JP2015520758A5 - - Google Patents
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- JP2015520758A5 JP2015520758A5 JP2015512801A JP2015512801A JP2015520758A5 JP 2015520758 A5 JP2015520758 A5 JP 2015520758A5 JP 2015512801 A JP2015512801 A JP 2015512801A JP 2015512801 A JP2015512801 A JP 2015512801A JP 2015520758 A5 JP2015520758 A5 JP 2015520758A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- heavy chain
- antibody
- variable region
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261649110P | 2012-05-18 | 2012-05-18 | |
| US61/649,110 | 2012-05-18 | ||
| US13/804,227 US20130309223A1 (en) | 2012-05-18 | 2013-03-14 | CD33 Antibodies And Use Of Same To Treat Cancer |
| US13/804,227 | 2013-03-14 | ||
| PCT/US2013/041209 WO2013173496A2 (en) | 2012-05-18 | 2013-05-15 | Cd33 antibodies and use of same to treat cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520758A JP2015520758A (ja) | 2015-07-23 |
| JP2015520758A5 true JP2015520758A5 (enExample) | 2016-05-19 |
| JP6454269B2 JP6454269B2 (ja) | 2019-01-16 |
Family
ID=49581477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015512801A Expired - Fee Related JP6454269B2 (ja) | 2012-05-18 | 2013-05-15 | Ｃｄ３３抗体及び癌を処置するためのその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US20130309223A1 (enExample) |
| EP (2) | EP2850104B1 (enExample) |
| JP (1) | JP6454269B2 (enExample) |
| KR (2) | KR102100467B1 (enExample) |
| CN (1) | CN104936617B (enExample) |
| AU (3) | AU2013262788B2 (enExample) |
| CA (1) | CA2873286C (enExample) |
| DK (1) | DK2850104T3 (enExample) |
| EA (1) | EA029987B1 (enExample) |
| ES (1) | ES2686618T3 (enExample) |
| IL (1) | IL235733B (enExample) |
| IN (1) | IN2014DN10653A (enExample) |
| MX (1) | MX350808B (enExample) |
| NZ (1) | NZ702748A (enExample) |
| SG (1) | SG11201407610WA (enExample) |
| TW (1) | TWI593707B (enExample) |
| WO (1) | WO2013173496A2 (enExample) |
| ZA (1) | ZA201409224B (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2099823T4 (da) * | 2006-12-01 | 2022-05-09 | Seagen Inc | Målbindingsmiddelvarianter og anvendelser deraf |
| US20130309223A1 (en) | 2012-05-18 | 2013-11-21 | Seattle Genetics, Inc. | CD33 Antibodies And Use Of Same To Treat Cancer |
| AU2014337555C1 (en) | 2013-10-15 | 2021-01-28 | Seagen Inc. | PEGylated drug-linkers for improved Ligand-Drug Conjugate pharmacokinetics |
| EP3074036B1 (en) * | 2013-11-25 | 2019-09-18 | Seattle Genetics, Inc. | Preparing antibodies from cho cell cultures for conjugation |
| CA2931340A1 (en) * | 2013-12-13 | 2015-06-18 | Genentech, Inc. | Anti-cd33 antibodies and immunoconjugates |
| US10464997B2 (en) | 2014-02-11 | 2019-11-05 | Seattle Genetics, Inc. | Selective reduction of proteins |
| WO2015123679A1 (en) | 2014-02-17 | 2015-08-20 | Seattle Genetics, Inc. | Hydrophilic antibody-drug conjugates |
| CN106795221B (zh) * | 2014-04-03 | 2022-06-07 | 塞勒克提斯公司 | 用于癌症免疫治疗的cd33特异性嵌合抗原受体 |
| US9777061B2 (en) * | 2014-07-21 | 2017-10-03 | Novartis Ag | Treatment of cancer using a CD33 chimeric antigen receptor |
| WO2016120218A1 (en) | 2015-01-26 | 2016-08-04 | Cellectis | ANTI-CLL1 SPECIFIC SINGLE-CHAIN CHIMERIC ANTIGEN RECEPTORS (scCARS) FOR CANCER IMMUNOTHERAPY |
