DE69730235D1 - Neuartige Verfahren und Zusammensetzungen zur Entdeckung von neuen multimerischen Molekülen, basierend auf einer kombinatorisichen Bibliothek - Google Patents

Neuartige Verfahren und Zusammensetzungen zur Entdeckung von neuen multimerischen Molekülen, basierend auf einer kombinatorisichen Bibliothek

Info

Publication number
DE69730235D1
DE69730235D1 DE69730235T DE69730235T DE69730235D1 DE 69730235 D1 DE69730235 D1 DE 69730235D1 DE 69730235 T DE69730235 T DE 69730235T DE 69730235 T DE69730235 T DE 69730235T DE 69730235 D1 DE69730235 D1 DE 69730235D1
Authority
DE
Germany
Prior art keywords
compositions
discovery
novel methods
combinatorial library
molecules based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69730235T
Other languages
English (en)
Inventor
Dorsey Stuart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Hawaii
Original Assignee
University of Hawaii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Hawaii filed Critical University of Hawaii
Application granted granted Critical
Publication of DE69730235D1 publication Critical patent/DE69730235D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/02—Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
    • C12N15/04—Fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69730235T 1996-07-09 1997-06-30 Neuartige Verfahren und Zusammensetzungen zur Entdeckung von neuen multimerischen Molekülen, basierend auf einer kombinatorisichen Bibliothek Expired - Lifetime DE69730235D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/678,462 US5683899A (en) 1994-02-03 1996-07-09 Methods and compositions for combinatorial-based discovery of new multimeric molecules
PCT/US1997/011425 WO1998001534A1 (en) 1996-07-09 1997-06-30 Novel methods and compositions for combinatorial-based discovery of new multimeric molecules

Publications (1)

Publication Number Publication Date
DE69730235D1 true DE69730235D1 (de) 2004-09-16

Family

ID=24722889

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69730235T Expired - Lifetime DE69730235D1 (de) 1996-07-09 1997-06-30 Neuartige Verfahren und Zusammensetzungen zur Entdeckung von neuen multimerischen Molekülen, basierend auf einer kombinatorisichen Bibliothek

Country Status (9)

