JP2020528768A5 - - Google Patents

Download PDF

Info

Publication number
JP2020528768A5
JP2020528768A5 JP2020527852A JP2020527852A JP2020528768A5 JP 2020528768 A5 JP2020528768 A5 JP 2020528768A5 JP 2020527852 A JP2020527852 A JP 2020527852A JP 2020527852 A JP2020527852 A JP 2020527852A JP 2020528768 A5 JP2020528768 A5 JP 2020528768A5
Authority
JP
Japan
Prior art keywords
seq
amino acid
acid sequence
antibody
chain variable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020527852A
Other languages
English (en)
Japanese (ja)
Other versions
JP7366897B2 (ja
JP2020528768A (ja
Filing date
Publication date
Priority claimed from BE2017/5535A external-priority patent/BE1025333B1/fr
Application filed filed Critical
Priority claimed from PCT/US2018/043968 external-priority patent/WO2019023504A1/en
Publication of JP2020528768A publication Critical patent/JP2020528768A/ja
Publication of JP2020528768A5 publication Critical patent/JP2020528768A5/ja
Priority to JP2023123773A priority Critical patent/JP2023153911A/ja
Application granted granted Critical
Publication of JP7366897B2 publication Critical patent/JP7366897B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020527852A 2017-07-27 2018-07-26 抗tigit抗体 Active JP7366897B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023123773A JP2023153911A (ja) 2017-07-27 2023-07-28 抗tigit抗体

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762606159P 2017-07-27 2017-07-27
US62/606,159 2017-07-27
EP17184102 2017-07-31
BE2017/5535A BE1025333B1 (fr) 2017-07-27 2017-07-31 Anticorps anti-tigit
EP17184102.6 2017-07-31
BE2017/5535 2017-07-31
US201862660640P 2018-04-20 2018-04-20
US62/660,640 2018-04-20
PCT/US2018/043968 WO2019023504A1 (en) 2017-07-27 2018-07-26 ANTI-TIGIT ANTIBODIES

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023123773A Division JP2023153911A (ja) 2017-07-27 2023-07-28 抗tigit抗体

Publications (3)

Publication Number Publication Date
JP2020528768A JP2020528768A (ja) 2020-10-01
JP2020528768A5 true JP2020528768A5 (enExample) 2021-09-02
JP7366897B2 JP7366897B2 (ja) 2023-10-23

Family

ID=65896429

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020527852A Active JP7366897B2 (ja) 2017-07-27 2018-07-26 抗tigit抗体
JP2023123773A Pending JP2023153911A (ja) 2017-07-27 2023-07-28 抗tigit抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023123773A Pending JP2023153911A (ja) 2017-07-27 2023-07-28 抗tigit抗体

Country Status (14)