| KR20180033502A (ko) | 2015-06-12 | 2018-04-03 | 알렉터 엘엘씨 | 항-cd33 항체 및 그의 사용 방법 |
| TW201709932A (zh) | 2015-06-12 | 2017-03-16 | 西雅圖遺傳學公司 | Ｃｄ１２３抗體及其共軛物 |
| US11174313B2 (en) | 2015-06-12 | 2021-11-16 | Alector Llc | Anti-CD33 antibodies and methods of use thereof |
| CN116063502A (zh) * | 2015-06-30 | 2023-05-05 | 西雅图基因公司 | 抗ntb-a抗体和相关组合物以及方法 |
| TWI852735B (zh) | 2015-12-04 | 2024-08-11 | 美商思進公司 | 四級胺化妥布賴森(tubulysin)化合物之結合物 |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| US11027021B2 (en) | 2016-03-15 | 2021-06-08 | Seagen Inc. | Combinations of PBD-based antibody drug conjugates with Bcl-2 inhibitors |
| KR102626498B1 (ko) | 2016-03-25 | 2024-01-19 | 씨젠 인크. | 페길화된 약물-링커 및 그의 중간체의 제조를 위한 공정 |
| EP3442591A4 (en) * | 2016-04-15 | 2019-11-20 | Seattle Genetics, Inc. | COMBINATIONS OF CD33 ANTIBODY-ACTIVE CONJUGATES WITH HYPOMETHYLATING AGENTS |
| US11110179B2 (en) | 2016-06-03 | 2021-09-07 | Seagen Inc. | Combination of CD33 antibody drug conjugates with chemotherapeutic agents |
| EP3469001A4 (en) | 2016-06-09 | 2020-05-06 | Seattle Genetics, Inc. | COMBINATIONS OF PBD-BASED ANTIBODY CONJUGATES WITH FLT3 INHIBITORS |
| MX2019001302A (es) | 2016-08-09 | 2019-06-12 | Seattle Genetics Inc | Conjugados de farmaco con enlazadores autoestabilizantes que tienen propiedades fisioquimicas mejoradas. |
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| IL324632A (en) | 2016-12-01 | 2026-01-01 | Regeneron Pharma | Radiolabeled anti-PD-L1 antibodies for immuno-PET imaging |
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| SG11201907288RA (en) | 2017-02-28 | 2019-09-27 | Seattle Genetics Inc | Cysteine mutated antibodies for conjugation |
| IL268895B2 (en) | 2017-02-28 | 2025-05-01 | Vor Biopharma Inc | Compositions and methods for inhibition of lineage specific proteins |
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| TWI868807B (zh) | 2017-08-03 | 2025-01-01 | 美商阿列克特有限責任公司 | 抗trem2抗體及其使用方法 |
| MA47691A (fr) * | 2017-08-03 | 2020-01-08 | Alector Llc | Anticorps anti-cd33 et leurs procédés d'utilisation |
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| JP7353576B2 (ja) | 2018-02-20 | 2023-10-02 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｃｄ３３、ｎｋｇ２ｄ、及びｃｄ１６に結合する多重特異性結合タンパク質、ならびにその使用方法 |
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| BR112021003016A2 (pt) | 2018-08-31 | 2021-05-18 | Alector Llc | anticorpos isolados, ácido nucleico isolado, vetor, célula hospedeira, métodos para produzir um anticorpo e para prevenir, reduzir o risco ou tratar uma doença e composição farmacêutica |
| US12398402B2 (en) | 2018-09-12 | 2025-08-26 | Fred Hutchinson Cancer Center | Reducing CD33 expression to selectively protect therapeutic cells |
| US12103969B2 (en) * | 2018-09-25 | 2024-10-01 | Academia Sinica | Anti-Siglec antibody, pharmaceutical composition comprising the same, and uses thereof |
| US20220226375A1 (en) * | 2018-11-07 | 2022-07-21 | Crispr Therapeutics Ag | Anti-cd33 immune cell cancer therapy |
| US20220016257A1 (en) | 2018-11-14 | 2022-01-20 | Daiichi Sankyo Company, Limited | Anti-cdh6 antibody-pyrrolobenzodiazepine derivative conjugate |
