JP2017537629A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017537629A5 JP2017537629A5 JP2017529741A JP2017529741A JP2017537629A5 JP 2017537629 A5 JP2017537629 A5 JP 2017537629A5 JP 2017529741 A JP2017529741 A JP 2017529741A JP 2017529741 A JP2017529741 A JP 2017529741A JP 2017537629 A5 JP2017537629 A5 JP 2017537629A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- set forth
- chain variable
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 claims description 1158
- 230000004048 modification Effects 0.000 claims description 404
- 238000012986 modification Methods 0.000 claims description 404
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 220
- 239000000427 antigen Substances 0.000 claims description 172
- 102000036639 antigens Human genes 0.000 claims description 172
- 108091007433 antigens Proteins 0.000 claims description 172
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 80
- 229920001184 polypeptide Polymers 0.000 claims description 76
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 76
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 56
- 150000007523 nucleic acids Chemical class 0.000 claims description 48
- 108020004707 nucleic acids Proteins 0.000 claims description 46
- 102000039446 nucleic acids Human genes 0.000 claims description 46
- 210000004027 cell Anatomy 0.000 claims description 44
- 206010028980 Neoplasm Diseases 0.000 claims description 34
- 230000009826 neoplastic cell growth Effects 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 21
- 208000034578 Multiple myelomas Diseases 0.000 claims description 20
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 20
- 230000011664 signaling Effects 0.000 claims description 16
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 14
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 14
- 230000000139 costimulatory effect Effects 0.000 claims description 14
- 102100021197 G-protein coupled receptor family C group 5 member D Human genes 0.000 claims description 12
- 230000003834 intracellular effect Effects 0.000 claims description 12
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims description 10
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims description 10
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 10
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims description 9
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
- 101001040713 Homo sapiens G-protein coupled receptor family C group 5 member D Proteins 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 102000004127 Cytokines Human genes 0.000 claims description 6
- 108090000695 Cytokines Proteins 0.000 claims description 6
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 6
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 6
- 239000003446 ligand Substances 0.000 claims description 6
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims description 4
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 4
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims description 4
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 4
- 101710174800 G-protein coupled receptor family C group 5 member D Proteins 0.000 claims description 4
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims description 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 230000004083 survival effect Effects 0.000 claims description 3
- 210000004881 tumor cell Anatomy 0.000 claims description 3
- 108010082808 4-1BB Ligand Proteins 0.000 claims description 2
- 102100036008 CD48 antigen Human genes 0.000 claims description 2
- 102100025221 CD70 antigen Human genes 0.000 claims description 2
