JP2019537449A5 - - Google Patents
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- JP2019537449A5 JP2019537449A5 JP2019527171A JP2019527171A JP2019537449A5 JP 2019537449 A5 JP2019537449 A5 JP 2019537449A5 JP 2019527171 A JP2019527171 A JP 2019527171A JP 2019527171 A JP2019527171 A JP 2019527171A JP 2019537449 A5 JP2019537449 A5 JP 2019537449A5
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- 102000025171 antigen binding proteins Human genes 0.000 claims 195
- 108091000831 antigen binding proteins Proteins 0.000 claims 195
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 76
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 67
- 239000000427 antigen Substances 0.000 claims 46
- 102000036639 antigens Human genes 0.000 claims 46
- 108091007433 antigens Proteins 0.000 claims 46
- 239000003814 drug Substances 0.000 claims 38
- 210000004027 cell Anatomy 0.000 claims 36
- 239000002773 nucleotide Substances 0.000 claims 34
- 125000003729 nucleotide group Chemical group 0.000 claims 34
- 239000002157 polynucleotide Substances 0.000 claims 32
- 102000040430 polynucleotide Human genes 0.000 claims 32
- 108091033319 polynucleotide Proteins 0.000 claims 32
- 239000012634 fragment Substances 0.000 claims 28
- 239000013604 expression vector Substances 0.000 claims 23
- 230000003308 immunostimulating effect Effects 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 229960001438 immunostimulant agent Drugs 0.000 claims 11
- 239000003022 immunostimulating agent Substances 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 210000003162 effector t lymphocyte Anatomy 0.000 claims 10
- 210000003289 regulatory T cell Anatomy 0.000 claims 10
- 102000047758 human TNFRSF18 Human genes 0.000 claims 9
- 235000001014 amino acid Nutrition 0.000 claims 8
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- 238000006467 substitution reaction Methods 0.000 claims 8
- 229940124597 therapeutic agent Drugs 0.000 claims 8
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- 101000597780 Mus musculus Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 claims 6
- 101000912551 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Fimbrin Proteins 0.000 claims 6
- 102100035283 Tumor necrosis factor ligand superfamily member 18 Human genes 0.000 claims 6
- 229940127089 cytotoxic agent Drugs 0.000 claims 6
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims 5
- -1 EGFR inhibitors Substances 0.000 claims 5
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 claims 4
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 claims 4
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
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- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
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- 102000004127 Cytokines Human genes 0.000 claims 2
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- 101710167313 Drebrin-like protein Proteins 0.000 claims 2
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- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 2
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- 102100025390 Integrin beta-2 Human genes 0.000 claims 2
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 2
- 102100035845 Peflin Human genes 0.000 claims 2
- 101100000443 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ACC1 gene Proteins 0.000 claims 2
- 101100489940 Schizosaccharomyces pombe (strain 972 / ATCC 24843) abp2 gene Proteins 0.000 claims 2
- 230000006052 T cell proliferation Effects 0.000 claims 2
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- 229910052739 hydrogen Inorganic materials 0.000 claims 2
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- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 1
- 241000711404 Avian avulavirus 1 Species 0.000 claims 1
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
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- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 1
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 1
- 101000971538 Homo sapiens Killer cell lectin-like receptor subfamily F member 1 Proteins 0.000 claims 1
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 1
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims 1
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 claims 1
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
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- 102100021458 Killer cell lectin-like receptor subfamily F member 1 Human genes 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
