|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4880935A
(en)
|
1986-07-11 |
1989-11-14 |
Icrf (Patents) Limited |
Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
|
|
US4880078A
(en)
|
1987-06-29 |
1989-11-14 |
Honda Giken Kogyo Kabushiki Kaisha |
Exhaust muffler
|
|
IL106992A
(en)
|
1988-02-11 |
1994-06-24 |
Bristol Myers Squibb Co |
Acylhydrazone derivatives of anthracycline and methods for their preparation
|
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
|
JPH06507404A
(ja)
|
1991-05-01 |
1994-08-25 |
ヘンリー エム.ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン |
感染性の呼吸性疾患の治療方法
|
|
EP0590058B1
(en)
|
1991-06-14 |
2003-11-26 |
Genentech, Inc. |
HUMANIZED Heregulin ANTIBODy
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
|
DK0871490T3
(da)
|
1995-12-22 |
2003-07-07 |
Bristol Myers Squibb Co |
Forgrenede hydrazonlinkere
|
|
ATE508733T1
(de)
|
1996-03-04 |
2011-05-15 |
Penn State Res Found |
Materialien und verfahren zur steigerung der zellulären internalisierung
|
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
|
WO1998031346A1
(en)
|
1997-01-16 |
1998-07-23 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
|
CA2336139C
(en)
|
1998-06-24 |
2008-10-14 |
Advanced Inhalation Research, Inc. |
Large porous particles emitted from an inhaler
|
|
US6019963A
(en)
|
1998-11-20 |
2000-02-01 |
D.S.C. Products, Inc. |
Deodorizing composition containing tea tree and eucalyptus oils
|
|
US7109019B2
(en)
|
1999-01-06 |
2006-09-19 |
The Regents Of The University Of California |
Gene cluster for production of the enediyne antitumor antibiotic C-1027
|
|
NZ529808A
(en)
|
2001-05-02 |
2007-02-23 |
Purdue Research Foundation |
Treatment and diagnosis of macrophage mediated disease
|
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
|
US7795210B2
(en)
|
2001-10-10 |
2010-09-14 |
Novo Nordisk A/S |
Protein remodeling methods and proteins/peptides produced by the methods
|
|
US8008252B2
(en)
|
2001-10-10 |
2011-08-30 |
Novo Nordisk A/S |
Factor VII: remodeling and glycoconjugation of Factor VII
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7297511B2
(en)
|
2001-10-10 |
2007-11-20 |
Neose Technologies, Inc. |
Interferon alpha: remodeling and glycoconjugation of interferon alpha
|
|
US7439043B2
(en)
|
2001-10-10 |
2008-10-21 |
Neose Technologies, Inc. |
Galactosyl nucleotide sugars
|
|
US7179617B2
(en)
|
2001-10-10 |
2007-02-20 |
Neose Technologies, Inc. |
Factor IX: remolding and glycoconjugation of Factor IX
|
|
US7125843B2
(en)
|
2001-10-19 |
2006-10-24 |
Neose Technologies, Inc. |
Glycoconjugates including more than one peptide
|
|
US7265085B2
(en)
|
2001-10-10 |
2007-09-04 |
Neose Technologies, Inc. |
Glycoconjugation methods and proteins/peptides produced by the methods
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
US7399613B2
(en)
|
2001-10-10 |
2008-07-15 |
Neose Technologies, Inc. |
Sialic acid nucleotide sugars
|
|
US7226903B2
(en)
|
2001-10-10 |
2007-06-05 |
Neose Technologies, Inc. |
Interferon beta: remodeling and glycoconjugation of interferon beta
|
|
US7696163B2
(en)
|
2001-10-10 |
2010-04-13 |
Novo Nordisk A/S |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7265084B2
(en)
|
2001-10-10 |
2007-09-04 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
|
EP1531846A4
(en)
|
2002-02-27 |
2006-04-19 |
Us Gov Health & Human Serv |
Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
|
|
CA2802205C
(en)
*
|
2002-07-31 |
2016-01-19 |
Seattle Genetics, Inc. |
Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
