SG10201500552PA - Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs - Google Patents
Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogsInfo
- Publication number
- SG10201500552PA SG10201500552PA SG10201500552PA SG10201500552PA SG10201500552PA SG 10201500552P A SG10201500552P A SG 10201500552PA SG 10201500552P A SG10201500552P A SG 10201500552PA SG 10201500552P A SG10201500552P A SG 10201500552PA SG 10201500552P A SG10201500552P A SG 10201500552PA
- Authority
- SG
- Singapore
- Prior art keywords
- halichondrin
- furo
- analogs
- synthesis
- derivatives useful
- Prior art date
Links
- DDNGARCZGUZLHY-UHFFFAOYSA-N 3aH-furo[3,2-b]pyran Chemical class O1C=CC=C2OC=CC21 DDNGARCZGUZLHY-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- FXNFULJVOQMBCW-VZBLNRDYSA-N halichondrin b Chemical class O([C@@H]1[C@@H](C)[C@@H]2O[C@@H]3C[C@@]4(O[C@H]5[C@@H](C)C[C@@]6(C[C@@H]([C@@H]7O[C@@H](C[C@@H]7O6)[C@@H](O)C[C@@H](O)CO)C)O[C@H]5C4)O[C@@H]3C[C@@H]2O[C@H]1C[C@@H]1C(=C)[C@H](C)C[C@@H](O1)CC[C@H]1C(=C)C[C@@H](O1)CC1)C(=O)C[C@H](O2)CC[C@H]3[C@H]2[C@H](O2)[C@@H]4O[C@@H]5C[C@@]21O[C@@H]5[C@@H]4O3 FXNFULJVOQMBCW-VZBLNRDYSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29833710P | 2010-01-26 | 2010-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201500552PA true SG10201500552PA (en) | 2015-03-30 |
Family
ID=43726543
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201500552PA SG10201500552PA (en) | 2010-01-26 | 2011-01-26 | Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs |
| SG2012053468A SG182612A1 (en) | 2010-01-26 | 2011-01-26 | Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012053468A SG182612A1 (en) | 2010-01-26 | 2011-01-26 | Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US8203010B2 (en) |
| EP (1) | EP2528914B1 (en) |
| JP (1) | JP5800834B2 (en) |
| CN (1) | CN102803254B (en) |
| BR (1) | BR112012018232B8 (en) |
| CA (1) | CA2787919C (en) |
| IL (1) | IL220913A (en) |
| MX (1) | MX2012008510A (en) |
| RU (1) | RU2579511C2 (en) |
| SG (2) | SG10201500552PA (en) |
| WO (1) | WO2011094339A1 (en) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI9911326B8 (en) * | 1998-06-17 | 2021-05-25 | Eisai Co Ltd | macrocyclic analogues and methods for their use and preparation |
| USRE45324E1 (en) | 2004-06-03 | 2015-01-06 | Eisai R&D Management Co., Ltd. | Intermediates for the preparation of analogs of halichondrin B |
| CN104311571B (en) | 2007-10-03 | 2019-07-02 | 卫材R&D管理有限公司 | Intermediate and method for synthesis of halichondrin b analogs |
| WO2009124237A1 (en) * | 2008-04-04 | 2009-10-08 | Eisai R&D Management Co., Ltd. | Halichondrin b analogs |
| CA2756811C (en) | 2009-03-30 | 2014-09-23 | Eisai R&D Management Co., Ltd. | Liposome composition of eribulin or its pharmacologically permissible salt |
| US8203010B2 (en) | 2010-01-26 | 2012-06-19 | Eisai R&D Management Co., Ltd. | Compounds useful in the synthesis of halichondrin B analogs |
| AU2012308184B2 (en) | 2011-09-18 | 2015-08-06 | Touch Tunes Music Corporation | Digital jukebox device with karaoke and/or photo booth features, and associated methods |
| WO2014087230A1 (en) | 2012-12-04 | 2014-06-12 | Eisai R&D Management Co., Ltd. | Use of eribulin in the treatment of breast cancer |
| CA2915005C (en) | 2013-06-26 | 2021-12-28 | Eisai R&D Management Co., Ltd. | Use of eribulin and lenvatinib as combination therapy for treatment of cancer |
| US9850254B2 (en) | 2013-07-03 | 2017-12-26 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing-SO2-(p-tolyl) groups |
| CN103483352A (en) * | 2013-10-18 | 2014-01-01 | 李友香 | Medicinal bulk drug for resisting tumors |
| WO2015066729A1 (en) * | 2013-11-04 | 2015-05-07 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b |
| HUE043088T2 (en) | 2013-12-06 | 2019-08-28 | Eisai R&D Man Co Ltd | Methods useful in the synthesis of halichondrin b analogs |
| JP2017516802A (en) | 2014-05-28 | 2017-06-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Use of eribulin in the treatment of cancer |