- -1 CD86 Proteins 0.000 claims description 2
- 101000716130 Homo sapiens CD48 antigen Proteins 0.000 claims description 2
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims description 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 2
- 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 claims description 2
- 108090000177 Interleukin-11 Proteins 0.000 claims description 2
- 108010065805 Interleukin-12 Proteins 0.000 claims description 2
- 108090000172 Interleukin-15 Proteins 0.000 claims description 2
- 108050003558 Interleukin-17 Proteins 0.000 claims description 2
- 108010002350 Interleukin-2 Proteins 0.000 claims description 2
- 108010002386 Interleukin-3 Proteins 0.000 claims description 2
- 108090001005 Interleukin-6 Proteins 0.000 claims description 2
- 108010002586 Interleukin-7 Proteins 0.000 claims description 2
- 102000017578 LAG3 Human genes 0.000 claims description 2
- 101150030213 Lag3 gene Proteins 0.000 claims description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 108010042215 OX40 Ligand Proteins 0.000 claims description 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 2
- 101100225046 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ecl2 gene Proteins 0.000 claims description 2
- 101100225047 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ecl3 gene Proteins 0.000 claims description 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 2
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 claims description 2
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims description 2
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 2
- 101150058725 ecl1 gene Proteins 0.000 claims description 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 108010074108 interleukin-21 Proteins 0.000 claims description 2
- 210000004698 lymphocyte Anatomy 0.000 claims description 2
- 210000003738 lymphoid progenitor cell Anatomy 0.000 claims description 2
- 210000004897 n-terminal region Anatomy 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 210000003289 regulatory T cell Anatomy 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 14
- 230000004043 responsiveness Effects 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462088286P | 2014-12-05 | 2014-12-05 | |
| US62/088,286 | 2014-12-05 | ||
| PCT/US2015/064102 WO2016090312A1 (en) | 2014-12-05 | 2015-12-04 | Chimeric antigen receptors targeting g-protein coupled receptor and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020198690A Division JP2021040652A (ja) | 2014-12-05 | 2020-11-30 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537629A JP2017537629A (ja) | 2017-12-21 |
| JP2017537629A5 true JP2017537629A5 (enExample) | 2019-01-17 |
| JP6919091B2 JP6919091B2 (ja) | 2021-08-18 |
Family
ID=56092565
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529741A Active JP6919091B2 (ja) | 2014-12-05 | 2015-12-04 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
| JP2020198690A Withdrawn JP2021040652A (ja) | 2014-12-05 | 2020-11-30 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
| JP2023079310A Withdrawn JP2023091037A (ja) | 2014-12-05 | 2023-05-12 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
| JP2025156538A Pending JP2025181929A (ja) | 2014-12-05 | 2025-09-19 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020198690A Withdrawn JP2021040652A (ja) | 2014-12-05 | 2020-11-30 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
| JP2023079310A Withdrawn JP2023091037A (ja) | 2014-12-05 | 2023-05-12 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
