JP2020536543A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020536543A5 JP2020536543A5 JP2020519704A JP2020519704A JP2020536543A5 JP 2020536543 A5 JP2020536543 A5 JP 2020536543A5 JP 2020519704 A JP2020519704 A JP 2020519704A JP 2020519704 A JP2020519704 A JP 2020519704A JP 2020536543 A5 JP2020536543 A5 JP 2020536543A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- sequence
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091008324 binding proteins Proteins 0.000 claims description 25
- 210000004027 cell Anatomy 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 129
- 229920001184 polypeptide Polymers 0.000 claims 48
- 102000004196 processed proteins & peptides Human genes 0.000 claims 48
- 108090000765 processed proteins & peptides Proteins 0.000 claims 48
- 238000006467 substitution reaction Methods 0.000 claims 32
- 102000014914 Carrier Proteins Human genes 0.000 claims 23
- 239000000427 antigen Substances 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 102000040430 polynucleotide Human genes 0.000 claims 17
- 108091033319 polynucleotide Proteins 0.000 claims 17
- 239000002157 polynucleotide Substances 0.000 claims 17
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 14
- 150000001413 amino acids Chemical class 0.000 claims 11
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 7
- 102000052645 human CD38 Human genes 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 4
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 3
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 3
- 102000018697 Membrane Proteins Human genes 0.000 claims 3
- 108010052285 Membrane Proteins Proteins 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 108010032595 Antibody Binding Sites Proteins 0.000 claims 2
- 241000282693 Cercopithecidae Species 0.000 claims 2
- 101100166600 Homo sapiens CD28 gene Proteins 0.000 claims 2
- 101100438926 Macaca fascicularis CD38 gene Proteins 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 241000282465 Canis Species 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 11
- 108090000695 Cytokines Proteins 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 230000003442 weekly effect Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 description 2
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 102000023732 binding proteins Human genes 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 108091008048 CMVpp65 Proteins 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- GAOZTHIDHYLHMS-UHFFFAOYSA-N Monensin A Natural products O1C(CC)(C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)CCC1C(O1)(C)CCC21CC(O)C(C)C(C(C)C(OC)C(C)C(O)=O)O2 GAOZTHIDHYLHMS-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000005917 in vivo anti-tumor Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 210000003289 regulatory T cell Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022031377A JP7387780B2 (ja) | 2017-10-10 | 2022-03-02 | 抗ｃｄ３８抗体および使用方法 |
| JP2023193393A JP7733711B2 (ja) | 2017-10-10 | 2023-11-14 | 抗ｃｄ３８抗体および使用方法 |