Country Link
US (2) US5683899A (de)
EP (1) EP0938545B1 (de)
JP (1) JP2000514296A (de)
AT (1) ATE273385T1 (de)
AU (1) AU738622B2 (de)
CA (1) CA2260360A1 (de)
DE (1) DE69730235D1 (de)
NZ (1) NZ333684A (de)
WO (1) WO1998001534A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268140B1 (en) * 1994-02-03 2001-07-31 Neugenesis Combinatorial metabolic libraries
US6420140B1 (en) 1996-10-11 2002-07-16 Abgenix, Inc. Production of multimeric protein by cell fusion method
US5916771A (en) * 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
DK1717322T3 (da) 1997-01-17 2012-10-22 Codexis Mayflower Holdings Llc Udvikling af hele celler og organismer ved rekursiv sekvensrekombination
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US7148054B2 (en) * 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US5989814A (en) * 1997-04-01 1999-11-23 Reagents Of The University Of California Screening methods in eucaryotic cells
US6497820B1 (en) 1998-02-03 2002-12-24 Arqule, Inc. Rapid method for separation of small molecules using reverse phase high performance liquid chromatography
US5968361A (en) * 1998-02-24 1999-10-19 Arqule, Inc. Rapid method for separation of small molecules using reverse phase high performance liquid chromatography
US8697394B2 (en) * 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
US7449308B2 (en) * 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
WO2002000879A2 (en) * 2000-06-28 2002-01-03 Glycofi, Inc. Methods for producing modified glycoproteins
EP1326892A2 (de) 2000-10-12 2003-07-16 University of Rochester Zusammensetzungen die die proliferation von krebszellen hemmen
JP2005532263A (ja) 2002-02-06 2005-10-27 ヴァイコー テクノロジーズ， インコーポレイテッド 抗梗塞分子
EP1495055B1 (de) * 2002-04-18 2013-08-14 Genencor International, Inc. Herstellung von funktionellen antikörpern in filamentösen pilzen
AU2003257181A1 (en) 2002-08-05 2004-02-23 University Of Rochester Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof
US20040053363A1 (en) * 2002-09-18 2004-03-18 Thomas Ryll Method for production of a multimeric protein by cell fusion
US20040053359A1 (en) * 2002-09-18 2004-03-18 Thomas Ryll Method for production of a multimeric protein by cell fusion
US7332299B2 (en) 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
JP4359286B2 (ja) * 2003-10-31 2009-11-04 ピレリ・タイヤ・ソチエタ・ペル・アツィオーニ タイヤ加硫装置用の膨張性ブラダ、その製造方法、及び車輪用のタイヤを製造するプロセス
US20060024782A1 (en) * 2004-01-21 2006-02-02 Novozymes A/S Production of a monoclonal antibody in a heterokaryon filamentous fungus or in a filamentous fungal host cell
CA2553731A1 (en) * 2004-01-21 2005-08-04 Novozymes A/S Production of a monoclonal antibody in a heterokaryon fungus or in a fungal host cell
EP1793858A4 (de) * 2004-09-08 2008-12-10 Univ Ohio State Res Found Menschliche monoklonale anti-ctla4-antikörper zur krebsbehandlung
EP1799261B1 (de) * 2004-10-15 2012-12-05 Intrexon Corporation Verfahren und zusammensetzungen zur kombinatorischen herstellung multivalenter rekombinanter antigene
CN101500481B (zh) 2005-04-05 2014-07-02 康宁股份有限公司 一种测定刺激事件对细胞产生的影响的方法
AU2005332058B2 (en) 2005-05-19 2011-12-01 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention Functional epitopes of Streptococcus pneumoniae PsaA antigen and uses thereof
AU2006304321B2 (en) 2005-10-14 2012-10-04 Musc Foundation For Research Development Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
US8080534B2 (en) 2005-10-14 2011-12-20 Phigenix, Inc Targeting PAX2 for the treatment of breast cancer
CA2981308C (en) 2006-09-21 2020-12-22 University Of Rochester Compositions and methods related to protein displacement therapy for myotonic dystrophy
WO2008136852A2 (en) 2006-11-01 2008-11-13 University Of Rochester Methods and compositions related to the structure and function of apobec3g
JP2010514839A (ja) 2007-01-03 2010-05-06 バーナム インスティテュート フォー メディカル リサーチ クロット結合化合物に関連する方法および組成物
CA2677665C (en) 2007-02-08 2019-11-05 University Of Utah Research Foundation Methods and compositions related to inhibition of viral entry
CA2734322A1 (en) * 2008-08-15 2010-02-18 Georgetown University Na channels, disease, and related assays and compositions
EP2370080A1 (de) 2008-12-02 2011-10-05 University of Utah Research Foundation Pde1 als zieltherapeutikum bei herzkrankheiten
WO2011022502A1 (en) 2009-08-18 2011-02-24 Georgetown University Boronic acid compositions and methods related to cancer
EP2485768A1 (de) 2009-10-07 2012-08-15 Sanford-Burnham Medical Research Institute Verfahren und zusammensetzungen im zusammenhang mit an gerinnseln bindenden lipidzusammensetzungen
CA2784145A1 (en) 2009-12-18 2011-06-23 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding compounds
EP2691105B1 (de) 2011-03-28 2018-07-11 University of Utah Research Foundation Verfahren und zusammensetzungen zur viruseindringungshemmung
DK3234160T3 (da) * 2014-12-16 2019-12-02 Danisco Us Inc Sammensætninger og fremgangsmåder til hjælper-stamme-medieret svampegenommodifikation
US12025615B2 (en) 2017-09-15 2024-07-02 Arizona Board Of Regents On Behalf Of Arizona State University Methods of classifying response to immunotherapy for cancer
EP4038222A4 (de) 2019-10-02 2023-10-18 Arizona Board of Regents on behalf of Arizona State University Verfahren und zusammensetzungen zur identifizierung von neoantigenen zur verwendung bei der behandlung und vorbeugung von krebs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486533A (en) * 1982-09-02 1984-12-04 St. Louis University Filamentous fungi functional replicating extrachromosomal element
US4727037A (en) * 1984-02-15 1988-02-23 Cetus Corporation Assay kit and method for the determination of antibody class and subclass
US4880734A (en) * 1984-05-11 1989-11-14 Chiron Corporation Eukaryotic regulatable transcription
US4816405A (en) * 1984-10-24 1989-03-28 The Regents Of The University Of California Vectors for transformation by ascomycetes
US4885249A (en) * 1984-12-05 1989-12-05 Allelix, Inc. Aspergillus niger transformation system
US5364770A (en) * 1985-08-29 1994-11-15 Genencor International Inc. Heterologous polypeptides expressed in aspergillus
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
JP3045539B2 (ja) * 1989-02-21 2000-05-29 ワシントン ユニバーシティ 改変型生殖ホルモン
US5506134A (en) 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
JPH0763363B2 (ja) * 1991-12-25 1995-07-12 萩原 義秀 融合細胞の取得方法
US5643745A (en) * 1994-02-03 1997-07-01 University Of Hawaii Heterologous dimeric proteins produced in heterokaryons