| JP2025156538A Pending JP2025181929A (ja) | 2014-12-05 | 2025-09-19 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US10633426B2 (enExample) |
| EP (2) | EP4015534A1 (enExample) |
| JP (4) | JP6919091B2 (enExample) |
| KR (1) | KR102612367B1 (enExample) |
| CN (4) | CN113968912B (enExample) |
| AU (2) | AU2015357518B2 (enExample) |
| CA (1) | CA2969864A1 (enExample) |
| CY (1) | CY1125008T1 (enExample) |
| DK (1) | DK3227339T3 (enExample) |
| ES (1) | ES2899779T3 (enExample) |
| HR (1) | HRP20211978T1 (enExample) |
| HU (1) | HUE057777T2 (enExample) |
| IL (2) | IL310130A (enExample) |
| LT (1) | LT3227339T (enExample) |
| MX (2) | MX385156B (enExample) |
| MY (1) | MY192065A (enExample) |
| PH (1) | PH12017501044A1 (enExample) |
| PL (1) | PL3227339T3 (enExample) |
| PT (1) | PT3227339T (enExample) |
| RS (1) | RS62870B1 (enExample) |
| RU (1) | RU2762359C2 (enExample) |
| SA (1) | SA517381665B1 (enExample) |
| SG (2) | SG10202007326QA (enExample) |
| SI (1) | SI3227339T1 (enExample) |
| SM (1) | SMT202200040T1 (enExample) |
| WO (1) | WO2016090312A1 (enExample) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113429484A (zh) * | 2014-12-05 | 2021-09-24 | 纪念斯隆-凯特琳癌症中心 | 靶向g-蛋白偶联受体的抗体和使用方法 |
| WO2016090312A1 (en) | 2014-12-05 | 2016-06-09 | Memorial Sloan-Kettering Cancer Center | Chimeric antigen receptors targeting g-protein coupled receptor and uses thereof |
| PT3298033T (pt) | 2015-05-18 | 2020-09-22 | Tcr2 Therapeutics Inc | Composições e utilizações médicas para reprogramação de tcr utilizando proteínas de fusão |
| CA3032498A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| JP6925421B2 (ja) * | 2016-08-05 | 2021-08-25 | ワイ−バイオロジクス・インコーポレイテッド | プログラム化された細胞死蛋白質リガンド−１（ｐｄ−ｌ１）に対する抗体及びその用途 |
| CN109689686B (zh) | 2016-10-07 | 2020-08-25 | T细胞受体治疗公司 | 使用融合蛋白进行t细胞受体重编程的组合物和方法 |
| EP3544996A2 (en) | 2016-11-22 | 2019-10-02 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| JP7685735B2 (ja) | 2016-12-02 | 2025-05-30 | アンヘレス セラピューティクス インコーポレイテッド | 合成免疫受容体およびその使用方法 |
| IL267862B2 (en) | 2017-01-05 | 2024-05-01 | Kahr Medical Ltd | A SIRPalpha-41BBL FUSION PROTEIN AND METHODS OF USE THEREOF |
| US11566060B2 (en) | 2017-01-05 | 2023-01-31 | Kahr Medical Ltd. | PD1-CD70 fusion protein and methods of use thereof |
| US11299530B2 (en) | 2017-01-05 | 2022-04-12 | Kahr Medical Ltd. | SIRP alpha-CD70 fusion protein and methods of use thereof |
| KR102597943B1 (ko) | 2017-01-05 | 2023-11-06 | 카 메디컬 리미티드 | Pd1-41bbl 융합 단백질 및 이의 이용 방법 |
| BR112019016204A2 (pt) * | 2017-02-07 | 2020-07-07 | Daiichi Sankyo Company, Limited | anticorpo ou fragmento de ligação a antígeno do anticorpo, polinucleotídeo, vetor, célula, imunócito artificial, métodos para produzir um anticorpo ou um fragmento de ligação a antígeno do anticorpo, para produzir uma molécula que se liga ao cd3 humano e cd3 de macaco cinomolgo e ao gprc5d humano, composição medicinal para tratamento e/ou prevenção, moléculas tendo atividade de ligação a antígeno e que se ligam ao cd3 humano e cd3 de macaco cinomolgo e ao gprc5d humano, e, usos para preparar um medicamento para tratar e/ou prevenir um câncer, para induzir citotoxicidade para as células expressando gprc5d e para redirecionamento de células t para as células expressando gprc5d |
| US11965021B2 (en) | 2017-04-26 | 2024-04-23 | Eureka Therapeutics, Inc. | Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof |
| MX2020001490A (es) | 2017-08-09 | 2020-08-06 | Juno Therapeutics Inc | Metodos para producir composiciones de celulas geneticamente modificadas y composiciones relacionadas. |
| MX2020001491A (es) | 2017-08-09 | 2020-08-06 | Juno Therapeutics Inc | Metodos y composiciones para preparar celulas geneticamente modificadas. |
