|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4880935A
(en)
|
1986-07-11 |
1989-11-14 |
Icrf (Patents) Limited |
Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
|
|
US4880078A
(en)
|
1987-06-29 |
1989-11-14 |
Honda Giken Kogyo Kabushiki Kaisha |
Exhaust muffler
|
|
FI102355B1
(fi)
|
1988-02-11 |
1998-11-30 |
Bristol Myers Squibb Co |
Menetelmä yhdistävän välikappaleen omaavien antrasykliini-immunokonjugaattien valmistamiseksi
|
|
ES2052027T5
(es)
|
1988-11-11 |
2005-04-16 |
Medical Research Council |
Clonacion de secuencias de dominio variable de inmunoglobulina.
|
|
ATE221379T1
(de)
|
1991-05-01 |
2002-08-15 |
Jackson H M Found Military Med |
Verfahren zur behandlung infektiöser respiratorischer erkrankungen
|
|
ATE255131T1
(de)
|
1991-06-14 |
2003-12-15 |
Genentech Inc |
Humanisierter heregulin antikörper
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
|
EP0871490B1
(en)
|
1995-12-22 |
2003-03-19 |
Bristol-Myers Squibb Company |
Branched hydrazone linkers
|
|
AU2063197A
(en)
|
1996-03-04 |
1997-09-22 |
Massachusetts Institute Of Technology |
Materials and methods for enhancing cellular internalization
|
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
|
ES2236832T3
(es)
|
1997-01-16 |
2005-07-16 |
Massachusetts Institute Of Technology |
Preparacion de particulas para inhalacion.
|
|
CA2336139C
(en)
|
1998-06-24 |
2008-10-14 |
Advanced Inhalation Research, Inc. |
Large porous particles emitted from an inhaler
|
|
US6019963A
(en)
|
1998-11-20 |
2000-02-01 |
D.S.C. Products, Inc. |
Deodorizing composition containing tea tree and eucalyptus oils
|
|
US7109019B2
(en)
|
1999-01-06 |
2006-09-19 |
The Regents Of The University Of California |
Gene cluster for production of the enediyne antitumor antibiotic C-1027
|
|
PL367102A1
(en)
|
2001-05-02 |
2005-02-21 |
Purdue Research Foundation |
Treatment and diagnosis of macrophage mediated disease
|
|
US7439043B2
(en)
|
2001-10-10 |
2008-10-21 |
Neose Technologies, Inc. |
Galactosyl nucleotide sugars
|
|
US7265085B2
(en)
|
2001-10-10 |
2007-09-04 |
Neose Technologies, Inc. |
Glycoconjugation methods and proteins/peptides produced by the methods
|
|
US7297511B2
(en)
|
2001-10-10 |
2007-11-20 |
Neose Technologies, Inc. |
Interferon alpha: remodeling and glycoconjugation of interferon alpha
|
|
US7226903B2
(en)
|
2001-10-10 |
2007-06-05 |
Neose Technologies, Inc. |
Interferon beta: remodeling and glycoconjugation of interferon beta
|
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
US7265084B2
(en)
|
2001-10-10 |
2007-09-04 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7179617B2
(en)
|
2001-10-10 |
2007-02-20 |
Neose Technologies, Inc. |
Factor IX: remolding and glycoconjugation of Factor IX
|
|
US7795210B2
(en)
|
2001-10-10 |
2010-09-14 |
Novo Nordisk A/S |
Protein remodeling methods and proteins/peptides produced by the methods
|
|
US7696163B2
(en)
|
2001-10-10 |
2010-04-13 |
Novo Nordisk A/S |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7399613B2
(en)
|
2001-10-10 |
2008-07-15 |
Neose Technologies, Inc. |
Sialic acid nucleotide sugars
|
|
US7125843B2
(en)
|
2001-10-19 |
2006-10-24 |
Neose Technologies, Inc. |
Glycoconjugates including more than one peptide
|
|
US8008252B2
(en)
|
2001-10-10 |
2011-08-30 |
Novo Nordisk A/S |
Factor VII: remodeling and glycoconjugation of Factor VII
|
|
AU2003224644A1
(en)
|
