JP2021501162A5 - - Google Patents
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- JP2021501162A5 JP2021501162A5 JP2020523768A JP2020523768A JP2021501162A5 JP 2021501162 A5 JP2021501162 A5 JP 2021501162A5 JP 2020523768 A JP2020523768 A JP 2020523768A JP 2020523768 A JP2020523768 A JP 2020523768A JP 2021501162 A5 JP2021501162 A5 JP 2021501162A5
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- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
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- antibody
- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17199542 | 2017-11-01 | ||
| EP17199542.6 | 2017-11-01 | ||
| PCT/EP2018/079781 WO2019086497A2 (en) | 2017-11-01 | 2018-10-31 | Combination therapy with targeted ox40 agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021501162A JP2021501162A (ja) | 2021-01-14 |
| JP2021501162A5 true JP2021501162A5 (enExample) | 2021-12-09 |
Family
ID=60201896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020523768A Pending JP2021501162A (ja) | 2017-11-01 | 2018-10-31 | 標的ｏｘ４０アゴニストとの併用療法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20200392237A1 (enExample) |
| EP (1) | EP3704155A2 (enExample) |
| JP (1) | JP2021501162A (enExample) |
| KR (1) | KR20200084006A (enExample) |
| CN (1) | CN111315781A (enExample) |
| AU (1) | AU2018359506A1 (enExample) |
| BR (1) | BR112020007630A2 (enExample) |
| CA (1) | CA3079036A1 (enExample) |
| IL (1) | IL273770A (enExample) |
| MX (1) | MX2020004573A (enExample) |
| TW (1) | TW201930353A (enExample) |
| WO (1) | WO2019086497A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6996979B2 (ja) | 2015-03-31 | 2022-02-04 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 三量体ｔｎｆファミリーリガンドを含む抗原結合分子 |
| WO2017055398A2 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for a costimulatory tnf receptor |
| EP3559034B1 (en) | 2016-12-20 | 2020-12-02 | H. Hoffnabb-La Roche Ag | Combination therapy of anti-cd20/anti-cd3 bispecific antibodies and 4-1bb (cd137) agonists |
| BR112019013189A2 (pt) | 2017-01-03 | 2019-12-10 | Hoffmann La Roche | moléculas de ligação ao antígeno biespecífica, polinucleotídeo, célula hospedeira, método de produção da molécula de ligação ao antígeno biespecífica, composição farmacêutica, uso, métodos para inibir o crescimento de células tumorais em um indivíduo e para tratar o câncer ou uma doença infecciosa |
| CN110382542B (zh) | 2017-03-29 | 2023-06-09 | 豪夫迈·罗氏有限公司 | 针对共刺激性tnf受体的双特异性抗原结合分子 |
| EP3601345A1 (en) * | 2017-03-29 | 2020-02-05 | H. Hoffnabb-La Roche Ag | Bispecific antigen binding molecule for a costimulatory tnf receptor |
| MX2019011770A (es) | 2017-04-03 | 2020-01-09 | Hoffmann La Roche | Inmunoconjugados de un anticuerpo anti-pd-1 con un mutante il-2 o con il-15. |
| BR112019017753B1 (pt) | 2017-04-04 | 2024-04-30 | F. Hoffmann-La Roche Ag | Molécula biespecífica de ligação ao antígeno, composição farmacêutica e uso da molécula biespecífica de ligação ao antígeno |
| TWI841551B (zh) | 2018-03-13 | 2024-05-11 | 瑞士商赫孚孟拉羅股份公司 | 使用靶向4-1bb (cd137)之促效劑的組合療法 |
| EP3774900A1 (en) | 2018-04-13 | 2021-02-17 | F. Hoffmann-La Roche AG | Her2-targeting antigen binding molecules comprising 4-1bbl |
| AR114732A1 (es) | 2018-09-18 | 2020-10-07 | Hoffmann La Roche | Utilización de un inhibidor de catepsina s contra la formación de anticuerpos antifármaco |
| WO2020070041A1 (en) | 2018-10-01 | 2020-04-09 | F. Hoffmann-La Roche Ag | Bispecific antigen binding molecules comprising anti-fap clone 212 |
| MY198034A (en) | 2018-12-21 | 2023-07-27 | Hoffmann La Roche | Tumor-targeted agonistic cd28 antigen binding molecules |
| KR20210134932A (ko) | 2019-03-29 | 2021-11-11 | 에프. 호프만-라 로슈 아게 | 정의된 조직에서 다중 발현 카세트의 표적화된 통합에 의해 FcRn 발현 세포를 생성하는 방법 |
| CA3140323A1 (en) * | 2019-06-19 | 2020-12-24 | Johannes Auer | Method for the generation of a multivalent, bispecific antibody expressing cell by targeted integration of multiple expression cassettes in a defined organization |
