JP2020514363A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020514363A5 JP2020514363A5 JP2019550705A JP2019550705A JP2020514363A5 JP 2020514363 A5 JP2020514363 A5 JP 2020514363A5 JP 2019550705 A JP2019550705 A JP 2019550705A JP 2019550705 A JP2019550705 A JP 2019550705A JP 2020514363 A5 JP2020514363 A5 JP 2020514363A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- amino acid
- acid sequence
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024009215A JP2024050684A (ja) | 2017-03-17 | 2024-01-25 | 腫瘍特異的細胞枯渇のためのＦｃ最適化抗ＣＤ２５ |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17161717 | 2017-03-17 | ||
| EP17161717.8 | 2017-03-17 | ||
| GB1710879.6 | 2017-07-06 | ||
| GBGB1710879.6A GB201710879D0 (en) | 2017-07-06 | 2017-07-06 | Methods and compounds for tumour-specific cell depletion |
| GB1714429.6 | 2017-09-07 | ||
| GBGB1714429.6A GB201714429D0 (en) | 2017-09-07 | 2017-09-07 | Compounds and methods for tumour-specific cell depletion |
| PCT/EP2018/056312 WO2018167104A1 (en) | 2017-03-17 | 2018-03-13 | Fc-optimized anti-cd25 for tumour specific cell depletion |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024009215A Division JP2024050684A (ja) | 2017-03-17 | 2024-01-25 | 腫瘍特異的細胞枯渇のためのＦｃ最適化抗ＣＤ２５ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020514363A JP2020514363A (ja) | 2020-05-21 |
| JP2020514363A5 true JP2020514363A5 (enExample) | 2021-04-30 |
Family
ID=61655786
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019550705A Pending JP2020514363A (ja) | 2017-03-17 | 2018-03-13 | 腫瘍特異的細胞枯渇のためのＦｃ最適化抗ＣＤ２５ |
| JP2024009215A Pending JP2024050684A (ja) | 2017-03-17 | 2024-01-25 | 腫瘍特異的細胞枯渇のためのＦｃ最適化抗ＣＤ２５ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024009215A Pending JP2024050684A (ja) | 2017-03-17 | 2024-01-25 | 腫瘍特異的細胞枯渇のためのＦｃ最適化抗ＣＤ２５ |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US11879014B2 (enExample) |
| EP (1) | EP3596123B1 (enExample) |
| JP (2) | JP2020514363A (enExample) |
| KR (1) | KR20190130137A (enExample) |
| CN (1) | CN110869388B (enExample) |
| AU (1) | AU2018233976B2 (enExample) |
| BR (1) | BR112019017017A2 (enExample) |
| CA (1) | CA3056506A1 (enExample) |
| CL (1) | CL2019002624A1 (enExample) |
| CR (1) | CR20190477A (enExample) |
| DK (1) | DK3596123T3 (enExample) |
| ES (1) | ES2975063T3 (enExample) |
| FI (1) | FI3596123T3 (enExample) |
| HR (1) | HRP20240469T1 (enExample) |
| HU (1) | HUE065999T2 (enExample) |
| IL (1) | IL269081B1 (enExample) |
| LT (1) | LT3596123T (enExample) |
| MX (1) | MX2019010974A (enExample) |
| MY (1) | MY208220A (enExample) |
| PE (1) | PE20191812A1 (enExample) |
| PL (1) | PL3596123T3 (enExample) |
| RS (1) | RS65351B1 (enExample) |
| SG (1) | SG11201908578YA (enExample) |
| SI (1) | SI3596123T1 (enExample) |
| WO (1) | WO2018167104A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11371066B2 (en) | 2015-07-13 | 2022-06-28 | Modular Genetics, Inc. | Generation of acyl alcohols |
| US11879014B2 (en) | 2017-03-17 | 2024-01-23 | Tusk Therapeutics Ltd. | Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody |
| US11814434B2 (en) | 2018-03-13 | 2023-11-14 | Tusk Therapeutics Ltd. | Anti-CD25 for tumour specific cell depletion |
| EP3880698A4 (en) * | 2018-11-14 | 2022-11-30 | RubrYc Therapeutics, Inc. | MANIPULATED CD25 POLYPEPTIDES AND USES THEREOF |
| EP3880227A4 (en) * | 2018-11-14 | 2022-11-09 | RubrYc Therapeutics, Inc. | ANTI-CD25 ANTIBODIES |
| EP3972997A1 (en) * | 2019-05-20 | 2022-03-30 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Novel anti-cd25 antibodies |
| KR102789146B1 (ko) * | 2019-06-10 | 2025-04-01 | 샨동 보안 바이오테크놀로지 컴퍼니, 리미티드 | 항-cd25 항체 및 이의 적용 |
| WO2021207691A1 (en) | 2020-04-10 | 2021-10-14 | Rakuten Medical, Inc. | Phthalocyanine dye compounds, conjugates and methods of use thereof |
| CN115397860B (zh) * | 2020-05-14 | 2025-06-13 | 江苏恒瑞医药股份有限公司 | 抗cd25抗体、其抗原结合片段及其医药用途 |
| US11124568B1 (en) * | 2020-08-19 | 2021-09-21 | Vitruviae LLC | CD3/CD25 antibodies for neuro-immune diseases |
| EP4247497A1 (en) * | 2020-11-20 | 2023-09-27 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Anti-cd25 antibodies |
| EP4247496A1 (en) * | 2020-11-20 | 2023-09-27 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Anti-cd25 antibodies |
| EP4255929A2 (en) | 2020-12-02 | 2023-10-11 | Vib Vzw | An ltbr agonist in combination therapy against cancer |
| US20240307541A1 (en) * | 2021-02-02 | 2024-09-19 | Rakuten Medical, Inc. | Methods for local and systemic treatment of cancers, tumors and tumor cells |
| WO2022184615A1 (en) | 2021-03-01 | 2022-09-09 | F. Hoffmann-La Roche Ag | Novel biomarkers and uses thereof |
| CN117916266A (zh) | 2021-09-02 | 2024-04-19 | 弗哈夫曼拉罗切有限公司 | 用于治疗aml的抗体 |
| WO2023208990A1 (en) | 2022-04-26 | 2023-11-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer comprising a fas axis antagonist and a t-reg cell depleting agent antagonist, |
| CN115181182B (zh) * | 2022-06-13 | 2024-03-29 | 南京融捷康生物科技有限公司 | 一种人源化的抗cd25的单域抗体及其应用 |
| WO2024006965A1 (en) * | 2022-06-30 | 2024-01-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cd25-specific antibodies and uses thereof |
| CA3260127A1 (en) | 2022-07-01 | 2024-01-04 | Neurogene Inc. | Variants of Neo-2/15 and their uses for preferentially stimulating regulatory T cells |
| WO2024088987A1 (en) | 2022-10-26 | 2024-05-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer |
| CN118240080A (zh) * | 2022-12-22 | 2024-06-25 | 深圳市福元生物科技有限公司 | 一种cd25单域抗体、人源化抗体、及制备方法 |
| CN120584138A (zh) | 2023-02-06 | 2025-09-02 | 豪夫迈·罗氏有限公司 | 组合疗法及其用途 |
| CN116087499B (zh) * | 2023-02-20 | 2023-10-31 | 深圳裕康医学检验实验室 | 一种癌样本的染色方法及试剂盒 |
| CN120314588B (zh) * | 2025-05-21 | 2025-10-17 | 成都蓉生药业有限责任公司 | 一种人免疫球蛋白抗体依赖性细胞介导的吞噬作用生物学活性的检测方法和检测试剂盒 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4208479A (en) | 1977-07-14 | 1980-06-17 | Syva Company | Label modified immunoassays |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化ｂ−ｂ１０ |
| NZ540555A (en) | 2002-11-15 | 2008-04-30 | Genmab As | Antibody therapeutics for treatingand/or preventing diseases associated with cells expressing CD25, including autoimmune diseases, inflammatory and hyperproliferative skin disorders |
