JP2020530289A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020530289A5 JP2020530289A5 JP2020506222A JP2020506222A JP2020530289A5 JP 2020530289 A5 JP2020530289 A5 JP 2020530289A5 JP 2020506222 A JP2020506222 A JP 2020506222A JP 2020506222 A JP2020506222 A JP 2020506222A JP 2020530289 A5 JP2020530289 A5 JP 2020530289A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- item
- sequence
- molecule
- molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 34
- 101100501552 Homo sapiens ENTPD1 gene Proteins 0.000 claims description 28
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 239000012228 culture supernatant Substances 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 239000013598 vector Substances 0.000 claims description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000025171 antigen binding proteins Human genes 0.000 description 26
- 108091000831 antigen binding proteins Proteins 0.000 description 26
- 108091035707 Consensus sequence Proteins 0.000 description 25
- 102100029722 Ectonucleoside triphosphate diphosphohydrolase 1 Human genes 0.000 description 17
- 101001012447 Homo sapiens Ectonucleoside triphosphate diphosphohydrolase 1 Proteins 0.000 description 17
- 230000002401 inhibitory effect Effects 0.000 description 16
- 210000001744 T-lymphocyte Anatomy 0.000 description 13
- 125000003275 alpha amino acid group Chemical group 0.000 description 12
- 102100025390 Integrin beta-2 Human genes 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 239000008194 pharmaceutical composition Substances 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 9
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 description 8
- 239000003446 ligand Substances 0.000 description 8
- 210000003289 regulatory T cell Anatomy 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 7
- 229960001438 immunostimulant agent Drugs 0.000 description 7
- 239000003022 immunostimulating agent Substances 0.000 description 7
- 230000003308 immunostimulating effect Effects 0.000 description 7
- 229910052757 nitrogen Inorganic materials 0.000 description 7
- 108091008034 costimulatory receptors Proteins 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 5
- 230000003915 cell function Effects 0.000 description 5
- 102000005962 receptors Human genes 0.000 description 5
- 108020003175 receptors Proteins 0.000 description 5
- 102100024263 CD160 antigen Human genes 0.000 description 4
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 description 4
- 108010043610 KIR Receptors Proteins 0.000 description 4
- 102000002698 KIR Receptors Human genes 0.000 description 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000012636 effector Substances 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 108091008042 inhibitory receptors Proteins 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- -1 ICOS (CD278) Proteins 0.000 description 3
- 108010002350 Interleukin-2 Proteins 0.000 description 3
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
- 239000013068 control sample Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 210000003162 effector t lymphocyte Anatomy 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 210000002865 immune cell Anatomy 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 230000002452 interceptive effect Effects 0.000 description 3
- 244000309459 oncolytic virus Species 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 229940124597 therapeutic agent Drugs 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 2
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 description 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 2