2002-02-27 |
2003-09-09 |
The Government Of The United States Of America, Represented By The Secretary, Department Of Healtan |
Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
|
|
ES2544527T3
(es)
*
|
2002-07-31 |
2015-09-01 |
Seattle Genetics, Inc. |
Conjugados de fármacos y su uso para tratar el cáncer, una enfermedad autoinmune o una enfermedad infecciosa
|
|
JP2004119755A
(ja)
|
2002-09-27 |
2004-04-15 |
Alps Electric Co Ltd |
磁気検出素子及びその製造方法
|
|
US20040071540A1
(en)
|
2002-10-15 |
2004-04-15 |
Lucas Philip J. |
Disposable/recyclable pallet system and method
|
|
US20080025989A1
(en)
|
2003-02-20 |
2008-01-31 |
Seattle Genetics, Inc. |
Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
|
|
NZ542586A
(en)
|
2003-04-09 |
2009-11-27 |
Biogenerix Ag |
Method of forming a covalent conjugate between a G-CSF peptide and PEG
|
|
AU2004273910A1
(en)
|
2003-09-18 |
2005-03-31 |
Combinatorx, Incorporated |
Combinations of drugs for the treatment of neoplasms
|
|
US6997024B2
(en)
|
2003-10-01 |
2006-02-14 |
Truth Hardware Corporation |
Pull door lock
|
|
US8012944B2
(en)
|
2003-10-30 |
2011-09-06 |
Pharmascience Inc. |
Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
|
|
US20050148535A1
(en)
|
2003-10-30 |
2005-07-07 |
Lacasse Eric |
IAP nucleobase oligomers and oligomeric complexes and uses thereof
|
|
EP1716179A2
(en)
|
2004-02-12 |
2006-11-02 |
Morphotek, Inc. |
Monoclonal antibodies that specifically bind to folate receptor alpha
|
|
US7117807B2
(en)
|
2004-02-17 |
2006-10-10 |
University Of Florida Research Foundation, Inc. |
Dynamically modifiable polymer coatings and devices
|
|
WO2006073419A2
(en)
|
2004-04-01 |
2006-07-13 |
Gang Zheng |
Lipoprotein nanoplatforms
|
|
EP1773389A4
(en)
|
2004-05-07 |
2008-09-10 |
Massachusetts Inst Technology |
METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER RELATING TO THE RECOGNITION OF THE BACH1 PHOSPHORYLE BRCA1 BRCT DOMAIN
|
|
PL2522663T3
(pl)
|
2004-06-03 |
2015-08-31 |
Eisai R&D Man Co Ltd |
Produkty pośrednie do otrzymywania halichondryny B
|
|
ES2579805T3
(es)
|
2004-09-23 |
2016-08-16 |
Genentech, Inc. |
Anticuerpos y conjugados modificados por ingeniería genética con cisteína
|
|
JO3000B1
(ar)
*
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
EP1831697A4
(en)
|
2004-12-09 |
2011-01-26 |
Eisai R&D Man Co Ltd |
SEARCH FOR TUBULINISOTYPES IN CANCER THERAPY USING HALICHONDRIN B ANALOG
|
|
EP1828776A4
(en)
|
2004-12-09 |
2010-03-17 |
Eisai R&D Man Co Ltd |
TUBULINISOTYPE SEARCH IN CANCER THERAPY WITH HEMIASTERLINANALOGES
|
|
JP5171621B2
(ja)
|
2005-07-07 |
2013-03-27 |
シアトル ジェネティックス， インコーポレイテッド |
フェニルアラニン側鎖修飾をｃ末端に有するモノメチルバリン化合物
|
|
WO2007008848A2
(en)
|
2005-07-07 |
2007-01-18 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
|
|
GB0515025D0
(en)
|
2005-07-21 |
2005-08-31 |
Novartis Ag |
Organic compounds
|
|
EP2374480A3
(en)
|
2005-08-19 |
2013-05-01 |
Endocyte, Inc. |
Mutli-drug ligand conjugates
|
|
AU2006290567A1
(en)
|
2005-09-14 |
2007-03-22 |
Ucb Pharma S.A |
Comb polymers
|
|
US8293726B2
(en)
|
2005-12-02 |
2012-10-23 |
Vianova Labs, Inc. |
Treatment of cancer and other diseases
|
|
US7901885B2
(en)
|
2006-05-09 |
2011-03-08 |
Dsm Ip Assets B.V. |
Genes and markers in type 2 diabetes and obesity
|
|
US20150030534A1
(en)
|
2013-07-26 |
2015-01-29 |
Rutgers, The State University Of New Jersey |
