|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
US5567610A
(en)
|
1986-09-04 |
1996-10-22 |
Bioinvent International Ab |
Method of producing human monoclonal antibodies and kit therefor
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
EP0307434B2
(en)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Altered antibodies
|
|
US5204244A
(en)
|
1987-10-27 |
1993-04-20 |
Oncogen |
Production of chimeric antibodies by homologous recombination
|
|
DE68925971T2
(de)
|
1988-09-23 |
1996-09-05 |
Cetus Oncology Corp |
Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5229275A
(en)
|
1990-04-26 |
1993-07-20 |
Akzo N.V. |
In-vitro method for producing antigen-specific human monoclonal antibodies
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
|
WO1992022653A1
(en)
|
1991-06-14 |
1992-12-23 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
FI941572A7
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
|
|
ATE503496T1
(de)
|
1992-02-06 |
2011-04-15 |
Novartis Vaccines & Diagnostic |
Biosynthetisches bindeprotein für tumormarker
|
|
EP0626012B1
(en)
|
1992-02-11 |
2003-07-09 |
Cell Genesys, Inc. |
Homogenotization of gene-targeting events
|
|
US5573905A
(en)
|
1992-03-30 |
1996-11-12 |
The Scripps Research Institute |
Encoded combinatorial chemical libraries
|
|
WO1994029351A2
(en)
|
1993-06-16 |
1994-12-22 |
Celltech Limited |
Antibodies
|
|
US5534615A
(en)
|
1994-04-25 |
1996-07-09 |
Genentech, Inc. |
Cardiac hypertrophy factor and uses therefor
|
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
|
GB9603256D0
(en)
|
1996-02-16 |
1996-04-17 |
Wellcome Found |
Antibodies
|
|
US6171586B1
(en)
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
|
PT994903E
(pt)
|
1997-06-24 |
2005-10-31 |
Genentech Inc |
Metodos e composicoes para glicoproteinas galactosiladas
|
|
WO1999022764A1
(en)
|
1997-10-31 |
1999-05-14 |
Genentech, Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
ES2292236T3
(es)
|
1998-04-02 |
2008-03-01 |
Genentech, Inc. |
Variantes de anticuerpos y sus fragmentos.
|
|
US20030175884A1
(en)
|
2001-08-03 |
2003-09-18 |
Pablo Umana |
Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
|
|
DE69942021D1
(de)
|
1998-04-20 |
2010-04-01 |
Glycart Biotechnology Ag |
Glykosylierungs-engineering von antikörpern zur verbesserung der antikörperabhängigen zellvermittelten zytotoxizität
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
CN1763097B
(zh)
|
1999-01-15 |
2011-04-13 |
杰南技术公司 |
具有改变的效应功能的多肽变体
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
PT1914244E
(pt)
|
1999-04-09 |
2013-07-26 |
Kyowa Hakko Kirin Co Ltd |
Processo para regular a actividade de moléculas funcionais sob o ponto de vista imunológico
|
|
US20080050809A1
(en)
|
1999-09-28 |
2008-02-28 |
Alejandro Abuin |
Novel human kinases and polynucleotides encoding the same
|
|
EP1229125A4
(en)
|
1999-10-19 |
2005-06-01 |
Kyowa Hakko Kogyo Kk |
PROCESS FOR PREPARING A POLYPEPTIDE
|
|
US7064191B2
(en)
|
2000-10-06 |
2006-06-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for purifying antibody
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
WO2002031140A1
(en)
|
2000-10-06 |
2002-04-18 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions
|
|
ES2360479T3
(es)
|
2000-12-18 |
2011-06-06 |
Dyax Corp. |
Bibliotecas focalizadas de paquetes genéticos.
