JP2020536543A5 - - Google Patents
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- JP2020536543A5 JP2020536543A5 JP2020519704A JP2020519704A JP2020536543A5 JP 2020536543 A5 JP2020536543 A5 JP 2020536543A5 JP 2020519704 A JP2020519704 A JP 2020519704A JP 2020519704 A JP2020519704 A JP 2020519704A JP 2020536543 A5 JP2020536543 A5 JP 2020536543A5
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- 108091008324 binding proteins Proteins 0.000 claims description 25
- 210000004027 cell Anatomy 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 129
- 229920001184 polypeptide Polymers 0.000 claims 48
- 102000004196 processed proteins & peptides Human genes 0.000 claims 48
- 108090000765 processed proteins & peptides Proteins 0.000 claims 48
- 238000006467 substitution reaction Methods 0.000 claims 32
- 102000014914 Carrier Proteins Human genes 0.000 claims 23
- 239000000427 antigen Substances 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 102000040430 polynucleotide Human genes 0.000 claims 17
- 108091033319 polynucleotide Proteins 0.000 claims 17
- 239000002157 polynucleotide Substances 0.000 claims 17
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 14
- 150000001413 amino acids Chemical class 0.000 claims 11
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 7
- 102000052645 human CD38 Human genes 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 4
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 3
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 3
- 102000018697 Membrane Proteins Human genes 0.000 claims 3
- 108010052285 Membrane Proteins Proteins 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 108010032595 Antibody Binding Sites Proteins 0.000 claims 2
- 241000282693 Cercopithecidae Species 0.000 claims 2
- 101100166600 Homo sapiens CD28 gene Proteins 0.000 claims 2
- 101100438926 Macaca fascicularis CD38 gene Proteins 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 241000282465 Canis Species 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 11
- 108090000695 Cytokines Proteins 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 230000003442 weekly effect Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 description 2
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 102000023732 binding proteins Human genes 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 108091008048 CMVpp65 Proteins 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- GAOZTHIDHYLHMS-UHFFFAOYSA-N Monensin A Natural products O1C(CC)(C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)CCC1C(O1)(C)CCC21CC(O)C(C)C(C(C)C(OC)C(C)C(O)=O)O2 GAOZTHIDHYLHMS-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000005917 in vivo anti-tumor Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 210000003289 regulatory T cell Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022031377A JP7387780B2 (ja) | 2017-10-10 | 2022-03-02 | 抗ｃｄ３８抗体および使用方法 |
| JP2023193393A JP7733711B2 (ja) | 2017-10-10 | 2023-11-14 | 抗ｃｄ３８抗体および使用方法 |
| JP2025136683A JP2025175288A (ja) | 2017-10-10 | 2025-08-20 | 抗ｃｄ３８抗体および使用方法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762570655P | 2017-10-10 | 2017-10-10 | |
| US62/570,655 | 2017-10-10 | ||
| US201762570660P | 2017-10-11 | 2017-10-11 | |
| US62/570,660 | 2017-10-11 | ||
| US201862676221P | 2018-05-24 | 2018-05-24 | |
| US62/676,221 | 2018-05-24 | ||
| EP18187186 | 2018-08-03 | ||
| EP18187186.4 | 2018-08-03 | ||
| PCT/US2018/055084 WO2019074973A2 (en) | 2017-10-10 | 2018-10-09 | ANTI-CD38 ANTIBODIES AND METHODS OF USE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031377A Division JP7387780B2 (ja) | 2017-10-10 | 2022-03-02 | 抗ｃｄ３８抗体および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020536543A JP2020536543A (ja) | 2020-12-17 |
| JP2020536543A5 true JP2020536543A5 (enExample) | 2021-10-07 |
| JP7036909B2 JP7036909B2 (ja) | 2022-03-15 |
Family
ID=63963620
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020519704A Active JP7036909B2 (ja) | 2017-10-10 | 2018-10-09 | 抗ｃｄ３８抗体および使用方法 |
| JP2022031377A Active JP7387780B2 (ja) | 2017-10-10 | 2022-03-02 | 抗ｃｄ３８抗体および使用方法 |
