05-27 TW TW082104263A patent/TW366339B/zh active
-
1994
- 1994-09-08 FI FI944134A patent/FI944134A/fi unknown
- 1994-09-09 US US08/304,006 patent/US5534535A/en not_active Expired - Lifetime
- 1994-09-09 KR KR1019940703149A patent/KR950700887A/ko not_active Application Discontinuation
-
1995
- 1995-09-11 KR KR1019970701554A patent/KR970705547A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2141952C1 (ru) | 1999-11-27 |
| RU94043771A (ru) | 1996-08-10 |
| KR970705547A (ko) | 1997-10-09 |
| ATE170846T1 (de) | 1998-09-15 |
| JP3450854B2 (ja) | 2003-09-29 |
| FI944134A0 (fi) | 1994-09-08 |
| EP0630368A1 (en) | 1994-12-28 |
| JPH07506816A (ja) | 1995-07-27 |
| US5534535A (en) | 1996-07-09 |
| DE69320945T2 (de) | 1999-02-04 |
| AU3643293A (en) | 1993-10-05 |
| IL104976A0 (en) | 1993-07-08 |
| DK0630368T3 (da) | 1999-06-07 |
| EP0630368B1 (en) | 1998-09-09 |
| NZ249554A (en) | 1996-05-28 |
| HU9402582D0 (en) | 1994-11-28 |
| WO1993018009A1 (en) | 1993-09-16 |
| AU672597B2 (en) | 1996-10-10 |
| IL104976A (en) | 1998-10-30 |
| CA2131693A1 (en) | 1993-09-16 |
| ES2123048T3 (es) | 1999-01-01 |
| HUT68445A (en) | 1995-06-28 |
| CZ209494A3 (en) | 1995-11-15 |
| FI944134A (fi) | 1994-11-07 |
| GB9205071D0 (en) | 1992-04-22 |
| TW366339B (en) | 1999-08-11 |
| DE69320945D1 (de) | 1998-10-15 |
| KR950700887A (ko) | 1995-02-20 |
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