|
|
JP2004119755A
(ja)
|
2002-09-27 |
2004-04-15 |
Alps Electric Co Ltd |
磁気検出素子及びその製造方法
|
|
US20040071540A1
(en)
|
2002-10-15 |
2004-04-15 |
Lucas Philip J. |
Disposable/recyclable pallet system and method
|
|
US20080025989A1
(en)
|
2003-02-20 |
2008-01-31 |
Seattle Genetics, Inc. |
Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
|
|
SG155777A1
(en)
|
2003-04-09 |
2009-10-29 |
Neose Technologies Inc |
Glycopegylation methods and proteins/peptides produced by the methods
|
|
AU2004273910A1
(en)
|
2003-09-18 |
2005-03-31 |
Combinatorx, Incorporated |
Combinations of drugs for the treatment of neoplasms
|
|
US6997024B2
(en)
|
2003-10-01 |
2006-02-14 |
Truth Hardware Corporation |
Pull door lock
|
|
US20050148535A1
(en)
|
2003-10-30 |
2005-07-07 |
Lacasse Eric |
IAP nucleobase oligomers and oligomeric complexes and uses thereof
|
|
US8012944B2
(en)
|
2003-10-30 |
2011-09-06 |
Pharmascience Inc. |
Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
|
|
AU2005214331B2
(en)
|
2004-02-12 |
2011-09-15 |
Eisai, Inc. |
Monoclonal antibodies that specifically bind to folate receptor alpha
|
|
US7117807B2
(en)
|
2004-02-17 |
2006-10-10 |
University Of Florida Research Foundation, Inc. |
Dynamically modifiable polymer coatings and devices
|
|
EP1778298A4
(en)
|
2004-04-01 |
2010-03-31 |
Univ Pennsylvania |
LIPOPROTEIN-NANO PLATFORMS
|
|
AU2005247346A1
(en)
|
2004-05-07 |
2005-12-08 |
Massachusetts Institute Of Technology |
Methods and compositions for cancer treatment relating to BRCA1 BRCT domain recognition of phosphorylated BACH1
|
|
PL2522663T3
(pl)
|
2004-06-03 |
2015-08-31 |
Eisai R&D Man Co Ltd |
Produkty pośrednie do otrzymywania halichondryny B
|
|
ES2579805T3
(es)
|
2004-09-23 |
2016-08-16 |
Genentech, Inc. |
Anticuerpos y conjugados modificados por ingeniería genética con cisteína
|
|
JO3000B1
(ar)
*
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
WO2006076100A2
(en)
|
2004-12-09 |
2006-07-20 |
Eisai Co. Ltd. |
Tubulin isotype screening in cancer therapy using halichondrin b analogs
|
|
US20060148014A1
(en)
|
2004-12-09 |
2006-07-06 |
Sergei Agoulnik |
Tubulin isotype screening in cancer therapy using hemiasterlin analogs
|
|
AU2006269422B2
(en)
|
2005-07-07 |
2012-12-06 |
Seagen Inc. |
Monomethylvaline compounds having phenylalanine side-chain modifications at the C-terminus
|
|
US8871720B2
(en)
|
2005-07-07 |
2014-10-28 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
|
|
GB0515025D0
(en)
|
2005-07-21 |
2005-08-31 |
Novartis Ag |
Organic compounds
|
|
BRPI0615354A2
(pt)
|
2005-08-19 |
2011-05-17 |
Endocyte Inc |
conjugado de liberação de fármaco de ligação de receptor, composição farmacêutica que o compreende, bem como seu uso
|
|
AU2006290567A1
(en)
|
2005-09-14 |
2007-03-22 |
Ucb Pharma S.A |
Comb polymers
|
|
EP1968607B1
(en)
|
2005-12-02 |
2014-01-15 |
Nabil Habib Lab |
Treatment of cancer and other diseases
|
|
EP2021502A4
(en)
|
2006-05-09 |
2010-08-25 |
Mas Metabolic Analytical Servi |
GENES AND ATYPICAL MARKERS IN TYPE 2 DIABETES AND OBESITY
|
|
US20150030534A1
(en)
|
2013-07-26 |
2015-01-29 |
Rutgers, The State University Of New Jersey |
Antibody cocktails for breast cancer radioimmunotherapy
|
|
US20140037539A1
(en)
|
2012-07-27 |
2014-02-06 |
Rutgers, The State University Of New Jersey |
Antibody cocktails for breast cancer radioimmunotherapy
|
|
US8398956B2
(en)
|
2007-01-11 |
2013-03-19 |
Immunomedics, Inc. |
In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
|
|
US20100104626A1