- 102100027207 CD27 antigen Human genes 0.000 description 2
- 102100038078 CD276 antigen Human genes 0.000 description 2
- 101710185679 CD276 antigen Proteins 0.000 description 2
- 101150013553 CD40 gene Proteins 0.000 description 2
- 102100035793 CD83 antigen Human genes 0.000 description 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 description 2
- 229940045513 CTLA4 antagonist Drugs 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 description 2
- 101150046249 Havcr2 gene Proteins 0.000 description 2
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 2
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 description 2
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 description 2
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 description 2
- 101000971538 Homo sapiens Killer cell lectin-like receptor subfamily F member 1 Proteins 0.000 description 2
- 101001138062 Homo sapiens Leukocyte-associated immunoglobulin-like receptor 1 Proteins 0.000 description 2
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 description 2
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 description 2
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 description 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 2
- 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 description 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 description 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 description 2
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 description 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 2
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 2
- 102100021458 Killer cell lectin-like receptor subfamily F member 1 Human genes 0.000 description 2
- 102000017578 LAG3 Human genes 0.000 description 2
- 101150030213 Lag3 gene Proteins 0.000 description 2
- 102100020943 Leukocyte-associated immunoglobulin-like receptor 1 Human genes 0.000 description 2
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 description 2
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 description 2
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 description 2
- 102100028749 Neuritin Human genes 0.000 description 2
- 101710189685 Neuritin Proteins 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 description 2
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 description 2
- 102100029198 SLAM family member 7 Human genes 0.000 description 2
- 102100027208 T-cell antigen CD7 Human genes 0.000 description 2
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 description 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 description 2
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 description 2
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 description 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 2
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 229960005305 adenosine Drugs 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000003018 immunosuppressive agent Substances 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 150000003287 riboflavins Chemical class 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 2
- 150000003505 terpenes Chemical class 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 239000004108 vegetable carbon Substances 0.000 description 2
- 235000019156 vitamin B Nutrition 0.000 description 2
- 239000011720 vitamin B Substances 0.000 description 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 1
- 102100023990 60S ribosomal protein L17 Human genes 0.000 description 1
