JP2020528768A5 - - Google Patents
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- JP2020528768A5 JP2020528768A5 JP2020527852A JP2020527852A JP2020528768A5 JP 2020528768 A5 JP2020528768 A5 JP 2020528768A5 JP 2020527852 A JP2020527852 A JP 2020527852A JP 2020527852 A JP2020527852 A JP 2020527852A JP 2020528768 A5 JP2020528768 A5 JP 2020528768A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- antibody
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023123773A JP2023153911A (ja) | 2017-07-27 | 2023-07-28 | 抗ｔｉｇｉｔ抗体 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762606159P | 2017-07-27 | 2017-07-27 | |
| US62/606,159 | 2017-07-27 | ||
| BE2017/5535 | 2017-07-31 | ||
| BE2017/5535A BE1025333B1 (fr) | 2017-07-27 | 2017-07-31 | Anticorps anti-tigit |
| EP17184102.6 | 2017-07-31 | ||
| EP17184102 | 2017-07-31 | ||
| US201862660640P | 2018-04-20 | 2018-04-20 | |
| US62/660,640 | 2018-04-20 | ||
| PCT/US2018/043968 WO2019023504A1 (en) | 2017-07-27 | 2018-07-26 | ANTI-TIGIT ANTIBODIES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023123773A Division JP2023153911A (ja) | 2017-07-27 | 2023-07-28 | 抗ｔｉｇｉｔ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020528768A JP2020528768A (ja) | 2020-10-01 |
| JP2020528768A5 true JP2020528768A5 (enExample) | 2021-09-02 |
| JP7366897B2 JP7366897B2 (ja) | 2023-10-23 |
Family
ID=65896429
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020527852A Active JP7366897B2 (ja) | 2017-07-27 | 2018-07-26 | 抗ｔｉｇｉｔ抗体 |
| JP2023123773A Pending JP2023153911A (ja) | 2017-07-27 | 2023-07-28 | 抗ｔｉｇｉｔ抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023123773A Pending JP2023153911A (ja) | 2017-07-27 | 2023-07-28 | 抗ｔｉｇｉｔ抗体 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US20200407445A1 (enExample) |
| EP (2) | EP3484925B1 (enExample) |
| JP (2) | JP7366897B2 (enExample) |
| KR (1) | KR102731476B1 (enExample) |
| CN (2) | CN119841950A (enExample) |
| AR (1) | AR112768A1 (enExample) |
| AU (1) | AU2018306463B2 (enExample) |
| BR (1) | BR112020001499A2 (enExample) |
| CA (1) | CA3070791A1 (enExample) |
| ES (1) | ES2812236T3 (enExample) |
| IL (1) | IL272227B2 (enExample) |
| MX (2) | MX2020000960A (enExample) |
| SG (1) | SG11202000660QA (enExample) |
| TW (1) | TWI812632B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11021537B2 (en) | 2017-05-01 | 2021-06-01 | Agenus Inc. | Anti-TIGIT antibodies and methods of use thereof |
| IL272227B2 (en) | 2017-07-27 | 2025-09-01 | iTeos Belgium SA | Anti-tigit antibodies |
| BR112020023746A2 (pt) | 2018-05-23 | 2021-02-17 | Beigene, Ltd. | anticorpo, composição farmacêutica, método para tratar câncer, ácido nucleico isolado, vetor, célula hospedeira, processo para a produção de um anticorpo e reagente de diagnóstico |
| CN113226324B (zh) | 2018-09-11 | 2024-12-31 | Iteos比利时公司 | 作为a2a抑制剂的硫代氨基甲酸酯衍生物、其药物组合物以及与抗癌剂的组合 |
| US12312401B2 (en) * | 2019-01-07 | 2025-05-27 | Iteos Belguim Sa | Anti-TIGIT antibodies |