| JP2025136683A JP2025175288A (ja) | 2017-10-10 | 2025-08-20 | 抗ｃｄ３８抗体および使用方法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762570655P | 2017-10-10 | 2017-10-10 | |
| US62/570,655 | 2017-10-10 | ||
| US201762570660P | 2017-10-11 | 2017-10-11 | |
| US62/570,660 | 2017-10-11 | ||
| US201862676221P | 2018-05-24 | 2018-05-24 | |
| US62/676,221 | 2018-05-24 | ||
| EP18187186.4 | 2018-08-03 | ||
| EP18187186 | 2018-08-03 | ||
| PCT/US2018/055084 WO2019074973A2 (en) | 2017-10-10 | 2018-10-09 | ANTI-CD38 ANTIBODIES AND METHODS OF USE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031377A Division JP7387780B2 (ja) | 2017-10-10 | 2022-03-02 | 抗ｃｄ３８抗体および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020536543A JP2020536543A (ja) | 2020-12-17 |
| JP2020536543A5 true JP2020536543A5 (enExample) | 2021-10-07 |
| JP7036909B2 JP7036909B2 (ja) | 2022-03-15 |
Family
ID=63963620
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020519704A Active JP7036909B2 (ja) | 2017-10-10 | 2018-10-09 | 抗ｃｄ３８抗体および使用方法 |
| JP2022031377A Active JP7387780B2 (ja) | 2017-10-10 | 2022-03-02 | 抗ｃｄ３８抗体および使用方法 |
| JP2023193393A Active JP7733711B2 (ja) | 2017-10-10 | 2023-11-14 | 抗ｃｄ３８抗体および使用方法 |
| JP2025136683A Pending JP2025175288A (ja) | 2017-10-10 | 2025-08-20 | 抗ｃｄ３８抗体および使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031377A Active JP7387780B2 (ja) | 2017-10-10 | 2022-03-02 | 抗ｃｄ３８抗体および使用方法 |
| JP2023193393A Active JP7733711B2 (ja) | 2017-10-10 | 2023-11-14 | 抗ｃｄ３８抗体および使用方法 |
| JP2025136683A Pending JP2025175288A (ja) | 2017-10-10 | 2025-08-20 | 抗ｃｄ３８抗体および使用方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US11186649B2 (enExample) |
| EP (2) | EP3694882B1 (enExample) |
| JP (4) | JP7036909B2 (enExample) |
| KR (1) | KR20200061402A (enExample) |
| CN (4) | CN120058938A (enExample) |
| AR (1) | AR116718A1 (enExample) |
| AU (1) | AU2018348093A1 (enExample) |
| BR (1) | BR112020007002A2 (enExample) |
| CA (1) | CA3078800A1 (enExample) |
| ES (1) | ES2986579T3 (enExample) |
| IL (1) | IL273871A (enExample) |
| MA (1) | MA50359A (enExample) |
| MX (1) | MX2020004129A (enExample) |
| MY (1) | MY199781A (enExample) |
| PH (1) | PH12020550408A1 (enExample) |
| SG (1) | SG11202003212PA (enExample) |
| TW (4) | TW202430563A (enExample) |
| UY (1) | UY37928A (enExample) |
| WO (1) | WO2019074973A2 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| TWI743461B (zh) * | 2011-03-28 | 2021-10-21 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| DK2943511T3 (da) | 2013-01-14 | 2019-10-21 | Xencor Inc | Nye heterodimeriske proteiner |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| CN107406512A (zh) | 2014-11-26 | 2017-11-28 | Xencor公司 | 结合cd3和cd38的异二聚体抗体 |
| KR102689285B1 (ko) | 2014-11-26 | 2024-07-31 | 젠코어 인코포레이티드 | Ｃｄ3 및 종양 항원과 결합하는 이종이량체 항체 |
| LT3247725T (lt) * | 2015-01-23 | 2020-10-12 | Sanofi | Anti-cd3 antikūnai, anti-cd123 antikūnai ir bispecifiniai antikūnai, specifiškai surišantys cd3 ir (arba) cd123 |
| NZ781602A (en) | 2015-10-25 | 2025-07-25 | Sanofi Sa | Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection |
| EP3443006B1 (en) | 2016-04-13 | 2023-08-02 | Sanofi | Trispecific and/or trivalent binding proteins |