- 108091006112 ATPases Proteins 0.000 description 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 241000711404 Avian avulavirus 1 Species 0.000 description 1
- 108010074708 B7-H1 Antigen Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102000034354 Gi proteins Human genes 0.000 description 1
- 108091006101 Gi proteins Proteins 0.000 description 1
- 102100035943 HERV-H LTR-associating protein 2 Human genes 0.000 description 1
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 description 1
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 description 1
- 108010052199 HLA-C Antigens Proteins 0.000 description 1
- 108010024164 HLA-G Antigens Proteins 0.000 description 1
- 101001021491 Homo sapiens HERV-H LTR-associating protein 2 Proteins 0.000 description 1
- 101000984189 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 2 Proteins 0.000 description 1
- 101000984186 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 4 Proteins 0.000 description 1
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010065805 Interleukin-12 Proteins 0.000 description 1
- 108090000172 Interleukin-15 Proteins 0.000 description 1
- 108010002616 Interleukin-5 Proteins 0.000 description 1
- 108010002586 Interleukin-7 Proteins 0.000 description 1
- 108010017736 Leukocyte Immunoglobulin-like Receptor B1 Proteins 0.000 description 1
- 102100025584 Leukocyte immunoglobulin-like receptor subfamily B member 1 Human genes 0.000 description 1
- 102100025583 Leukocyte immunoglobulin-like receptor subfamily B member 2 Human genes 0.000 description 1
- 102100025578 Leukocyte immunoglobulin-like receptor subfamily B member 4 Human genes 0.000 description 1
- 241000282567 Macaca fascicularis Species 0.000 description 1
- 208000037581 Persistent Infection Diseases 0.000 description 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 description 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 1
- 108091008874 T cell receptors Proteins 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 201000005787 hematologic cancer Diseases 0.000 description 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022118008A JP2022145720A (ja) | 2017-07-31 | 2022-07-25 | 抗ｃｄ３９抗体、抗ｃｄ３９抗体を含む組成物、および抗ｃｄ３９抗体を使用する方法 |
| JP2024053368A JP7690085B2 (ja) | 2017-07-31 | 2024-03-28 | 抗ｃｄ３９抗体、抗ｃｄ３９抗体を含む組成物、および抗ｃｄ３９抗体を使用する方法 |
| JP2025088950A JP2025116106A (ja) | 2017-07-31 | 2025-05-28 | 抗ｃｄ３９抗体、抗ｃｄ３９抗体を含む組成物、および抗ｃｄ３９抗体を使用する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762539527P | 2017-07-31 | 2017-07-31 | |
| US62/539,527 | 2017-07-31 | ||
| PCT/US2018/044449 WO2019027935A1 (en) | 2017-07-31 | 2018-07-30 | ANTI-CD39 ANTIBODIES, COMPOSITIONS COMPRISING ANTI-CD39 ANTIBODIES AND METHODS OF USING ANTI-CD39 ANTIBODIES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022118008A Division JP2022145720A (ja) | 2017-07-31 | 2022-07-25 | 抗ｃｄ３９抗体、抗ｃｄ３９抗体を含む組成物、および抗ｃｄ３９抗体を使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020530289A JP2020530289A (ja) | 2020-10-22 |
| JP2020530289A5 true JP2020530289A5 (enExample) | 2021-09-09 |
| JP7113071B2 JP7113071B2 (ja) | 2022-08-04 |
Family
ID=65233024
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020506222A Active JP7113071B2 (ja) | 2017-07-31 | 2018-07-30 | 抗ｃｄ３９抗体、抗ｃｄ３９抗体を含む組成物、および抗ｃｄ３９抗体を使用する方法 |
| JP2022118008A Withdrawn JP2022145720A (ja) | 2017-07-31 | 2022-07-25 | 抗ｃｄ３９抗体、抗ｃｄ３９抗体を含む組成物、および抗ｃｄ３９抗体を使用する方法 |
| JP2024053368A Active JP7690085B2 (ja) | 2017-07-31 | 2024-03-28 | 抗ｃｄ３９抗体、抗ｃｄ３９抗体を含む組成物、および抗ｃｄ３９抗体を使用する方法 |
| JP2025088950A Pending JP2025116106A (ja) | 2017-07-31 | 2025-05-28 | 抗ｃｄ３９抗体、抗ｃｄ３９抗体を含む組成物、および抗ｃｄ３９抗体を使用する方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022118008A Withdrawn JP2022145720A (ja) | 2017-07-31 | 2022-07-25 | 抗ｃｄ３９抗体、抗ｃｄ３９抗体を含む組成物、および抗ｃｄ３９抗体を使用する方法 |