| BR112021025436A2 (pt) | 2019-06-19 | 2022-02-01 | Hoffmann La Roche | Métodos para produzir um anticorpo biespecífico trivalente, biespecífico bivalente, biespecífico multivalente, para produzir uma célula de mamífero recombinante e para produzir um anticorpo trivalente, ácidos desoxirribonucleicos, usos de um ácido desoxirribonucleico, células de mamífero recombinante, composições e uso de mrna de recombinase cre |
| BR112022001460A2 (pt) * | 2019-07-31 | 2022-03-22 | Hoffmann La Roche | Moléculas de ligação ao antígeno biespecíficas, um ou mais polinucleotídeos isolados, célula hospedeira, método para produzir uma molécula de ligação ao antígeno biespecífica e para tratar uma doença em um indivíduo, composição farmacêutica, uso da molécula de ligação ao antígeno biespecífica e invenção |
| US20230075633A1 (en) * | 2019-12-20 | 2023-03-09 | Shandong Boan Biotechnology Co., Ltd. | Optimized anti-cd3 arm in the generation of t-cell bispecific antibodies for immunotherapy |
| AR121706A1 (es) * | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
| US12492252B2 (en) | 2020-07-01 | 2025-12-09 | Shandong Boan Biotechnology Co., Ltd. | Anti-GPC3 antibody, anti-GPC3 chimeric antigen receptor and GPC3/CD3 bispecific antibody |
| CN115433282A (zh) * | 2021-06-02 | 2022-12-06 | 启愈生物技术(上海)有限公司 | 抗cd3抗体变异体、融合蛋白及应用 |
| EP4475879A1 (en) | 2022-02-08 | 2024-12-18 | Hookipa Biotech GmbH | Combination therapy with arenavirus particles and immune checkpoint modulators or cytokines |
| CN120826234A (zh) * | 2023-03-06 | 2025-10-21 | 豪夫迈·罗氏有限公司 | 抗EGFRvIII/抗CD3抗体与肿瘤靶向性4-1BB激动剂的组合疗法 |
| TW202509071A (zh) | 2023-05-12 | 2025-03-01 | 丹麥商珍美寶股份有限公司 | 能夠與ｏｘ４０結合之抗體、其變異體及其用途 |
| AU2024311339A1 (en) * | 2023-06-21 | 2026-01-08 | F. Hoffmann-La Roche Ag | Combination therapy with fap-targeted lymphotoxin beta receptor agonists |
| TW202540189A (zh) | 2023-11-30 | 2025-10-16 | 德商生物新技術公司 | 在組合療法中能夠結合ｏｘ４０之抗體 |
| TW202540200A (zh) | 2023-12-01 | 2025-10-16 | 美商基利科學股份有限公司 | 抗ｆａｐ－ｌｉｇｈｔ融合蛋白及其用途 |
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| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
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| EA031214B1 (ru) * | 2013-02-26 | 2018-12-28 | Роше Гликарт Аг | Биспецифические антигенсвязывающие молекулы, активирующие т-клетки |
| MA40972B1 (fr) * | 2014-11-20 | 2020-11-30 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t ciblant folr1 et cd3 |
| JP6944369B2 (ja) * | 2014-11-20 | 2021-10-06 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｔ細胞活性化二重特異性抗原結合分子ｃｄ３ ａｂｄ葉酸受容体１（ｆｏｌｒ１）及びｐｄ−１軸結合アンタゴニストの併用療法 |
| AU2016274584A1 (en) * | 2015-06-08 | 2018-01-04 | Genentech, Inc. | Methods of treating cancer using anti-OX40 antibodies and PD-1 axis binding antagonists |
| MA43025A (fr) * | 2015-10-02 | 2021-05-26 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t anti-ceaxcd3 |
| WO2017055398A2 (en) * | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for a costimulatory tnf receptor |
| CR20180171A (es) * | 2015-10-07 | 2018-05-03 | Hoffmann La Roche | Anticuerpos biespecíficos con tetravalencia para un receptor de fnt coestimulador |
| JP6949030B2 (ja) * | 2016-01-08 | 2021-10-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｐｄ−１軸結合アンタゴニスト及び抗ｃｅａ／抗ｃｄ３二重特異性抗体を用いたｃｅａ陽性がんの治療方法 |
| JP7082604B2 (ja) * | 2016-03-21 | 2022-06-08 | マレンゴ・セラピューティクス，インコーポレーテッド | 多重特異性および多機能性分子ならびにその使用 |
-
2018
- 2018-10-31 CN CN201880071376.8A patent/CN111315781A/zh active Pending
- 2018-10-31 BR BR112020007630-9A patent/BR112020007630A2/pt not_active IP Right Cessation
- 2018-10-31 EP EP18800545.8A patent/EP3704155A2/en not_active Withdrawn
- 2018-10-31 JP JP2020523768A patent/JP2021501162A/ja active Pending
- 2018-10-31 AU AU2018359506A patent/AU2018359506A1/en not_active Abandoned
- 2018-10-31 WO PCT/EP2018/079781 patent/WO2019086497A2/en not_active Ceased
- 2018-10-31 KR KR1020207015459A patent/KR20200084006A/ko not_active Ceased
- 2018-10-31 MX MX2020004573A patent/MX2020004573A/es unknown
- 2018-10-31 CA CA3079036A patent/CA3079036A1/en active Pending
- 2018-10-31 TW TW107138607A patent/TW201930353A/zh unknown
-
2020
- 2020-04-02 IL IL273770A patent/IL273770A/en unknown
- 2020-04-28 US US16/860,552 patent/US20200392237A1/en not_active Abandoned
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