| EP4257193B1 (en) | 2016-04-13 | 2025-12-31 | Sanofi | TRISPECIFIC AND/OR TRIVALENT LINKING PROTEINS |
| KR20190020341A (ko) | 2016-06-28 | 2019-02-28 | 젠코어 인코포레이티드 | 소마토스타틴 수용체 2에 결합하는 이종이량체 항체 |
| EP3559035A1 (en) | 2016-12-21 | 2019-10-30 | TeneoBio, Inc. | Anti-bcma heavy chain-only antibodies |
| CA3067584A1 (en) | 2017-06-20 | 2018-12-27 | Teneobio, Inc. | Anti-bcma heavy chain-only antibodies |
| CN120058938A (zh) * | 2017-10-10 | 2025-05-30 | 赛诺菲 | 抗cd38抗体及与抗cd3和抗cd28抗体的组合 |
| AU2018366199A1 (en) | 2017-11-08 | 2020-05-28 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-PD-1 sequences |
| AU2019247415A1 (en) | 2018-04-04 | 2020-10-22 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
| KR20250024101A (ko) | 2018-04-25 | 2025-02-18 | 프로메테우스 바이오사이언시즈, 인크. | 최적화된 항tl1a 항체 |
| KR20210075129A (ko) | 2018-10-09 | 2021-06-22 | 사노피 | 삼중특이적 항-cd38, 항-cd28, 및 항-cd3 결합 단백질 및 바이러스 감염을 치료하기 위한 사용 방법 |
| EA202192736A1 (ru) | 2019-04-05 | 2022-01-27 | Тенеобио, Инк. | Антитела, содержащие только тяжелые цепи, которые связываются с псма |
| PH12021500041A1 (en) * | 2019-04-09 | 2022-06-06 | Sanofi Sa | Trispecific binding proteins, methods, and uses thereof |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| AU2020299600A1 (en) * | 2019-07-03 | 2022-01-06 | Crystal Bioscience Inc. | Anti-CD38 antibody and methods of use thereof |
| WO2021041878A1 (en) * | 2019-08-30 | 2021-03-04 | Dragonfly Therapeutics, Inc. | Pharmaceutical formulations and dosage regimens for multi-specific binding proteins that bind her2, nkg2d, and cd16 for cancer treatment |
| IL292419A (en) | 2019-10-24 | 2022-06-01 | Prometheus Biosciences Inc | Humanized antibodies to tnf-like ligand 1a (tl1a) and uses thereof |
| AU2020371500A1 (en) | 2019-10-25 | 2022-06-09 | Sanofi | Methods for analyzing chain mispairing in multispecific binding proteins |
| CN112876563B (zh) * | 2019-11-29 | 2022-08-16 | 康诺亚生物医药科技（成都）有限公司 | 药物组合物及其制备方法和应用 |
| KR20250007022A (ko) * | 2020-04-29 | 2025-01-13 | 테네오원, 인코포레이티드 | 변형된 중쇄 불변 영역을 갖는 다중특이적 중쇄 항체 |
| CA3214992A1 (en) * | 2020-04-29 | 2021-11-04 | Teneobio, Inc. | Multispecific heavy chain antibodies with modified heavy chain constant regions |
| US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
| KR20230166150A (ko) | 2020-08-19 | 2023-12-06 | 젠코어 인코포레이티드 | 항-cd28 조성물 |
| JP2023543152A (ja) | 2020-09-18 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｃｄ３８及び／又はｃｄ２８を結合する抗原結合分子及びその使用 |
| WO2022182891A1 (en) | 2021-02-25 | 2022-09-01 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| WO2022192403A1 (en) | 2021-03-09 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
| JP2024509274A (ja) | 2021-03-10 | 2024-02-29 | ゼンコア インコーポレイテッド | Ｃｄ３及びｇｐｃ３に結合するヘテロ二量体抗体 |
| TW202325743A (zh) * | 2021-07-14 | 2023-07-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 特異性結合ｃｄ３８、ｂｃｍａ和ｃｄ３的抗原結合分子及其醫藥用途 |
| US20250277051A1 (en) * | 2021-08-02 | 2025-09-04 | Hangzhou Unogen Biotech, Ltd | Anti-cd38 antibodies, anti-cd3 antibodies, and bispecific antibodies, and uses thereof |