| WO2016003975A1 (en) | 2014-06-30 | 2016-01-07 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| RU2737216C2 (en) | 2015-03-04 | 2020-11-26 | Мерк Шарп Энд Дохме Корп. | Combination of pd-1 antagonist and eribulin for treating cancer |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| RU2739034C2 (en) | 2015-05-07 | 2020-12-21 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Macrocyclisation reaction and intermediate compound and other fragments, useful in synthesis of macrolides of halichondrins |
| US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| US10548986B2 (en) | 2016-03-02 | 2020-02-04 | Eisai R&D Management Co., Ltd. | Eribulin-based antibody-drug conjugates and methods of use |
| EP3449921B1 (en) | 2016-04-28 | 2023-05-31 | Eisai R&D Management Co., Ltd. | Eribulin for inhibiting tumor growth |
| EP3478691A4 (en) | 2016-06-30 | 2020-07-22 | Eisai R&D Management Co., Ltd. | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
| US20190263927A1 (en) | 2016-10-14 | 2019-08-29 | Merck Sharp & Dohme Corp. | Combination of a pd-1 antagonist and eribulin for treating urothelial cancer |
| JP6978758B2 (en) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Palladium-mediated ketolization |
| CN108658956B (en) * | 2017-03-28 | 2021-02-02 | 上海时莱生物技术有限公司 | Eribulin intermediate and preparation method thereof |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| SI3606928T1 (en) | 2017-04-05 | 2023-02-28 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| CN108948064B (en) | 2017-05-17 | 2021-02-02 | 上海时莱生物技术有限公司 | Eribulin intermediate and preparation method thereof |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| BR112020000141A2 (en) | 2017-07-06 | 2020-07-14 | President And Fellows Of Harvard College | halicondrin synthesis |
| US20190046513A1 (en) | 2017-08-10 | 2019-02-14 | Huya Bioscience International, Llc | Combination therapies of hdac inhibitors and tubulin inhibitors |
| CN111566113B (en) | 2017-11-15 | 2024-01-09 | 哈佛大学的校长及成员们 | Macrocyclic compounds and uses thereof |
| EP3713565A1 (en) | 2017-11-20 | 2020-09-30 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| KR20200105877A (en) | 2018-01-03 | 2020-09-09 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Prince reactions and compounds useful for the synthesis of halichondrial macrolide and analogs thereof |
| US11083705B2 (en) | 2019-07-26 | 2021-08-10 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| US12036204B2 (en) | 2019-07-26 | 2024-07-16 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU652180A1 (en) * | 1975-12-16 | 1979-03-15 | Краснодарский политехнический институт | Method of obtaining 1-(furyl-2')-2-(2-"formyl-furyl-5") ethylene and its methyl derivative as intermediate product for synthesis of furan-2,5-dicarboxylic acid |
| US5338865A (en) * | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| US5436238A (en) * | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| GB9206244D0 (en) | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
| TW255880B (en) | 1992-09-09 | 1995-09-01 | Hoechst Ag | |
| WO1998009942A1 (en) | 1996-09-06 | 1998-03-12 | Eli Lilly And Company | Catalytic selective sulfonylation process |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| BRPI9911326B8 (en) * | 1998-06-17 | 2021-05-25 | Eisai Co Ltd | macrocyclic analogues and methods for their use and preparation |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| CN109180615A (en) * | 2004-06-03 | 2019-01-11 | 卫材R&D管理有限公司 | It is used to prepare the intermediate of the analog of halichondrin B |
| USRE45324E1 (en) * | 2004-06-03 | 2015-01-06 | Eisai R&D Management Co., Ltd. | Intermediates for the preparation of analogs of halichondrin B |
| US20060045846A1 (en) | 2004-08-30 | 2006-03-02 | Horstmann Thomas E | Reagents and methods for labeling terminal olefins |
| US20060154312A1 (en) | 2004-12-09 | 2006-07-13 | Sergei Agoulnik | Tubulin isotype screening in cancer therapy using halichondrin B analogs |
| WO2008010776A1 (en) | 2006-07-21 | 2008-01-24 | Agency For Science, Technology And Research | Aigialomycin d and derivatives thereof and their use in treating cancer or malaria or a microbial infection |