| TWI760751B (zh) | 2019-05-29 | 2022-04-11 | 美商美國禮來大藥廠 | Tigit及pd-1/tigit-結合分子 |
| AU2020290916A1 (en) * | 2019-06-13 | 2021-11-04 | Green Cross Corporation | Antibody to TIGIT and use thereof |
| JP7122354B2 (ja) * | 2019-09-24 | 2022-08-19 | 財團法人工業技術研究院 | 抗ｔｉｇｉｔ抗体および使用方法 |
| CN114746446A (zh) * | 2019-11-21 | 2022-07-12 | 百济神州有限公司 | 使用抗ox40抗体与抗tigit抗体组合治疗癌症的方法 |
| WO2021113831A1 (en) | 2019-12-05 | 2021-06-10 | Compugen Ltd. | Anti-pvrig and anti-tigit antibodies for enhanced nk-cell based tumor killing |
| CN113563470B (zh) * | 2020-04-29 | 2023-02-10 | 广州昂科免疫生物技术有限公司 | 结合tigit抗原的抗体及其制备方法与应用 |
| WO2021258337A1 (en) * | 2020-06-24 | 2021-12-30 | Huahui Health Ltd. | Human monoclonal antibodies against tigit for immune related diseases |
| IL302411A (en) * | 2020-10-26 | 2023-06-01 | Akeso Biopharma Inc | Anti-Tigit antibody, and the composition of the drugs and their use |
| WO2022111612A1 (zh) * | 2020-11-26 | 2022-06-02 | 信达生物制药(苏州)有限公司 | 包含抗tigit/pd-1双特异性抗体的制剂及其制备方法和用途 |
| CN114539418A (zh) * | 2020-11-26 | 2022-05-27 | 上海华奥泰生物药业股份有限公司 | 双特异性抗体及其用途 |
| CN114762678B (zh) * | 2021-01-14 | 2024-03-15 | 上海君实生物医药科技股份有限公司 | 抗tigit抗体药物组合物及其用途 |
| CN114790241B (zh) * | 2021-01-26 | 2024-12-13 | 北京免疫方舟医药科技有限公司 | 抗tigit抗体及其应用 |
| CN112794909B (zh) * | 2021-02-04 | 2022-06-14 | 广州爱思迈生物医药科技有限公司 | 一种抗tigit单克隆抗体及其应用 |
| WO2022179567A1 (zh) * | 2021-02-24 | 2022-09-01 | 克莱格医学有限公司 | Tigit工程化细胞及其组合物 |
| CN114989300A (zh) * | 2021-03-02 | 2022-09-02 | 百奥泰生物制药股份有限公司 | 抗tigit抗体在治疗肿瘤或癌症中的应用 |
| CN114984227A (zh) * | 2021-03-02 | 2022-09-02 | 百奥泰生物制药股份有限公司 | 抗tigit抗体在联合用药中的应用 |
| CN113150156B (zh) * | 2021-04-22 | 2022-06-07 | 浙江博锐生物制药有限公司 | 抗tigit抗体及其用途 |
| TW202304965A (zh) | 2021-05-04 | 2023-02-01 | 美商艾吉納斯公司 | 抗ｔｉｇｉｔ抗體、抗ｃｄ９６抗體及其使用方法 |
| BR112023023453A8 (pt) | 2021-05-10 | 2024-02-15 | Medimabbio Inc | Anticorpo anti-tigit ou um fragmento de ligação ao antígeno deste, composições farmacêuticas e usos do referido anticorpo anti-tigit ou um fragmento de ligação ao antígeno deste |
| CA3228504A1 (en) * | 2021-08-09 | 2023-02-16 | Tianhang ZHAI | Anti-tigit antibody and use thereof |
| CN115838424A (zh) * | 2021-09-22 | 2023-03-24 | 上海康岱生物医药技术股份有限公司 | 靶向tigit的单克隆抗体 |
| WO2023046097A1 (zh) * | 2021-09-24 | 2023-03-30 | 广东菲鹏制药股份有限公司 | 抗tigit人源化抗体或其抗原结合片段及其应用 |
| CN116135884A (zh) * | 2021-11-17 | 2023-05-19 | 普米斯生物技术(珠海)有限公司 | 抗tigit-抗pd-l1双特异性抗体、其药物组合物及用途 |
| CN116143923B (zh) * | 2022-12-30 | 2025-11-11 | 合肥天港免疫药物有限公司 | 高亲和力tigit抗体及其应用 |
| CN121620534A (zh) * | 2023-06-06 | 2026-03-06 | 上海药明生物技术有限公司 | 抗tigit抗体及其用途 |
| CN119751676A (zh) * | 2023-10-11 | 2025-04-04 | 首都医科大学附属北京胸科医院 | 抗人tigit单克隆抗体tigit-m006或其功能性片段及其应用 |
| WO2025255297A1 (en) * | 2024-06-05 | 2025-12-11 | Agilent Technologies, Inc. | Anti-human tigit antibodies for in vitro diagnostics |
| WO2026013616A1 (en) * | 2024-07-10 | 2026-01-15 | Takeda Pharmaceutical Company Limited | Compositions and methods for treating cancer |