Antibody cocktails for breast cancer radioimmunotherapy
|
|
US20140037539A1
(en)
|
2012-07-27 |
2014-02-06 |
Rutgers, The State University Of New Jersey |
Antibody cocktails for breast cancer radioimmunotherapy
|
|
US8398956B2
(en)
|
2007-01-11 |
2013-03-19 |
Immunomedics, Inc. |
In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
|
|
US20100104626A1
(en)
|
2007-02-16 |
2010-04-29 |
Endocyte, Inc. |
Methods and compositions for treating and diagnosing kidney disease
|
|
NZ580132A
(en)
|
2007-03-14 |
2012-11-30 |
Endocyte Inc |
Binding ligand linked drug delivery conjugates of tubulysins to vitamins
|
|
EP1977765A1
(en)
|
2007-04-03 |
2008-10-08 |
Diatos |
Peptide prodrugs
|
|
CN108948039B
(zh)
|
2007-10-03 |
2021-12-31 |
卫材R&D管理有限公司 |
用于合成软海绵素b类似物的中间体和方法
|
|
AU2008312457B2
(en)
*
|
2007-10-19 |
2014-04-17 |
Genentech, Inc. |
Cysteine engineered anti-TENB2 antibodies and antibody drug conjugates
|
|
CN101884058B
(zh)
|
2007-10-30 |
2012-07-25 |
富士通株式会社 |
移动终端装置
|
|
EP2265283B1
(en)
|
2008-03-18 |
2014-09-03 |
Seattle Genetics, Inc. |
Auristatin drug linker conjugates
|
|
US8741861B2
(en)
|
2008-03-27 |
2014-06-03 |
Vascular Biosciences |
Methods of novel therapeutic candidate identification through gene expression analysis in vascular-related diseases
|
|
JP5646457B2
(ja)
|
2008-04-29 |
2014-12-24 |
アッヴィ・インコーポレイテッド |
二重可変ドメイン免疫グロブリン及びその使用
|
|
US20100260668A1
(en)
|
2008-04-29 |
2010-10-14 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
|
RU2487877C2
(ru)
*
|
2008-04-30 |
2013-07-20 |
Иммьюноджен, Инк. |
Высокоэффективные конъюгаты и гидрофильные сшивающие агенты (линкеры)
|
|
EP3002299A1
(en)
|
2008-06-03 |
2016-04-06 |
AbbVie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
PE20100054A1
(es)
|
2008-06-03 |
2010-03-03 |
Abbott Lab |
Inmunoglobulina con dominio variable dual
|
|
MX2010014574A
(es)
|
2008-07-08 |
2011-04-27 |
Abbott Lab |
Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas.
|
|
EA018420B1
(ru)
|
2008-09-12 |
2013-07-30 |
Сантен Фармасьютикал Ко., Лтд. |
Агонист глюкокортикоидного рецептора, содержащий новые производные 1,2,3,4-тетрагидрохиноксалина с фенильной группой, имеющей структуру эфира сульфоновой кислоты, введенной в нее в качестве заместителя
|
|
US20100233079A1
(en)
|
2008-12-04 |
2010-09-16 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
|
TW201613969A
(en)
|
2009-03-05 |
2016-04-16 |
Abbvie Inc |
IL-17 binding proteins
|
|
US20140339088A1
(en)
|
2009-03-09 |
2014-11-20 |
Virginia Tech Intellectual Properties, Inc. |
Dielectrophoresis methods for determining a property of a plurality of cancer cells
|
|
CN102459347A
(zh)
|
2009-05-01 |
2012-05-16 |
雅培制药有限公司 |
双重可变结构域免疫球蛋白及其用途
|
|
US8686520B2
(en)
*
|
2009-05-29 |
2014-04-01 |
International Business Machines Corporation |
Spin-torque magnetoresistive structures
|
|
TW201109438A
(en)
|
2009-07-29 |
2011-03-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
MX336476B
(es)
*
|
2009-08-15 |
2016-01-20 |
Genentech Inc |
Terapia anti-angiogenesis para el tratamiento de cancer de mama previamente tratado.
|
|
AR078254A1
(es)
*
|
2009-09-01 |
2011-10-26 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
GB0917044D0
(en)
|
2009-09-29 |
2009-11-18 |
Cytoguide As |
Agents, uses and methods
|
|
MX2012004415A
(es)
|
2009-10-15 |
2012-05-08 |
Abbott Lab |
Inmunoglobulinas de dominio variable doble y usos de las mismas.