| US20050181375A1 (en) | 2003-01-10 | 2005-08-18 | Natasha Aziz | Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer |
| GB0409799D0 (en) | 2004-04-30 | 2004-06-09 | Isis Innovation | Method of generating improved immune response |
| GB0507696D0 (en) | 2005-04-15 | 2005-05-25 | Novartis Ag | Organic compounds |
| EP2032159B1 (en) | 2006-06-26 | 2015-01-07 | MacroGenics, Inc. | Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof |
| CA2656700A1 (en) | 2006-07-06 | 2008-01-10 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Compositions and methods for enhancing the efficacy of il-2 mediated immune responses |
| HRP20140081T1 (hr) | 2006-08-18 | 2014-03-28 | Novartis Ag | Prlr-specifiäśna antitijela i njihova uporaba |
| RU2391401C2 (ru) | 2008-02-12 | 2010-06-10 | Общество с ограниченной ответственностью "Лаборатория клеточного мониторинга" | СПОСОБ ПОЛУЧЕНИЯ ПОПУЛЯЦИИ CD4+CD25+Foxp3+ Т-ЛИМФОЦИТОВ ЧЕЛОВЕКА ex vivo, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ |
| DK2356270T3 (da) | 2008-11-07 | 2016-12-12 | Fabrus Llc | Kombinatoriske antistofbiblioteker og anvendelser deraf |
| US8642292B2 (en) | 2009-09-22 | 2014-02-04 | Probiogen Ag | Process for producing molecules containing specialized glycan structures |
| MY156743A (en) * | 2009-12-21 | 2016-03-31 | Regeneron Pharma | Humanized fc?r mice |
| AR079944A1 (es) | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | Anticuerpo neutralizante de la actividad de un anticoagulante |
| KR20130048242A (ko) | 2010-07-22 | 2013-05-09 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 항-종양 항원 항체 및 이용 방법 |
| BR112015023086A2 (pt) | 2013-03-15 | 2017-11-21 | Abbvie Biotechnology Ltd | anticorpo anti-cd25 monoclonal ou um fragmento ligante anti-cd25 de um anticorpo monoclonal, conjugado de anticorpo-droga, composição farmacêutica, ácido nucleico, vetor, célula hospedeira, métodos para produção de um anticorpo anti-cd25 ou fragmento ligante anti cd25, para prevenção de rejeição de órgãos transplantados e para tratamento de uma doença. |
| EP3421495A3 (en) | 2013-03-15 | 2019-05-15 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
| CN105377892A (zh) | 2013-03-15 | 2016-03-02 | 艾伯维生物技术有限公司 | 抗cd25抗体及其用途 |
| GB2526139A (en) | 2014-05-15 | 2015-11-18 | Biolnvent Internat Ab | Medicaments, uses and methods |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| CA3020204A1 (en) | 2016-04-07 | 2017-10-12 | Cancer Research Technology Limited | Anti cd25 fc gamma receptor bispecific antibodies for tumor specific cell depletion |
| WO2018089420A1 (en) | 2016-11-08 | 2018-05-17 | Delinia, Inc. | Il-2 variants for the treatment of autoimmune diseases |
| US11879014B2 (en) | 2017-03-17 | 2024-01-23 | Tusk Therapeutics Ltd. | Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody |
| UA129536C2 (uk) | 2018-03-13 | 2025-05-28 | Туск Терап'Ютікс Лтд | Анти-cd25 для виснаження пухлиноспецифічних клітин |
-
2018
- 2018-03-03 US US16/494,962 patent/US11879014B2/en active Active
