ES2379194T3 - Anticuerpos de unión a TGF-beta - Google Patents
Anticuerpos de unión a TGF-beta Download PDFInfo
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- ES2379194T3 ES2379194T3 ES06840328T ES06840328T ES2379194T3 ES 2379194 T3 ES2379194 T3 ES 2379194T3 ES 06840328 T ES06840328 T ES 06840328T ES 06840328 T ES06840328 T ES 06840328T ES 2379194 T3 ES2379194 T3 ES 2379194T3
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Landscapes
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| JP5818688B2 (ja) * | 2009-01-08 | 2015-11-18 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | 核酸増幅反応の効率を改善するための方法および組成物 |
| EP3141561B1 (en) * | 2009-04-24 | 2018-09-12 | Vanderbilt University | Anti-tgf-beta induction of bone growth |
| PH12013502489B1 (en) | 2011-06-03 | 2019-04-24 | Xoma Technology Ltd | Antibodies specific for tgf-beta |
| WO2013134665A1 (en) | 2012-03-08 | 2013-09-12 | Selig Sealing Products, Inc. | Container sealing member with protected security component and removal tab |
| EP2822592B1 (en) | 2012-03-08 | 2018-08-15 | Ludwig Institute for Cancer Research Limited | Tgf- 1 specific antibodies and methods and uses thereof |
| CN111000997A (zh) | 2013-03-20 | 2020-04-14 | 建新公司 | 用于治疗成骨不全的方法 |
| WO2016024628A1 (ja) * | 2014-08-14 | 2016-02-18 | 学校法人東京医科大学 | 樹状細胞の抗癌免疫賦活能の促進方法およびその用途 |
| WO2016115345A1 (en) | 2015-01-14 | 2016-07-21 | The Brigham And Women's Hospital, | Treatment of cancer with anti-lap monoclonal antibodies |
| TWI726870B (zh) | 2015-03-04 | 2021-05-11 | 美商健臻公司 | 具有高親和性、結合性及專一性之結合轉形生長因子-β１的ｓｃＦｖ-Ｆｃ二聚體 |
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| EP3307772B1 (en) | 2015-06-12 | 2020-09-09 | Ludwig Institute For Cancer Research Limited | Tgf-beta 3 specific antibodies and methods and uses thereof |
| MX2018014047A (es) | 2016-05-17 | 2019-06-20 | Genentech Inc | Firmas de genes estromales para el diagnóstico y uso en inmunoterapia. |
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| US10537637B2 (en) | 2017-01-05 | 2020-01-21 | Gensun Biopharma Inc. | Checkpoint regulator antagonists |
| TWI832600B (zh) * | 2017-01-20 | 2024-02-11 | 美商健臻公司 | 骨靶向抗體 |
| MX2020004567A (es) | 2017-11-06 | 2020-08-13 | Genentech Inc | Metodos diagnosticos y terapeuticos para el cancer. |
| AU2019293047A1 (en) | 2018-06-29 | 2021-01-28 | Gensun Biopharma Inc. | Antitumor immune checkpoint regulator antagonists |
| CA3118186A1 (en) | 2018-11-05 | 2020-05-14 | Ludwig Institute For Cancer Research Ltd | Humanized and variant tgf-.beta.1 specific antibodies and methods and uses thereof |
| CN113613726B (zh) | 2018-11-05 | 2025-07-15 | 路德维格癌症研究所有限公司 | 人源化和变体TGF-β3特异性抗体及其方法和用途 |
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| CA3152371A1 (en) | 2019-08-01 | 2021-02-04 | Vaccinex, Inc. | Combined inhibition of semaphorin-4d and tgf.beta. and compositions therefor |
| AU2021223336A1 (en) | 2020-02-19 | 2022-10-06 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing TGFB antagonist prodrugs useful in the treatment of cancer and methods thereof |