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- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 101100425749 Mus musculus Tnfrsf18 gene Proteins 0.000 claims 1
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- 102100027208 T-cell antigen CD7 Human genes 0.000 claims 1
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 1
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- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
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- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 1
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- 230000030741 antigen processing and presentation Effects 0.000 claims 1
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- 108010074108 interleukin-21 Proteins 0.000 claims 1
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- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims 1
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- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662497428P | 2016-11-19 | 2016-11-19 | |
| US62/497,428 | 2016-11-19 | ||
| US201762448644P | 2017-01-20 | 2017-01-20 | |
| US62/448,644 | 2017-01-20 | ||
| PCT/US2017/062443 WO2018094300A1 (en) | 2016-11-19 | 2017-11-19 | Anti-gitr antigen-binding proteins and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019537449A JP2019537449A (ja) | 2019-12-26 |
| JP2019537449A5 true JP2019537449A5 (enExample) | 2021-01-07 |
| JP7572147B2 JP7572147B2 (ja) | 2024-10-23 |
Family
ID=62146165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019527171A Active JP7572147B2 (ja) | 2016-11-19 | 2017-11-19 | 抗ｇｉｔｒ抗原結合タンパク質およびその使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10988545B2 (enExample) |
| EP (1) | EP3541845A1 (enExample) |
| JP (1) | JP7572147B2 (enExample) |
| KR (1) | KR102574071B1 (enExample) |
| CN (1) | CN110248960A (enExample) |
| AU (1) | AU2017362721A1 (enExample) |
| BR (1) | BR112019010128A2 (enExample) |
| CO (1) | CO2019006424A2 (enExample) |
| IL (1) | IL266720A (enExample) |
| JO (1) | JOP20190100A1 (enExample) |
| MA (1) | MA46844A (enExample) |
| MX (1) | MX2019005821A (enExample) |
| PH (1) | PH12019501108A1 (enExample) |
| TW (1) | TWI783953B (enExample) |
| UA (1) | UA126389C2 (enExample) |
| WO (1) | WO2018094300A1 (enExample) |
| ZA (1) | ZA201902939B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102239781B1 (ko) * | 2019-04-08 | 2021-04-13 | 주식회사 녹십자 | Gpnmb 및 cd3에 특이적으로 결합하는 이중특이적 항체 및 이의 용도 |
| US10994021B1 (en) * | 2020-04-11 | 2021-05-04 | Bliss Biopharmaceutical (Hangzhou) Co., Ltd. | Tetravalent antibody-drug conjugates and use thereof |
| CA3180541A1 (en) | 2020-06-08 | 2021-12-16 | George Ueda | Antibody-bound nanoparticles |
| WO2022240161A1 (ko) * | 2021-05-10 | 2022-11-17 | 메디맵바이오 주식회사 | 항-gitr 항체 및 이의 용도 |
| EP4437112A1 (en) * | 2021-11-24 | 2024-10-02 | Formycon AG | Improved ace2 fusion proteins |
| US20250179204A1 (en) | 2022-03-15 | 2025-06-05 | Yeda Research And Development Co. Ltd. | Anti glucocorticoid-induced tnfr-related (gitr) protein antibodies and uses thereof |
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| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
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-
2017
- 2017-06-16 JO JOP/2019/0100A patent/JOP20190100A1/ar unknown
- 2017-11-19 MA MA046844A patent/MA46844A/fr unknown
- 2017-11-19 CN CN201780071351.3A patent/CN110248960A/zh active Pending
- 2017-11-19 EP EP17817953.7A patent/EP3541845A1/en active Pending
- 2017-11-19 AU AU2017362721A patent/AU2017362721A1/en not_active Abandoned
- 2017-11-19 MX MX2019005821A patent/MX2019005821A/es unknown
- 2017-11-19 JP JP2019527171A patent/JP7572147B2/ja active Active
- 2017-11-19 UA UAA201906793A patent/UA126389C2/uk unknown
- 2017-11-19 WO PCT/US2017/062443 patent/WO2018094300A1/en not_active Ceased
- 2017-11-19 BR BR112019010128-4A patent/BR112019010128A2/pt not_active IP Right Cessation
- 2017-11-19 KR KR1020197017116A patent/KR102574071B1/ko active Active
- 2017-11-20 TW TW106140182A patent/TWI783953B/zh not_active IP Right Cessation
-
2018
- 2018-02-20 US US15/900,168 patent/US10988545B2/en active Active
-
2019
- 2019-05-10 ZA ZA2019/02939A patent/ZA201902939B/en unknown
- 2019-05-17 PH PH12019501108A patent/PH12019501108A1/en unknown
- 2019-05-19 IL IL266720A patent/IL266720A/en unknown
- 2019-06-19 CO CONC2019/0006424A patent/CO2019006424A2/es unknown
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2021
- 2021-03-10 US US17/197,547 patent/US20210269542A1/en not_active Abandoned
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