(en)
|
2007-02-16 |
2010-04-29 |
Endocyte, Inc. |
Methods and compositions for treating and diagnosing kidney disease
|
|
WO2008112873A2
(en)
|
2007-03-14 |
2008-09-18 |
Endocyte, Inc. |
Binding ligand linked drug delivery conjugates of tubulysins
|
|
EP1977765A1
(en)
|
2007-04-03 |
2008-10-08 |
Diatos |
Peptide prodrugs
|
|
EP2578576B9
(en)
|
2007-10-03 |
2016-09-14 |
Eisai R&D Management Co., Ltd. |
Intermediates for the synthesis of halichondrin B analogs
|
|
MY188455A
(en)
*
|
2007-10-19 |
2021-12-09 |
Genentech Inc |
Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
|
|
CN101884058B
(zh)
|
2007-10-30 |
2012-07-25 |
富士通株式会社 |
移动终端装置
|
|
DK2842575T3
(da)
|
2008-03-18 |
2017-11-27 |
Seattle Genetics Inc |
Auristatin-lægemiddel-linker-konjugater
|
|
WO2009121031A1
(en)
|
2008-03-27 |
2009-10-01 |
Vascular Biosciences, Inc. |
Methods of novel therapeutic candidate identification through gene expression analysis in vascular-related diseases
|
|
US20100260668A1
(en)
|
2008-04-29 |
2010-10-14 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
|
CN102076355B
(zh)
|
2008-04-29 |
2014-05-07 |
Abbvie公司 |
双重可变结构域免疫球蛋白及其用途
|
|
BRPI0911442A2
(pt)
*
|
2008-04-30 |
2019-03-12 |
Immunogen, Inc. |
conjugados potentes e ligantes hidrofílicos
|
|
AU2009256246B2
(en)
|
2008-06-03 |
2013-07-18 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
SG191639A1
(en)
|
2008-06-03 |
2013-07-31 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
AU2009268585C1
(en)
|
2008-07-08 |
2014-10-02 |
Abbvie Inc. |
Prostaglandin E2 dual variable domain immunoglobulins and uses thereof
|
|
GEP20135804B
(en)
|
2008-09-12 |
2013-04-10 |
Santen Pharmaceutical Co Ltd |
Glucocorticoid receptor agonist comprising novel 1,2,3,4-tetrahydroquinoxaline derivative containing phenyl group having sulfonic acid ester introduced therein as substituent
|
|
SG171812A1
(en)
|
2008-12-04 |
2011-07-28 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
PE20160653A1
(es)
|
2009-03-05 |
2016-07-24 |
Abbvie Inc |
Proteinas de union a il-17
|
|
US20140339088A1
(en)
|
2009-03-09 |
2014-11-20 |
Virginia Tech Intellectual Properties, Inc. |
Dielectrophoresis methods for determining a property of a plurality of cancer cells
|
|
AU2010242830C1
(en)
|
2009-05-01 |
2014-02-13 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
US8686520B2
(en)
*
|
2009-05-29 |
2014-04-01 |
International Business Machines Corporation |
Spin-torque magnetoresistive structures
|
|
TW201109438A
(en)
|
2009-07-29 |
2011-03-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
TW201431558A
(zh)
*
|
2009-08-15 |
2014-08-16 |
建南德克公司 |
用於治療先前治療過之乳癌之抗-血管新生療法
|
|
TW201119673A
(en)
|
2009-09-01 |
2011-06-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
GB0917044D0
(en)
|
2009-09-29 |
2009-11-18 |
Cytoguide As |
Agents, uses and methods
|
|
UY32948A
(es)
|
2009-10-15 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
UY32979A
(es)
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
BR112012012156A2
(pt)
|
2009-11-06 |
2015-09-08 |
Plexxikon Inc |
compostos e métodos para modulação de cinase, e indicações para esta
|
|
SG182612A1
(en)
|
2010-01-26 |
2012-08-30 |
Eisai R&D Man Co Ltd |
Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs
|
|
CN103037690B
(zh)
|
2010-03-24 |
2016-04-27 |
俄亥俄州立大学 |
用于葡萄糖转运抑制的组合物和方法
|
|
US8710035B2
(en)
|
2010-03-24 |
2014-04-29 |
The University Of Chicago |
Methods and compositions related to glucocorticoid receptor antagonists and breast cancer
|
|
EP2571532B1
(en)