| MA50079A (fr) | 2017-09-07 | 2020-07-15 | Juno Therapeutics Inc | Procédés d'identification de caractéristiques cellulaires relatives à des réponses associées à une thérapie cellulaire |
| US20210254000A1 (en) | 2017-11-01 | 2021-08-19 | Juno Therapeutics, Inc. | Process for producing a t cell composition |
| MX2020004243A (es) | 2017-11-01 | 2020-09-25 | Juno Therapeutics Inc | Receptores de anticuerpos y de antigenos quimericos especificos para el antigeno de maduracion de celulas b. |
| MA50855A (fr) | 2017-11-01 | 2020-09-09 | Juno Therapeutics Inc | Procédé de génération de compositions thérapeutiques de cellules modifiées |
| US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| PE20200850A1 (es) | 2017-11-01 | 2020-08-20 | Juno Therapeutics Inc | Receptores de antigenos quimericos especificos para el antigeno de maduracion de celulas b y polinucleotidos que codifican los mismos |
| WO2019089848A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| CA3082570A1 (en) | 2017-11-14 | 2019-05-23 | Memorial Sloan-Kettering Cancer Center | Il-36 secreting immunoresponsive cells and uses thereof |
| EP3716980A1 (en) | 2017-12-01 | 2020-10-07 | Juno Therapeutics, Inc. | Methods for dosing and for modulation of genetically engineered cells |
| KR102862251B1 (ko) | 2017-12-08 | 2025-09-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 요법을 위한 표현형 마커 및 관련 방법 |
| JP2021505168A (ja) | 2017-12-08 | 2021-02-18 | ジュノー セラピューティクス インコーポレイテッド | 操作されたｔ細胞の組成物を製造するための方法 |
| CN112041430A (zh) | 2017-12-08 | 2020-12-04 | 朱诺治疗学股份有限公司 | 用于培养细胞的无血清培养基配制品及其使用方法 |
| CN112888709B (zh) * | 2018-03-30 | 2024-10-29 | 优瑞科生物技术公司 | 标靶cd22的构建体和其用途 |
| CN120285175A (zh) | 2018-05-16 | 2025-07-11 | 詹森生物科技公司 | 治疗癌症并增强t细胞重定向治疗剂的功效的方法 |
| BR112021000347A2 (pt) | 2018-07-11 | 2021-04-13 | Kahr Medical Ltd. | Proteína de fusão variante pd1-4-1bbl e métodos de uso da mesma |
| AU2019301316B2 (en) | 2018-07-11 | 2025-09-04 | Kahr Medical Ltd. | Sirpalpha-4-1BBL variant fusion protein and methods of use thereof |
| MX2021001519A (es) | 2018-08-09 | 2021-05-27 | Juno Therapeutics Inc | Metodos para valorar acidos nucleicos integrados. |
| SG11202101204TA (en) | 2018-08-09 | 2021-03-30 | Juno Therapeutics Inc | Processes for generating engineered cells and compositions thereof |
| CN113454115B (zh) * | 2018-10-19 | 2025-06-13 | 纪念斯隆-凯特琳癌症中心 | 靶向唾液酸化路易斯a的嵌合抗原受体及其用途 |
| BR112021008133A2 (pt) | 2018-10-31 | 2021-10-05 | Juno Therapeutics Gmbh | Métodos para seleção e estimulação de células e aparelhos para os mesmos |
| PE20211058A1 (es) * | 2018-11-01 | 2021-06-07 | Juno Therapeutics Inc | Receptores de antigenos quimericos especificos para el miembro d del grupo 5 de la clase c del receptor acoplado a proteina g (gprc5d) |
| SG11202104188VA (en) | 2018-11-01 | 2021-05-28 | Juno Therapeutics Inc | Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen |
| DK3886875T3 (da) | 2018-11-30 | 2024-07-29 | Juno Therapeutics Inc | Behandlingsfremgangsmåder under anvendelse af adoptiv celleterapi |
| CA3127025A1 (en) * | 2019-01-18 | 2020-07-23 | Janssen Biotech, Inc. | Gprc5d chimeric antigen receptors and cells expressing the same |
| WO2020223535A1 (en) | 2019-05-01 | 2020-11-05 | Juno Therapeutics, Inc. | Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods |
| BR112021021200A2 (pt) | 2019-05-01 | 2021-12-21 | Juno Therapeutics Inc | Células expressando um receptor quimérico de um locus cd247 modificado, polinucleotídeos relacionados e métodos |
| SG11202113356XA (en) | 2019-06-12 | 2021-12-30 | Juno Therapeutics Inc | Combination therapy of a cell-mediated cytotoxic therapy and an inhibitor of a prosurvival bcl2 family protein |