|
|
BR0213761A
(pt)
|
2001-10-25 |
2005-04-12 |
Genentech Inc |
Composições, preparação farmacêutica, artigo industrializado, método de tratamento de mamìferos, célula hospedeira, método para a produção de uma glicoproteìna e uso da composição
|
|
US20030215914A1
(en)
|
2001-12-10 |
2003-11-20 |
Erwin Houtzager |
Structure for presenting desired peptide sequences
|
|
US20040093621A1
(en)
|
2001-12-25 |
2004-05-13 |
Kyowa Hakko Kogyo Co., Ltd |
Antibody composition which specifically binds to CD20
|
|
US20040258678A1
(en)
|
2002-02-22 |
2004-12-23 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
US7193069B2
(en)
|
2002-03-22 |
2007-03-20 |
Research Association For Biotechnology |
Full-length cDNA
|
|
US20040132140A1
(en)
|
2002-04-09 |
2004-07-08 |
Kyowa Hakko Kogyo Co., Ltd. |
Production process for antibody composition
|
|
JPWO2003084569A1
(ja)
|
2002-04-09 |
2005-08-11 |
協和醗酵工業株式会社 |
抗体組成物含有医薬
|
|
WO2003085102A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Cell with depression or deletion of the activity of protein participating in gdp-fucose transport
|
|
US20050031613A1
(en)
|
2002-04-09 |
2005-02-10 |
Kazuyasu Nakamura |
Therapeutic agent for patients having human FcgammaRIIIa
|
|
WO2003085107A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells with modified genome
|
|
AU2003236018A1
(en)
|
2002-04-09 |
2003-10-20 |
Kyowa Hakko Kirin Co., Ltd. |
METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcGamma RECEPTOR IIIa
|
|
AU2003270439B2
(en)
|
2002-09-11 |
2009-09-24 |
Genentech, Inc. |
Novel composition and methods for the treatment of immune related diseases
|
|
US7361740B2
(en)
|
2002-10-15 |
2008-04-22 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
BRPI0316779B1
(pt)
|
2002-12-16 |
2020-04-28 |
Genentech Inc |
anticorpo humanizado que liga cd20 humano, composição, artigo manufaturado, método de indução da apoptose, método de tratamento de câncer cd20 positivo, métodos de tratamento de doenças autoimunes, ácidos nucléicos isolados, vetores de expressão, células hospedeiras, método para a produção de um anticorpo 2h7 humanizado, polipeptídeo isolado, formulação líquida, método de tratamento de artrite reumatóide (ra) e anticorpos de ligação de cd20 humanizados
|
|
PT1622648E
(pt)
|
2003-03-24 |
2010-08-31 |
Scripps Research Inst |
Vacinas de adn contra crescimento tumoral e métodos para sua utilização
|
|
JPWO2005035586A1
(ja)
|
2003-10-08 |
2007-11-22 |
協和醗酵工業株式会社 |
融合蛋白質組成物
|
|
US20070134759A1
(en)
|
2003-10-09 |
2007-06-14 |
Harue Nishiya |
Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase
|
|
DE602004026470D1
(de)
|
2003-11-05 |
2010-05-20 |
Roche Glycart Ag |
Fc-rezeptor und effektorfunktion
|
|
WO2005053742A1
(ja)
|
2003-12-04 |
2005-06-16 |
Kyowa Hakko Kogyo Co., Ltd. |
抗体組成物を含有する医薬
|
|
EP2374817B1
(en)
|
2004-04-13 |
2017-09-06 |
F. Hoffmann-La Roche AG |
Anti-P-selectin antibodies
|
|
TWI380996B
(zh)
|
2004-09-17 |
2013-01-01 |
Hoffmann La Roche |
抗ｏｘ４０ｌ抗體
|
|
SI1791565T1
(sl)
|
2004-09-23 |
2016-08-31 |
Genentech, Inc. |
Cisteinsko konstruirana protitelesa in konjugati
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
EP2399932B1
(en)
|
2005-05-12 |
2016-11-16 |
ZymoGenetics, Inc. |
Compositions and methods for modulating immune responses
|
|
AU2006261127B2
(en)
|
2005-06-17 |
2012-03-15 |
Merck Sharp & Dohme Corp. |
ILT3 binding molecules and uses therefor
|
|
EP1963534A2
(en)
|
2005-12-19 |
2008-09-03 |
Genizon Biosciences Inc. |
Genemap of the human gene associated with crohn's disease
|
|
US20080226635A1
(en)
|
2006-12-22 |
2008-09-18 |
Hans Koll |
Antibodies against insulin-like growth factor I receptor and uses thereof