|
2010-05-14 |
2017-05-03 |
Abbvie Inc. |
Il-1 binding proteins
|
|
SMT201700547T1
(it)
|
2010-06-15 |
2018-01-11 |
Genmab As |
Coniugati di farmaco anticorpo umano contro il fattore tissutale
|
|
UY33492A
(es)
|
2010-07-09 |
2012-01-31 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
TW201206473A
(en)
|
2010-08-03 |
2012-02-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
CN103260639A
(zh)
|
2010-08-26 |
2013-08-21 |
Abbvie公司 |
双重可变结构域免疫球蛋白及其用途
|
|
US9089570B2
(en)
|
2010-09-03 |
2015-07-28 |
Tactical Therapeutics Inc |
Compositions for treating cancers having acquired resitance to prior chemotherapeutic and targeted drugs using carboxyamidotriazole orotate
|
|
EP2613810B9
(en)
|
2010-09-07 |
2016-02-17 |
Johannes Kepler Universität Linz |
Biodegradable, water soluble and ph responsive poly(organo)phosphazenes
|
|
WO2012065057A2
(en)
|
2010-11-12 |
2012-05-18 |
Exelixis, Inc. |
Phosphatidylinositol 3-kinase inhibitors and methods of their use
|
|
WO2012065019A2
(en)
|
2010-11-12 |
2012-05-18 |
Exelixis, Inc. |
Pyridopyrimidinone inhibitors of p13k alpha
|
|
EP2646055A4
(en)
|
2010-12-02 |
2015-04-08 |
Immunomedics Inc |
COPPER-FREE IN VIVO CLICK CHEMISTRY FOR THE DISPOSAL OF THERAPY AND / OR DIAGNOSTIC PRODUCTS
|
|
MY163368A
(en)
|
2010-12-21 |
2017-09-15 |
Abbvie Inc |
Il-1-alpha and -beta bispecific dual variable domain immunoglobulins and their use
|
|
WO2012088290A2
(en)
|
2010-12-22 |
2012-06-28 |
Abbott Laboratories |
Tri-variable domain binding proteins and uses thereof
|
|
WO2012088302A2
(en)
|
2010-12-22 |
2012-06-28 |
Abbott Laboratories |
Half immunoglobulin binding proteins and uses thereof
|
|
US10005820B2
(en)
|
2011-02-15 |
2018-06-26 |
Vaxiion Therapeutics, Llc |
Therapeutic compositions and methods for antibody and Fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells
|
|
WO2012116277A1
(en)
|
2011-02-25 |
2012-08-30 |
Arena Pharmaceuticals, Inc. |
Cannabinoid receptor modulators
|
|
JP2014508165A
(ja)
*
|
2011-03-02 |
2014-04-03 |
モルフォテック、インク. |
乳癌の治療のためのエリブリンおよびファーレツズマブの共投与
|
|
WO2012118978A1
(en)
|
2011-03-03 |
2012-09-07 |
The Regents Of The University Of Colorado, A Body Corporate |
Methods for treating oncovirus positive cancers
|
|
CN103502218B
(zh)
|
2011-03-04 |
2016-08-17 |
生命科技公司 |
用于缀合生物分子的化合物和方法
|
|
AU2012229123B2
(en)
|
2011-03-15 |
2017-02-02 |
British Columbia Cancer Agency Branch |
Methods of treating breast cancer with anthracycline therapy
|
|
EP2686441B1
(en)
|
2011-03-18 |
2019-05-08 |
Eisai R&D Management Co., Ltd. |
Methods and uses for predicting response to eribulin
|
|
EP2508525A1
(en)
|
2011-04-05 |
2012-10-10 |
Bayer Pharma Aktiengesellschaft |
Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
|
|
EP2670866A4
(en)
|
2011-04-05 |
2015-09-02 |
Translational Genomics Res Inst |
BIOMARKERS AND METHOD OF APPLICATION THEREFOR
|
|
US9132131B2
(en)
|
2011-04-21 |
2015-09-15 |
Saint Louis University |
Use of adenosine A3 receptor agonists for treatment of neuropathic pain
|
|
ES2898854T3
(es)
|
2011-05-27 |
2022-03-09 |
Ambrx Inc |
Composiciones que contienen, métodos que implican, y usos de derivados de dolastatina enlazados con aminoácidos no naturales
|
|
US9796754B2
(en)
|
2011-05-27 |
2017-10-24 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
|
|
WO2012170640A1
(en)
|
2011-06-07 |
2012-12-13 |
The Trustees Of Columbia University In The City Of New York |
Methods and compositions for trail-drug combination therapy
|
|
US8815226B2
(en)
|
2011-06-10 |