| CN114555112A (zh) | 2019-08-22 | 2022-05-27 | 朱诺治疗学股份有限公司 | T细胞疗法和zeste增强子同源物2(ezh2)抑制剂的组合疗法及相关方法 |
| EP4051402A1 (en) | 2019-10-30 | 2022-09-07 | Juno Therapeutics GmbH | Cell selection and/or stimulation devices and methods of use |
| US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
| KR20220146480A (ko) | 2020-01-28 | 2022-11-01 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ｔ 세포 형질도입 방법 |
| MX2022012685A (es) | 2020-04-10 | 2023-03-08 | Invivyd Inc | Compuestos específicos contra la proteína s de coronavirus y usos de los mismos. |
| CN115803824A (zh) | 2020-05-13 | 2023-03-14 | 朱诺治疗学股份有限公司 | 鉴定与临床反应相关的特征的方法及其用途 |
| CN116234558A (zh) | 2020-06-26 | 2023-06-06 | 朱诺治疗学有限公司 | 条件性地表达重组受体的工程化t细胞、相关多核苷酸和方法 |
| JP2023549780A (ja) | 2020-11-04 | 2023-11-29 | ジュノー セラピューティクス インコーポレイテッド | 改変されたインバリアントｃｄ３免疫グロブリンスーパーファミリー鎖遺伝子座からキメラ受容体を発現する細胞ならびに関連するポリヌクレオチドおよび方法 |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| WO2022148370A1 (en) * | 2021-01-05 | 2022-07-14 | Lanova Medicines Development Co., Ltd. | Anti-gprc5d monoclonal antibodies and uses thereof |
| JP2024509853A (ja) | 2021-03-03 | 2024-03-05 | ジュノー セラピューティクス インコーポレイテッド | Ｔ細胞療法およびｄｇｋ阻害剤の組合せ |
| MX2023010916A (es) | 2021-03-17 | 2023-12-14 | Myeloid Therapeutics Inc | Composiciones de proteinas de fusion quimericas modificadas por ingenieria y metodos de uso de las mismas. |
| CN117321200A (zh) | 2021-03-22 | 2023-12-29 | 朱诺治疗学股份有限公司 | 评估病毒载体颗粒效力的方法 |
| US20240168012A1 (en) | 2021-03-22 | 2024-05-23 | Juno Therapeutics, Inc. | Methods of determining potency of a therapeutic cell composition |
| CN116964100A (zh) * | 2021-04-07 | 2023-10-27 | 株式会社Lg化学 | Gucy2c结合多肽及其用途 |
| US20250283037A1 (en) | 2021-05-06 | 2025-09-11 | Juno Therapeutics Gmbh | Methods for stimulating and transducing t cells |
| WO2022247756A1 (zh) * | 2021-05-23 | 2022-12-01 | 上海邦耀生物科技有限公司 | 靶向gprc5d的嵌合抗原受体及其用途 |
| WO2023030272A1 (zh) | 2021-08-30 | 2023-03-09 | 原启生物科技(上海)有限责任公司 | 抗gprc5d抗原结合蛋白及其用途 |
| JP2024540304A (ja) | 2021-11-03 | 2024-10-31 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｃｄ３８抗体による治療におけるコルチコステロイドの減少 |
| JP2025504803A (ja) | 2022-01-14 | 2025-02-19 | オリセル セラピューティクス カンパニー リミテッド | Ｇｐｒｃ５ｄを標的とするキメラ抗原受容体及びその使用 |
| JP2025504002A (ja) | 2022-01-28 | 2025-02-06 | ジュノー セラピューティクス インコーポレイテッド | 細胞組成物を製造する方法 |
| KR20240137090A (ko) | 2022-01-29 | 2024-09-19 | 카스젠 라이프 사이언스 씨오., 엘티디. | Gprc5d 항체 및 그 용도 |
| WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| CN119562820A (zh) | 2022-05-17 | 2025-03-04 | 优莫佳生物制药股份有限公司 | 制造病毒颗粒 |
| EP4532695A1 (en) | 2022-05-25 | 2025-04-09 | Celgene Corporation | Methods of manufacturing t cell therapies |
| EP4536693A1 (en) | 2022-06-10 | 2025-04-16 | Umoja Biopharma, Inc. | Engineered stem cells and uses thereof |
| US20250177530A1 (en) * | 2022-06-24 | 2025-06-05 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Molecules that bind to enpp1 polypeptides |
| KR20250060188A (ko) | 2022-06-30 | 2025-05-07 | 인답타 세라뷰틱스 인코포레이티드 | 조작된 자연 살해(nk) 세포 및 항체 요법의 조합 및 관련 방법 |
| AU2023320568A1 (en) | 2022-08-05 | 2025-02-06 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for gprc5d and bcma |
| CN116003598B (zh) | 2022-08-30 | 2024-04-26 | 苏州缔码生物科技有限公司 | 靶向人gprc5d的重组人源化单克隆抗体及其应用 |
| JP2025531850A (ja) | 2022-09-08 | 2025-09-25 | ジュノー セラピューティクス インコーポレイテッド | Ｔ細胞療法および継続的または間欠的ｄｇｋ阻害剤投薬の組合せ |
| TW202434735A (zh) | 2022-11-04 | 2024-09-01 | 美商烏莫賈生物製藥股份有限公司 | 展示黏著分子融合的顆粒 |
| WO2024100604A1 (en) | 2022-11-09 | 2024-05-16 | Juno Therapeutics Gmbh | Methods for manufacturing engineered immune cells |
| WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
| AU2024214593A1 (en) | 2023-02-03 | 2025-08-07 | C3S2 Gmbh | Methods for non-viral manufacturing of engineered immune cells |
| CN121311765A (zh) | 2023-04-18 | 2026-01-09 | 朱诺治疗学股份有限公司 | 评估治疗性细胞组合物的效力的细胞毒性测定 |
| WO2024243365A2 (en) | 2023-05-23 | 2024-11-28 | Juno Therapeutics, Inc. | Activation markers of t cells and method for assessing t cell activation |
| EP4520346A1 (en) * | 2023-09-06 | 2025-03-12 | Gyncentrum Sp. z o.o. | Cells, methods and systems for use in the treatment of a cancer with dual-car-t |
| WO2025059362A1 (en) | 2023-09-13 | 2025-03-20 | Juno Therapeutics, Inc. | Combination therapies with a cell therapy expressing a gprc5d-targeting car and related methods and uses |
| WO2025076472A1 (en) | 2023-10-06 | 2025-04-10 | Juno Therapeutics, Inc. | Combination therapies with a cell therapy expressing a gprc5d-targeting car and related methods and uses |
| CN120005019A (zh) * | 2023-11-14 | 2025-05-16 | 成都优赛诺生物科技有限公司 | 一种靶向gprc5d的单域抗体、嵌合抗原受体及其应用 |
| WO2025129084A1 (en) | 2023-12-13 | 2025-06-19 | Umoja Biopharma, Inc. | Engineered induced stem cell derived myeloid cells and methods of differentiating and using same |
| WO2025147545A1 (en) | 2024-01-03 | 2025-07-10 | Juno Therapeutics, Inc. | Lipid nanoparticles for delivery of nucleic acids and related methods and uses |
| WO2025231174A1 (en) | 2024-04-30 | 2025-11-06 | Umoja Biopharma, Inc. | Manufacturing viral particles |
| WO2025231372A2 (en) | 2024-05-03 | 2025-11-06 | Janssen Biotech, Inc. | Methods for treating multiple myeloma with car-t cells and bispecific antibodies |
| WO2025231408A2 (en) | 2024-05-03 | 2025-11-06 | Janssen Biotech, Inc. | Methods for treating multiple myeloma with car-t cells and bispecific antibodies |
| WO2025235604A1 (en) | 2024-05-08 | 2025-11-13 | Umoja Biopharma, Inc. | Fusion protein for use as immune cell engager |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| JPS6412935A (en) | 1987-07-02 | 1989-01-17 | Mitsubishi Electric Corp | Constant-speed travel device for vehicle |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| EP2281843B1 (en) | 2000-06-16 | 2016-10-12 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to BLyS |
| CA2457496A1 (en) | 2001-08-20 | 2003-02-27 | Curagen Corporation | Gpcr-like retinoic acid-induced gene 1 protein and nucleic acid |
| EP1468694A1 (en) * | 2001-12-27 | 2004-10-20 | Sumitomo Pharmaceuticals Company, Limited | Remedies for anorexia or lifestyle-related diseases and method of screening the same |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| US20040110139A1 (en) * | 2002-12-10 | 2004-06-10 | Isis Pharmaceuticals Inc. | Modulation of G protein-coupled receptor 3 expression |
| AU2003299778A1 (en) | 2002-12-20 | 2004-07-22 | Protein Design Labs, Inc. | Antibodies against gpr64 and uses thereof |
| BRPI0407446A (pt) | 2003-02-13 | 2006-01-31 | Pharmacia Corp | Anticorpos para c-met para o tratamento de cânceres |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| NZ547499A (en) * | 2003-12-10 | 2009-04-30 | Medarex Inc | IP-10 antibodies and their uses |
| US20050266008A1 (en) * | 2004-03-29 | 2005-12-01 | Medarex, Inc. | Human anti-IRTA-5 antibodies |
| CN101553505B (zh) | 2006-08-03 | 2013-07-17 | 阿斯利康(瑞典)有限公司 | 针对αVβ6的抗体及其应用 |
| US9512236B2 (en) | 2006-12-19 | 2016-12-06 | Ablynx N.V. | Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
| AU2008233051B2 (en) | 2007-03-30 | 2014-04-10 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes |
| EP2192922A4 (en) | 2007-09-17 | 2010-09-29 | Univ California | INTERNATIONALIZING HUMAN MONOCLONAL ANTIBODIES TO PROMOTE IN SITU ON PROSTATAZELLES |
