JP2015520758A5 - - Google Patents
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- JP2015520758A5 JP2015520758A5 JP2015512801A JP2015512801A JP2015520758A5 JP 2015520758 A5 JP2015520758 A5 JP 2015520758A5 JP 2015512801 A JP2015512801 A JP 2015512801A JP 2015512801 A JP2015512801 A JP 2015512801A JP 2015520758 A5 JP2015520758 A5 JP 2015520758A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- heavy chain
- antibody
- variable region
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261649110P | 2012-05-18 | 2012-05-18 | |
| US61/649,110 | 2012-05-18 | ||
| US13/804,227 | 2013-03-14 | ||
| US13/804,227 US20130309223A1 (en) | 2012-05-18 | 2013-03-14 | CD33 Antibodies And Use Of Same To Treat Cancer |
| PCT/US2013/041209 WO2013173496A2 (en) | 2012-05-18 | 2013-05-15 | Cd33 antibodies and use of same to treat cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520758A JP2015520758A (ja) | 2015-07-23 |
| JP2015520758A5 true JP2015520758A5 (enExample) | 2016-05-19 |
| JP6454269B2 JP6454269B2 (ja) | 2019-01-16 |
Family
ID=49581477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015512801A Expired - Fee Related JP6454269B2 (ja) | 2012-05-18 | 2013-05-15 | Ｃｄ３３抗体及び癌を処置するためのその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US20130309223A1 (enExample) |
| EP (2) | EP2850104B1 (enExample) |
| JP (1) | JP6454269B2 (enExample) |
| KR (2) | KR102241478B1 (enExample) |
| CN (1) | CN104936617B (enExample) |
| AU (3) | AU2013262788B2 (enExample) |
| CA (1) | CA2873286C (enExample) |
| DK (1) | DK2850104T3 (enExample) |
| EA (1) | EA029987B1 (enExample) |
| ES (1) | ES2686618T3 (enExample) |
| IL (1) | IL235733B (enExample) |
| IN (1) | IN2014DN10653A (enExample) |
| MX (1) | MX350808B (enExample) |
| NZ (1) | NZ702748A (enExample) |
| SG (1) | SG11201407610WA (enExample) |
| TW (1) | TWI593707B (enExample) |
| WO (1) | WO2013173496A2 (enExample) |
| ZA (1) | ZA201409224B (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2523915T5 (es) * | 2006-12-01 | 2022-05-26 | Seagen Inc | Agentes de unión a la diana variantes y usos de los mismos |
| US20130309223A1 (en) | 2012-05-18 | 2013-11-21 | Seattle Genetics, Inc. | CD33 Antibodies And Use Of Same To Treat Cancer |
| BR112016007622A2 (pt) | 2013-10-15 | 2018-01-23 | Seattle Genetics, Inc. | composto, composição farmacêutica, conjugado de ligante-droga, e, método para tratar câncer |
| WO2015077605A1 (en) * | 2013-11-25 | 2015-05-28 | Seattle Genetics, Inc. | Preparing antibodies from cho cell cultures for conjugation |
| AU2014362238A1 (en) * | 2013-12-13 | 2016-06-09 | Genentech, Inc. | Anti-CD33 antibodies and immunoconjugates |
| EP4190809A1 (en) | 2014-02-11 | 2023-06-07 | Seagen Inc. | Selective reduction of proteins |
| KR20240036143A (ko) | 2014-02-17 | 2024-03-19 | 씨젠 인크. | 친수성 항체-약물 컨쥬게이트 |
| ES2765710T3 (es) * | 2014-04-03 | 2020-06-10 | Cellectis | Receptores de antígeno quimérico específicos de CD33 para la inmunoterapia del cáncer |
| BR112017001242A2 (pt) * | 2014-07-21 | 2017-12-05 | Novartis Ag | tratamento de câncer usando um receptor antigênico quimérico a cd33 |
| CA2973529A1 (en) | 2015-01-26 | 2016-08-04 | Cellectis | Cll1-specific multi-chain chimeric antigen receptor |