| US20250000973A1 (en) * | 2021-08-20 | 2025-01-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| WO2023164510A1 (en) | 2022-02-23 | 2023-08-31 | Xencor, Inc. | Anti-cd28 x anti-psma antibodies |
| WO2023245187A2 (en) | 2022-06-17 | 2023-12-21 | Apogee Biologics, Inc. | Antibodies that bind interleukin 13 and methods of use |
| CN119487071A (zh) * | 2022-06-24 | 2025-02-18 | 北京可瑞生物科技有限公司 | 基于t细胞受体的双特异性多肽分子及其用途 |
| WO2024206439A2 (en) * | 2023-03-28 | 2024-10-03 | Nkarta, Inc. | Antibodies and chimeric antigen receptors specific for cd38 |
| WO2025027003A1 (en) | 2023-07-31 | 2025-02-06 | Sanofi | Methods and uses for anti-cd38 t cell engagers in treatment of peripheral t-cell lymphomas |
| WO2025209593A1 (zh) * | 2024-04-06 | 2025-10-09 | 华深智药生物科技(苏州)有限公司 | 一种多特异性抗体t细胞衔接器 |
| WO2025209594A1 (zh) * | 2024-04-06 | 2025-10-09 | 华深智药生物科技(苏州)有限公司 | 一种抗gucy2c抗体及其多特异性抗体的用途 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3850542T2 (de) | 1987-09-23 | 1994-11-24 | Bristol Myers Squibb Co | Antikörper-Heterokonjugate zur Töting von HIV-infizierten Zellen. |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| DE69937291T2 (de) | 1998-04-02 | 2008-07-10 | Genentech, Inc., South San Francisco | Antikörpervarianten und fragmente davon |
| CN1294148C (zh) | 2001-04-11 | 2007-01-10 | 中国科学院遗传与发育生物学研究所 | 环状单链三特异抗体 |
| EP2395017A3 (en) * | 2003-05-30 | 2012-12-19 | Merus B.V. | Design and use of paired variable regions of specific binding molecules |
| US20050163782A1 (en) | 2003-06-27 | 2005-07-28 | Biogen Idec Ma Inc. | Modified binding molecules comprising connecting peptides |
| ES2541436T3 (es) * | 2004-02-06 | 2015-07-20 | Morphosys Ag | Anticuerpos humanos anti-CD38 y usos para ellos |
| US9200061B2 (en) * | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
| CN100376599C (zh) | 2004-04-01 | 2008-03-26 | 北京安波特基因工程技术有限公司 | 基因工程重组抗cea抗cd3抗cd28线性单链三特异抗体 |
| MX2007011064A (es) * | 2005-03-23 | 2008-02-19 | Genmab As | Anticuerpos contra cd38 para tratamiento de mieloma multiple. |
| US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| US9175070B2 (en) | 2009-09-25 | 2015-11-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to HIV-1 and their use |
| JP6093696B2 (ja) | 2010-06-09 | 2017-03-08 | ゲンマブ エー／エス | ヒトｃｄ３８に対する抗体 |
| JOP20210044A1 (ar) * | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| TWI743461B (zh) | 2011-03-28 | 2021-10-21 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| WO2012154312A1 (en) | 2011-05-09 | 2012-11-15 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Neutralizing antibodies to hiv-1 and their use |
| AU2012255266B2 (en) | 2011-05-17 | 2017-05-25 | California Institute Of Technology | Human immunodeficiency virus neutralizing antibodies and methods of use thereof |
| BR112014010823B1 (pt) | 2011-11-07 | 2021-02-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | anticorpos que se ligam a gp41 e neutralizam o vírus da imunodeficiência humana tipo 1 (hiv-1), seus usos, molécula de ácido nucleico, vetor de expressão, composição, kit, bem como métodos de detecção de infecção pelo hiv-1 e de teste de imunógeno potencial |