2014-08-26 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
KR101972303B1
(ko)
|
2011-06-10 |
2019-04-25 |
메르사나 테라퓨틱스, 인코포레이티드 |
단백질-중합체-약물 접합체
|
|
US8722019B2
(en)
|
2011-08-05 |
2014-05-13 |
Bioasis Technologies, Inc. |
P97 fragments with transfer activity
|
|
AU2012344697A1
(en)
|
2011-11-30 |
2014-07-10 |
Alphora Research Inc. |
Process for preparation of (3R)-2,4-di-leaving group-3-methylbut-1-ene
|
|
JP2015501818A
(ja)
|
2011-12-16 |
2015-01-19 |
アルフォラ リサーチ インコーポレイテッドAlphora Research Inc. |
3−((2s,5s)−4−メチレン−5−(3−オキソプロピル)テトラヒドロフラン−2−イル)プロパノール誘導体およびそれらの有用な中間体を調製する方法
|
|
WO2013093809A1
(en)
|
2011-12-23 |
2013-06-27 |
Pfizer Inc. |
Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
|
|
WO2013092998A1
(en)
|
2011-12-23 |
2013-06-27 |
Innate Pharma |
Enzymatic conjugation of antibodies
|
|
IN2014MN01521A
(enExample)
|
2011-12-29 |
2015-05-01 |
Alphora Res Inc |
|
|
AR092790A1
(es)
|
2012-02-01 |
2015-05-06 |
Euro Celtique Sa |
Derivados bencimidazolicos del acido hidroxamico
|
|
WO2013130093A1
(en)
*
|
2012-03-02 |
2013-09-06 |
Genentech, Inc. |
Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
|
|
AU2013201584A1
(en)
|
2012-03-12 |
2013-09-26 |
Merrimack Pharmaceuticals, Inc. |
Methods for treating pancreatic cancer using combination therapies comprising an anti-ErbB3 antibody
|
|
US9358235B2
(en)
*
|
2012-03-19 |
2016-06-07 |
Plexxikon Inc. |
Kinase modulation, and indications therefor
|
|
US20150216937A1
(en)
|
2012-03-29 |
2015-08-06 |
Altor Bioscience Corporation |
Methods for treating neoplasia
|
|
WO2013142999A1
(en)
|
2012-03-30 |
2013-10-03 |
Alphora Research Inc. |
Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein
|
|
JP2015514113A
(ja)
|
2012-04-02 |
2015-05-18 |
メリマック ファーマシューティカルズ インコーポレーティッド |
単一特異性および二重特異性抗igf−1rおよび抗erbb3抗体の用法および用量
|
|
WO2013172955A1
(en)
|
2012-05-15 |
2013-11-21 |
Diatech Oncology |
Tumor cell isolation/purification process and methods for use thereof
|
|
EP2849797B1
(en)
|
2012-05-15 |
2019-12-18 |
Concortis Biosystems, Corp |
Drug-conjugates, conjugation methods, and uses thereof
|
|
EP2858676B1
(en)
|
2012-06-07 |
2019-03-13 |
Ambrx, Inc. |
Prostate-specific membrane antigen antibody drug conjugates
|
|
KR101915942B1
(ko)
|
2012-06-08 |
2018-11-06 |
에프. 호프만-라 로슈 아게 |
암의 치료를 위한 포스포이노시타이드 3 키나제 억제제 화합물 및 화학치료제의 돌연변이체 선택성 및 조합물
|
|
KR102190832B1
(ko)
|
2012-06-19 |
2020-12-15 |
암브룩스, 인코포레이티드 |
항cd70 항체 약물 컨쥬게이트
|
|
WO2014005010A2
(en)
|
2012-06-29 |
2014-01-03 |
Nanostring Technologies, Inc. |
Methods of treating breast cancer with gemcitabine therapy
|
|
WO2014005089A2
(en)
|
2012-06-29 |
2014-01-03 |
The Research Foundation Of State University Of New York |
Polyenolic zinc-binding agents (pezbins) actively promote inactivation of cancer stem cells and potentiate cytotoxic anti-tumor drug substances
|
|
PL3210627T3
(pl)
|
2012-07-12 |
2023-04-17 |
Hangzhou Dac Biotech Co., Ltd |
Koniugaty zawierające cząsteczki wiążące się z komórką i środek cytotoksyczny
|
|
US20140069822A1
(en)
|
2012-09-10 |
2014-03-13 |
Antec Leyden B.V. |
Electrochemical reduction of disulfide bonds in proteinaceous substances and electrochemical cell for carrying out such reduction
|
|
WO2014047199A1
(en)
|
2012-09-19 |
2014-03-27 |
The Research Foundation For The State University Of New York |
Novel prodrugs for selective anticancer therapy
|
|
BR112015007144A2
(pt)
|
2012-10-04 |
2017-12-12 |
Ab Science |
uso de masitinib para o tratamento de câncer em subpopulações de paciente identificadas usando fatores prognosticadores