|
|
UY32979A
(es)
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
ES2633317T3
(es)
|
2009-11-06 |
2017-09-20 |
Plexxikon, Inc. |
Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
|
|
CN102803254B
(zh)
|
2010-01-26 |
2016-09-14 |
卫材R&D管理有限公司 |
用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物
|
|
US8710035B2
(en)
|
2010-03-24 |
2014-04-29 |
The University Of Chicago |
Methods and compositions related to glucocorticoid receptor antagonists and breast cancer
|
|
CN103037690B
(zh)
|
2010-03-24 |
2016-04-27 |
俄亥俄州立大学 |
用于葡萄糖转运抑制的组合物和方法
|
|
AU2011252883B2
(en)
|
2010-05-14 |
2015-09-10 |
Abbvie Inc. |
IL-1 binding proteins
|
|
SMT201700547T1
(it)
|
2010-06-15 |
2018-01-11 |
Genmab As |
Coniugati di farmaco anticorpo umano contro il fattore tissutale
|
|
UY33492A
(es)
|
2010-07-09 |
2012-01-31 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
US8735546B2
(en)
|
2010-08-03 |
2014-05-27 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
PH12013500337A1
(en)
|
2010-08-26 |
2017-08-23 |
Abbvie Inc |
Dual variable domain immunoglobulins and uses thereof
|
|
US9089570B2
(en)
|
2010-09-03 |
2015-07-28 |
Tactical Therapeutics Inc |
Compositions for treating cancers having acquired resitance to prior chemotherapeutic and targeted drugs using carboxyamidotriazole orotate
|
|
US9192677B2
(en)
|
2010-09-07 |
2015-11-24 |
Johannes Kepler Universität Linz |
Biodegradable, water soluble and pH responsive poly(organo)phosphazenes
|
|
WO2012065057A2
(en)
|
2010-11-12 |
2012-05-18 |
Exelixis, Inc. |
Phosphatidylinositol 3-kinase inhibitors and methods of their use
|
|
WO2012065019A2
(en)
|
2010-11-12 |
2012-05-18 |
Exelixis, Inc. |
Pyridopyrimidinone inhibitors of p13k alpha
|
|
CN103221072A
(zh)
|
2010-12-02 |
2013-07-24 |
免疫医疗公司 |
用于递送治疗剂和/或诊断剂的体内无铜催化的点击化学
|
|
WO2012121775A2
(en)
|
2010-12-21 |
2012-09-13 |
Abbott Laboratories |
Dual variable domain immunoglobulins and uses thereof
|
|
WO2012088290A2
(en)
|
2010-12-22 |
2012-06-28 |
Abbott Laboratories |
Tri-variable domain binding proteins and uses thereof
|
|
UY33827A
(es)
|
2010-12-22 |
2012-07-31 |
Abbott Lab |
Proteínas de unión a media-inmunoglobulina y sus usos
|
|
US20140024539A1
(en)
|
2011-02-02 |
2014-01-23 |
Translational Genomics Research Institute |
Biomarkers and methods of use thereof
|
|
EP3527222B1
(en)
|
2011-02-15 |
2021-04-07 |
Vaxiion Therapeutics, LLC |
Therapeutic compositions and methods for antibody and fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells
|
|
US9597340B2
(en)
|
2011-02-25 |
2017-03-21 |
Arena Pharmaceuticals, Inc. |
Cannabinoid receptor modulators
|
|
EP2680839A1
(en)
|
2011-03-02 |
2014-01-08 |
Morphotek, Inc. |
Co -administration of eribulin and farletuzumab for the treatment of breast cancer
|
|
WO2012118978A1
(en)
|
2011-03-03 |
2012-09-07 |
The Regents Of The University Of Colorado, A Body Corporate |
Methods for treating oncovirus positive cancers
|
|
EP2681196B1
(en)
|
2011-03-04 |
2015-09-09 |
Life Technologies Corporation |
Compounds and methods for conjugation of biomolecules
|
|
US9066963B2
(en)
|
2011-03-15 |
2015-06-30 |
The University Of North Carolina At Chapel Hill |
Methods of treating breast cancer with anthracycline therapy
|
|
WO2012129100A1
(en)
|
2011-03-18 |
2012-09-27 |
Eisai R&D Management Co., Ltd. |
Methods and compositions for predicting response to eribulin
|
|
EP2508525A1
(en)
|
2011-04-05 |
2012-10-10 |
Bayer Pharma Aktiengesellschaft |
Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
|
|
US9132131B2
(en)
|
2011-04-21 |
2015-09-15 |
Saint Louis University |
Use of adenosine A3 receptor agonists for treatment of neuropathic pain
|
|
CN103717595A
(zh)
|
2011-05-27 |