| EP2788376B1 (en) | 2011-12-08 | 2018-10-03 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Neutralizing antibodies to hiv-1 and their use |
| BR112014015018A2 (pt) * | 2011-12-19 | 2020-10-27 | Synimmune Gmbh | moléculas de anticorpo biespecífico e seu método de produção, bem como composição farmacêutica e molécula de ácido nucleico |
| WO2013163427A1 (en) | 2012-04-25 | 2013-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Antibodies to treat hiv-1 infection |
| CN104955847A (zh) | 2012-12-04 | 2015-09-30 | 马里兰州大学(巴尔的摩) | HIV-1 Env结合抗体、融合蛋白及其使用方法 |
| US20140213772A1 (en) | 2012-12-28 | 2014-07-31 | Abbvie, Inc. | Cross-over dual variable domain immunoglobulin constructs |
| US10487155B2 (en) * | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
| US20140242077A1 (en) | 2013-01-23 | 2014-08-28 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
| WO2014144299A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Inc. | DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST TNFα |
| AP2016009222A0 (en) * | 2013-11-04 | 2016-05-31 | Glenmark Pharmaceuticals Sa | Production of t cell retargeting hetero-dimeric immunoglobulins |
| BR112016022385A2 (pt) | 2014-03-28 | 2018-06-19 | Xencor, Inc | anticorpos específicos que se ligam a cd38 e cd3 |
| DK3189132T3 (da) | 2014-09-04 | 2020-08-10 | Stemcell Tech Inc | Opløselige antistofkomplekser til T-celle- eller NK-celle-aktivering og -ekspansion |
| SG10202006538TA (en) * | 2014-12-23 | 2020-08-28 | Bristol Myers Squibb Co | Antibodies to tigit |
| LT3247725T (lt) | 2015-01-23 | 2020-10-12 | Sanofi | Anti-cd3 antikūnai, anti-cd123 antikūnai ir bispecifiniai antikūnai, specifiškai surišantys cd3 ir (arba) cd123 |
| WO2016196740A1 (en) | 2015-06-02 | 2016-12-08 | The Rockefeller University | Tri-specific antibodies for hiv therapy |
| NZ781602A (en) | 2015-10-25 | 2025-07-25 | Sanofi Sa | Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection |
| CN105837688B (zh) * | 2015-11-20 | 2019-02-26 | 北京大学深圳研究生院 | 单域抗体及其编码基因，免疫毒素及其编码基因、制备方法、表达载体、应用，及宿主细胞 |
| EP3443006B1 (en) | 2016-04-13 | 2023-08-02 | Sanofi | Trispecific and/or trivalent binding proteins |
| US12234479B2 (en) | 2016-12-30 | 2025-02-25 | Cytocares (Shanghai) Inc. | Bifunctional molecule and use thereof |
| US10626169B2 (en) | 2017-02-17 | 2020-04-21 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| CN120058938A (zh) | 2017-10-10 | 2025-05-30 | 赛诺菲 | 抗cd38抗体及与抗cd3和抗cd28抗体的组合 |
| KR20210075129A (ko) | 2018-10-09 | 2021-06-22 | 사노피 | 삼중특이적 항-cd38, 항-cd28, 및 항-cd3 결합 단백질 및 바이러스 감염을 치료하기 위한 사용 방법 |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
-
2018
- 2018-10-09 CN CN202510116993.7A patent/CN120058938A/zh active Pending
- 2018-10-09 WO PCT/US2018/055084 patent/WO2019074973A2/en not_active Ceased
- 2018-10-09 ES ES18792827T patent/ES2986579T3/es active Active
- 2018-10-09 CA CA3078800A patent/CA3078800A1/en active Pending
- 2018-10-09 CN CN202311405579.5A patent/CN117964758A/zh active Pending
- 2018-10-09 JP JP2020519704A patent/JP7036909B2/ja active Active
- 2018-10-09 AU AU2018348093A patent/AU2018348093A1/en not_active Abandoned
