SA517381665B1 - مستقبلات مولد ضد خيمري تستهدف مستقبل مقترن ببروتين واستخداماتها g - Google Patents

مستقبلات مولد ضد خيمري تستهدف مستقبل مقترن ببروتين واستخداماتها g

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SA517381665B1
SA517381665B1 SA517381665A SA517381665A SA517381665B1 SA 517381665 B1 SA517381665 B1 SA 517381665B1 SA 517381665 A SA517381665 A SA 517381665A SA 517381665 A SA517381665 A SA 517381665A SA 517381665 B1 SA517381665 B1 SA 517381665B1
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Saudi Arabia
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coupled receptor
protein coupled
chimeric antigen
antigen receptors
cars
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SA517381665A
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English (en)
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ال سميث إيريك
ليو تشينج
جيه برينت جينس رينـير
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.إوريكا ثيرابيوتكس، إنك
ميموريال سلوان - كيترينج كانسر سنتر
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Publication of SA517381665B1 publication Critical patent/SA517381665B1/ar

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464469—Tumor associated carbohydrates
    • A61K39/46447—Mucins, e.g. MUC-1
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2319/00—Fusion polypeptide
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Abstract

يتعلق الاختراع الحالي بتقديم في المادة الحالية التي تم الكشف عنها حالياً طرق وتركيبات لعلاج ورم نخاعي متعدد treating multiple myeloma. ويتعلق بمستقبلات مولد ضد خيمري chimeric antigen receptors (CARs) تستهدف على وجه التحديد مستقبل مقترن ببروتين G G-protein coupled receptor على سبيل المثال، عضو member D لمجموعة 5 من عائلة family C لمستقبل مقترن ببروتين G (GPRC5D))، وخلايا مخمدة مناعية immunoresponsive cells تشتمل على CARs المذكورة. تستهدف CARs التي تم الكشف عنها حالياً مستقبل مقترن ببروتين G (على سبيل المثال، GPRC5D) تتسم بخواص تنشيط مناعي محسنة، بما في ذلك تنشيط مضاد للورم anti-tumor activity.
SA517381665A 2014-12-05 2017-06-05 مستقبلات مولد ضد خيمري تستهدف مستقبل مقترن ببروتين واستخداماتها g SA517381665B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462088286P 2014-12-05 2014-12-05
PCT/US2015/064102 WO2016090312A1 (en) 2014-12-05 2015-12-04 Chimeric antigen receptors targeting g-protein coupled receptor and uses thereof

Publications (1)

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SA517381665B1 true SA517381665B1 (ar) 2022-01-24

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US (4) US10633426B2 (ar)
EP (2) EP3227339B1 (ar)
JP (3) JP6919091B2 (ar)
KR (1) KR102612367B1 (ar)
CN (4) CN118271463A (ar)
AU (2) AU2015357518B2 (ar)
BR (1) BR112017011920A2 (ar)
CA (1) CA2969864A1 (ar)
CY (1) CY1125008T1 (ar)
DK (1) DK3227339T3 (ar)
ES (1) ES2899779T3 (ar)
HR (1) HRP20211978T1 (ar)
HU (1) HUE057777T2 (ar)
IL (2) IL310130A (ar)
LT (1) LT3227339T (ar)
MX (2) MX2017007242A (ar)
MY (1) MY192065A (ar)
PH (1) PH12017501044A1 (ar)
PL (1) PL3227339T3 (ar)
PT (1) PT3227339T (ar)
RS (1) RS62870B1 (ar)
RU (1) RU2762359C2 (ar)
SA (1) SA517381665B1 (ar)
SG (2) SG10202007326QA (ar)
SI (1) SI3227339T1 (ar)
WO (1) WO2016090312A1 (ar)

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