| JP2024053368A Active JP7690085B2 (ja) | 2017-07-31 | 2024-03-28 | 抗ｃｄ３９抗体、抗ｃｄ３９抗体を含む組成物、および抗ｃｄ３９抗体を使用する方法 |
| JP2025088950A Pending JP2025116106A (ja) | 2017-07-31 | 2025-05-28 | 抗ｃｄ３９抗体、抗ｃｄ３９抗体を含む組成物、および抗ｃｄ３９抗体を使用する方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (6) | US20190062448A1 (enExample) |
| EP (1) | EP3661966A4 (enExample) |
| JP (4) | JP7113071B2 (enExample) |
| KR (2) | KR102718932B1 (enExample) |
| CN (2) | CN111448211B (enExample) |
| AR (1) | AR112639A1 (enExample) |
| AU (1) | AU2018312251B2 (enExample) |
| BR (1) | BR112020002012A8 (enExample) |
| CA (1) | CA3071540A1 (enExample) |
| CL (1) | CL2020000281A1 (enExample) |
| CO (1) | CO2020001983A2 (enExample) |
| CR (1) | CR20200101A (enExample) |
| DO (1) | DOP2020000021A (enExample) |
| IL (2) | IL272367B2 (enExample) |
| MX (1) | MX2020001270A (enExample) |
| MY (1) | MY202018A (enExample) |
| PE (1) | PE20200617A1 (enExample) |
| PH (1) | PH12020500240A1 (enExample) |
| SG (2) | SG10202111869SA (enExample) |
| TW (2) | TWI798242B (enExample) |
| WO (1) | WO2019027935A1 (enExample) |
| ZA (1) | ZA202000608B (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2238170T3 (en) | 2008-01-31 | 2017-02-27 | Inserm - Inst Nat De La Santé Et De La Rech Médicale | ANTIBODIES AGAINST HUMAN CD39 AND ITS USE FOR INHIBITING ACTIVITY OF T-REGULATORY CELLS |
| MX2019010848A (es) | 2017-03-16 | 2019-10-30 | Innate Pharma | Composiciones y procedimientos para el tratamiento del cancer. |
| SG10202111869SA (en) | 2017-07-31 | 2021-11-29 | Trishula Therapeutics Inc | Anti-cd39 antibodies, compositions comprising anti-cd39 antibodies and methods of using anti-cd39 antibodies |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| CN113754768B (zh) * | 2018-03-14 | 2023-01-06 | 表面肿瘤学公司 | 结合cd39的抗体及其用途 |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| JP7368453B2 (ja) | 2018-05-03 | 2023-10-24 | シャンハイ エピムアブ バイオセラピューティクス カンパニー リミテッド | Ｐｄ－１およびｌａｇ－３に対する高親和性抗体ならびにそれらから作製された二重特異性結合タンパク質 |
| JP7500442B2 (ja) | 2018-06-18 | 2024-06-17 | イナート・ファルマ・ソシエテ・アノニム | 癌を処置するための組成物及び方法 |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| EP3927748A1 (en) * | 2019-02-21 | 2021-12-29 | Trishula Therapeutics, Inc. | Combination therapy involving anti-cd39 antibodies and anti-pd-1 or anti-pd-l1 antibodies |
| WO2020172605A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Antibody molecules that bind to nkp30 and uses thereof |
| JP7710373B2 (ja) | 2019-02-21 | 2025-07-18 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用 |
| KR20220061977A (ko) * | 2019-08-12 | 2022-05-13 | 퓨리노미아 바이오테크, 아이엔씨. | Cd39 발현 세포의 adcc 표적화를 통해 t 세포 매개 면역 반응을 촉진 및 강화하기 위한 방법 및 조성물 |
| JP7727387B2 (ja) | 2019-08-27 | 2025-08-21 | エルピサイエンス（スーチョウ）・バイオファーマ，リミテッド | 新規の抗ｃｄ３９抗体 |
| US11655303B2 (en) * | 2019-09-16 | 2023-05-23 | Surface Oncology, Inc. | Anti-CD39 antibody compositions and methods |
| CN110407941B (zh) * | 2019-09-25 | 2020-01-14 | 上海岸迈生物科技有限公司 | Cd39的高亲和力抗体及其用途 |
| US12391756B2 (en) | 2019-11-05 | 2025-08-19 | Jacobio Pharmaceuticals Co., Ltd. | Binding molecule specific for CD39 and use thereof |
| CA3166629A1 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| WO2021203058A2 (en) * | 2020-04-03 | 2021-10-07 | Trishula Therapeutics, Inc. | Combination therapy involving anti-cd39 antibodies and adoptive cell therapy |
| IL299245A (en) | 2020-06-22 | 2023-02-01 | Ngm Biopharmaceuticals Inc | LAIR-1 binding agents and methods of using them |
| WO2021260966A1 (ja) * | 2020-06-25 | 2021-12-30 | 学校法人埼玉医科大学 | アデノシン産生酵素を標的とする組成物 |