2014-04-09 |
Ambrx公司 |
含有非天然氨基酸连接的海兔毒素衍生物的组合物、涉及该海兔毒素衍生物的方法及其用途
|
|
EP2714685B1
(en)
|
2011-05-27 |
2016-10-19 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
|
|
WO2012170640A1
(en)
|
2011-06-07 |
2012-12-13 |
The Trustees Of Columbia University In The City Of New York |
Methods and compositions for trail-drug combination therapy
|
|
CA2837840C
(en)
|
2011-06-10 |
2020-08-04 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
US8815226B2
(en)
|
2011-06-10 |
2014-08-26 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
AU2012294673B2
(en)
|
2011-08-05 |
2015-11-26 |
Bioasis Technologies Inc. |
p97 fragments with transfer activity
|
|
CA2857385A1
(en)
|
2011-11-30 |
2013-06-06 |
Alphora Research Inc. |
Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene
|
|
US9174956B2
(en)
|
2011-12-16 |
2015-11-03 |
Alphora Research Inc. |
Process for preparation of 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof
|
|
EP3539982B1
(en)
|
2011-12-23 |
2025-02-19 |
Pfizer Inc. |
Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
|
|
AU2012356894B2
(en)
|
2011-12-23 |
2018-01-18 |
Araris Biotech Ltd. |
Enzymatic conjugation of polypeptides
|
|
JP6300030B2
(ja)
|
2011-12-29 |
2018-03-28 |
サンド アクツィエンゲゼルシャフト |
２−（（２ｓ，３ｓ，４ｒ，５ｒ）−５−（（ｓ）−３−アミノ−２−ヒドロキシプロプ−１−イル）−４−メトキシ−３−（フェニルスルホニルメチル）テトラヒドロフラン−２−イル）アセトアルデヒド誘導体およびこれらを調製するためのプロセス
|
|
AR092790A1
(es)
|
2012-02-01 |
2015-05-06 |
Euro Celtique Sa |
Derivados bencimidazolicos del acido hidroxamico
|
|
WO2013130093A1
(en)
|
2012-03-02 |
2013-09-06 |
Genentech, Inc. |
Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
|
|
AU2013201584A1
(en)
|
2012-03-12 |
2013-09-26 |
Merrimack Pharmaceuticals, Inc. |
Methods for treating pancreatic cancer using combination therapies comprising an anti-ErbB3 antibody
|
|
US9358235B2
(en)
|
2012-03-19 |
2016-06-07 |
Plexxikon Inc. |
Kinase modulation, and indications therefor
|
|
KR20190134832A
(ko)
|
2012-03-29 |
2019-12-04 |
알토 바이오사이언스 코포레이션 |
종양 형성 치료방법
|
|
US9278979B2
(en)
|
2012-03-30 |
2016-03-08 |
Alphora Research Inc. |
Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein
|
|
EP2833915A1
(en)
|
2012-04-02 |
2015-02-11 |
Merrimack Pharmaceuticals, Inc. |
Dosage and administration of monospecific and bispecific anti-igf-1r and anti-erbb3 antibodies
|
|
WO2013172955A1
(en)
|
2012-05-15 |
2013-11-21 |
Diatech Oncology |
Tumor cell isolation/purification process and methods for use thereof
|
|
EP3925627A1
(en)
|
2012-05-15 |
2021-12-22 |
Concortis Biosystems, Corp |
Drug-conjugates and uses thereof
|
|
MX363116B
(es)
|
2012-06-07 |
2019-03-11 |
Ambrx Inc |
Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata.
|
|
KR101915942B1
(ko)
|
2012-06-08 |
2018-11-06 |
에프. 호프만-라 로슈 아게 |
암의 치료를 위한 포스포이노시타이드 3 키나제 억제제 화합물 및 화학치료제의 돌연변이체 선택성 및 조합물
|
|
EP4406612A3
(en)
|
2012-06-19 |
2024-10-16 |
Ambrx, Inc. |
Anti-cd70 antibody drug conjugates
|
|
US9220695B2
(en)
|
2012-06-29 |
2015-12-29 |
The Research Foundation For The State University Of New York |
Polyenolic zinc-binding agents (pezbins) actively promote inactivation of cancer stem cells and potentiate cytotoxic anti-tumor drug substances
|
|
AU2013282391A1
(en)
|
2012-06-29 |
2015-01-22 |
Nanostring Technologies, Inc. |
Methods of treating breast cancer with gemcitabine therapy
|
|
EP3210627B1
(en)
|
2012-07-12 |
2022-12-21 |
Hangzhou Dac Biotech Co., Ltd |
Conjugates of cell binding molecules with cytotoxic agents
|
|
US20140069822A1
(en)
|
2012-09-10 |
2014-03-13 |
Antec Leyden B.V. |
Electrochemical reduction of disulfide bonds in proteinaceous substances and electrochemical cell for carrying out such reduction
|
|
US9872919B2
(en)
|
2012-09-19 |
2018-01-23 |