| JP2023193393A Active JP7733711B2 (ja) | 2017-10-10 | 2023-11-14 | 抗ｃｄ３８抗体および使用方法 |
| JP2025136683A Pending JP2025175288A (ja) | 2017-10-10 | 2025-08-20 | 抗ｃｄ３８抗体および使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031377A Active JP7387780B2 (ja) | 2017-10-10 | 2022-03-02 | 抗ｃｄ３８抗体および使用方法 |
| JP2023193393A Active JP7733711B2 (ja) | 2017-10-10 | 2023-11-14 | 抗ｃｄ３８抗体および使用方法 |
| JP2025136683A Pending JP2025175288A (ja) | 2017-10-10 | 2025-08-20 | 抗ｃｄ３８抗体および使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US11186649B2 (enExample) |
| EP (2) | EP3694882B1 (enExample) |
| JP (4) | JP7036909B2 (enExample) |
| KR (1) | KR20200061402A (enExample) |
| CN (4) | CN120058938A (enExample) |
| AR (1) | AR116718A1 (enExample) |
| AU (1) | AU2018348093A1 (enExample) |
| BR (1) | BR112020007002A2 (enExample) |
| CA (1) | CA3078800A1 (enExample) |
| ES (1) | ES2986579T3 (enExample) |
| IL (1) | IL273871A (enExample) |
| MA (1) | MA50359A (enExample) |
| MX (1) | MX2020004129A (enExample) |
| MY (1) | MY199781A (enExample) |
| PH (1) | PH12020550408A1 (enExample) |
| PY (1) | PY1888702A (enExample) |
| SG (1) | SG11202003212PA (enExample) |
| TW (4) | TW202432580A (enExample) |
| UY (1) | UY37928A (enExample) |
| WO (1) | WO2019074973A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| TWI588156B (zh) * | 2011-03-28 | 2017-06-21 | 賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| CN105051069B (zh) | 2013-01-14 | 2019-12-10 | Xencor股份有限公司 | 新型异二聚体蛋白 |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| CA2967426A1 (en) | 2014-11-26 | 2016-06-02 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and tumor antigens |
| BR112017011166A2 (pt) | 2014-11-26 | 2018-02-27 | Xencor, Inc. | anticorpos heterodiméricos que se ligam a cd3 e cd38 |
| MY191964A (en) * | 2015-01-23 | 2022-07-21 | Sanofi Sa | Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123 |
| MX2018005048A (es) | 2015-10-25 | 2018-09-06 | Sanofi Sa | Proteinas de union triespecificas y/o trivalantes para la prevencion o el tratamiento de la infeccion por vih. |
| BR112018070998A2 (pt) | 2016-04-13 | 2019-02-26 | Sanofi | proteínas de ligação triespecíficas e/ou trivalentes |
| SI3443006T1 (sl) | 2016-04-13 | 2024-01-31 | Sanofi | Trispecifični in/ali trivalentni vezni proteini |
| MX2018016265A (es) | 2016-06-28 | 2019-07-04 | Xencor Inc | Anticuerpos heterodimericos que se unen al receptor 2 de somatostatina. |
| BR112019012354A2 (pt) | 2016-12-21 | 2019-11-26 | Teneobio, Inc. | anticorpos apenas de cadeia pesada anti-bcma |
| CN110891971B (zh) | 2017-06-20 | 2024-01-12 | 特尼奥生物股份有限公司 | 仅有重链的抗bcma抗体 |
| CN120058938A (zh) * | 2017-10-10 | 2025-05-30 | 赛诺菲 | 抗cd38抗体及与抗cd3和抗cd28抗体的组合 |
| KR20200085828A (ko) | 2017-11-08 | 2020-07-15 | 젠코어 인코포레이티드 | 신규의 항-pd-1 서열을 사용한 이중특이적 및 단일특이적 항체 |
| EP3773911A2 (en) | 2018-04-04 | 2021-02-17 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
| MA52366A (fr) | 2018-04-25 | 2021-03-03 | Prometheus Biosciences Inc | Anticorps anti-tl1a optimisés |
| MX2021004147A (es) * | 2018-10-09 | 2021-09-08 | Sanofi Sa | Proteínas de unión triespecíficas anti-cd38, anti-cd28 y anti-cd3 y métodos de uso para tratar una infección viral. |
| AU2020252556B2 (en) | 2019-04-05 | 2026-02-05 | Teneobio, Inc. | Heavy chain antibodies binding to PSMA |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| CN113950484B (zh) * | 2019-04-09 | 2025-07-29 | 赛诺菲 | 三特异性结合蛋白、其方法和用途 |
| WO2021003074A1 (en) * | 2019-07-03 | 2021-01-07 | Crystal Bioscience Inc. | Anti-cd38 antibody and methods of use thereof |
| CN118924895A (zh) * | 2019-08-30 | 2024-11-12 | 蜻蜓疗法股份有限公司 | 用于癌症治疗的结合her2、nkg2d和cd16的多特异性结合蛋白的药物制剂和剂量方案 |
| PH12022550978A1 (en) | 2019-10-24 | 2023-10-09 | Cedars Sinai Medical Center | Humanized antibodies to tnf-like ligand 1a (tl1a) and uses thereof |
| EP4048690A1 (en) | 2019-10-25 | 2022-08-31 | Sanofi | Methods for analyzing chain mispairing in multispecific binding proteins |
| CN112876563B (zh) * | 2019-11-29 | 2022-08-16 | 康诺亚生物医药科技（成都）有限公司 | 药物组合物及其制备方法和应用 |