|
|
CA2691357C
(en)
|
2007-06-18 |
2014-09-23 |
N.V. Organon |
Antibodies to human programmed death receptor pd-1
|
|
JP5933894B2
(ja)
|
2007-09-14 |
2016-06-15 |
アディマブ， エルエルシー |
合理的に設計された、合成抗体ライブラリおよびその使用
|
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
CA2905334A1
(en)
|
2008-04-09 |
2009-10-15 |
Genentech, Inc. |
Novel compositions and methods for the treatment of immune related diseases
|
|
NZ599840A
(en)
|
2009-12-22 |
2014-06-27 |
Hoffmann La Roche |
Sequence dependent aggregation
|
|
EP2388336A1
(en)
|
2010-05-19 |
2011-11-23 |
Signature Diagnostics AG |
Method and kits for diagnosing colorectal cancer
|
|
WO2011156356A1
(en)
|
2010-06-09 |
2011-12-15 |
Zymogenetics, Inc. |
Dimeric vstm3 fusion proteins and related compositions and methods
|
|
US8907053B2
(en)
|
2010-06-25 |
2014-12-09 |
Aurigene Discovery Technologies Limited |
Immunosuppression modulating compounds
|
|
CA3086837C
(en)
|
2010-07-16 |
2023-03-07 |
Adimab, Llc |
Libraries comprising segmental pools, and methods for their preparation and use
|
|
CN106008569B9
(zh)
|
2010-10-26 |
2020-05-22 |
马尔斯公司 |
作为精氨酸酶抑制剂的硼酸盐及其组合物和用途
|
|
DE102011005235B4
(de)
|
2011-03-08 |
2017-05-24 |
Sirs-Lab Gmbh |
Verfahren zum Identifizieren einer Teilmenge von Polynucleotiden aus einer dem Humangenom entsprechenden Ausgangsmenge von Polynucleotiden zur in vitro Bestimmung eines Schweregrads der Wirtsantwort eines Patienten
|
|
WO2013151665A2
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins associated with human disease
|
|
MX2014014951A
(es)
|
2012-06-06 |
2015-03-13 |
Oncomed Pharm Inc |
Agentes aglutinantes que modulan la trayectoria hippo y sus usos.
|
|
EP3677310A1
(en)
*
|
2012-10-08 |
2020-07-08 |
St. Jude Children's Research Hospital |
Therapies based on control of regulatory t cell stability and function via a neuropilin-1:semaphorin axis
|
|
PL2925350T3
(pl)
|
2012-12-03 |
2019-07-31 |
Bristol-Myers Squibb Company |
Zwiększenie aktywności przeciwnowotworowej immunomodulacyjnych białek fuzyjnych fc
|
|
NZ709059A
(en)
|
2012-12-04 |
2016-11-25 |
Oncomed Pharm Inc |
Immunotherapy with binding agents
|
|
US20140323315A1
(en)
|
2013-04-29 |
2014-10-30 |
Adimab, Llc |
Polyspecificity reagents, methods for their preparation and use
|
|
BR112016000853A2
(pt)
*
|
2013-07-16 |
2017-12-12 |
Genentech Inc |
métodos para tratar ou retardar, reduzir ou inibir a recidiva ou a progressão do câncer e a progressão de uma doença imune-relacionada em um indivíduo, para aumentar, melhorar ou estimular uma resposta ou função imune em um indivíduo e kit
|
|
EA036311B1
(ru)
|
2014-08-19 |
2020-10-26 |
Мерк Шарп И Доум Корп. |
Антитела против tigit
|
|
EP3215536A1
(en)
|
2014-11-06 |
2017-09-13 |
F. Hoffmann-La Roche AG |
Combination therapy comprising ox40 binding agonists and tigit inhibitors
|
|
TN2017000267A1
(en)
*
|
2014-12-23 |
2018-10-19 |
Bristol Myers Squibb Co |
Antibodies to tigit
|
|
TWI715587B
(zh)
*
|
2015-05-28 |
2021-01-11 |
美商安可美德藥物股份有限公司 |
Ｔｉｇｉｔ結合劑和彼之用途
|
|
EP3344658B1
(en)
*
|
2015-09-02 |
2022-05-11 |
Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. |
Antibodies specific to human t-cell immunoglobulin and itim domain (tigit)
|
|
CN106554347B
(zh)
|
2015-09-25 |
2020-10-30 |
浙江博生医药有限公司 |
Egfr激酶抑制剂及其制备方法和应用
|
|
SG10201912736UA
(en)
|
2015-10-01 |
2020-02-27 |
Potenza Therapeutics Inc |
Anti-tigit antigen-binding proteins and methods of use thereof
|
|
JOP20190134A1
(ar)
*
|
2016-12-23 |
2019-06-02 |
Potenza Therapeutics Inc |
بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها
|
|
SG11202106963YA
(en)
*
|
2019-01-11 |
2021-07-29 |
Omeros Corp |
Methods and compositions for treating cancer
|