DE69932446D1 - Verfahren zur herstellung von nukleinsäure- und polypeptidbanken durch in vivo rekombination und ihre verwendungen - Google Patents
Verfahren zur herstellung von nukleinsäure- und polypeptidbanken durch in vivo rekombination und ihre verwendungenInfo
- Publication number
- DE69932446D1 DE69932446D1 DE69932446T DE69932446T DE69932446D1 DE 69932446 D1 DE69932446 D1 DE 69932446D1 DE 69932446 T DE69932446 T DE 69932446T DE 69932446 T DE69932446 T DE 69932446T DE 69932446 D1 DE69932446 D1 DE 69932446D1
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- recombination
- polypeptide
- methods
- replication
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Ceramic Products (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI982509 | 1998-11-19 | ||
IT1998MI002509A IT1303776B1 (it) | 1998-11-19 | 1998-11-19 | Processo per la preparazione di genoteche, di polipeptidi utilizzandodette genoteche e i polipepti ottenuti. |
PCT/EP1999/008856 WO2000031246A2 (en) | 1998-11-19 | 1999-11-18 | Methods for the preparation by in vivo recombination of nucleic acid and polypeptide libraries and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69932446D1 true DE69932446D1 (de) | 2006-08-31 |
DE69932446T2 DE69932446T2 (de) | 2007-01-04 |
Family
ID=11381090
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69932446T Expired - Lifetime DE69932446T2 (de) | 1998-11-19 | 1999-11-18 | Verfahren zur herstellung von nukleinsäure- und polypeptidbanken durch in vivo rekombination und ihre verwendungen |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1131421B1 (de) |
AT (1) | ATE333502T1 (de) |
AU (1) | AU3790300A (de) |
CA (1) | CA2350779A1 (de) |
DE (1) | DE69932446T2 (de) |
ES (1) | ES2268907T3 (de) |
IL (2) | IL143123A0 (de) |
IT (1) | IT1303776B1 (de) |
WO (1) | WO2000031246A2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6780620B1 (en) | 1998-12-23 | 2004-08-24 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
US6686154B2 (en) * | 2000-06-05 | 2004-02-03 | Zyomyx, Inc. | Screening of phage displayed peptides without clearing of the cell culture |
WO2003044198A1 (fr) * | 2001-11-22 | 2003-05-30 | Keio University | Banque d'anticorps artificiels dotee d'un super repertoire |
CN103189073B (zh) | 2010-05-04 | 2015-08-12 | 梅里麦克制药股份有限公司 | 抗表皮生长因子受体(egfr)的抗体及其用途 |
US8691231B2 (en) | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
US9399672B2 (en) | 2012-05-17 | 2016-07-26 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Hepatitis C virus neutralizing antibody |
US9751931B2 (en) | 2012-10-26 | 2017-09-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hepatitis C virus neutralizing antibodies and methods |
WO2018129451A2 (en) | 2017-01-09 | 2018-07-12 | Merrimack Pharmaceuticals, Inc. | Anti-fgfr antibodies and methods of use |
TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
EP3694552A1 (de) | 2017-10-10 | 2020-08-19 | Tilos Therapeutics, Inc. | Anti-lap-antikörper und verwendungen davon |
CA3153959A1 (en) | 2018-09-18 | 2020-03-26 | Merrimack Pharmaceuticals, Inc. | Anti-tnfr2 antibodies and uses thereof |
CN113164780A (zh) | 2018-10-10 | 2021-07-23 | 泰洛斯治疗公司 | 抗lap抗体变体及其用途 |
CN112912392A (zh) * | 2018-10-26 | 2021-06-04 | 豪夫迈·罗氏有限公司 | 利用重组酶介导的盒式交换的多特异性抗体筛选方法 |
CA3131953A1 (en) | 2019-03-01 | 2020-09-10 | Merrimack Pharmaceuticals, Inc. | Anti-tnfr2 antibodies and uses thereof |
WO2021207449A1 (en) | 2020-04-09 | 2021-10-14 | Merck Sharp & Dohme Corp. | Affinity matured anti-lap antibodies and uses thereof |
CN117430696A (zh) * | 2022-07-22 | 2024-01-23 | 北京智仁美博生物科技有限公司 | 用于表达Fab片段库的重组系统 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6117679A (en) * | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US5728557A (en) * | 1995-06-01 | 1998-03-17 | Merck & Co., Inc. | Method of making herpes simplex type 1 mutants and mutants so produced |
WO1998028416A1 (en) * | 1996-12-20 | 1998-07-02 | Novo Nordisk A/S | In vivo recombination |
-
1998
- 1998-11-19 IT IT1998MI002509A patent/IT1303776B1/it active
-
1999
- 1999-11-18 WO PCT/EP1999/008856 patent/WO2000031246A2/en active IP Right Grant
- 1999-11-18 AU AU37903/00A patent/AU3790300A/en not_active Abandoned
- 1999-11-18 EP EP99972677A patent/EP1131421B1/de not_active Expired - Lifetime
- 1999-11-18 DE DE69932446T patent/DE69932446T2/de not_active Expired - Lifetime
- 1999-11-18 ES ES99972677T patent/ES2268907T3/es not_active Expired - Lifetime
- 1999-11-18 IL IL14312399A patent/IL143123A0/xx unknown
- 1999-11-18 AT AT99972677T patent/ATE333502T1/de not_active IP Right Cessation
- 1999-11-18 CA CA002350779A patent/CA2350779A1/en not_active Abandoned
-
2001
- 2001-05-14 IL IL143123A patent/IL143123A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69932446T2 (de) | 2007-01-04 |
IT1303776B1 (it) | 2001-02-23 |
ITMI982509A1 (it) | 2000-05-19 |
ES2268907T3 (es) | 2007-03-16 |
WO2000031246A2 (en) | 2000-06-02 |
EP1131421A2 (de) | 2001-09-12 |
CA2350779A1 (en) | 2000-06-02 |
WO2000031246A3 (en) | 2000-08-17 |
IL143123A0 (en) | 2002-04-21 |
IL143123A (en) | 2009-11-18 |
ATE333502T1 (de) | 2006-08-15 |
AU3790300A (en) | 2000-06-13 |
EP1131421B1 (de) | 2006-07-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |