JP2020511947A5 - - Google Patents
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- JP2020511947A5 JP2020511947A5 JP2019533631A JP2019533631A JP2020511947A5 JP 2020511947 A5 JP2020511947 A5 JP 2020511947A5 JP 2019533631 A JP2019533631 A JP 2019533631A JP 2019533631 A JP2019533631 A JP 2019533631A JP 2020511947 A5 JP2020511947 A5 JP 2020511947A5
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- 102000025171 antigen binding proteins Human genes 0.000 claims 164
- 108091000831 antigen binding proteins Proteins 0.000 claims 164
- 239000002157 polynucleotide Substances 0.000 claims 35
- 102000040430 polynucleotide Human genes 0.000 claims 35
- 108091033319 polynucleotide Proteins 0.000 claims 35
- 210000004027 cell Anatomy 0.000 claims 34
- 239000002773 nucleotide Substances 0.000 claims 31
- 125000003729 nucleotide group Chemical group 0.000 claims 31
- 239000003814 drug Substances 0.000 claims 27
- 239000000427 antigen Substances 0.000 claims 26
- 102000036639 antigens Human genes 0.000 claims 26
- 108091007433 antigens Proteins 0.000 claims 26
- 239000008194 pharmaceutical composition Substances 0.000 claims 26
- 206010028980 Neoplasm Diseases 0.000 claims 25
- 239000012634 fragment Substances 0.000 claims 23
- 239000013604 expression vector Substances 0.000 claims 22
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- 229940124597 therapeutic agent Drugs 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 229960001438 immunostimulant agent Drugs 0.000 claims 9
- 239000003022 immunostimulating agent Substances 0.000 claims 9
- 230000003308 immunostimulating effect Effects 0.000 claims 9
- 102100024952 Protein CBFA2T1 Human genes 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 8
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- 239000000203 mixture Substances 0.000 claims 7
- -1 MAB6 Proteins 0.000 claims 6
- 102000014105 Semaphorin Human genes 0.000 claims 6
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- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims 5
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 5
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- YJSXHUXXMDAOCE-UHFFFAOYSA-N 5-hydroxy-8,8-dimethyl-6-(2-methylbutanoyl)-4-phenylpyrano[2,3-h]chromen-2-one Chemical compound C=1C(=O)OC=2C=3C=CC(C)(C)OC=3C(C(=O)C(C)CC)=C(O)C=2C=1C1=CC=CC=C1 YJSXHUXXMDAOCE-UHFFFAOYSA-N 0.000 claims 4
- AVIZABGQXBMRCJ-UHFFFAOYSA-N Mammea A/AB cyclo F Chemical compound C12=C(O)C(C(=O)C(C)CC)=C3OC(C(C)(C)O)CC3=C2OC(=O)C=C1C1=CC=CC=C1 AVIZABGQXBMRCJ-UHFFFAOYSA-N 0.000 claims 4
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 claims 4
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
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- AVIZABGQXBMRCJ-DYVFJYSZSA-N 1,2-Dihydro-5-hydroxy-2-(1-hydroxy-1-methylethyl)-4-(2-methylbutyryl)-6-phenylfurano[2,3-h][1]benzopyran-8-one Natural products O=C([C@@H](CC)C)c1c(O)c2C(c3ccccc3)=CC(=O)Oc2c2c1O[C@H](C(O)(C)C)C2 AVIZABGQXBMRCJ-DYVFJYSZSA-N 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 101100344898 Arabidopsis thaliana MED13 gene Proteins 0.000 claims 2
- 101100516975 Arabidopsis thaliana NPY1 gene Proteins 0.000 claims 2
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- 102100027207 CD27 antigen Human genes 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 101100022187 Caenorhabditis elegans mab-10 gene Proteins 0.000 claims 2
- 101100075829 Caenorhabditis elegans mab-3 gene Proteins 0.000 claims 2
- 101100075830 Caenorhabditis elegans mab-5 gene Proteins 0.000 claims 2
- 101100075831 Caenorhabditis elegans mab-7 gene Proteins 0.000 claims 2
- 101100313161 Caenorhabditis elegans mab-9 gene Proteins 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 2
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 2
- 102100025390 Integrin beta-2 Human genes 0.000 claims 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 2
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 2
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- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
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- 239000000556 agonist Substances 0.000 claims 2
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- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 1
- 241000711404 Avian avulavirus 1 Species 0.000 claims 1
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims 1
- 102100032976 CCR4-NOT transcription complex subunit 6 Human genes 0.000 claims 1
- 102100024263 CD160 antigen Human genes 0.000 claims 1
- 102100035793 CD83 antigen Human genes 0.000 claims 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 102100026980 Exocyst complex component 5 Human genes 0.000 claims 1
- 101150046249 Havcr2 gene Proteins 0.000 claims 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 1
- 101000911703 Homo sapiens Exocyst complex component 5 Proteins 0.000 claims 1
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 1
- 101000971538 Homo sapiens Killer cell lectin-like receptor subfamily F member 1 Proteins 0.000 claims 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 1
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 1
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims 1
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 claims 1
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101001102797 Homo sapiens Transmembrane protein PVRIG Proteins 0.000 claims 1
- 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102000002698 KIR Receptors Human genes 0.000 claims 1
- 108010043610 KIR Receptors Proteins 0.000 claims 1
- 102100021458 Killer cell lectin-like receptor subfamily F member 1 Human genes 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 101150030213 Lag3 gene Proteins 0.000 claims 1
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- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 1
- 102100028749 Neuritin Human genes 0.000 claims 1
- 101710189685 Neuritin Proteins 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 1
- 102100029198 SLAM family member 7 Human genes 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 230000006052 T cell proliferation Effects 0.000 claims 1
- 102100027208 T-cell antigen CD7 Human genes 0.000 claims 1
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 1
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 102100039630 Transmembrane protein PVRIG Human genes 0.000 claims 1
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 1
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000030741 antigen processing and presentation Effects 0.000 claims 1
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
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- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662438733P | 2016-12-23 | 2016-12-23 | |
| US62/438,733 | 2016-12-23 | ||
| PCT/US2017/067782 WO2018119171A1 (en) | 2016-12-23 | 2017-12-21 | Anti-neuropilin antigen-binding proteins and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511947A JP2020511947A (ja) | 2020-04-23 |
| JP2020511947A5 true JP2020511947A5 (enExample) | 2021-01-28 |
| JP7621734B2 JP7621734B2 (ja) | 2025-01-27 |
Family
ID=61025050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533631A Active JP7621734B2 (ja) | 2016-12-23 | 2017-12-21 | 抗ニューロピリン抗原結合タンパク質およびその使用の方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US10227413B2 (enExample) |
| EP (1) | EP3558365B1 (enExample) |
| JP (1) | JP7621734B2 (enExample) |
| KR (1) | KR20190099254A (enExample) |
| CN (1) | CN110167590A (enExample) |
| AR (1) | AR110659A1 (enExample) |
| AU (1) | AU2017379062A1 (enExample) |
| BR (1) | BR112019012796A2 (enExample) |
| CA (1) | CA3046313A1 (enExample) |
| CO (1) | CO2019007846A2 (enExample) |
| EA (1) | EA201991546A1 (enExample) |
| ES (1) | ES2963746T3 (enExample) |
| IL (1) | IL267097A (enExample) |
| JO (1) | JOP20190134A1 (enExample) |
| MA (1) | MA47113A (enExample) |
| MX (1) | MX2019007554A (enExample) |
| PH (1) | PH12019501405A1 (enExample) |
| SA (1) | SA519402159B1 (enExample) |
| SG (1) | SG10201913855TA (enExample) |
| TW (1) | TWI797100B (enExample) |
| WO (1) | WO2018119171A1 (enExample) |
| ZA (1) | ZA202003695B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190134A1 (ar) | 2016-12-23 | 2019-06-02 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها |
| EP3579848B1 (en) | 2017-02-08 | 2024-10-30 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| JP7685821B2 (ja) | 2017-02-20 | 2025-05-30 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｈｅｒ２、ＮＫＧ２ＤおよびＣＤ１６に結合するタンパク質 |
| JOP20190203A1 (ar) * | 2017-03-30 | 2019-09-03 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها |
| MX2020008336A (es) | 2018-02-08 | 2020-09-21 | Dragonfly Therapeutics Inc | Dominios variables de anticuerpos que se dirigen al receptor nkg2d. |
| BR112020015994A2 (pt) | 2018-02-08 | 2020-12-15 | Dragonfly Therapeutics, Inc. | Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer |
| JP7353576B2 (ja) | 2018-02-20 | 2023-10-02 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｃｄ３３、ｎｋｇ２ｄ、及びｃｄ１６に結合する多重特異性結合タンパク質、ならびにその使用方法 |
| EA202190468A1 (ru) | 2018-08-08 | 2021-07-06 | Драгонфлай Терапьютикс, Инк. | Мультиспецифические связывающие белки, которые связывают bcma, nkg2d и cd16, и способы их применения |
| EA202091888A1 (ru) * | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| SG11202101298XA (en) | 2018-08-08 | 2021-03-30 | Dragonfly Therapeutics Inc | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
| WO2020109627A1 (en) * | 2018-11-30 | 2020-06-04 | Institut Gustave Roussy | Anti-neuropilin-1 and anti-programmed cell death-1 combination therapy for treating cancer |
| CN113574386A (zh) * | 2019-01-03 | 2021-10-29 | 国家医疗保健研究所 | 用于增强癌症患者的cd8+t细胞依赖性免疫应答的方法和药物组合物 |
| TWI859339B (zh) | 2019-09-24 | 2024-10-21 | 德商百靈佳殷格翰國際股份有限公司 | 抗nrp1a抗體及其用於治療眼或眼部疾病之用途 |
| AR122018A1 (es) | 2020-05-06 | 2022-08-03 | Dragonfly Therapeutics Inc | Proteínas que se unen a nkg2d, cd16 y clec12a |
| US20240018248A1 (en) | 2020-12-02 | 2024-01-18 | Vib Vzw | An ltbr agonist in combination therapy against cancer |
| CN117222663A (zh) | 2021-03-03 | 2023-12-12 | 蜻蜓疗法股份有限公司 | 使用结合nkg2d、cd16和肿瘤相关抗原的多特异性结合蛋白治疗癌症的方法 |
| JP2025527465A (ja) * | 2022-08-15 | 2025-08-22 | エムブレース セラピューティクス，インコーポレーテッド | 細胞内在標的に対する抗体を産生する無細胞方法 |
| EP4403578A1 (en) | 2023-01-19 | 2024-07-24 | Theranovir | Antibody aginst a glycosaminoglycan-modified neuropilin-1 epitope and methods of use thereof |
| EP4652196A1 (en) | 2023-01-19 | 2025-11-26 | Theranovir | Neuropilin-1-peptide based antibody, highliting new epitope associated to glycosaminoglycan-modified neuropilin-1 and methods of use thereof |
| WO2025029618A1 (en) * | 2023-07-28 | 2025-02-06 | Pinetree Therapeutics, Inc. | Non-receptor tyrosine kinase compositions for targeted lysosomal degradaton and methods of use thereof |
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| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
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2017
- 2017-06-16 JO JOP/2019/0134A patent/JOP20190134A1/ar unknown
- 2017-12-21 CA CA3046313A patent/CA3046313A1/en active Pending
- 2017-12-21 MX MX2019007554A patent/MX2019007554A/es unknown
- 2017-12-21 EA EA201991546A patent/EA201991546A1/ru unknown
- 2017-12-21 CN CN201780079177.7A patent/CN110167590A/zh active Pending
- 2017-12-21 AR ARP170103623A patent/AR110659A1/es not_active Application Discontinuation
- 2017-12-21 ES ES17835532T patent/ES2963746T3/es active Active
- 2017-12-21 WO PCT/US2017/067782 patent/WO2018119171A1/en not_active Ceased
- 2017-12-21 BR BR112019012796-8A patent/BR112019012796A2/pt unknown
- 2017-12-21 KR KR1020197020999A patent/KR20190099254A/ko not_active Ceased
- 2017-12-21 SG SG10201913855TA patent/SG10201913855TA/en unknown
- 2017-12-21 MA MA047113A patent/MA47113A/fr unknown
- 2017-12-21 EP EP17835532.7A patent/EP3558365B1/en active Active
- 2017-12-21 TW TW106145004A patent/TWI797100B/zh active
- 2017-12-21 AU AU2017379062A patent/AU2017379062A1/en not_active Abandoned
- 2017-12-21 JP JP2019533631A patent/JP7621734B2/ja active Active
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2018
- 2018-02-20 US US15/900,158 patent/US10227413B2/en active Active
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- 2019-06-05 IL IL267097A patent/IL267097A/en unknown
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- 2019-06-21 SA SA519402159A patent/SA519402159B1/ar unknown
- 2019-07-22 CO CONC2019/0007846A patent/CO2019007846A2/es unknown
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2020
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2021
- 2021-10-25 US US17/509,351 patent/US20220098312A1/en not_active Abandoned
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