| TW201709932A (zh) * | 2015-06-12 | 2017-03-16 | 西雅圖遺傳學公司 | Ｃｄ１２３抗體及其共軛物 |
| CN107922480B (zh) | 2015-06-12 | 2022-09-23 | 艾利妥 | 抗cd33抗体及其使用方法 |
| HK1252675A1 (zh) | 2015-06-12 | 2019-05-31 | Alector Llc | 抗cd33抗体及其使用方法 |
| SG10202005460RA (en) | 2015-06-30 | 2020-07-29 | Seattle Genetics Inc | Anti-ntb-a antibodies and related compositions and methods |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| SG11201804268RA (en) | 2015-12-04 | 2018-06-28 | Seattle Genetics Inc | Conjugates of quaternized tubulysin compounds |
| US11027021B2 (en) | 2016-03-15 | 2021-06-08 | Seagen Inc. | Combinations of PBD-based antibody drug conjugates with Bcl-2 inhibitors |
| BR112018069273A2 (pt) | 2016-03-25 | 2019-01-22 | Seattle Genetics Inc | métodos para preparação de um composto e para tratamento de um indivíduo com uma malignidade hematológica, composto, composição, e, intermediário ligante de fármaco ou composto ligante de fármaco |
| US20190117787A1 (en) * | 2016-04-15 | 2019-04-25 | Seattle Genetics, Inc. | Combinations of cd33 antibody drug conjugates with hypomethylating agents |
| EP3463463A4 (en) | 2016-06-03 | 2020-01-15 | Seattle Genetics, Inc. | Combination of cd33 antibody drug conjugates with chemotherapeutic agents |
| WO2017214433A1 (en) | 2016-06-09 | 2017-12-14 | Seattle Genetics, Inc. | Combinations of pbd-based antibody drug conjugates with flt3 inhibitors |
| BR112019001945A2 (pt) | 2016-08-09 | 2019-05-07 | Seattle Genetics, Inc. | composição de conjugado de fármaco aglutinante, formulação farmaceuticamente aceitável, métodos para tratar uma doença ou afecção hiperproliferativa, para inibir a multiplicação de uma célula tumoral ou célula cancerígena e para preparar uma composição de conjugado de fármaco aglutinado, e, composto |
| SG11201903013SA (en) | 2016-10-18 | 2019-05-30 | Seattle Genetics Inc | Targeted delivery of nicotinamide adenine dinucleotide salvage pathway inhibitors |
| EP3548515A1 (en) | 2016-12-01 | 2019-10-09 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging |
| CA3044682A1 (en) | 2016-12-02 | 2018-06-07 | University Of Southern California | Synthetic immune receptors and methods of use thereof |
| BR112019017751A2 (pt) | 2017-02-28 | 2020-04-07 | Vor Biopharma, Inc. | composições e métodos de inibição de proteínas de linhagem específica |
| CN110352074B (zh) | 2017-02-28 | 2024-07-16 | 思进股份有限公司 | 用于偶联的半胱氨酸突变抗体 |
| US11730822B2 (en) | 2017-03-24 | 2023-08-22 | Seagen Inc. | Process for the preparation of glucuronide drug-linkers and intermediates thereof |
| WO2018201087A1 (en) | 2017-04-27 | 2018-11-01 | Seattle Genetics, Inc. | Quaternized nicotinamide adenine dinucleotide salvage pathway inhibitor conjugates |
| EP3624839A4 (en) * | 2017-05-17 | 2021-06-16 | Immunogen, Inc. | DOSING PLANS FOR ANTI-CD33 IMMUNE CONJUGATES |
| US12116406B2 (en) * | 2017-05-26 | 2024-10-15 | Fred Hutchinson Cancer Center | Anti-CD33 antibodies and uses thereof |
| PE20200486A1 (es) | 2017-08-03 | 2020-03-03 | Alector Llc | Anticuerpos anti-cd33 y metodos para utilizarlos |
| HRP20230675T1 (hr) | 2017-08-03 | 2023-09-29 | Alector Llc | Anti-trem2 protutijela i postupci njihove uporabe |