| WO2009051633A1 (en) | 2007-10-15 | 2009-04-23 | The Board Of Trustees Of The Leland Stanford Junior University | Gpcr crystalization method using an antibody |
| NZ585589A (en) * | 2007-10-25 | 2012-07-27 | Trellis Bioscience Inc | Anti-rsv g protein antibodies |
| BRPI0907718A2 (pt) | 2008-02-11 | 2017-06-13 | Curetech Ltd | método para tratar um tumor, método para melhorar a tolerabilidade a pelo menos um agente quimiterápico, método para aumentar a sobrevida de um indivíduo que tem um tumor, método para reduzir ou prevenir recidiva tumoral, uso de um anticorpo monoclonal humanizado ou seu fragmento e anticorpo monoclonal humanizado ou seu fragmento |
| US9217032B2 (en) | 2010-01-08 | 2015-12-22 | Les Laboratoires Servier | Methods for treating colorectal cancer |
| ES2739711T3 (es) | 2010-07-22 | 2020-02-03 | John W Schrader | Anticuerpo de protección cruzada contra la infección por el virus de la gripe |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2013033626A2 (en) * | 2011-08-31 | 2013-03-07 | Trustees Of Dartmouth College | Nkp30 receptor targeted therapeutics |
| CN103483452B (zh) * | 2012-06-12 | 2021-08-13 | 上海细胞治疗集团有限公司 | 双信号独立的嵌合抗原受体及其用途 |
| WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
| JO3519B1 (ar) | 2013-01-25 | 2020-07-05 | Amgen Inc | تركيبات أجسام مضادة لأجل cdh19 و cd3 |
| KR102332790B1 (ko) * | 2013-02-15 | 2021-12-01 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 키메라 항원 수용체 및 이의 이용 방법 |
| US9745368B2 (en) * | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| EP3004337B1 (en) * | 2013-05-29 | 2017-08-02 | Cellectis | Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system |
| CN106163547A (zh) | 2014-03-15 | 2016-11-23 | 诺华股份有限公司 | 使用嵌合抗原受体治疗癌症 |
| CN106661119A (zh) | 2014-07-01 | 2017-05-10 | 辉瑞公司 | 双特异性异二聚化双抗体及其用途 |
| WO2016014530A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
| WO2016090312A1 (en) | 2014-12-05 | 2016-06-09 | Memorial Sloan-Kettering Cancer Center | Chimeric antigen receptors targeting g-protein coupled receptor and uses thereof |
| CN113429484A (zh) * | 2014-12-05 | 2021-09-24 | 纪念斯隆-凯特琳癌症中心 | 靶向g-蛋白偶联受体的抗体和使用方法 |
| SG10201913245UA (en) | 2015-10-23 | 2020-02-27 | Eureka Therapeutics Inc | Antibody/t-cell receptor chimeric constructs and uses thereof |
| AU2016362402A1 (en) | 2015-12-04 | 2018-06-28 | Eureka Therapeutics, Inc. | Antibodies targeting Fc receptor-like 5 and methods of use |
| KR20230148844A (ko) | 2016-03-29 | 2023-10-25 | 유니버시티 오브 써던 캘리포니아 | 암을 표적하는 키메라 항원 수용체 |
| US11768203B2 (en) | 2016-03-31 | 2023-09-26 | University Of Southern California | Highly sensitive and specific luciferase based reporter assay for antigen detection |
| CN108239144B (zh) | 2018-01-26 | 2021-05-25 | 重庆精准生物技术有限公司 | 改造的铰链及其在构建car骨架中的应用 |
| PE20211058A1 (es) | 2018-11-01 | 2021-06-07 | Juno Therapeutics Inc | Receptores de antigenos quimericos especificos para el miembro d del grupo 5 de la clase c del receptor acoplado a proteina g (gprc5d) |
-
2015
- 2015-12-04 WO PCT/US2015/064102 patent/WO2016090312A1/en not_active Ceased
- 2015-12-04 DK DK15865633.0T patent/DK3227339T3/da active
- 2015-12-04 AU AU2015357518A patent/AU2015357518B2/en active Active
- 2015-12-04 SG SG10202007326QA patent/SG10202007326QA/en unknown
- 2015-12-04 HR HRP20211978TT patent/HRP20211978T1/hr unknown
- 2015-12-04 CA CA2969864A patent/CA2969864A1/en active Pending
- 2015-12-04 HU HUE15865633A patent/HUE057777T2/hu unknown
- 2015-12-04 KR KR1020177018389A patent/KR102612367B1/ko active Active
- 2015-12-04 CN CN202111119531.9A patent/CN113968912B/zh active Active