| US12441793B2 (en) * | 2019-02-22 | 2025-10-14 | Memorial Sloan Kettering Cancer Center | CD33 antibodies and methods of using the same to treat cancer |
| TWI856078B (zh) | 2019-03-25 | 2024-09-21 | 日商第一三共股份有限公司 | 抗體–吡咯并苯二氮呯衍生物結合物、其製造方法及其用途 |
| WO2020196475A1 (ja) | 2019-03-25 | 2020-10-01 | 第一三共株式会社 | 抗ｈｅｒ２抗体－ピロロベンゾジアゼピン誘導体コンジュゲート |
| BR112021017350A2 (pt) | 2019-03-27 | 2021-11-16 | Daiichi Sankyo Co Ltd | Combinação de conjugado de anticorpo-derivado de pirrolobenzodiazepina e inibidor de parp |
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| CA3142886A1 (en) * | 2019-06-06 | 2020-12-10 | Mythic Therapeutics, Inc. | Antigen-binding protein constructs and uses thereof |
| WO2021138407A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
| WO2021202726A2 (en) * | 2020-03-31 | 2021-10-07 | Fred Hutchinson Cancer Research Center | Anti-cd33 antibodies and uses thereof |
| US20230144405A1 (en) * | 2020-03-31 | 2023-05-11 | Fred Hutchinson Cancer Center | Human anti-cd33 antibodies and uses thereof |
| BR112022020332A2 (pt) | 2020-04-10 | 2022-12-13 | Seagen Inc | Composto conjugado anticorpo-droga, composição, método de tratamento de câncer e de um distúrbio autoimune |
| US20210402001A1 (en) * | 2020-06-30 | 2021-12-30 | David I. Cohen | Zinc Porters, and their Monoclonal Antibody Conjugates, for the Prevention and Treatment of COVID-19 (SARS-CoV-2), Other Infections, and Cancers |
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| CN117062611A (zh) | 2021-01-26 | 2023-11-14 | 惠和生物技术(上海)有限公司 | 嵌合抗原受体（car）构建体和表达car构建体的nk细胞 |
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| IL308795A (en) | 2021-05-28 | 2024-01-01 | Seagen Inc | Anthracycline antibody conjugates |
| KR20240113514A (ko) | 2021-11-30 | 2024-07-22 | 다이이찌 산쿄 가부시키가이샤 | 프로테아제 분해성 마스크 항체 |
| KR20240141757A (ko) | 2022-02-09 | 2024-09-27 | 다이이찌 산쿄 가부시키가이샤 | 환경 응답성 마스킹 항체 및 그 이용 |
| TW202346322A (zh) | 2022-03-02 | 2023-12-01 | 日商第一三共股份有限公司 | 含Ｆｃ分子之製造方法 |
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| CN116375874B (zh) * | 2023-04-14 | 2023-12-26 | 上海精翰生物科技有限公司 | 一种cd33抗体及其应用 |
| WO2025090774A1 (en) | 2023-10-24 | 2025-05-01 | Seagen Inc. | Chemotherapeutic compounds and methods of use |
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| WO2025174974A1 (en) * | 2024-02-14 | 2025-08-21 | Bristol-Myers Squibb Company | Anti-cd33 antibodies and uses thereof |
| CN121673409A (zh) * | 2024-09-12 | 2026-03-17 | 安诺柏德生物医药科技(苏州)有限公司 | 靶向人cd33的人源化抗体及其应用 |
| CN119080935B (zh) * | 2024-10-11 | 2026-04-14 | 上海市同仁医院 | 一种抗人SMIM45-107aa单克隆抗体及其用途 |
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-
2013
- 2013-03-14 US US13/804,227 patent/US20130309223A1/en not_active Abandoned
- 2013-05-15 MX MX2014013866A patent/MX350808B/es active IP Right Grant
- 2013-05-15 WO PCT/US2013/041209 patent/WO2013173496A2/en not_active Ceased
- 2013-05-15 US US14/401,837 patent/US9587019B2/en active Active
- 2013-05-15 EP EP13790467.8A patent/EP2850104B1/en active Active
- 2013-05-15 ES ES13790467.8T patent/ES2686618T3/es active Active
- 2013-05-15 IN IN10653DEN2014 patent/IN2014DN10653A/en unknown
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