|
|
WO2014058317A1
(en)
|
2012-10-10 |
2014-04-17 |
Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis |
Methods and means for predicting resistance to anti-cancer treatment
|
|
CN103775148A
(zh)
|
2012-10-22 |
2014-05-07 |
张玉良 |
自冷式热力做功方法
|
|
JP6855661B2
(ja)
|
2012-10-23 |
2021-04-07 |
シンアフィックス ビー.ブイ. |
修飾抗体、抗体コンジュゲート及びそれらを調製する方法
|
|
RU2618523C2
(ru)
|
2012-11-05 |
2017-05-04 |
Пфайзер Инк. |
Аналоги сплицеостатина
|
|
EP2922818B1
(en)
|
2012-11-24 |
2018-09-05 |
Hangzhou Dac Biotech Co., Ltd |
Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
|
|
CA2892817A1
(en)
|
2012-12-03 |
2014-06-12 |
Calithera Biosciences Inc. |
Treatment of cancer with heterocyclic inhibitors of glutaminase
|
|
TW201425336A
(zh)
*
|
2012-12-07 |
2014-07-01 |
Amgen Inc |
Bcma抗原結合蛋白質
|
|
US9243058B2
(en)
|
2012-12-07 |
2016-01-26 |
Amgen, Inc. |
BCMA antigen binding proteins
|
|
US10226535B2
(en)
|
2012-12-10 |
2019-03-12 |
Mersana Therapeutics, Inc. |
Auristatin compounds and conjugates thereof
|
|
EP2928504B1
(en)
|
2012-12-10 |
2019-02-20 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
US9872918B2
(en)
|
2012-12-12 |
2018-01-23 |
Mersana Therapeutics, Inc. |
Hydroxyl-polymer-drug-protein conjugates
|
|
EP2934596A1
(en)
|
2012-12-21 |
2015-10-28 |
Glykos Finland Oy |
Linker-payload molecule conjugates
|
|
US20150182634A1
(en)
|
2012-12-28 |
2015-07-02 |
Cody P. Coyne |
Molecular Design and Chemical Synthesis of Pharmaceutical-Ligands and Pharmaceutical-Pharmaceutical Analogs with Multiple Mechanisms of Action
|
|
EP2945631A4
(en)
|
2013-01-19 |
2016-06-29 |
Univ New York |
OLIGOOXOPIPERAZINE FOR THE REACTIVATION OF P53
|
|
US20140205681A1
(en)
|
2013-01-19 |
2014-07-24 |
New York University |
HYDROGEN-BOND SURROGATE PEPTIDES AND PEPTIDOMIMETICS FOR p53 REACTIVATION
|
|
US20140220110A1
(en)
|
2013-02-01 |
2014-08-07 |
Zoneone Pharma, Inc. |
Remote loading of sparingly water-soluble drugs into liposomes
|
|
WO2014121235A2
(en)
|
2013-02-01 |
2014-08-07 |
Zoneone Pharma, Inc. |
Transformation of drug cyclodextrin complex compositions into compositions of mixtures of lipid vesicle encapsulated drug and cyclodextrin drug complexes
|
|
WO2014124329A1
(en)
|
2013-02-08 |
2014-08-14 |
University Of Louisville Research Foundation, Inc. |
Nanoparticles for drug delivery
|
|
US9333211B2
(en)
|
2013-02-22 |
2016-05-10 |
University Of Houston System |
Phosphaplatin mediated modulation of pigment epithelial derived factor and uses thereof
|
|
WO2015073072A1
(en)
|
2013-11-15 |
2015-05-21 |
Oncoceutics, Inc. |
7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one
|
|
US9376437B2
(en)
|
2013-03-13 |
2016-06-28 |
Oncoceutics, Inc |
7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
|
|
JP6444902B2
(ja)
*
|
2013-03-13 |
2018-12-26 |
メドイミューン・リミテッドMedImmune Limited |
ピロロベンゾジアゼピン及びその結合体
|
|
ES2734568T3
(es)
|
2013-03-13 |
2019-12-10 |
Oncoceutics Inc |
7-Bencil-10-(2-metilbencil)-2,6,7,8,9,10-hexahidroimidazo[1,2-a]pirido[4,3-d]pirimidin-5(3H)-ona para su uso en el tratamiento de cáncer
|
|
US20140271923A1
(en)
|
2013-03-14 |
2014-09-18 |
Christopher Brian Reid |
Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions
|
|
WO2014160360A1
(en)
|
2013-03-14 |
2014-10-02 |
Mersana Therapeutics Inc. |
Tubulysin compounds and conjugates thereof
|
|
CN110420329A
(zh)
|
2013-03-14 |
2019-11-08 |
佛罗里达大学研究基金会 |
利用天然化合物和/或饮食调控癌症
|
|
MX368258B
(es)
|
2013-03-15 |
2019-09-25 |
Zymeworks Inc |
Compuestos citotoxicos y antimitoticos y metodos de uso de los mismos.