| TW202233673A (zh) | 2020-10-23 | 2022-09-01 | 美商雅雪生物治療公司 | 含調節免疫細胞功能之ｃｄ８抗原結合分子之融合物 |
| AU2021389989A1 (en) * | 2020-11-27 | 2023-06-08 | Elpiscience (Suzhou) Biopharma, Ltd. | Novel conjugate molecules targeting cd39 and tgfβeta |
| MX2023009100A (es) | 2021-02-03 | 2023-09-25 | Mozart Therapeutics Inc | Agentes aglutinantes y métodos para usar los mismos. |
| WO2022245500A1 (en) | 2021-05-19 | 2022-11-24 | Asher Biotherapeutics, Inc. | Il-21 polypeptides and targeted constructs |
| WO2023076876A1 (en) | 2021-10-26 | 2023-05-04 | Mozart Therapeutics, Inc. | Modulation of immune responses to viral vectors |
| CN118715243A (zh) * | 2022-01-24 | 2024-09-27 | 上海华奥泰生物药业股份有限公司 | Cd39抗原结合蛋白及其应用 |
| KR20240156633A (ko) | 2022-03-03 | 2024-10-30 | 아르커스 바이오사이언시즈 인코포레이티드 | 항-cd39 항체 및 이의 용도 |
| WO2023164872A1 (en) * | 2022-03-03 | 2023-09-07 | Arcus Biosciences, Inc. | Anti-cd39 antibodies and use thereof |
| CN119013304A (zh) * | 2022-03-04 | 2024-11-22 | 翠舒拉治疗股份有限公司 | 在胃癌中使用抗人cd39抗体、抗人pd-1抗体和化疗的组合 |
| WO2023182530A1 (ja) | 2022-03-25 | 2023-09-28 | ブライトパス・バイオ株式会社 | 抗ｃｄ３９抗体 |
| KR20250004779A (ko) | 2022-04-13 | 2025-01-08 | 길리애드 사이언시즈, 인코포레이티드 | Trop-2 발현 암을 치료하기 위한 병용 요법 |
| WO2024030956A2 (en) * | 2022-08-03 | 2024-02-08 | Mozart Therapeutics, Inc. | Cd39-specific binding agents and methods of using the same |
| WO2024115935A1 (en) | 2022-11-29 | 2024-06-06 | Inserm | Methods for the treatment of b-cell lymphoma using cd39 inhibitors |
| WO2024175760A1 (en) * | 2023-02-24 | 2024-08-29 | Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of endometriosis |
| CN116589584B (zh) * | 2023-05-24 | 2025-02-14 | 深圳市先康达生命科学有限公司 | 靶向人Nectin4蛋白的抗体或其片段和应用 |
| KR102879536B1 (ko) * | 2023-06-09 | 2025-10-31 | 주식회사 브이티 | 시카 추출물이 함침된 마이크로 니들을 유효성분으로 포함하는 화장료 조성물 및 이의 제조방법 |
| US20250230168A1 (en) | 2023-12-22 | 2025-07-17 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| CN119798442B (zh) * | 2023-12-27 | 2025-12-16 | 华润生物医药有限公司 | 特异性结合cd39的纳米抗体及其用途 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4485696A (en) | 1995-01-18 | 1996-08-07 | Boehringer Mannheim Gmbh | Anti-cd 30 antibodies preventing proteolytic cleavage and release of membrane-bound cd 30 antigen |
| WO1996032471A2 (en) | 1995-04-10 | 1996-10-17 | Universite De Sherbrooke | Atp-diphosphohydrolases, process of purification thereof and process of producing thereof by recombinant technology |
| JP2002520040A (ja) | 1998-07-16 | 2002-07-09 | ハイセック，インコーポレーテッド | 新規ｃｄ３９様ポリペプチドに関する方法および材料 |
| US6476211B1 (en) | 1998-07-16 | 2002-11-05 | Hyseq, Inc. | Methods and materials relating to CD39-like polypeptides |
| US6387645B1 (en) | 1998-07-16 | 2002-05-14 | Hyseq, Inc. | Methods and materials relating to novel CD39-like polypeptides |
| US6447771B1 (en) | 1999-03-19 | 2002-09-10 | Hyseq, Inc. | Methods and materials relating to novel CD39-like polypeptides |
| US6350447B1 (en) | 1999-01-29 | 2002-02-26 | Hyseq, Inc. | Methods and compositions relating to CD39-like polypeptides and nucleic acids |
| US6899875B1 (en) | 1999-01-29 | 2005-05-31 | Nuvelo, Inc. | Methods and compositions relating to CD39-like polypeptides and nucleic acids |
| US6780977B1 (en) | 1999-01-29 | 2004-08-24 | Nuvelo, Inc. | Methods and compositions relating to CD39-like polypeptides and nucleic acids |
| US6335013B1 (en) | 1999-03-19 | 2002-01-01 | Hyseq, Inc. | Methods and materials relating to CD39-like polypeptides |
| WO2003052121A2 (en) | 2001-12-17 | 2003-06-26 | Beth Israel Deaconess Medical Center | Method of reducing angiogenesis |
