SG11201907870VA - Compositions and methods for inhibition of lineage specific proteins - Google Patents

Compositions and methods for inhibition of lineage specific proteins

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Publication number
SG11201907870VA
SG11201907870VA SG11201907870VA SG11201907870VA SG11201907870VA SG 11201907870V A SG11201907870V A SG 11201907870VA SG 11201907870V A SG11201907870V A SG 11201907870VA SG 11201907870V A SG11201907870V A SG 11201907870VA SG 11201907870V A SG11201907870V A SG 11201907870VA
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Singapore
Prior art keywords
international
boston
compositions
suite
methods
Prior art date
Application number
SG11201907870VA
Inventor
Joseph Bolen
Aleksandar Radovic-Moreno
John Lydeard
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Vor Biopharma Inc
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Publication date
Application filed by Vor Biopharma Inc filed Critical Vor Biopharma Inc
Publication of SG11201907870VA publication Critical patent/SG11201907870VA/en

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • A61K39/461—Cellular immunotherapy characterised by the cell type used
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2319/00—Fusion polypeptide
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Abstract

Modifiedor deleted epitope No Lysis -1 cc 00 O C N (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIPO I PCT omit VIII °nolo omioolimmoiflo oimIE (10) International Publication Number WO 2018/160768 Al AML Cell Lysis (51) International Patent Classification: A61K 35/12 (2015.01) CO7K 14/705 (2006.01) A61K 35/14 (2015.01) CO7K 16/28 (2006.01) A61K 35/17 (2015.01) C12N 5/078 (2010.01) A61K 35/38 (2015.01) C12N 5/0789 (2010.01) (21) International Application Number: PCT/US2018/020327 (22) International Filing Date: 28 February 2018 (28.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/464,975 28 February 2017 (28.02.2017) US (71) Applicant: VOR BIOPHARMA, INC. [US/US]; 501 Boylston Street, Suite 6102, Boston, MA 02116 (US). (72) Inventors: BOLEN, Joseph; 501 Boylston Street, Suite 6102, Boston, MA 02116 (US). RADOVIC-MORENO, Aleksandar, Filip; 501 Boylston Street, Suite 6102, Boston, MA 02116 (US). LYDEARD, John; 501 Boylston Street, Suite 6102, Boston, MA 02116 (US). (74) Agent: WITTE-GARCIA, Chelsea, E.; Wolf, Green- field & Sacks, P.C., 600 Atlantic Avenue, Boston, MA 02210-2206 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: COMPOSITIONS AND METHODS FOR INHIBITION LINEAGE SPECIFIC PROTEINS FIGURE 3 B Targeting CD33+AML Cells No Binding to Edited Donor Graft Cells (57) : Disclosed herein are compositions, methods, and kits for use in treating hematopoietic malignancies, the compositions, methods, and kits comprise a cytotoxic agent targeting cells expressing a lineage-specific cell-surface protein and a population of hematopoietic cells that express the lineage-specific cell-surface protein, the hematopoietic cells being manipulated such that they do not bind the cytotoxic agent. [Continued on next page] WO 2018/160768 Al MIDEDIMOMMIDIREIDIDEMIEHEIHISIONVOIMIE EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))
SG11201907870VA 2017-02-28 2018-02-28 Compositions and methods for inhibition of lineage specific proteins SG11201907870VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762464975P 2017-02-28 2017-02-28
PCT/US2018/020327 WO2018160768A1 (en) 2017-02-28 2018-02-28 Compositions and methods for inhibition lineage specific proteins

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SG11201907870VA true SG11201907870VA (en) 2019-09-27

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US (1) US11975029B2 (en)
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