- 2018-10-09 KR KR1020207013073A patent/KR20200061402A/ko active Pending
- 2018-10-09 CN CN201880079045.9A patent/CN111788225B/zh active Active
- 2018-10-09 SG SG11202003212PA patent/SG11202003212PA/en unknown
- 2018-10-09 MY MYPI2020001741A patent/MY199781A/en unknown
- 2018-10-09 MA MA050359A patent/MA50359A/fr unknown
- 2018-10-09 EP EP18792827.0A patent/EP3694882B1/en active Active
- 2018-10-09 CN CN202510123093.5A patent/CN120058939A/zh active Pending
- 2018-10-09 US US16/155,807 patent/US11186649B2/en active Active
- 2018-10-09 EP EP23173927.7A patent/EP4249068A3/en active Pending
- 2018-10-09 BR BR112020007002-5A patent/BR112020007002A2/pt not_active IP Right Cessation
- 2018-10-09 MX MX2020004129A patent/MX2020004129A/es unknown
- 2018-10-10 UY UY0001037928A patent/UY37928A/es not_active Application Discontinuation
- 2018-10-11 TW TW112139669A patent/TW202430563A/zh unknown
- 2018-10-11 TW TW112124284A patent/TW202342544A/zh unknown
- 2018-10-11 TW TW107135898A patent/TWI821202B/zh not_active IP Right Cessation
- 2018-10-11 TW TW112139671A patent/TW202432580A/zh unknown
-
2019
- 2019-10-08 AR ARP190102858A patent/AR116718A1/es unknown
-
2020
- 2020-04-07 IL IL273871A patent/IL273871A/en unknown
- 2020-04-10 PH PH12020550408A patent/PH12020550408A1/en unknown
-
2021
- 2021-10-15 US US17/503,038 patent/US11365261B2/en active Active
-
2022
- 2022-03-02 JP JP2022031377A patent/JP7387780B2/ja active Active
- 2022-05-05 US US17/737,814 patent/US20220275102A1/en active Pending
-
2023
- 2023-11-14 JP JP2023193393A patent/JP7733711B2/ja active Active
-
2025
- 2025-08-20 JP JP2025136683A patent/JP2025175288A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020536543A5 (enExample) | ||
| JP7662516B2 (ja) | Ｐｄ－１標的化ｉｌ－１５／ｉｌ－１５ｒアルファｆｃ融合タンパク質およびその組み合わせ療法での使用 | |
| JP6518005B2 (ja) | Ｐｄ−ｌ１抗体 | |
| CN110914306B (zh) | 检查点抑制物双特异性抗体 | |
| TWI788286B (zh) | 三特異性和/或三價結合蛋白 | |
| JP2021098732A (ja) | Ｎｋｇ２ｄ、ｃｄ１６、およびｅｇｆｒ、ｃｃｒ４、またはｐｄ−ｌ１に結合するタンパク質 | |
| JP2018531219A6 (ja) | Ｐｄ−ｌ１抗体 | |
| CN104903352A (zh) | 多价结合蛋白组合物 | |
| JP2021533161A (ja) | Ｈｅｒ２、ｎｋｇ２ｄおよびｃｄ１６に結合する多重特異性結合タンパク質ならびに使用方法 | |
| RU2019134352A (ru) | Новые биспецифические антигенсвязывающие молекулы, обладающие способностью специфически связываться с cd40 и fap | |
| JP2017532287A (ja) | 多重特異的抗原結合タンパク質 | |
| TW201333035A (zh) | 針對ｉｌ－１３及／或ｉｌ－１７之雙特異性結合蛋白 | |
| CN116396386A (zh) | Cd3抗体及其药物用途 | |
| JP2022552183A (ja) | 特性が改善されたｐｄ－１標的化ｉｌ－１５／ｉｌ－１５ｒαｆｃ融合タンパク質 | |
| TW201333033A (zh) | 雙可變域免疫球蛋白及其用途 | |
| US20240010748A1 (en) | Bispecific antibody for claudin 18a2 and cd3 and application of bispecific antibody | |
| JP2024530451A (ja) | 抗ｐｖｒｉｇ／抗ｔｉｇｉｔ二重特異性抗体及び応用 | |
| US20240002544A1 (en) | Cd28 bispecific antibodies for targeted t cell activation | |
| JP7080219B2 (ja) | 共刺激受容体およびチェックポイント受容体に連結する二重特異性免疫調節抗体 | |
| US20230365709A1 (en) | Trispecific binders | |
| TW202136315A (zh) | 一種雙特異性融合蛋白及其應用 | |
| JP7418326B2 (ja) | 二重特異性抗体並びにその製造方法及び使用方法 | |
| JP2019529368A5 (enExample) | ||
| JP2019537449A5 (enExample) | ||
| US20250188166A1 (en) | Il-18 polypeptides fused to immune cell antigen specific binding polypeptides and uses thereof |