| IL301638B2 (en) | 2017-09-29 | 2024-09-01 | Daiichi Sankyo Co Ltd | Antibody-pyrrolobenzodiazepine derivative conjugate |
| JP2021513990A (ja) | 2018-02-20 | 2021-06-03 | シージェン インコーポレイテッド | 疎水性アウリスタチンｆ化合物およびそのコンジュゲート |
| WO2019164929A1 (en) * | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting cd33, and use thereof |
| KR102832460B1 (ko) | 2018-02-20 | 2025-07-11 | 드래곤플라이 쎄라퓨틱스, 인크. | Cd33, nkg2d, 및 cd16에 결합하는 다중-특이적 결합 단백질, 및 이의 사용 방법 |
| SG11202101994XA (en) | 2018-08-28 | 2021-03-30 | Vor Biopharma Inc | Genetically engineered hematopoietic stem cells and uses thereof |
| BR112021003016A2 (pt) | 2018-08-31 | 2021-05-18 | Alector Llc | anticorpos isolados, ácido nucleico isolado, vetor, célula hospedeira, métodos para produzir um anticorpo e para prevenir, reduzir o risco ou tratar uma doença e composição farmacêutica |
| US12398402B2 (en) | 2018-09-12 | 2025-08-26 | Fred Hutchinson Cancer Center | Reducing CD33 expression to selectively protect therapeutic cells |
| WO2020068058A1 (en) * | 2018-09-25 | 2020-04-02 | Academia Sinica | Anti-siglec antibody, pharmaceutical composition comprising the same, and uses thereof |
| WO2020095107A1 (en) * | 2018-11-07 | 2020-05-14 | Crispr Therapeutics Ag | Anti-cd33 immune cell cancer therapy |
| WO2020100954A1 (ja) | 2018-11-14 | 2020-05-22 | 第一三共株式会社 | 抗ｃｄｈ６抗体－ピロロベンゾジアゼピン誘導体コンジュゲート |
| BR112021016398A2 (pt) | 2019-02-22 | 2021-11-23 | Memorial Sloan Kettering Cancer Center | Anticorpos cd33 e métodos de uso dos mesmos para tratar o câncer |
| JP7627655B2 (ja) | 2019-03-25 | 2025-02-06 | 第一三共株式会社 | 抗体－ピロロベンゾジアゼピン誘導体コンジュゲート |
| WO2020196475A1 (ja) | 2019-03-25 | 2020-10-01 | 第一三共株式会社 | 抗ｈｅｒ２抗体－ピロロベンゾジアゼピン誘導体コンジュゲート |
| CA3139180A1 (en) | 2019-03-27 | 2020-10-01 | Daiichi Sankyo Company, Limited | Combination of antibody-pyrrolobenzodiazepine derivative conjugate and parp inhibitor |
| SG11202111130SA (en) | 2019-04-30 | 2021-11-29 | Senti Biosciences Inc | Chimeric receptors and methods of use thereof |
| WO2020247878A1 (en) * | 2019-06-06 | 2020-12-10 | Mythic Therapeutics, Inc. | Antigen-binding protein constructs and uses thereof |
| WO2021138407A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
| EP4126248A4 (en) * | 2020-03-31 | 2024-07-10 | Fred Hutchinson Cancer Center | HUMAN ANTI-CD33 ANTIBODIES AND THEIR USES |
| CN115297932A (zh) * | 2020-03-31 | 2022-11-04 | 弗莱德哈钦森癌症中心 | 抗cd33抗体和其用途 |
| US20230173093A1 (en) | 2020-04-10 | 2023-06-08 | Seagen Inc. | Charge variant linkers |
| US20210402001A1 (en) * | 2020-06-30 | 2021-12-30 | David I. Cohen | Zinc Porters, and their Monoclonal Antibody Conjugates, for the Prevention and Treatment of COVID-19 (SARS-CoV-2), Other Infections, and Cancers |
| KR20230061360A (ko) | 2020-09-02 | 2023-05-08 | 다이이찌 산쿄 가부시키가이샤 | 신규 엔도-β-N-아세틸글루코사미니다아제 |
| JP2023552919A (ja) * | 2020-11-11 | 2023-12-19 | ベルサピューティクス インコーポレイテッド | Ｗｎｔ受容体ｒｙｋに対する抗体バリアント |
| CA3204628A1 (en) | 2021-01-13 | 2022-07-21 | John T. POIRIER | Antibody-pyrrolobenzodiazepine derivative conjugate |
| US20240115607A1 (en) | 2021-01-26 | 2024-04-11 | Cytocares (Shanghai) Inc. | Chimeric antigen receptor (car) constructs and nk cells expressing car constructs |