| CN119431580B (zh) * | 2024-09-29 | 2025-11-18 | 上海百英生物科技股份有限公司 | 一种抗人tigit单克隆抗体及其应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| WO2003072035A2 (en) | 2002-02-22 | 2003-09-04 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
| DE60335552D1 (de) | 2002-09-11 | 2011-02-10 | Genentech Inc | Neue zusammensetzung und verfahren zur behandlung von immunerkrankungen |
| DE602004029581D1 (de) * | 2003-08-13 | 2010-11-25 | Pfizer Prod Inc | Modifizierte humane igf-1r antikörper |
| ES2609429T3 (es) | 2005-05-12 | 2017-04-20 | Zymogenetics, Inc. | Composiciones y métodos para modular respuestas inmunitarias |
| WO2007073478A2 (en) | 2005-12-19 | 2007-06-28 | Genizon Biosciences Inc. | Genemap of the human genes associated with crohn's disease |
| JP5933894B2 (ja) | 2007-09-14 | 2016-06-15 | アディマブ， エルエルシー | 合理的に設計された、合成抗体ライブラリおよびその使用 |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| HUE036780T2 (hu) | 2008-04-09 | 2018-07-30 | Genentech Inc | Új kompozíciók és eljárások immunológiai vonatkozású betegségek kezelésére |
| AU2010225456B2 (en) | 2009-03-18 | 2016-03-17 | Carina Biotech Pty Ltd | Biomarkers and uses thereof |
| EP2388336A1 (en) | 2010-05-19 | 2011-11-23 | Signature Diagnostics AG | Method and kits for diagnosing colorectal cancer |
| MX2012013899A (es) | 2010-06-09 | 2013-03-20 | Zymogenetics Inc | Proteinas de fusion vstm3 dimericas y composiciones y metodos relacionados. |
| KR102810907B1 (ko) | 2010-07-16 | 2025-05-21 | 아디맵 엘엘씨 | 항체 라이브러리 |
| DE102011005235B4 (de) | 2011-03-08 | 2017-05-24 | Sirs-Lab Gmbh | Verfahren zum Identifizieren einer Teilmenge von Polynucleotiden aus einer dem Humangenom entsprechenden Ausgangsmenge von Polynucleotiden zur in vitro Bestimmung eines Schweregrads der Wirtsantwort eines Patienten |
| EP2834259A4 (en) | 2012-04-02 | 2016-08-24 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES |
| JP2015520192A (ja) | 2012-06-06 | 2015-07-16 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｈｉｐｐｏ経路を調節する結合剤およびその使用 |
| WO2014089113A1 (en) | 2012-12-03 | 2014-06-12 | Bristol-Myers Squibb Company | Enhancing anti-cancer activity of immunomodulatory fc fusion proteins |
| US20140323315A1 (en) | 2013-04-29 | 2014-10-30 | Adimab, Llc | Polyspecificity reagents, methods for their preparation and use |
| AU2014290069B2 (en) * | 2013-07-16 | 2019-01-03 | Genentech, Inc. | Methods of treating cancer using PD-1 axis binding antagonists and TIGIT inhibitors |
| JP2017522311A (ja) | 2014-07-16 | 2017-08-10 | ジェネンテック， インコーポレイテッド | Ｔｉｇｉｔ阻害剤及び抗癌剤を使用する癌の治療方法 |
| MY198017A (en) * | 2014-08-19 | 2023-07-26 | Merck Sharp & Dohme | Anti-tigit antibodies |
| KR20170072343A (ko) | 2014-11-06 | 2017-06-26 | 제넨테크, 인크. | Ox40 결합 효능제 및 tigit 억제제를 포함하는 병용 요법 |
| AR103268A1 (es) * | 2014-12-23 | 2017-04-26 | Bristol Myers Squibb Co | Anticuerpos contra tigit |
| TWI715587B (zh) * | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Ｔｉｇｉｔ結合劑和彼之用途 |