The Research Foundation For The State University Of New York |
Prodrugs for selective anticancer therapy
|
|
KR102149483B1
(ko)
|
2012-10-04 |
2020-08-28 |
에이비 사이언스 |
예측변수 인자들을 이용하여 동정된 환자 부분 모집단에서 암 치료를 위한 마시티닙의 용도
|
|
US20150275306A1
(en)
|
2012-10-10 |
2015-10-01 |
Stichting Het Nederlands Kanker Instituut Antoni van Leeuwenhoek Ziekenhuis |
Methods and means for predicting resistance to anti-cancer treatment
|
|
WO2014063443A1
(zh)
|
2012-10-22 |
2014-05-01 |
Zhang Yuliang |
自冷式热力做功方法
|
|
ES2659270T5
(en)
|
2012-10-23 |
2026-02-11 |
Synaffix Bv |
Modified antibody, antibody-conjugate and process for the preparation thereof
|
|
ES2656298T3
(es)
|
2012-11-05 |
2018-02-26 |
Pfizer Inc. |
Análogos de ayustoestatina
|
|
AU2012395148B2
(en)
|
2012-11-24 |
2016-10-27 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
|
|
KR20150091389A
(ko)
|
2012-12-03 |
2015-08-10 |
칼리테라 바이오사이언시즈 인코포레이티드 |
글루타미나제의 헤테로사이클릭 억제제에 의한 암 치료
|
|
US9243058B2
(en)
|
2012-12-07 |
2016-01-26 |
Amgen, Inc. |
BCMA antigen binding proteins
|
|
TW201425336A
(zh)
*
|
2012-12-07 |
2014-07-01 |
Amgen Inc |
Ｂｃｍａ抗原結合蛋白質
|
|
WO2014093379A1
(en)
|
2012-12-10 |
2014-06-19 |
Mersana Therapeutics, Inc. |
Auristatin compounds and conjugates thereof
|
|
CA2892863C
(en)
|
2012-12-10 |
2022-03-15 |
Mersana Therapeutics, Inc. |
Polymeric scaffold based on phf for targeted drug delivery
|
|
EP2931316B1
(en)
|
2012-12-12 |
2019-02-20 |
Mersana Therapeutics, Inc. |
Hydroxyl-polymer-drug-protein conjugates
|
|
US20150314007A1
(en)
|
2012-12-21 |
2015-11-05 |
Glykos Finland Oy |
Linker-payload molecule conjugates
|
|
US20150182634A1
(en)
|
2012-12-28 |
2015-07-02 |
Cody P. Coyne |
Molecular Design and Chemical Synthesis of Pharmaceutical-Ligands and Pharmaceutical-Pharmaceutical Analogs with Multiple Mechanisms of Action
|
|
CN105246481A
(zh)
|
2013-01-19 |
2016-01-13 |
纽约大学 |
用于p53再活化的低聚氧代哌嗪
|
|
US9605026B2
(en)
|
2013-01-19 |
2017-03-28 |
New York University |
Hydrogen-bond surrogate peptides and peptidomimetics for p53 reactivation
|
|
WO2014121235A2
(en)
|
2013-02-01 |
2014-08-07 |
Zoneone Pharma, Inc. |
Transformation of drug cyclodextrin complex compositions into compositions of mixtures of lipid vesicle encapsulated drug and cyclodextrin drug complexes
|
|
KR102554628B1
(ko)
|
2013-02-01 |
2023-07-12 |
존원 파마, 인코포레이티드 |
리포좀 내로 난수용성 약물의 원격 부하
|
|
WO2014124329A1
(en)
|
2013-02-08 |
2014-08-14 |
University Of Louisville Research Foundation, Inc. |
Nanoparticles for drug delivery
|
|
WO2014130776A1
(en)
|
2013-02-22 |
2014-08-28 |
University Of Houston |
Phosphaplatins as neuroprotective agents
|
|
US9376437B2
(en)
|
2013-03-13 |
2016-06-28 |
Oncoceutics, Inc |
7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
|
|
WO2015073072A1
(en)
|
2013-11-15 |
2015-05-21 |
Oncoceutics, Inc. |
7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one
|
|
CA2905181C
(en)
*
|
2013-03-13 |
2020-06-02 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof for providing targeted therapy
|
|
KR20220123335A
(ko)
|
2013-03-13 |
2022-09-06 |
온코슈틱스 인코포레이티드 |
7-벤질-10-(2-메틸벤질)-2,6,7,8,9,10-헥사하이드로이미다조[1,2-a]피리도[4,3-d]피리미딘-5(3h)-온과의 조합 치료요법
|
|
BR112015023190A2
(pt)
|
2013-03-14 |
2017-07-18 |
Univ Florida |
regulação de câncer com o uso de compostos e/ou dieta naturais
|
|
WO2014160360A1
(en)
|
2013-03-14 |
2014-10-02 |
Mersana Therapeutics Inc. |
Tubulysin compounds and conjugates thereof
|
|
US20140271923A1
(en)
|
2013-03-14 |
2014-09-18 |
Christopher Brian Reid |
Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions
|
|
US9522876B2
(en)
|
2013-03-15 |
2016-12-20 |
Zymeworks Inc. |
Cytotoxic and anti-mitotic compounds, and methods of using the same
|
|
US9295731B2
(en)
