IT1303776B1 - Processo per la preparazione di genoteche, di polipeptidi utilizzandodette genoteche e i polipepti ottenuti. - Google Patents

Processo per la preparazione di genoteche, di polipeptidi utilizzandodette genoteche e i polipepti ottenuti.

Info

Publication number
IT1303776B1
IT1303776B1 IT1998MI002509A ITMI982509A IT1303776B1 IT 1303776 B1 IT1303776 B1 IT 1303776B1 IT 1998MI002509 A IT1998MI002509 A IT 1998MI002509A IT MI982509 A ITMI982509 A IT MI982509A IT 1303776 B1 IT1303776 B1 IT 1303776B1
Authority
IT
Italy
Prior art keywords
nucleic acid
recombination
genoteche
methods
replication
Prior art date
Application number
IT1998MI002509A
Other languages
English (en)
Inventor
Andrew Raymon Morton Bradbury
Daniele Sblattero
Original Assignee
S I S S A Scuola Internaz Supe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT1998MI002509A priority Critical patent/IT1303776B1/it
Application filed by S I S S A Scuola Internaz Supe filed Critical S I S S A Scuola Internaz Supe
Priority to CA002350779A priority patent/CA2350779A1/en
Priority to EP99972677A priority patent/EP1131421B1/en
Priority to IL14312399A priority patent/IL143123A0/xx
Priority to AU37903/00A priority patent/AU3790300A/en
Priority to DE69932446T priority patent/DE69932446T2/de
Priority to PCT/EP1999/008856 priority patent/WO2000031246A2/en
Priority to AT99972677T priority patent/ATE333502T1/de
Priority to ES99972677T priority patent/ES2268907T3/es
Publication of ITMI982509A1 publication Critical patent/ITMI982509A1/it
Application granted granted Critical
Publication of IT1303776B1 publication Critical patent/IT1303776B1/it
Priority to IL143123A priority patent/IL143123A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
IT1998MI002509A 1998-11-19 1998-11-19 Processo per la preparazione di genoteche, di polipeptidi utilizzandodette genoteche e i polipepti ottenuti. IT1303776B1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT1998MI002509A IT1303776B1 (it) 1998-11-19 1998-11-19 Processo per la preparazione di genoteche, di polipeptidi utilizzandodette genoteche e i polipepti ottenuti.
EP99972677A EP1131421B1 (en) 1998-11-19 1999-11-18 Methods for the preparation by in vivo recombination of nucleic acid and polypeptide libraries and uses thereof
IL14312399A IL143123A0 (en) 1998-11-19 1999-11-18 Methods for the preparation of nucleic acid and polypeptide libraries and uses thereof
AU37903/00A AU3790300A (en) 1998-11-19 1999-11-18 Methods for the preparation of nucleic acid and polypeptide libraries and uses thereof
CA002350779A CA2350779A1 (en) 1998-11-19 1999-11-18 Methods for the preparation of nucleic acid and polypeptide libraries and uses thereof
DE69932446T DE69932446T2 (de) 1998-11-19 1999-11-18 Verfahren zur herstellung von nukleinsäure- und polypeptidbanken durch in vivo rekombination und ihre verwendungen
PCT/EP1999/008856 WO2000031246A2 (en) 1998-11-19 1999-11-18 Methods for the preparation by in vivo recombination of nucleic acid and polypeptide libraries and uses thereof
AT99972677T ATE333502T1 (de) 1998-11-19 1999-11-18 Verfahren zur herstellung von nukleinsäure- und polypeptidbanken durch in vivo rekombination und ihre verwendungen
ES99972677T ES2268907T3 (es) 1998-11-19 1999-11-18 Metodos para la preparacion de acidos nucleicos y polipeptidos mediante la recombinacion in vivo, y utilizaciones de las mismas.
IL143123A IL143123A (en) 1998-11-19 2001-05-14 Methods for the preparation by in vivo recombination of nucleic acid and polypeptide libraries and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI002509A IT1303776B1 (it) 1998-11-19 1998-11-19 Processo per la preparazione di genoteche, di polipeptidi utilizzandodette genoteche e i polipepti ottenuti.

Publications (2)

Publication Number Publication Date
ITMI982509A1 ITMI982509A1 (it) 2000-05-19
IT1303776B1 true IT1303776B1 (it) 2001-02-23

Family

ID=11381090

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1998MI002509A IT1303776B1 (it) 1998-11-19 1998-11-19 Processo per la preparazione di genoteche, di polipeptidi utilizzandodette genoteche e i polipepti ottenuti.

Country Status (9)

Country Link
EP (1) EP1131421B1 (it)
AT (1) ATE333502T1 (it)
AU (1) AU3790300A (it)
CA (1) CA2350779A1 (it)
DE (1) DE69932446T2 (it)
ES (1) ES2268907T3 (it)
IL (2) IL143123A0 (it)
IT (1) IT1303776B1 (it)
WO (1) WO2000031246A2 (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780620B1 (en) 1998-12-23 2004-08-24 Bristol-Myers Squibb Company Microbial transformation method for the preparation of an epothilone
US6686154B2 (en) 2000-06-05 2004-02-03 Zyomyx, Inc. Screening of phage displayed peptides without clearing of the cell culture
ATE384129T1 (de) * 2001-11-22 2008-02-15 Univ Keio Künstliche antikörperbibliothek mit super- repertoire
CA2798273A1 (en) 2010-05-04 2011-11-10 Merrimack Pharmaceuticals, Inc. Antibodies against epidermal growth factor receptor (egfr) and uses thereof
US8691231B2 (en) 2011-06-03 2014-04-08 Merrimack Pharmaceuticals, Inc. Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies
US9399672B2 (en) 2012-05-17 2016-07-26 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Hepatitis C virus neutralizing antibody
US9751931B2 (en) 2012-10-26 2017-09-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hepatitis C virus neutralizing antibodies and methods
US20180244785A1 (en) 2017-01-09 2018-08-30 Merrimack Pharmaceuticals, Inc. Anti-fgfr antibodies and methods of use
TWI788340B (zh) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 抗icos促效劑抗體及其用途
US11230601B2 (en) 2017-10-10 2022-01-25 Tilos Therapeutics, Inc. Methods of using anti-lap antibodies
KR20210089143A (ko) 2018-09-18 2021-07-15 메리맥 파마슈티컬즈, 인크. 항-tnfr2 항체 및 그의 용도
WO2020076969A2 (en) 2018-10-10 2020-04-16 Tilos Therapeutics, Inc. Anti-lap antibody variants and uses thereof
KR102559149B1 (ko) * 2018-10-26 2023-07-24 에프. 호프만-라 로슈 아게 재조합효소 매개 카세트 교환을 이용한 다중특이적 항체 스크리닝 방법
EP3930846A1 (en) 2019-03-01 2022-01-05 Merrimack Pharmaceuticals, Inc. Anti-tnfr2 antibodies and uses thereof
US20230272056A1 (en) 2020-04-09 2023-08-31 Merck Sharp & Dohme Llc Affinity matured anti-lap antibodies and uses thereof
CN117430696A (zh) * 2022-07-22 2024-01-23 北京智仁美博生物科技有限公司 用于表达Fab片段库的重组系统

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117679A (en) * 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5728557A (en) * 1995-06-01 1998-03-17 Merck & Co., Inc. Method of making herpes simplex type 1 mutants and mutants so produced
CN1208456C (zh) * 1996-12-20 2005-06-29 诺维信公司 体内重组

Also Published As

Publication number Publication date
EP1131421B1 (en) 2006-07-19
IL143123A (en) 2009-11-18
DE69932446D1 (de) 2006-08-31
ITMI982509A1 (it) 2000-05-19
WO2000031246A3 (en) 2000-08-17
ES2268907T3 (es) 2007-03-16
IL143123A0 (en) 2002-04-21
EP1131421A2 (en) 2001-09-12
WO2000031246A2 (en) 2000-06-02
DE69932446T2 (de) 2007-01-04
CA2350779A1 (en) 2000-06-02
AU3790300A (en) 2000-06-13
ATE333502T1 (de) 2006-08-15

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