| JO3620B1 (ar) | 2015-08-05 | 2020-08-27 | Amgen Res Munich Gmbh | مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم |
| WO2017030823A2 (en) * | 2015-08-14 | 2017-02-23 | Merck Sharp & Dohme Corp. | Anti-tigit antibodies |
| KR20250021613A (ko) * | 2015-09-25 | 2025-02-13 | 제넨테크, 인크. | 항-tigit 항체 및 이의 이용 방법 |
| KR20180068990A (ko) | 2015-10-01 | 2018-06-22 | 포텐자 테라퓨틱스, 인코포레이티드 | 항-tigit 항체-결합 단백질 및 이의 사용 방법 |
| US10537633B2 (en) | 2016-03-04 | 2020-01-21 | Jn Biosciences Llc | Antibodies to TIGIT |
| CN109071656B (zh) | 2017-01-05 | 2021-05-18 | 璟尚生物制药公司 | 检查点调节物拮抗剂 |
| MX2019010206A (es) * | 2017-02-28 | 2019-12-11 | Seattle Genetics Inc | Anticuerpos anti inmunorreceptor de linfocitos t con dominios de motivo de inactivación basado en tirosina de inmunorreceptor e inmunoglobulina (tigit). |
| US11021537B2 (en) | 2017-05-01 | 2021-06-01 | Agenus Inc. | Anti-TIGIT antibodies and methods of use thereof |
| WO2018229163A1 (en) * | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
| IL272227B2 (en) | 2017-07-27 | 2025-09-01 | iTeos Belgium SA | Anti-tigit antibodies |
| WO2019232484A1 (en) * | 2018-06-01 | 2019-12-05 | Compugen Ltd | Anti-pvrig/anti-tigit bispecific antibodies and methods of use |
| US12312401B2 (en) * | 2019-01-07 | 2025-05-27 | Iteos Belguim Sa | Anti-TIGIT antibodies |
-
2018
- 2018-07-25 IL IL272227A patent/IL272227B2/en unknown
- 2018-07-26 MX MX2020000960A patent/MX2020000960A/es unknown
- 2018-07-26 SG SG11202000660QA patent/SG11202000660QA/en unknown
- 2018-07-26 KR KR1020207005664A patent/KR102731476B1/ko active Active
- 2018-07-26 CN CN202411294417.3A patent/CN119841950A/zh active Pending
- 2018-07-26 CN CN201880048693.8A patent/CN110997720B/zh active Active
- 2018-07-26 CA CA3070791A patent/CA3070791A1/en active Pending
- 2018-07-26 EP EP18750302.4A patent/EP3484925B1/en active Active
- 2018-07-26 JP JP2020527852A patent/JP7366897B2/ja active Active
- 2018-07-26 ES ES18750302T patent/ES2812236T3/es active Active
- 2018-07-26 EP EP20173561.0A patent/EP3719040A1/en active Pending
- 2018-07-26 AU AU2018306463A patent/AU2018306463B2/en active Active
- 2018-07-26 US US16/634,506 patent/US20200407445A1/en not_active Abandoned
- 2018-07-26 BR BR112020001499-0A patent/BR112020001499A2/pt not_active Application Discontinuation
- 2018-07-27 AR ARP180102114A patent/AR112768A1/es unknown
- 2018-07-27 TW TW107126050A patent/TWI812632B/zh active
- 2018-10-12 US US16/159,506 patent/US10329349B2/en active Active
-
2019
- 2019-05-15 US US16/413,557 patent/US11439705B2/en active Active
-
2020
- 2020-01-24 MX MX2024000742A patent/MX2024000742A/es unknown
-
2022
- 2022-07-25 US US17/872,494 patent/US20230190931A1/en not_active Abandoned
- 2022-09-16 US US17/946,158 patent/US20230181731A1/en not_active Abandoned
-
2023
- 2023-07-28 JP JP2023123773A patent/JP2023153911A/ja active Pending
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