| US12036286B2 (en) | 2021-03-18 | 2024-07-16 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| MX2023012364A (es) | 2021-04-20 | 2023-11-01 | Seagen Inc | Modulacion de citotoxicidad celular dependiente de anticuerpos. |
| WO2022251850A1 (en) | 2021-05-28 | 2022-12-01 | Seagen Inc. | Anthracycline antibody conjugates |
| IL312728A (en) | 2021-11-30 | 2024-07-01 | Daiichi Sankyo Co Ltd | Protease-cleavable masked antibodies |
| KR20240141757A (ko) | 2022-02-09 | 2024-09-27 | 다이이찌 산쿄 가부시키가이샤 | 환경 응답성 마스킹 항체 및 그 이용 |
| TW202346322A (zh) | 2022-03-02 | 2023-12-01 | 日商第一三共股份有限公司 | 含Ｆｃ分子之製造方法 |
| EP4493223A2 (en) | 2022-03-17 | 2025-01-22 | Seagen Inc. | Camptothecin conjugates |
| EP4634227A1 (en) | 2022-12-13 | 2025-10-22 | Seagen Inc. | Site-specific engineered cysteine antibody drug conjugates |
| CN116375874B (zh) * | 2023-04-14 | 2023-12-26 | 上海精翰生物科技有限公司 | 一种cd33抗体及其应用 |
| WO2025090774A1 (en) | 2023-10-24 | 2025-05-01 | Seagen Inc. | Chemotherapeutic compounds and methods of use |
| WO2025149947A1 (en) | 2024-01-12 | 2025-07-17 | Seagen Inc. | Antibody-drug conjugates |
| WO2025174974A1 (en) * | 2024-02-14 | 2025-08-21 | Bristol-Myers Squibb Company | Anti-cd33 antibodies and uses thereof |
| CN119080935A (zh) * | 2024-10-11 | 2024-12-06 | 上海市同仁医院 | 一种抗人SMIM45-107aa单克隆抗体及其用途 |
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-
2013
- 2013-03-14 US US13/804,227 patent/US20130309223A1/en not_active Abandoned
- 2013-05-15 KR KR1020207010113A patent/KR102241478B1/ko active Active
- 2013-05-15 JP JP2015512801A patent/JP6454269B2/ja not_active Expired - Fee Related
- 2013-05-15 NZ NZ702748A patent/NZ702748A/en not_active IP Right Cessation
- 2013-05-15 SG SG11201407610WA patent/SG11201407610WA/en unknown
- 2013-05-15 EP EP13790467.8A patent/EP2850104B1/en active Active
- 2013-05-15 EP EP18171884.2A patent/EP3421048A1/en not_active Withdrawn
- 2013-05-15 CN CN201380026079.9A patent/CN104936617B/zh active Active
- 2013-05-15 AU AU2013262788A patent/AU2013262788B2/en not_active Ceased
- 2013-05-15 DK DK13790467.8T patent/DK2850104T3/en active
- 2013-05-15 US US14/401,837 patent/US9587019B2/en active Active
- 2013-05-15 WO PCT/US2013/041209 patent/WO2013173496A2/en not_active Ceased
- 2013-05-15 MX MX2014013866A patent/MX350808B/es active IP Right Grant
- 2013-05-15 IN IN10653DEN2014 patent/IN2014DN10653A/en unknown
- 2013-05-15 EA EA201492137A patent/EA029987B1/ru unknown
- 2013-05-15 ES ES13790467.8T patent/ES2686618T3/es active Active
- 2013-05-15 CA CA2873286A patent/CA2873286C/en active Active
- 2013-05-15 KR KR1020147035516A patent/KR102100467B1/ko active Active
- 2013-05-17 TW TW102117539A patent/TWI593707B/zh active
-
2014
- 2014-11-17 IL IL235733A patent/IL235733B/en unknown
- 2014-12-15 ZA ZA2014/09224A patent/ZA201409224B/en unknown
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2017
- 2017-01-20 US US15/411,947 patent/US10787514B2/en active Active
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2018
- 2018-05-17 AU AU2018203508A patent/AU2018203508C1/en not_active Ceased
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2020
- 2020-05-22 AU AU2020203365A patent/AU2020203365B2/en not_active Ceased
- 2020-07-29 US US16/942,647 patent/US20210047404A1/en not_active Abandoned