|
2013-04-01 |
2016-03-29 |
Mark Quang Nguyen |
Cleavable drug conjugates, compositions thereof and methods of use
|
|
US10233219B2
(en)
|
2013-04-12 |
2019-03-19 |
Tufts Medical Center |
Methods and systems for designing and/or characterizing soluble lipidated ligand agents
|
|
HK1222122A1
(zh)
|
2013-04-22 |
2017-06-23 |
Avelas Biosciences, Inc. |
选择性药物递送组合物及使用方法
|
|
GB2513405A
(en)
|
2013-04-26 |
2014-10-29 |
Adc Biotechnology Ltd |
Method of synthesising ADCs using affinity resins
|
|
ES2759503T3
(es)
|
2013-05-02 |
2020-05-11 |
Glykos Finland Oy |
Conjugados de una glicoproteína o un glicano con una carga útil tóxica
|
|
AU2014268086A1
(en)
|
2013-05-15 |
2015-11-05 |
Alphora Research Inc. |
3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof
|
|
GB201309807D0
(en)
|
2013-05-31 |
2013-07-17 |
Pharma Mar Sau |
Antibody drug conjugates
|
|
US20140363454A1
(en)
|
2013-06-06 |
2014-12-11 |
Igenica Biotherapeutics, Inc. |
Antibody-Drug Conjugates, Compositions and Methods of Use
|
|
WO2014197854A1
(en)
|
2013-06-06 |
2014-12-11 |
Igenica Biotherapeutics, Inc. |
Novel linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
|
|
WO2014202773A1
(en)
|
2013-06-20 |
2014-12-24 |
Innate Pharma |
Enzymatic conjugation of polypeptides
|
|
JP6744212B2
(ja)
|
2013-06-21 |
2020-08-19 |
イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． |
ポリペプチドの酵素的結合
|
|
US20160299147A1
(en)
|
2013-06-26 |
2016-10-13 |
Afg Technologies S.À.R.L. |
Screening, diagnosis, prognostication and treatment of ovarian cancer
|
|
US9850254B2
(en)
|
2013-07-03 |
2017-12-26 |
Sandoz Ag |
Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing-SO2-(p-tolyl) groups
|
|
WO2015017729A1
(en)
|
2013-07-31 |
2015-02-05 |
Virginia Tech Intellectual Properties, Inc. |
Dielectrophoresis methods for determining a property of a plurality of cancer cells
|
|
US20160166637A1
(en)
|
2013-08-02 |
2016-06-16 |
Virginia Tech Intellectual Properties, Inc. |
Methods of treating a cancer through targeted disruption of alpha connexin 43-zonula occludens-1 (zo-1) interaction
|
|
CA2922529A1
(en)
|
2013-08-28 |
2015-03-05 |
Stemcentrx, Inc. |
Novel sez6 modulators and methods of use
|
|
EP3038657A2
(en)
|
2013-08-28 |
2016-07-06 |
Bioasis Technologies Inc. |
Cns-targeted conjugates having modified fc regions and methods of use thereof
|
|
PE20160674A1
(es)
|
2013-08-28 |
2016-07-21 |
Stemcentrx Inc |
Metodos de conjugacion de anticuerpos especificos de sitio y composiciones
|
|
JP2016537010A
(ja)
|
2013-09-09 |
2016-12-01 |
ブリティッシュ コロンビア キャンサー エージェンシー ブランチ |
予後を予測するための方法及びキット、並びに、放射線照射療法を用いた乳癌の治療方法及びキット
|
|
WO2015038426A1
(en)
|
2013-09-13 |
2015-03-19 |
Asana Biosciences, Llc |
Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof
|
|
US20150093331A1
(en)
|
2013-10-01 |
2015-04-02 |
OncoLock Co., Ltd. |
Biomarkers for breast cancer
|
|
US9878049B2
(en)
|
2013-10-09 |
2018-01-30 |
The University Of Akron |
High drug loading system to co-deliver anticancer drugs and nucleic acids for cancer therapy
|
|
KR102087850B1
(ko)
|
2013-10-11 |
2020-03-12 |
메르사나 테라퓨틱스, 인코포레이티드 |
단백질-고분자-약물 접합체
|
|
KR102572149B1
(ko)
|
2013-10-11 |
2023-08-30 |
아사나 바이오사이언시스 엘엘씨 |
단백질-폴리머-약물 접합체
|
|
ES2764833T3
(es)
|
2013-10-11 |
2020-06-04 |
The United States Of America Represented By The Sec Dep Of Health And Human Services |
Anticuerpos contra TEM8 y su uso
|
|
CA2965114A1
(en)
|
2013-10-21 |
2015-04-30 |
Hemoshear, Llc |
In vitro model for a tumor microenvironment
|
|
CN105683198B
(zh)
|
2013-11-04 |
2019-03-12 |
卫材R&D管理有限公司 |
软海绵素b的类似物合成中有用的大环化反应和中间体
|
|
US9457019B2
(en)
|
2013-11-07 |
2016-10-04 |
Deciphera Pharmaceuticals, Llc |
Methods for inhibiting tie-2 kinase useful in the treatment of cancer