| CN113563473A (zh) | 2020-04-29 | 2021-10-29 | 三生国健药业（上海）股份有限公司 | 四价双特异性抗体、其制备方法和用途 |
| US20240002479A1 (en) * | 2020-11-23 | 2024-01-04 | The Regents Of The University Of Michigan | Single-chain antibody against flavivirus ns1 protein |
| WO2022115611A1 (en) | 2020-11-25 | 2022-06-02 | Catamaran Bio, Inc. | Cellular therapeutics engineered with signal modulators and methods of use thereof |
| CN112940119B (zh) * | 2021-04-26 | 2022-05-20 | 北京芳渟阳生生物科技有限公司 | 一种单克隆抗体及其与间充质干细胞外泌体的联合应用 |
| CN115707716A (zh) * | 2021-08-18 | 2023-02-21 | 丹生医药技术(上海)有限公司 | 一种TGF-β/VEGF双功能抗体融合蛋白 |
| WO2023080900A1 (en) | 2021-11-05 | 2023-05-11 | Genentech, Inc. | Methods and compositions for classifying and treating kidney cancer |
| WO2023221936A1 (zh) | 2022-05-17 | 2023-11-23 | 苏州创胜医药集团有限公司 | 双功能蛋白质及其制剂和用途 |
| EP4599089A1 (en) | 2022-10-05 | 2025-08-13 | Genentech, Inc. | Methods and compositions for classifying and treating bladder cancer |
| WO2024077166A1 (en) | 2022-10-05 | 2024-04-11 | Genentech, Inc. | Methods and compositions for classifying and treating lung cancer |
| TW202434643A (zh) * | 2023-01-09 | 2024-09-01 | 大陸商北京拓界生物醫藥科技有限公司 | ＴＧＦβ１結合分子、ＧＡＲＰ－ＴＧＦβ１結合分子及其醫藥用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
| EP1646655A2 (en) * | 2003-07-09 | 2006-04-19 | Eli Lilly And Company | Tgf-beta1 ligands |
| KR101245983B1 (ko) * | 2004-03-31 | 2013-06-28 | 제넨테크, 인크. | 인간화 항-ｔｇｆ-베타 항체 |
| ATE545657T1 (de) * | 2005-12-23 | 2012-03-15 | Lilly Co Eli | Tgf-beta antikörper |
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2006
- 2006-12-20 AT AT06840328T patent/ATE545657T1/de active
- 2006-12-20 JP JP2008547744A patent/JP2009521496A/ja not_active Ceased
- 2006-12-20 CA CA002632799A patent/CA2632799A1/en not_active Abandoned
- 2006-12-20 EP EP06840328A patent/EP1966243B1/en not_active Not-in-force
- 2006-12-20 CN CN2006800485519A patent/CN101346394B/zh not_active Expired - Fee Related
- 2006-12-20 ES ES06840328T patent/ES2379194T3/es active Active
- 2006-12-20 BR BRPI0620240-3A patent/BRPI0620240A2/pt not_active IP Right Cessation
- 2006-12-20 AU AU2006330542A patent/AU2006330542B2/en not_active Ceased
- 2006-12-20 US US12/096,383 patent/US7494651B2/en not_active Expired - Fee Related
- 2006-12-20 WO PCT/US2006/062397 patent/WO2007076391A1/en not_active Ceased
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| WO2007076391A9 (en) | 2008-08-28 |
| US20100136021A1 (en) | 2010-06-03 |
| AU2006330542B2 (en) | 2012-05-24 |
| US7927593B2 (en) | 2011-04-19 |
| AU2006330542A1 (en) | 2007-07-05 |
| CN101346394A (zh) | 2009-01-14 |
| JP2009521496A (ja) | 2009-06-04 |
| US20090155285A1 (en) | 2009-06-18 |
| US20080292638A1 (en) | 2008-11-27 |
| CN101346394B (zh) | 2012-07-25 |
| CA2632799A1 (en) | 2007-07-05 |
| EP1966243A1 (en) | 2008-09-10 |
| WO2007076391A1 (en) | 2007-07-05 |
| BRPI0620240A2 (pt) | 2011-11-08 |
| EP1966243B1 (en) | 2012-02-15 |
| ATE545657T1 (de) | 2012-03-15 |
| US7494651B2 (en) | 2009-02-24 |
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