- 2018-03-13 CR CR20190477A patent/CR20190477A/es unknown
- 2018-03-13 WO PCT/EP2018/056312 patent/WO2018167104A1/en not_active Ceased
- 2018-03-13 CA CA3056506A patent/CA3056506A1/en active Pending
- 2018-03-13 MX MX2019010974A patent/MX2019010974A/es unknown
- 2018-03-13 EP EP18711313.9A patent/EP3596123B1/en active Active
- 2018-03-13 FI FIEP18711313.9T patent/FI3596123T3/fi active
- 2018-03-13 DK DK18711313.9T patent/DK3596123T3/da active
- 2018-03-13 PL PL18711313.9T patent/PL3596123T3/pl unknown
- 2018-03-13 MY MYPI2019005313A patent/MY208220A/en unknown
- 2018-03-13 ES ES18711313T patent/ES2975063T3/es active Active
- 2018-03-13 CN CN201880018976.8A patent/CN110869388B/zh active Active
- 2018-03-13 AU AU2018233976A patent/AU2018233976B2/en active Active
- 2018-03-13 HU HUE18711313A patent/HUE065999T2/hu unknown
- 2018-03-13 BR BR112019017017-0A patent/BR112019017017A2/pt unknown
- 2018-03-13 HR HRP20240469TT patent/HRP20240469T1/hr unknown
- 2018-03-13 KR KR1020197030283A patent/KR20190130137A/ko not_active Ceased
- 2018-03-13 JP JP2019550705A patent/JP2020514363A/ja active Pending
- 2018-03-13 PE PE2019001847A patent/PE20191812A1/es unknown
- 2018-03-13 SI SI201831085T patent/SI3596123T1/sl unknown
- 2018-03-13 LT LTEPPCT/EP2018/056312T patent/LT3596123T/lt unknown
- 2018-03-13 SG SG11201908578Y patent/SG11201908578YA/en unknown
- 2018-03-13 RS RS20240376A patent/RS65351B1/sr unknown
-
2019
- 2019-09-02 IL IL269081A patent/IL269081B1/en unknown
- 2019-09-13 CL CL2019002624A patent/CL2019002624A1/es unknown
-
2024
- 2024-01-25 JP JP2024009215A patent/JP2024050684A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020514363A5 (enExample) | ||
| EP3897845B1 (en) | Bifunctional molecule directed against human pd-1 | |
| JP7397055B2 (ja) | Ｃｄ１３７及びｏｘ４０に結合する抗体分子 | |
| JP7575100B2 (ja) | 免疫細胞活性化のための二重特異性抗体 | |
| JP2024050684A (ja) | 腫瘍特異的細胞枯渇のためのＦｃ最適化抗ＣＤ２５ | |
| ES2980623T3 (es) | Anticuerpos de unión a CD3 | |
| CN109641049B (zh) | Cd3结合抗体 | |
| JP7225135B2 (ja) | 腫瘍特異的細胞枯渇のための化合物及び方法 | |
| JP2019513725A5 (enExample) | ||
| JP2020521759A (ja) | 免疫トレランスを調節するための多機能性の抗体−リガンド・トラップ | |
| IL323895A (en) | Bifunctional anti-pd-1/il-7 molecule | |
| IL259495B1 (en) | Antibodies and methods for using them | |
| JP2017511379A (ja) | アゴニストまたはアンタゴニスト性を誘発する修飾されたＩｇＧ２ドメインを含む修飾された抗体及びその使用 | |
| CN114269785A (zh) | 免疫刺激性多聚体结合分子 | |
| KR20180037924A (ko) | 항-ctla-4 항체 및 이의 사용 방법 | |
| JP7680208B2 (ja) | 抗ｃｄ２７抗体およびその使用 | |
| JP2016513467A5 (enExample) | ||
| EP4314068A1 (en) | Antibodies against cleaved cdcp1 and uses thereof | |
| KR20210110818A (ko) | Rank 길항제 및 이에 대한 용도 | |
| JP2022553129A (ja) | ポリオウイルス受容体（ｐｖｒ）に対する抗体およびその使用 | |
| US20250002600A1 (en) | Multispecific binding agents against pd-l1 and cd137 in combination therapy | |
| JP7284759B2 (ja) | 抗ｃｄ４０抗体およびその使用 | |
| KR20250089513A (ko) | 암 치료에 있어서의 pd-1 시그널 저해제와의 조합에 의한 항cldn4-항cd137 이중특이성 항체의 사용 | |
| CA3259108A1 (en) | Attenuated Anti-PD1-IL2 Immunoconjugates and Their Uses | |
| JPWO2022072601A5 (enExample) |