|
|
US9295731B2
(en)
|
2013-04-01 |
2016-03-29 |
Mark Quang Nguyen |
Cleavable drug conjugates, compositions thereof and methods of use
|
|
US10233219B2
(en)
|
2013-04-12 |
2019-03-19 |
Tufts Medical Center |
Methods and systems for designing and/or characterizing soluble lipidated ligand agents
|
|
EP2988786A4
(en)
|
2013-04-22 |
2016-12-21 |
Avelas Biosciences Inc |
COMPOSITIONS FOR SELECTIVE DRUG ADMINISTRATION AND METHOD OF USE
|
|
GB2513405A
(en)
|
2013-04-26 |
2014-10-29 |
Adc Biotechnology Ltd |
Method of synthesising ADCs using affinity resins
|
|
PL2991683T3
(pl)
|
2013-05-02 |
2020-03-31 |
Glykos Finland Oy |
Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem
|
|
CA2909209A1
(en)
|
2013-05-15 |
2014-11-20 |
Alphora Research Inc. |
3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof
|
|
GB201309807D0
(en)
|
2013-05-31 |
2013-07-17 |
Pharma Mar Sau |
Antibody drug conjugates
|
|
WO2014197871A2
(en)
|
2013-06-06 |
2014-12-11 |
Igenica Biotherapeutics, Inc. |
Antibody-drug conjugates, compositions and methods of use
|
|
US11229711B2
(en)
|
2013-06-06 |
2022-01-25 |
Magenta Therapeutics, Inc. |
Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
|
|
WO2014202773A1
(en)
|
2013-06-20 |
2014-12-24 |
Innate Pharma |
Enzymatic conjugation of polypeptides
|
|
KR20160042871A
(ko)
|
2013-06-21 |
2016-04-20 |
이나뜨 파르마, 에스.아. |
폴리펩티드의 효소적 콘쥬게이션
|
|
WO2014206466A1
(en)
|
2013-06-26 |
2014-12-31 |
Afg Technologies S.À.R.L |
Screening, diagnosis, prognostication and treatment of ovarian cancer
|
|
JP6511613B2
(ja)
|
2013-07-03 |
2019-05-15 |
サンド・アクチエンゲゼルシヤフト |
ハリコンドリンBの大環状C1−ケト類似体の製造のための合成方法及び該方法に有用な中間体、例えば−SO2−(p−トリル)基を含有する中間体
|
|
WO2015017729A1
(en)
|
2013-07-31 |
2015-02-05 |
Virginia Tech Intellectual Properties, Inc. |
Dielectrophoresis methods for determining a property of a plurality of cancer cells
|
|
US20160166637A1
(en)
|
2013-08-02 |
2016-06-16 |
Virginia Tech Intellectual Properties, Inc. |
Methods of treating a cancer through targeted disruption of alpha connexin 43-zonula occludens-1 (zo-1) interaction
|
|
AU2014312190A1
(en)
|
2013-08-28 |
2016-02-18 |
Bioasis Technologies Inc. |
CNS-targeted conjugates of antibodies
|
|
PE20160674A1
(es)
|
2013-08-28 |
2016-07-21 |
Stemcentrx Inc |
Metodos de conjugacion de anticuerpos especificos de sitio y composiciones
|
|
EP3338793A1
(en)
|
2013-08-28 |
2018-06-27 |
AbbVie Stemcentrx LLC |
Novel sez6 modulators and methods of use
|
|
AU2014317843A1
(en)
|
2013-09-09 |
2016-03-24 |
British Columbia Cancer Agency Branch |
Methods and kits for predicting outcome and methods and kits for treating breast cancer with radiation therapy
|
|
WO2015038426A1
(en)
|
2013-09-13 |
2015-03-19 |
Asana Biosciences, Llc |
Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof
|
|
US20150093331A1
(en)
|
2013-10-01 |
2015-04-02 |
OncoLock Co., Ltd. |
Biomarkers for breast cancer
|
|
US9878049B2
(en)
|
2013-10-09 |
2018-01-30 |
The University Of Akron |
High drug loading system to co-deliver anticancer drugs and nucleic acids for cancer therapy
|
|
US9765142B2
(en)
|
2013-10-11 |
2017-09-19 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
TEM8 antibodies and their use in treatment and detection of tumors
|
|
ES2726850T3
(es)
|
2013-10-11 |
2019-10-09 |
Mersana Therapeutics Inc |
Conjugados de proteína-polímero-fármaco
|
|
PL3054992T3
(pl)
|
2013-10-11 |
2020-01-31 |
Asana Biosciences, Llc |
Koniugaty białko-polimer-lek
|
|
JP6684706B2
(ja)
|
2013-10-21 |
2020-04-22 |
ヘモシアー・リミテッド・ライアビリティ・カンパニーHemoShear, LLC |
腫瘍微細環境のための試験管内モデル
|
|
HUE049387T2
(hu)
|
2013-11-04 |
2020-09-28 |
Eisai R&D Man Co Ltd |