| MX2022013453A (es) | 2020-04-29 | 2022-11-16 | Teneobio Inc | Anticuerpos de cadena pesada multiespecificos con regiones constantes de cadena pesada modificadas. |
| UY40898A (es) * | 2020-04-29 | 2024-10-15 | Teneobio Inc | Anticuerpos de cadena pesada multiespecíficos con regiones constantes de cadena pesada modificadas |
| US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
| JP7773528B2 (ja) | 2020-08-19 | 2025-11-19 | ゼンコア インコーポレイテッド | 抗ｃｄ２８組成物 |
| CN116348495A (zh) * | 2020-09-18 | 2023-06-27 | 瑞泽恩制药公司 | 结合cd38和/或cd28的抗原结合分子及其用途 |
| CA3172530A1 (en) | 2021-02-25 | 2022-09-01 | Spencer PARK | Ror1 targeting chimeric antigen receptor |
| CA3212665A1 (en) | 2021-03-09 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
| KR20230154311A (ko) | 2021-03-10 | 2023-11-07 | 젠코어 인코포레이티드 | Cd3 및 gpc3에 결합하는 이종이량체 항체 |
| TW202325743A (zh) * | 2021-07-14 | 2023-07-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 特異性結合ｃｄ３８、ｂｃｍａ和ｃｄ３的抗原結合分子及其醫藥用途 |
| US20250277051A1 (en) * | 2021-08-02 | 2025-09-04 | Hangzhou Unogen Biotech, Ltd | Anti-cd38 antibodies, anti-cd3 antibodies, and bispecific antibodies, and uses thereof |
| WO2023021477A1 (en) * | 2021-08-20 | 2023-02-23 | Novartis Ag | Methods of making chimeric antigen receptor–expressing cells |
| US12365743B2 (en) | 2022-02-23 | 2025-07-22 | Xencor, Inc. | Anti-CD28 x anti-PSMA antibodies |
| JP2025522482A (ja) | 2022-06-17 | 2025-07-15 | アポジー バイオロジクス， インコーポレイテッド | インターロイキン１３に結合する抗体及び使用方法 |
| CN119487071A (zh) * | 2022-06-24 | 2025-02-18 | 北京可瑞生物科技有限公司 | 基于t细胞受体的双特异性多肽分子及其用途 |
| EP4688860A2 (en) * | 2023-03-28 | 2026-02-11 | Nkarta, Inc. | Antibodies and chimeric antigen receptors specific for cd38 |
| WO2025027003A1 (en) | 2023-07-31 | 2025-02-06 | Sanofi | Methods and uses for anti-cd38 t cell engagers in treatment of peripheral t-cell lymphomas |
| WO2025209594A1 (zh) * | 2024-04-06 | 2025-10-09 | 华深智药生物科技(苏州)有限公司 | 一种抗gucy2c抗体及其多特异性抗体的用途 |
| WO2025209593A1 (zh) * | 2024-04-06 | 2025-10-09 | 华深智药生物科技(苏州)有限公司 | 一种多特异性抗体t细胞衔接器 |
| WO2026019667A1 (en) * | 2024-07-17 | 2026-01-22 | Jn Biosciences Llc | Trispecific antibodies for activation of immune cells |
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| MY191964A (en) | 2015-01-23 | 2022-07-21 | Sanofi Sa | Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123 |
| WO2016196740A1 (en) | 2015-06-02 | 2016-12-08 | The Rockefeller University | Tri-specific antibodies for hiv therapy |
| MX2018005048A (es) | 2015-10-25 | 2018-09-06 | Sanofi Sa | Proteinas de union triespecificas y/o trivalantes para la prevencion o el tratamiento de la infeccion por vih. |
| CN105837688B (zh) | 2015-11-20 | 2019-02-26 | 北京大学深圳研究生院 | 单域抗体及其编码基因，免疫毒素及其编码基因、制备方法、表达载体、应用，及宿主细胞 |
| BR112018070998A2 (pt) * | 2016-04-13 | 2019-02-26 | Sanofi | proteínas de ligação triespecíficas e/ou trivalentes |
| US12234479B2 (en) | 2016-12-30 | 2025-02-25 | Cytocares (Shanghai) Inc. | Bifunctional molecule and use thereof |
| US10626169B2 (en) | 2017-02-17 | 2020-04-21 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| CN120058938A (zh) | 2017-10-10 | 2025-05-30 | 赛诺菲 | 抗cd38抗体及与抗cd3和抗cd28抗体的组合 |
| MX2021004147A (es) | 2018-10-09 | 2021-09-08 | Sanofi Sa | Proteínas de unión triespecíficas anti-cd38, anti-cd28 y anti-cd3 y métodos de uso para tratar una infección viral. |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
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2018
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- 2018-10-09 EP EP18792827.0A patent/EP3694882B1/en active Active
- 2018-10-09 SG SG11202003212PA patent/SG11202003212PA/en unknown
- 2018-10-09 AU AU2018348093A patent/AU2018348093A1/en not_active Abandoned
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- 2018-10-09 CN CN202510123093.5A patent/CN120058939A/zh active Pending
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- 2018-10-09 BR BR112020007002-5A patent/BR112020007002A2/pt not_active IP Right Cessation
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- 2018-10-10 UY UY0001037928A patent/UY37928A/es not_active Application Discontinuation
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