| US20050037382A1 (en) | 2003-04-08 | 2005-02-17 | Robson Simon C. | Methods and compositions for treating and preventing autoimmune disorders |
| WO2006111986A1 (en) | 2005-04-19 | 2006-10-26 | Fondazione Santa Lucia I.R.C.C.S. | Method for the detection and the isolation of immunosuppressive regulatory t cells and uses thereof |
| WO2009021754A2 (en) | 2007-08-15 | 2009-02-19 | Bayer Schering Pharma Aktiengesellschaft | Monospecific and multispecific antibodies and method of use |
| EP2211908A2 (en) | 2007-11-30 | 2010-08-04 | Bristol-Myers Squibb Company | Conjugates of anti-rg-1 antibodies |
| DK2238170T3 (en) | 2008-01-31 | 2017-02-27 | Inserm - Inst Nat De La Santé Et De La Rech Médicale | ANTIBODIES AGAINST HUMAN CD39 AND ITS USE FOR INHIBITING ACTIVITY OF T-REGULATORY CELLS |
| DK2356270T3 (da) * | 2008-11-07 | 2016-12-12 | Fabrus Llc | Kombinatoriske antistofbiblioteker og anvendelser deraf |
| DK2654789T3 (en) * | 2010-12-22 | 2018-09-03 | Orega Biotech | ANTIBODIES AGAINST HUMAN CD39 AND USE THEREOF |
| US10633451B2 (en) * | 2012-02-03 | 2020-04-28 | Hoffmann-La Roche Inc. | Bispecific antibody molecules with antigen-transfected T-cells and their use in medicine |
| RU2736495C2 (ru) * | 2014-04-01 | 2020-11-17 | Рубиус Терапьютикс, Инк. | Способ и композиции для иммуномодуляции |
| EP3215538A4 (en) | 2014-11-07 | 2018-07-04 | Igenica Biotherapeutics, Inc. | Anti-cd39 antibodies and uses thereof |
| LT3221363T (lt) | 2014-11-21 | 2020-08-10 | Bristol-Myers Squibb Company | Antikūnai prieš cd73 ir jų panaudojimas |
| WO2016191703A2 (en) | 2015-05-27 | 2016-12-01 | The Trustees Of Columbia University In The City Of New York | Tumor deliverable iron and protein synthesis inhibitors as a new class of drugs for the diagnosis and treatment of cancer |
| CN108368176B (zh) | 2015-10-01 | 2022-06-07 | 波滕扎治疗公司 | 抗tigit抗原结合蛋白及其使用方法 |
| US11130817B2 (en) | 2015-10-12 | 2021-09-28 | Innate Pharma | CD73 blocking agents |
| CA3005986A1 (en) | 2015-11-23 | 2017-06-01 | Innate Pharma | Cd39 vascular isoform targeting agents |
| EP3912681A1 (en) | 2016-03-14 | 2021-11-24 | Orega Biotech | Anti-cd39 antibodies |
| ES2912453T3 (es) | 2016-05-06 | 2022-05-26 | Inst Nat Sante Rech Med | Composiciones farmacéuticas para el tratamiento de la leucemia mieloide aguda (LMA) quimiorresistente |
| WO2018065552A1 (en) | 2016-10-06 | 2018-04-12 | Innate Pharma | Anti-cd39 antibodies |
| CN110402249A (zh) | 2016-12-22 | 2019-11-01 | 卡利泰拉生物科技公司 | 外核苷酸酶抑制剂及其使用方法 |
| MX2019010848A (es) | 2017-03-16 | 2019-10-30 | Innate Pharma | Composiciones y procedimientos para el tratamiento del cancer. |
| SG10202111869SA (en) | 2017-07-31 | 2021-11-29 | Trishula Therapeutics Inc | Anti-cd39 antibodies, compositions comprising anti-cd39 antibodies and methods of using anti-cd39 antibodies |
| EP3692068B1 (en) | 2017-10-06 | 2022-12-07 | Innate Pharma | Restoration of t cell activity via the cd39/cd73 axis |
| CA3075371A1 (en) | 2017-11-15 | 2019-05-23 | Innate Pharma | Potentiating the effect of atp release |
| CN113754768B (zh) | 2018-03-14 | 2023-01-06 | 表面肿瘤学公司 | 结合cd39的抗体及其用途 |
| KR20220061977A (ko) | 2019-08-12 | 2022-05-13 | 퓨리노미아 바이오테크, 아이엔씨. | Cd39 발현 세포의 adcc 표적화를 통해 t 세포 매개 면역 반응을 촉진 및 강화하기 위한 방법 및 조성물 |
| JP7727387B2 (ja) | 2019-08-27 | 2025-08-21 | エルピサイエンス（スーチョウ）・バイオファーマ，リミテッド | 新規の抗ｃｄ３９抗体 |
| US11655303B2 (en) | 2019-09-16 | 2023-05-23 | Surface Oncology, Inc. | Anti-CD39 antibody compositions and methods |
| CN110407941B (zh) | 2019-09-25 | 2020-01-14 | 上海岸迈生物科技有限公司 | Cd39的高亲和力抗体及其用途 |
-
2018
- 2018-07-30 SG SG10202111869SA patent/SG10202111869SA/en unknown
- 2018-07-30 SG SG11202000820PA patent/SG11202000820PA/en unknown