| CN104311571B (en) | 2007-10-03 | 2019-07-02 | 卫材R&D管理有限公司 | Intermediate and method for synthesis of halichondrin b analogs |
| EP2220094A1 (en) | 2007-11-16 | 2010-08-25 | Eisai R&D Management Co., Ltd. | Novel intermediate for halichondrin b analog synthesis and novel desulfonylation reaction used for the intermediate |
| WO2009124237A1 (en) * | 2008-04-04 | 2009-10-08 | Eisai R&D Management Co., Ltd. | Halichondrin b analogs |
| US8203010B2 (en) | 2010-01-26 | 2012-06-19 | Eisai R&D Management Co., Ltd. | Compounds useful in the synthesis of halichondrin B analogs |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| CA2857385A1 (en) | 2011-11-30 | 2013-06-06 | Alphora Research Inc. | Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene |
| EP2831082B1 (en) | 2012-03-30 | 2019-02-20 | Sandoz AG | Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein |
| US9850254B2 (en) | 2013-07-03 | 2017-12-26 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing-SO2-(p-tolyl) groups |
| WO2015066729A1 (en) | 2013-11-04 | 2015-05-07 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b |
| HUE043088T2 (en) | 2013-12-06 | 2019-08-28 | Eisai R&D Man Co Ltd | Methods useful in the synthesis of halichondrin b analogs |
| RU2739034C2 (en) | 2015-05-07 | 2020-12-21 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Macrocyclisation reaction and intermediate compound and other fragments, useful in synthesis of macrolides of halichondrins |
| US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| EP3478691A4 (en) | 2016-06-30 | 2020-07-22 | Eisai R&D Management Co., Ltd. | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
-
2011
- 2011-01-26 US US13/014,517 patent/US8203010B2/en active Active
- 2011-01-26 SG SG10201500552PA patent/SG10201500552PA/en unknown
- 2011-01-26 RU RU2012136468/04A patent/RU2579511C2/en active
- 2011-01-26 SG SG2012053468A patent/SG182612A1/en unknown
- 2011-01-26 WO PCT/US2011/022611 patent/WO2011094339A1/en active Application Filing
- 2011-01-26 BR BR112012018232A patent/BR112012018232B8/en active IP Right Grant
- 2011-01-26 EP EP11702900.9A patent/EP2528914B1/en active Active
- 2011-01-26 JP JP2012551271A patent/JP5800834B2/en active Active
- 2011-01-26 MX MX2012008510A patent/MX2012008510A/en unknown
- 2011-01-26 CN CN201180015757.2A patent/CN102803254B/en active Active
- 2011-01-26 CA CA2787919A patent/CA2787919C/en active Active
-
2012
- 2012-05-22 US US13/477,483 patent/US8350067B2/en active Active
- 2012-07-12 IL IL220913A patent/IL220913A/en active IP Right Grant
-
2013
- 2013-01-07 US US13/735,516 patent/US8927597B2/en active Active
-
2014
- 2014-12-19 US US14/577,417 patent/US9382262B2/en active Active
-
2016
- 2016-06-29 US US15/196,600 patent/US9856276B2/en active Active
-
2017
- 2017-12-13 US US15/840,109 patent/US10494388B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013518116A (en) | 2013-05-20 |
| CN102803254A (en) | 2012-11-28 |
| US8203010B2 (en) | 2012-06-19 |
| CN102803254B (en) | 2016-09-14 |
| CA2787919A1 (en) | 2011-08-04 |
| BR112012018232B1 (en) | 2022-11-29 |
| CA2787919C (en) | 2018-07-31 |
| US20130123519A1 (en) | 2013-05-16 |
| US9382262B2 (en) | 2016-07-05 |
| MX2012008510A (en) | 2012-11-21 |
| EP2528914B1 (en) | 2014-06-11 |
| RU2012136468A (en) | 2014-03-10 |
| US20160376294A1 (en) | 2016-12-29 |
| US8927597B2 (en) | 2015-01-06 |
| BR112012018232A2 (en) | 2016-02-23 |
| IL220913A (en) | 2016-11-30 |
| US10494388B2 (en) | 2019-12-03 |
| EP2528914A1 (en) | 2012-12-05 |
| WO2011094339A1 (en) | 2011-08-04 |
| RU2579511C2 (en) | 2016-04-10 |
| SG182612A1 (en) | 2012-08-30 |
| US20110184190A1 (en) | 2011-07-28 |
| US20120289718A1 (en) | 2012-11-15 |
| US20150175620A1 (en) | 2015-06-25 |
| JP5800834B2 (en) | 2015-10-28 |
| BR112012018232B8 (en) | 2023-01-10 |
| US9856276B2 (en) | 2018-01-02 |
| US8350067B2 (en) | 2013-01-08 |
| US20180162885A1 (en) | 2018-06-14 |
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