WO1999009417A3 - Method of drug selection - Google Patents

Method of drug selection Download PDF

Info

Publication number
WO1999009417A3
WO1999009417A3 PCT/GB1998/002510 GB9802510W WO9909417A3 WO 1999009417 A3 WO1999009417 A3 WO 1999009417A3 GB 9802510 W GB9802510 W GB 9802510W WO 9909417 A3 WO9909417 A3 WO 9909417A3
Authority
WO
WIPO (PCT)
Prior art keywords
library
identified
members
selecting
amino acid
Prior art date
Application number
PCT/GB1998/002510
Other languages
French (fr)
Other versions
WO1999009417A2 (en
WO1999009417A9 (en
Inventor
Henry Raphael Wolfe
Original Assignee
Nycomed Imaging As
Cockbain Julian
Henry Raphael Wolfe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As, Cockbain Julian, Henry Raphael Wolfe filed Critical Nycomed Imaging As
Priority to AU88173/98A priority Critical patent/AU8817398A/en
Publication of WO1999009417A2 publication Critical patent/WO1999009417A2/en
Publication of WO1999009417A9 publication Critical patent/WO1999009417A9/en
Publication of WO1999009417A3 publication Critical patent/WO1999009417A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/24—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • G01N2333/245—Escherichia (G)

Abstract

The invention provides a method for selecting a candidate drug compound, said method comprising i) identifying a starting oligopeptide having a binding affinity for a cell surface or other receptor site; ii) generating a plurality of homologous oligopeptides having single site amino acid modifications relative to said starting oligopeptide; iii) identifying components of said starting oligopeptide responsible for the secondary structure thereof; iv) for modification sites identified in step (ii) selecting a set of amino acids; v) for components identified in step (iii) selecting at least one non-natural amino acid which mimics the secondary structure of the component; vi) generating a first combinatorial library of oligopeptides having at said identified modification sites amino acid residues corresponding to said selected sets of amino acids; vii) identifying members of said first library having a binding affinity value above a predetermined minimum and generating a further combinatorial library of oligopeotides having members not present in said first library, and identifying members of said further library having improved binding affinity values relative to the identified members of said first library, and with the proviso that at least one of said first and further libraries contains oligopeptides containing residues of said non-natural amino acid or acids; and (viii) selecting from the identified members of said library or library a drug candidate.
PCT/GB1998/002510 1997-08-20 1998-08-20 Method of drug selection WO1999009417A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU88173/98A AU8817398A (en) 1997-08-20 1998-08-20 Method of drug selection

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5685997P 1997-08-20 1997-08-20
GB9717652.3 1997-08-20
GBGB9717652.3A GB9717652D0 (en) 1997-08-20 1997-08-20 Method

Publications (3)

Publication Number Publication Date
WO1999009417A2 WO1999009417A2 (en) 1999-02-25
WO1999009417A9 WO1999009417A9 (en) 1999-05-27
WO1999009417A3 true WO1999009417A3 (en) 1999-08-12

Family

ID=10817781

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/GB1998/002504 WO1999009416A2 (en) 1997-08-20 1998-08-20 Method of drug selection
PCT/GB1998/002510 WO1999009417A2 (en) 1997-08-20 1998-08-20 Method of drug selection

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/002504 WO1999009416A2 (en) 1997-08-20 1998-08-20 Method of drug selection

Country Status (7)

Country Link
EP (1) EP1005655A2 (en)
JP (1) JP2001516029A (en)
AU (2) AU8817398A (en)
CA (1) CA2300903A1 (en)
GB (1) GB9717652D0 (en)
NO (1) NO20000811L (en)
WO (2) WO1999009416A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9809782D0 (en) * 1998-05-07 1998-07-08 Nycomed Imaging As Method
GB9809776D0 (en) * 1998-05-07 1998-07-08 Nycomed Imaging As Method
GB9809780D0 (en) * 1998-05-07 1998-07-08 Nycomed Imaging As Method
EP2129683A4 (en) * 2007-02-26 2011-01-05 Ironwood Pharmaceuticals Inc Methods and compositions for the treatment of heart failure and other disorders
CA2707840A1 (en) 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
CN105658661B (en) * 2013-02-20 2020-07-24 卑尔根技术交易股份公司 Vaccine
US20220249644A1 (en) * 2018-08-24 2022-08-11 Vestlandets Innovasjonsselskap As (Vis) Heat-Stable Enterotoxins Mutants as Antidiarrheal Vaccine Antigens

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432018A (en) * 1990-06-20 1995-07-11 Affymax Technologies N.V. Peptide library and screening systems
WO1997000267A1 (en) * 1995-06-16 1997-01-03 Pence Conformationally-restricted combinatorial library composition and method
WO1997022617A1 (en) * 1995-12-18 1997-06-26 Praecis Pharmaceuticals Incorporated Methods for identifying compounds that bind to a target

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075211A (en) * 1986-03-26 1991-12-24 Genetic Systems Corporation Synthetic antigen for the detection of AIDS-related disease
US4965343A (en) * 1988-01-28 1990-10-23 Hoffmann-La Roche Inc. Method of peptide synthesis
JPH0768271B2 (en) * 1989-08-31 1995-07-26 三菱化学株式会社 Method for producing human osteocalcin
CS89491A3 (en) * 1990-04-09 1992-01-15 Chugai Pharmaceutical Co Ltd Hybrid calcitonin
US5911997A (en) * 1995-06-07 1999-06-15 Connetics Corporation Relaxin-like factor and methods and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432018A (en) * 1990-06-20 1995-07-11 Affymax Technologies N.V. Peptide library and screening systems
WO1997000267A1 (en) * 1995-06-16 1997-01-03 Pence Conformationally-restricted combinatorial library composition and method
WO1997022617A1 (en) * 1995-12-18 1997-06-26 Praecis Pharmaceuticals Incorporated Methods for identifying compounds that bind to a target

Also Published As

Publication number Publication date
AU8817398A (en) 1999-03-08
WO1999009417A2 (en) 1999-02-25
JP2001516029A (en) 2001-09-25
WO1999009417A9 (en) 1999-05-27
EP1005655A2 (en) 2000-06-07
NO20000811L (en) 2000-04-12
NO20000811D0 (en) 2000-02-18
WO1999009416A3 (en) 1999-10-21
CA2300903A1 (en) 1999-02-25
AU8816898A (en) 1999-03-08
WO1999009416A2 (en) 1999-02-25
GB9717652D0 (en) 1997-10-22

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