Also Published As

Publication number Publication date
CA2260360A1 (en) 1998-01-15
US5683899A (en) 1997-11-04
AU738622B2 (en) 2001-09-20
NZ333684A (en) 2000-06-23
AU3511997A (en) 1998-02-02
ATE273385T1 (de) 2004-08-15
US7267944B1 (en) 2007-09-11
EP0938545A1 (de) 1999-09-01
JP2000514296A (ja) 2000-10-31
EP0938545B1 (de) 2004-08-11
EP0938545A4 (de) 2001-04-11
WO1998001534A1 (en) 1998-01-15

Similar Documents

Publication Publication Date Title
DE69730235D1 (de) Neuartige Verfahren und Zusammensetzungen zur Entdeckung von neuen multimerischen Molekülen, basierend auf einer kombinatorisichen Bibliothek
PT1007654E (pt) Biblioteca de expressao de proteina ou peptido in vitro
MX9708186A (es) Metodo para general y seleccionar rutas metabolicas novedosas.
HUP0200400A2 (hu) Fehérjék izolálása és elemzése
DK1143006T3 (da) Vektorer/DNA-sekvenser fra humane kombinatoriske antistofbiblioteker
FI925986A0 (fi) Slumpartat bio-oligomer bibliotek, ett foerfarande foer syntetisering avdet samt ett foerfarande foer anvaendning av det
DK1712623T3 (da) Udvælgelse af proteiner ved anvendelse af RNA-proteinfusioner
ATE255163T1 (de) Methode zur in vitro molekularen evolution einer proteinfunktion
DE69710077D1 (de) Verfahren zur erkennung von verbindungen, die die interaktion von rna und rna-bindeproteinen beeinflussen
DE69623014D1 (de) Verfahren zur identifizierung und isolierung von einem molekül und von diesem erkannte moleküle
DE69519033D1 (de) Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophoren
ATE335498T1 (de) Methode mit hoher durchsatzrate zur funktionellen klassifizierung von in einem genomischen versuchsansatz identifizierten proteinen
DE69018117D1 (de) Zur Synthese von Karotinoiden verwendbare DNA-Sequenzen.
DE69633563D1 (de) Neues verfahren zur gewinnung und reinigung von fusionsproteinen
WO2002068698A3 (en) Use of nucleic acid libraries to create toxicological profiles
ATE311443T1 (de) Methoden zur durchforstung (screenen) von proteinen
DK1082423T3 (da) Cyclin E2-gener og -proteiner
DE60036794D1 (de) Proteomabbau
ATE427959T1 (de) Gereinigtes sr-p70 protein
ATE278702T1 (de) Verfahren zur synthese von phosphorothioat- oligonukelotiden
ATE412067T1 (de) Polypeptide mit spezieller, funktioneller domäne, verfahren zu ihrer identifikation und anwendungen derselben
DE69733948D1 (de) In vivo herstellung von replicativen molekülen
ATA904998A (de) Vorrichtung zur ton- bzw. klangsimulation von orchestermusik
DE69533804D1 (de) Mimetika von aus alternden zellen abgeleitete hemmer der dna synthese
ATE340249T1 (de) Produkt zur proteinstabilisierung von weinen

Legal Events

Date Code Title Description
8332 No legal effect for de