- 2018-07-30 AU AU2018312251A patent/AU2018312251B2/en active Active
- 2018-07-30 WO PCT/US2018/044449 patent/WO2019027935A1/en not_active Ceased
- 2018-07-30 BR BR112020002012A patent/BR112020002012A8/pt unknown
- 2018-07-30 CA CA3071540A patent/CA3071540A1/en active Pending
- 2018-07-30 KR KR1020207005353A patent/KR102718932B1/ko active Active
- 2018-07-30 IL IL272367A patent/IL272367B2/en unknown
- 2018-07-30 EP EP18841649.9A patent/EP3661966A4/en active Pending
- 2018-07-30 IL IL316357A patent/IL316357A/en unknown
- 2018-07-30 CR CR20200101A patent/CR20200101A/es unknown
- 2018-07-30 CN CN201880064027.3A patent/CN111448211B/zh active Active
- 2018-07-30 US US16/049,736 patent/US20190062448A1/en not_active Abandoned
- 2018-07-30 JP JP2020506222A patent/JP7113071B2/ja active Active
- 2018-07-30 CN CN202410622919.8A patent/CN118978594A/zh active Pending
- 2018-07-30 US US16/635,526 patent/US11345757B2/en active Active
- 2018-07-30 MX MX2020001270A patent/MX2020001270A/es unknown
- 2018-07-30 KR KR1020247034153A patent/KR20240153413A/ko active Pending
- 2018-07-30 PE PE2020000166A patent/PE20200617A1/es unknown
- 2018-07-30 MY MYPI2020000520A patent/MY202018A/en unknown
- 2018-07-31 TW TW107126546A patent/TWI798242B/zh active
- 2018-07-31 TW TW112113090A patent/TW202344516A/zh unknown
- 2018-07-31 AR ARP180102152 patent/AR112639A1/es unknown
-
2020
- 2020-01-29 ZA ZA2020/00608A patent/ZA202000608B/en unknown
- 2020-01-31 DO DO2020000021A patent/DOP2020000021A/es unknown
- 2020-01-31 PH PH12020500240A patent/PH12020500240A1/en unknown
- 2020-01-31 CL CL2020000281A patent/CL2020000281A1/es unknown
- 2020-02-25 CO CONC2020/0001983A patent/CO2020001983A2/es unknown
-
2021
- 2021-09-07 US US17/468,366 patent/US20210403593A1/en not_active Abandoned
-
2022
- 2022-04-20 US US17/725,142 patent/US20220340680A1/en not_active Abandoned
- 2022-05-30 US US17/827,989 patent/US20220372163A1/en not_active Abandoned
- 2022-07-25 JP JP2022118008A patent/JP2022145720A/ja not_active Withdrawn
-
2024
- 2024-03-28 JP JP2024053368A patent/JP7690085B2/ja active Active
- 2024-09-24 US US18/895,094 patent/US20250026850A1/en active Pending
-
2025
- 2025-05-28 JP JP2025088950A patent/JP2025116106A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020530289A5 (enExample) | ||
| JP2024079809A5 (enExample) | ||
| JP2018533371A5 (enExample) | ||
| US12448423B2 (en) | Targeted heterodimeric Fc fusion proteins containing NKG2D antigen binding domains | |
| CN107847587B (zh) | Cd30×cd16抗体与pd-1拮抗剂的联合药物 | |
| JP2022115922A5 (enExample) | ||
| TW202344516A (zh) | 抗ｃｄ３９抗體、包含抗ｃｄ３９抗體之組成物及使用抗ｃｄ３９抗體之方法 | |
| JP2020514363A5 (enExample) | ||
| JP2020511947A5 (enExample) | ||
| JP2018518939A5 (enExample) | ||
| US12098210B2 (en) | Methods of treating cancers and enhancing efficacy of BCMAxCD3 bispecific antibodies | |
| JP2022044795A (ja) | Ｂｔｌａアゴニスト抗体を用いた免疫応答のモジュレーション | |
| JP2025000681A (ja) | Ｂｔｌａ抗体 | |
| JP2022501433A (ja) | 標的化された免疫寛容 | |
| JP2020512973A5 (enExample) | ||
| JP2019537449A5 (enExample) | ||
| US20250376491A1 (en) | T-Cell Modulatory Multimeric Polypeptides and Methods of Use Thereof | |
| US20230235064A1 (en) | Bispecific immune cell engagers with binding specificity for hla-g and another antigen | |
| JPWO2020069133A5 (enExample) | ||
| JP2024073580A (ja) | Ｂｔｌａ抗体 | |
| US20250019411A1 (en) | T-Cell Engaging Polypeptides and Methods of Use Thereof | |
| WO2023031943A2 (en) | Cd28 shedding blocking agents | |
| JPWO2022072601A5 (enExample) | ||
| JPWO2021183207A5 (enExample) | ||
| RU2019118800A (ru) | Антигенсвязывающие белки против gitr и способы их прменения |