Country Link
US (5) US20200407445A1 (enExample)
EP (2) EP3719040A1 (enExample)
JP (2) JP7366897B2 (enExample)
KR (1) KR102731476B1 (enExample)
CN (2) CN119841950A (enExample)
AR (1) AR112768A1 (enExample)
AU (1) AU2018306463B2 (enExample)
BR (1) BR112020001499A2 (enExample)
CA (1) CA3070791A1 (enExample)
ES (1) ES2812236T3 (enExample)
IL (1) IL272227B2 (enExample)
MX (2) MX2020000960A (enExample)
SG (1) SG11202000660QA (enExample)
TW (1) TWI812632B (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3618863T (lt) 2017-05-01 2023-10-10 Agenus Inc. Anti-tigit antikūnai ir jų panaudojimo būdai
IL272227B2 (en) * 2017-07-27 2025-09-01 iTeos Belgium SA Anti-tigit antibodies
CN112566935B (zh) 2018-05-23 2024-12-13 百济神州有限公司 抗ox40抗体和使用方法
KR20250035608A (ko) 2018-09-11 2025-03-12 아이테오스 벨지움 에스에이 A2a 억제제로서 싸이오카바메이트 유도체, 이의 약학 조성물 및 항암제와의 조합물
SG11202107474RA (en) * 2019-01-07 2021-08-30 iTeos Belgium SA Anti-tigit antibodies
TWI760751B (zh) * 2019-05-29 2022-04-11 美商美國禮來大藥廠 Tigit及pd-1/tigit-結合分子
CA3139641A1 (en) * 2019-06-13 2020-12-17 Green Cross Corporation Antibody to tigit and use thereof
TWI764291B (zh) * 2019-09-24 2022-05-11 財團法人工業技術研究院 抗tigit抗體及使用方法
KR20220103709A (ko) * 2019-11-21 2022-07-22 베이진 엘티디 항-tigit 항체와의 병용물 형태로 항-ox40 항체를 사용하는 암 치료의 방법
WO2021113831A1 (en) 2019-12-05 2021-06-10 Compugen Ltd. Anti-pvrig and anti-tigit antibodies for enhanced nk-cell based tumor killing
CN113563470B (zh) * 2020-04-29 2023-02-10 广州昂科免疫生物技术有限公司 结合tigit抗原的抗体及其制备方法与应用
WO2021258337A1 (en) * 2020-06-24 2021-12-30 Huahui Health Ltd. Human monoclonal antibodies against tigit for immune related diseases
KR20230098221A (ko) * 2020-10-26 2023-07-03 아케소 바이오파마, 인크. 항-tigit 항체, 약학 조성물 및 이의 용도
TW202222345A (zh) * 2020-11-26 2022-06-16 大陸商信達生物製藥(蘇州)有限公司 包含抗tigit/pd-1雙特異性抗體的製劑及其製備方法和用途
CN114539418A (zh) * 2020-11-26 2022-05-27 上海华奥泰生物药业股份有限公司 双特异性抗体及其用途
EP4293045A4 (en) * 2021-01-14 2024-12-11 Shanghai Junshi Biosciences Co., Ltd. PHARMACEUTICAL COMPOSITION OF ANTI-TIGIT ANTIBODY AND ITS APPLICATION
CN114790241B (zh) * 2021-01-26 2024-12-13 北京免疫方舟医药科技有限公司 抗tigit抗体及其应用
CN112794909B (zh) * 2021-02-04 2022-06-14 广州爱思迈生物医药科技有限公司 一种抗tigit单克隆抗体及其应用
CN116897202A (zh) * 2021-02-24 2023-10-17 科济生物医药(上海)有限公司 Tigit工程化细胞及其组合物
WO2022184068A1 (zh) * 2021-03-02 2022-09-09 百奥泰生物制药股份有限公司 抗tigit抗体在治疗肿瘤或癌症中的应用
CN114984227A (zh) * 2021-03-02 2022-09-02 百奥泰生物制药股份有限公司 抗tigit抗体在联合用药中的应用
CN113150156B (zh) * 2021-04-22 2022-06-07 浙江博锐生物制药有限公司 抗tigit抗体及其用途
CA3217279A1 (en) 2021-05-04 2022-11-10 Olga Ignatovich Anti-tigit antibodies and methods of use thereof
AR125753A1 (es) 2021-05-04 2023-08-09 Agenus Inc Anticuerpos anti-tigit, anticuerpos anti-cd96 y métodos de uso de estos
US12558406B2 (en) 2021-05-10 2026-02-24 Medimabbio Inc. Anti-TIGIT antibodies and use thereof
KR20240043786A (ko) * 2021-08-09 2024-04-03 바이오세우스 인크. 항-tigit 항체 및 이의 용도
CN115838424A (zh) * 2021-09-22 2023-03-24 上海康岱生物医药技术股份有限公司 靶向tigit的单克隆抗体
CN115925945B (zh) * 2021-09-24 2026-07-07 广东菲鹏制药股份有限公司 抗tigit人源化抗体或其抗原结合片段及其应用
CN116135884A (zh) * 2021-11-17 2023-05-19 普米斯生物技术(珠海)有限公司 抗tigit-抗pd-l1双特异性抗体、其药物组合物及用途
CN116143923B (zh) * 2022-12-30 2025-11-11 合肥天港免疫药物有限公司 高亲和力tigit抗体及其应用
JP2026519841A (ja) * 2023-06-06 2026-06-18 ウーシー バイオロジクス アイルランド リミテッド 抗tigit抗体及びその使用
CN117343182B (zh) * 2023-10-11 2024-12-03 首都医科大学附属北京胸科医院 抗人tigit抗体或其功能性片段及其应用
WO2025255297A1 (en) * 2024-06-05 2025-12-11 Agilent Technologies, Inc. Anti-human tigit antibodies for in vitro diagnostics
WO2026013616A1 (en) * 2024-07-10 2026-01-15 Takeda Pharmaceutical Company Limited Compositions and methods for treating cancer
CN119431580B (zh) * 2024-09-29 2025-11-18 上海百英生物科技股份有限公司 一种抗人tigit单克隆抗体及其应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
US20040258678A1 (en) 2002-02-22 2004-12-23 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US7193069B2 (en) 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
EP2277532A1 (en) 2002-09-11 2011-01-26 Genentech, Inc. Novel composition and methods for the treatment of immune related diseases
CN1835975B (zh) * 2003-08-13 2012-11-21 辉瑞产品公司 经修饰的人类igf-1r抗体
EP3683230A1 (en) 2005-05-12 2020-07-22 ZymoGenetics, Inc. Compositions and methods for modulating immune responses
EP1963534A2 (en) 2005-12-19 2008-09-03 Genizon Biosciences Inc. Genemap of the human gene associated with crohn's disease
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
WO2009036379A2 (en) 2007-09-14 2009-03-19 Adimab, Inc. Rationally designed, synthetic antibody libraries and uses therefor
WO2009126688A2 (en) 2008-04-09 2009-10-15 Genentech, Inc. Novel compositions and methods for the treatment of immune related diseases
WO2010105298A1 (en) 2009-03-18 2010-09-23 Simon Barry Peptidase inhibitor 16 (pi16) as a biomarker for regulatory t (treg) cells and uses thereof
EP2388336A1 (en) 2010-05-19 2011-11-23 Signature Diagnostics AG Method and kits for diagnosing colorectal cancer
EP2580238A1 (en) 2010-06-09 2013-04-17 Zymogenetics, Inc. Dimeric vstm3 fusion proteins and related compositions and methods
MX381912B (es) 2010-07-16 2025-03-13 Adimab Llc Colecciones de anticuerpos.
DE102011005235B4 (de) 2011-03-08 2017-05-24 Sirs-Lab Gmbh Verfahren zum Identifizieren einer Teilmenge von Polynucleotiden aus einer dem Humangenom entsprechenden Ausgangsmenge von Polynucleotiden zur in vitro Bestimmung eines Schweregrads der Wirtsantwort eines Patienten
WO2013151664A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins
MX2014014951A (es) 2012-06-06 2015-03-13 Oncomed Pharm Inc Agentes aglutinantes que modulan la trayectoria hippo y sus usos.
SMT201900242T1 (it) 2012-12-03 2019-05-10 Bristol Myers Squibb Co Incremento dell'attivita' anti-cancro di proteine di fuzione a fc immunomodulatrici
HK1221908A1 (zh) 2013-04-29 2017-06-16 Adimab, Llc 多特异(polyspecificity)试剂,其制备方法和用途
TWI888366B (zh) 2013-07-16 2025-07-01 美商建南德克公司 利用pd-1軸結合拮抗劑及tigit抑制劑治療癌症之方法
MX2016017288A (es) 2014-07-16 2017-06-27 Genentech Inc Metodos para tratar el cancer con inhibidores de tigit y agentes contra el cancer.
CA2957722C (en) * 2014-08-19 2022-05-31 Merck Sharp & Dohme Corp. Anti-tigit antibodies
CA2963974A1 (en) 2014-11-06 2016-05-12 Genentech, Inc. Combination therapy comprising ox40 binding agonists and tigit inhibitors
AR103268A1 (es) * 2014-12-23 2017-04-26 Bristol Myers Squibb Co Anticuerpos contra tigit
TWI715587B (zh) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Tigit結合劑和彼之用途
JO3620B1 (ar) 2015-08-05 2020-08-27 Amgen Res Munich Gmbh مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم
CN115925931A (zh) * 2015-08-14 2023-04-07 默沙东公司 抗tigit抗体
SG10202007764TA (en) 2015-09-25 2020-09-29 Genentech Inc Anti-tigit antibodies and methods of use
PT3356413T (pt) 2015-10-01 2022-04-04 Potenza Therapeutics Inc Proteínas de ligação a antigénio anti-tigit e métodos de utilização das mesmas
MX2018010485A (es) 2016-03-04 2019-01-10 Jn Biosciences Llc Anticuerpos para inmunoreceptor de celulas t con dominios de ig e itim (tigit).
EP3565839A4 (en) 2017-01-05 2021-04-21 Gensun Biopharma Inc. CHECKPOINT REGULATOR ANTAGONISTS
CN111050788A (zh) * 2017-02-28 2020-04-21 西雅图基因公司 抗tigit抗体
LT3618863T (lt) 2017-05-01 2023-10-10 Agenus Inc. Anti-tigit antikūnai ir jų panaudojimo būdai
WO2018229163A1 (en) * 2017-06-14 2018-12-20 King's College London Methods of activating v delta 2 negative gamma delta t cells
IL272227B2 (en) * 2017-07-27 2025-09-01 iTeos Belgium SA Anti-tigit antibodies
SG11202011461TA (en) * 2018-06-01 2020-12-30 Compugen Ltd Anti-pvrig/anti-tigit bispecific antibodies and methods of use
SG11202107474RA (en) * 2019-01-07 2021-08-30 iTeos Belgium SA Anti-tigit antibodies