|
|
EP3065549A4
(en)
|
2013-11-07 |
2017-05-24 |
Deciphera Pharmaceuticals, LLC |
Methods for inhibiting tie2 kinase useful in the treatment of cancer
|
|
ES2724331T3
(es)
|
2013-11-15 |
2019-09-10 |
Oncoceutics Inc |
7-Bencil-4-(2-metilbencil)-2,4,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(1H)-ona, sales de la misma y procedimientos de uso
|
|
CN105744935B
(zh)
|
2013-11-27 |
2022-09-30 |
雷德伍德生物科技股份有限公司 |
肼基-吡咯并化合物及用于生成缀合物的方法
|
|
HUE043088T2
(hu)
|
2013-12-06 |
2019-08-28 |
Eisai R&D Man Co Ltd |
Halikondrin B analógok szintézisében alkalmazható eljárások
|
|
WO2015095784A1
(en)
|
2013-12-19 |
2015-06-25 |
Luminus Biosciences, Inc. |
Solid nanoparticle formulation of microtubule inhibitors with reduced ostwald ripening for oral administration
|
|
EP3091970B1
(en)
|
2014-01-10 |
2020-10-28 |
Rgenix, Inc. |
Lxr agonists and uses thereof
|
|
EP3092255A4
(en)
|
2014-01-10 |
2017-09-20 |
Birdie Biopharmaceuticals Inc. |
Compounds and compositions for treating egfr expressing tumors
|
|
US20160375234A1
(en)
|
2014-01-10 |
2016-12-29 |
Atossa Genetic Inc. |
Transpapillary methods and compositions for diagnosing and treating breast conditions
|
|
CN104784699B
(zh)
|
2014-01-20 |
2019-05-03 |
博瑞生物医药（苏州）股份有限公司 |
叶酸受体结合配体-药物偶联物
|
|
CA2937034A1
(en)
*
|
2014-02-03 |
2015-08-06 |
Riken |
Anti-tissue factor monoclonal antibody
|
|
CA2938574C
(en)
|
2014-02-03 |
2019-04-02 |
Eidgenoessische Technische Hochschule Zurich |
Low molecular weight drug conjugates for binding to carbonic anhydrase ix
|
|
EP2913064A1
(en)
|
2014-02-26 |
2015-09-02 |
celares GmbH |
Branched drug-linker conjugates for the coupling to biological targeting molecules
|
|
TW201617326A
(zh)
|
2014-03-06 |
2016-05-16 |
Ａｌｐｈｏｒａ研發股份有限公司 |
（ｓ）－１－（（２ｒ，３ｒ，４ｓ，５ｓ）－５－烯丙－３－甲氧－４－（對甲苯磺醯甲基）四氫呋喃－２－基）－３－氨基丙－２－醇之結晶衍生物
|
|
US9855270B2
(en)
|
2014-03-13 |
2018-01-02 |
Genentech, Inc. |
Methods and compositions for modulating estrogen receptor mutants
|
|
US9260478B2
(en)
*
|
2014-04-04 |
2016-02-16 |
Shanghui Hu |
Potent and efficient cytotoxic peptides and antibody-drug conjugates thereof and their synthesis
|
|
KR102755267B1
(ko)
|
2014-04-08 |
2025-01-15 |
더 메서디스트 하스피틀 |
iNOS-억제 조성물들 및 이들의 유방암 치료제로서의 용도
|
|
JP2017516760A
(ja)
|
2014-04-14 |
2017-06-22 |
エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． |
耐性がんを治療し、併用療法に用いるための薬物送達複合体
|
|
WO2015161247A1
(en)
*
|
2014-04-17 |
2015-10-22 |
Igenica Biotherapeutics, Inc. |
Humanized anti-c16orf54 antibodies and methods of use thereof
|
|
CN106470708B
(zh)
*
|
2014-04-25 |
2019-12-31 |
皮埃尔法布雷医药公司 |
抗体-药物-缀合物和其用于治疗癌症的用途
|
|
KR101628872B1
(ko)
*
|
2014-05-28 |
2016-06-09 |
주식회사 레고켐 바이오사이언스 |
자가-희생 기를 포함하는 화합물
|
|
TWI695011B
(zh)
*
|
2014-06-18 |
2020-06-01 |
美商梅爾莎納醫療公司 |
抗ｈｅｒ２表位之單株抗體及其使用之方法
|
|
WO2015195925A1
(en)
*
|
2014-06-18 |
2015-12-23 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates and methods of using same
|
|
WO2016008112A1
(en)
*
|
2014-07-16 |
2016-01-21 |
Medshine Discovery Inc. |
Linkers and application towards adc thereof
|
|
EP3069734A1
(en)
*
|
2015-03-17 |
2016-09-21 |
Exiris S.r.l. |
Cryptophycin-based antibody-drug conjugates with novel self-immolative linkers
|
|
US10975112B2
(en)
*
|
2015-06-16 |
2021-04-13 |
Hangzhou Dac Biotech Co., Ltd. |
Linkers for conjugation of cell-binding molecules
|
|
WO2015151079A2
(en)
|
2015-06-20 |
2015-10-08 |
Hangzhou Dac Biotech Co, Ltd |
Auristatin analogues and their conjugates with cell-binding molecules
|
|
MA45280B1
(fr)
*
|
2016-03-02 |
2021-08-31 |
Eisai R&D Man Co Ltd |
Conjugués anticorps-médicament à base d'éribuline et leurs procédés d'utilisation
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