A halichondrin B analógjainak szintézisében hasznos makrociklizációs reakciók és köztitermékek
|
|
US9457019B2
(en)
|
2013-11-07 |
2016-10-04 |
Deciphera Pharmaceuticals, Llc |
Methods for inhibiting tie-2 kinase useful in the treatment of cancer
|
|
JP6568093B2
(ja)
|
2013-11-07 |
2019-08-28 |
デシフェラ ファーマシューティカルズ,エルエルシー |
ガンの処置に有用なtie2キナーゼの阻害方法
|
|
CN106163524B
(zh)
|
2013-11-15 |
2019-11-08 |
昂克希尔迪克斯有限公司 |
7-苄基-4-(2-甲基苄基)-2,4,6,7,8,9-六氢咪唑并[1,2-a]吡啶并[3,4-e]嘧啶-5(1H)-酮、其盐及应用方法
|
|
JP6745218B2
(ja)
|
2013-11-27 |
2020-08-26 |
レッドウッド バイオサイエンス, インコーポレイテッド |
ヒドラジニル−ピロロ化合物及び複合体を生成するための方法
|
|
SG11201604545XA
(en)
|
2013-12-06 |
2016-07-28 |
Eisai R&D Man Co Ltd |
Methods useful in the synthesis of halichondrin b analogs
|
|
US20170020817A1
(en)
|
2013-12-19 |
2017-01-26 |
Luminus Biosciences, Inc. |
Solid nanoparticle formulation of microtuble inhibitors with reduced ostwald repening for oral administration
|
|
CA2936377A1
(en)
|
2014-01-10 |
2015-07-16 |
Shanghai Birdie Biotech, Inc. |
Compounds and compositions for treating egfr expressing tumors
|
|
US20160375234A1
(en)
|
2014-01-10 |
2016-12-29 |
Atossa Genetic Inc. |
Transpapillary methods and compositions for diagnosing and treating breast conditions
|
|
WO2015106164A1
(en)
|
2014-01-10 |
2015-07-16 |
Rgenix, Inc. |
Lxr agonists and uses thereof
|
|
CN104784699B
(zh)
|
2014-01-20 |
2019-05-03 |
博瑞生物医药(苏州)股份有限公司 |
叶酸受体结合配体-药物偶联物
|
|
JP5957637B2
(ja)
*
|
2014-02-03 |
2016-07-27 |
国立研究開発法人国立がん研究センター |
抗TissueFactorモノクローナル抗体
|
|
CA2938574C
(en)
|
2014-02-03 |
2019-04-02 |
Eidgenoessische Technische Hochschule Zurich |
Low molecular weight drug conjugates for binding to carbonic anhydrase ix
|
|
EP2913064A1
(en)
|
2014-02-26 |
2015-09-02 |
celares GmbH |
Branched drug-linker conjugates for the coupling to biological targeting molecules
|
|
TW201617326A
(zh)
|
2014-03-06 |
2016-05-16 |
Alphora研發股份有限公司 |
(s)-1-((2r,3r,4s,5s)-5-烯丙-3-甲氧-4-(對甲苯磺醯甲基)四氫呋喃-2-基)-3-氨基丙-2-醇之結晶衍生物
|
|
WO2015136017A1
(en)
|
2014-03-13 |
2015-09-17 |
F. Hoffmann-La Roche Ag |
Methods and compositions for modulating estrogen receptor mutants
|
|
US9260478B2
(en)
*
|
2014-04-04 |
2016-02-16 |
Shanghui Hu |
Potent and efficient cytotoxic peptides and antibody-drug conjugates thereof and their synthesis
|
|
AU2015243537B2
(en)
|
2014-04-08 |
2020-10-22 |
The Methodist Hospital |
INOS-inhibitory compositions and their use as breast cancer therapeutics
|
|
AU2015247806A1
(en)
|
2014-04-14 |
2016-10-27 |
Endocyte, Inc. |
Drug delivery conjugates for treating resistant cancer and for use in combination therapy
|
|
WO2015161247A1
(en)
*
|
2014-04-17 |
2015-10-22 |
Igenica Biotherapeutics, Inc. |
Humanized anti-c16orf54 antibodies and methods of use thereof
|
|
PL3134125T3
(pl)
*
|
2014-04-25 |
2020-04-30 |
Pierre Fabre Médicament |
Koniugat przeciwciało-lek i jego zastosowanie do leczenia raka
|
|
KR101628872B1
(ko)
*
|
2014-05-28 |
2016-06-09 |
주식회사 레고켐 바이오사이언스 |
자가-희생 기를 포함하는 화합물
|
|
TWI695011B
(zh)
*
|
2014-06-18 |
2020-06-01 |
美商梅爾莎納醫療公司 |
抗her2表位之單株抗體及其使用之方法
|
|
WO2015195925A1
(en)
*
|
2014-06-18 |
2015-12-23 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates and methods of using same
|
|
WO2016008112A1
(en)
*
|
2014-07-16 |
2016-01-21 |
Medshine Discovery Inc. |
Linkers and application towards adc thereof
|
|
EP3069734A1
(en)
*
|
2015-03-17 |
2016-09-21 |
Exiris S.r.l. |
Cryptophycin-based antibody-drug conjugates with novel self-immolative linkers
|
|
US10975112B2
(en)
*
|
2015-06-16 |
2021-04-13 |
Hangzhou Dac Biotech Co., Ltd. |
Linkers for conjugation of cell-binding molecules
|
|
CN116726190A
(zh)
|
2015-06-20 |
2023-09-12 |
杭州多禧生物科技有限公司 |
澳瑞他汀类似物及其与细胞结合分子的共轭偶联物
|