Similar Documents

Publication Publication Date Title
JP2021527431A5 (enExample)
JP2022177090A5 (enExample)
JP2020079252A5 (enExample)
RU2019140602A (ru) АНТИ-GARP-TGF-β-АНТИТЕЛА
JP2022510964A5 (enExample)
IL312961A (en) Anti-tmprss2 antibodies and antigen-binding fragments
RU2018145852A (ru) Антитело против lag-3, его антигенсвязывающий фрагмент и их фармацевтическое применение
JP2022533538A5 (enExample)
JP2023505218A5 (enExample)
RU2013125459A (ru) АНТИТЕЛА ПРОТИВ БЕЛКА РЕЦЕПТОРА c-Met
JP2018502060A5 (enExample)
JP2025183307A5 (enExample)
RU2009136913A (ru) Биспецифические связывающие агенты с межвидовой специфичностью
HRP20220637T1 (hr) Protutijela anti-komplementa c1s i njihova upotreba
JP2024520666A5 (enExample)
JP2021510736A5 (enExample)
US12173081B2 (en) CD19/CD38 multispecific antibodies
CN101535344A (zh) 新型抗增殖抗体
RU2014153440A (ru) Антитела против cd26 и их применение
RU2008138541A (ru) Способы разрушения клеток с использованием эффекторных функций анти-epha4 антител
JP2019528046A5 (enExample)
RU2019103991A (ru) Анти-il-22r-антитела
JP2018529672A5 (enExample)
IL321721A (en) Antidote conjugation against BDCA2 and its use
IL277899B2 (en) Methods and preparations for treating yellow fever