- 2015-12-04 MY MYPI2017000855A patent/MY192065A/en unknown
- 2015-12-04 CN CN201580075557.4A patent/CN107428829B/zh active Active
- 2015-12-04 IL IL310130A patent/IL310130A/en unknown
- 2015-12-04 RU RU2017123551A patent/RU2762359C2/ru active
- 2015-12-04 SG SG11201704547RA patent/SG11201704547RA/en unknown
- 2015-12-04 CN CN202410434671.2A patent/CN118271463A/zh active Pending
- 2015-12-04 JP JP2017529741A patent/JP6919091B2/ja active Active
- 2015-12-04 RS RS20211596A patent/RS62870B1/sr unknown
- 2015-12-04 MX MX2017007242A patent/MX385156B/es unknown
- 2015-12-04 PL PL15865633T patent/PL3227339T3/pl unknown
- 2015-12-04 SM SM20220040T patent/SMT202200040T1/it unknown
- 2015-12-04 IL IL252621A patent/IL252621B2/en unknown
- 2015-12-04 LT LTEPPCT/US2015/064102T patent/LT3227339T/lt unknown
- 2015-12-04 EP EP21201788.3A patent/EP4015534A1/en active Pending
- 2015-12-04 CN CN202111126092.4A patent/CN113683711A/zh active Pending
- 2015-12-04 ES ES15865633T patent/ES2899779T3/es active Active
- 2015-12-04 EP EP15865633.0A patent/EP3227339B1/en active Active
- 2015-12-04 PT PT158656330T patent/PT3227339T/pt unknown
- 2015-12-04 SI SI201531772T patent/SI3227339T1/sl unknown
-
2017
- 2017-06-05 SA SA517381665A patent/SA517381665B1/ar unknown
- 2017-06-05 MX MX2021008798A patent/MX2021008798A/es unknown
- 2017-06-05 PH PH12017501044A patent/PH12017501044A1/en unknown
- 2017-06-05 US US15/613,800 patent/US10633426B2/en active Active
-
2020
- 2020-02-21 US US16/798,059 patent/US11820806B2/en active Active
- 2020-02-21 US US16/798,151 patent/US10906956B2/en active Active
- 2020-02-21 US US16/798,104 patent/US11866478B2/en active Active
- 2020-11-30 JP JP2020198690A patent/JP2021040652A/ja not_active Withdrawn
-
2022
- 2022-01-06 AU AU2022200052A patent/AU2022200052A1/en not_active Abandoned
- 2022-02-07 CY CY20221100105T patent/CY1125008T1/el unknown
-
2023
- 2023-05-12 JP JP2023079310A patent/JP2023091037A/ja not_active Withdrawn
- 2023-11-22 US US18/517,766 patent/US20240294599A1/en active Pending
-
2025
- 2025-09-19 JP JP2025156538A patent/JP2025181929A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017537629A5 (enExample) | ||
| JP2017537925A5 (enExample) | ||
| RU2017123551A (ru) | Химерные антигенные рецепторы, нацеленные на рецептор, связанный с g-белками, и их применение | |
| RU2017123548A (ru) | Химерные антигенные рецепторы, нацеленные на антиген созревания в-клеток, и их применение | |
| JP2018504094A5 (enExample) | ||
| JP7781243B2 (ja) | ガイダンス及びナビゲーションコントロール蛋白質並びにその生産及び使用方法 | |
| JP7267921B2 (ja) | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 | |
| US12421292B2 (en) | Anti-DLL3 chimeric antigen receptors and uses thereof | |
| US11951172B2 (en) | Therapeutic molecules that bind to LAG3 and PD1 | |
| AU2018363291A1 (en) | Single domain antibodies that bind to CD137 | |
| JP2017524367A5 (enExample) | ||
| HRP20241057T1 (hr) | Kimerni antigenski receptori na osnovu jedno-domenskih antitijela i načini njihove uporabe | |
| JP2016520074A5 (enExample) | ||
| WO2020229844A1 (en) | Binding molecules | |
| JPWO2021016585A5 (enExample) | ||
| JPWO2020081988A5 (enExample) | ||
| RU2017123546A (ru) | Химерные антигенные рецепторы, нацеленные на подобный fc- рецептору белок 5, и их применение | |
| CA2974434C (en) | Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof | |
| RU2020123705A (ru) | Композиции vcar и способы применения | |
| RU2022123916A (ru) | Клетки, экспрессирующие химерные активирующие рецепторы и химерные стимулирующие рецепторы, и их применение | |
| HK40001773A (en) | Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof |