DK3189132T3 - Opløselige antistofkomplekser til T-celle- eller NK-celle-aktivering og -ekspansion - Google Patents
Opløselige antistofkomplekser til T-celle- eller NK-celle-aktivering og -ekspansion Download PDFInfo
- Publication number
- DK3189132T3 DK3189132T3 DK15838102.0T DK15838102T DK3189132T3 DK 3189132 T3 DK3189132 T3 DK 3189132T3 DK 15838102 T DK15838102 T DK 15838102T DK 3189132 T3 DK3189132 T3 DK 3189132T3
- Authority
- DK
- Denmark
- Prior art keywords
- cell
- expansion
- antibody complexes
- soluble antibody
- cell activation
- Prior art date
Links
- 230000006051 NK cell activation Effects 0.000 title 1
- 230000006044 T cell activation Effects 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/53—CD2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045591P | 2014-09-04 | 2014-09-04 | |
| PCT/CA2015/050846 WO2016033690A1 (en) | 2014-09-04 | 2015-09-03 | Soluble antibody complexes for t cell or nk cell activation and expansion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3189132T3 true DK3189132T3 (da) | 2020-08-10 |
Family
ID=55436953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15838102.0T DK3189132T3 (da) | 2014-09-04 | 2015-09-03 | Opløselige antistofkomplekser til T-celle- eller NK-celle-aktivering og -ekspansion |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10961506B2 (da) |
| EP (1) | EP3189132B1 (da) |
| JP (1) | JP6998763B2 (da) |
| CN (1) | CN106687584B (da) |
| BR (1) | BR112017004270B1 (da) |
| CA (1) | CA2996848C (da) |
| DK (1) | DK3189132T3 (da) |
| ES (1) | ES2808914T3 (da) |
| WO (1) | WO2016033690A1 (da) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014117121A1 (en) | 2013-01-28 | 2014-07-31 | St. Jude Children's Research Hospital, Inc. | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| JP6694819B2 (ja) * | 2014-01-21 | 2020-05-20 | ステムセル テクノロジーズ インコーポレイテッド | 表面に結合した単一特異性四量体抗体複合体の組成物を使用して、試料から標的実体を分離する方法 |
| CA2948462A1 (en) | 2014-05-15 | 2015-11-19 | National University Of Singapore | Modified natural killer cells and uses thereof |
| JP7169190B2 (ja) | 2015-10-25 | 2022-11-10 | サノフイ | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
| KR101683614B1 (ko) * | 2016-02-15 | 2016-12-07 | 신동혁 | Nk세포배양용 배지첨가키트 및 상기 키트를 이용한 nk세포배양방법 |
| EP4257193A3 (en) | 2016-04-13 | 2024-01-24 | Sanofi | Trispecific and/or trivalent binding proteins |
| KR20190037243A (ko) * | 2016-06-28 | 2019-04-05 | 지니우스 바이오테크놀로지 인코포레이티드 | 면역치료를 위한 티 세포 조성물 |
| WO2018013797A1 (en) * | 2016-07-13 | 2018-01-18 | President And Fellows Of Harvard College | Antigen-presenting cell-mimetic scaffolds and methods for making and using the same |
| CN106222140A (zh) * | 2016-08-04 | 2016-12-14 | 英普乐孚生物技术(上海)有限公司 | 一种nk细胞无血清培养基及其配制方法 |
| US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
| SG10202007963SA (en) * | 2016-09-30 | 2020-10-29 | Poseida Therapeutics Inc | Modified stem cell memory t cells, methods of making and methods of using same |
| US20190119636A1 (en) | 2017-10-23 | 2019-04-25 | Poseida Therapeutics, Inc. | Modified stem cell memory t cells, methods of making and methods of using same |
| PT3443006T (pt) | 2017-03-17 | 2023-10-26 | Sanofi Sa | Proteínas de ligação triespecíficas e/ou trivalentes |
| BR112019020001A2 (pt) | 2017-03-27 | 2020-04-28 | Nat Univ Singapore | linhagens celulares estimuladoras para expansão ex vivo e ativação de células exterminadoras naturais |
| CN117384929A (zh) | 2017-03-27 | 2024-01-12 | 新加坡国立大学 | 一种编码由细胞表达的嵌合受体的多核苷酸 |
| US20200306303A1 (en) * | 2017-09-29 | 2020-10-01 | Chiou Hwa YUH | Methods and compositions enhancing survival and functionality of anti-tumor and anti-viral t cells |
| EP3694882B1 (en) | 2017-10-10 | 2024-06-19 | Sanofi | Anti-cd38 antibodies and combinations with anti-cd3 and anti-cd28 antibodies |
| EP3765517A1 (en) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| EP3818083A2 (en) | 2018-07-03 | 2021-05-12 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| KR20200030337A (ko) * | 2018-09-12 | 2020-03-20 | 주식회사 녹십자랩셀 | 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물 |
| TWI856979B (zh) | 2018-10-09 | 2024-10-01 | 法商賽諾菲公司 | 三特異性抗ｃｄ３８、抗ｃｄ２８和抗ｃｄ３結合蛋白和用於治療病毒感染的使用方法 |
| KR20210137085A (ko) | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| JP2022527994A (ja) * | 2019-04-09 | 2022-06-07 | サノフイ | 三重特異性結合性タンパク質、方法、およびその使用 |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| CN115003387A (zh) * | 2019-11-25 | 2022-09-02 | Ksq治疗公司 | 用于活化和扩增肿瘤浸润淋巴细胞的方法 |
| US20210324331A1 (en) * | 2020-04-15 | 2021-10-21 | Amgen Inc. | Process for generating genetically engineered autologous t cells |
| JP2023546269A (ja) * | 2020-10-15 | 2023-11-01 | サニーブルック リサーチ インスティチュート | Ｔ細胞を増殖させるための二重特異性コンストラクトおよび関連する方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| NL8501219A (nl) * | 1985-04-29 | 1986-11-17 | Stichting Vrienden Van De Stic | Immunologisch complex, de bereiding en toepassing daarvan. |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| AU1333195A (en) * | 1994-06-03 | 1996-01-04 | Dana-Farber Cancer Institute | Methods for selectively stimulating proliferation of t cells |
| EP1918303A3 (en) | 1999-04-09 | 2008-05-14 | Universität Zürich | method for the stabilization of chimeric immunoglobulins or immunoglobulin fragments, and stabilized anti-egp-2 scfv fragment |
| JP4526749B2 (ja) * | 1999-05-28 | 2010-08-18 | ステムセル テクノロジース インコーポレーテッド | 免疫ロゼットを用いる細胞分離法 |
| MXPA02007473A (es) * | 2000-02-01 | 2003-09-22 | Tanox Inc | Moleculas activadoras de celulas presentadoras de antigenos (apc) que se unen a cd40. |
| US20030235908A1 (en) * | 2000-02-24 | 2003-12-25 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| BR0108545A (pt) * | 2000-02-24 | 2004-06-29 | Xcyte Therapies Inc | Estimulação e concentração simultâneas das células |
| CA2411392C (en) | 2001-11-07 | 2012-10-16 | Stemcell Technologies Inc. | Tetrameric antibody complexes for blocking non-specific binding of antigens |
| US7592431B2 (en) | 2004-02-26 | 2009-09-22 | Immunovative Therapies, Ltd. | Biodegradable T-cell Activation device |
| JP5663135B2 (ja) * | 2005-03-17 | 2015-02-04 | ユーシーエル ビジネス ピーエルシー | 腫瘍細胞調製物によってｉｎｖｉｔｒｏでナチュラルキラー細胞を活性化させるための方法 |
| JP2006345852A (ja) | 2005-06-16 | 2006-12-28 | Virxsys Corp | 抗体複合体 |
| KR101525199B1 (ko) * | 2012-09-13 | 2015-06-04 | (주)케이셀바이오 | 100㎖ 이하 말초혈액으로부터 ｎｋ세포의 대량 증식 방법 |
| EP2711418B1 (en) | 2012-09-25 | 2017-08-23 | Miltenyi Biotec GmbH | Method for polyclonal stimulation of T cells by flexible nanomatrices |
-
2015
- 2015-09-03 EP EP15838102.0A patent/EP3189132B1/en active Active
- 2015-09-03 CA CA2996848A patent/CA2996848C/en active Active
- 2015-09-03 WO PCT/CA2015/050846 patent/WO2016033690A1/en active Application Filing
- 2015-09-03 ES ES15838102T patent/ES2808914T3/es active Active
- 2015-09-03 BR BR112017004270-3A patent/BR112017004270B1/pt active IP Right Grant
- 2015-09-03 JP JP2017512742A patent/JP6998763B2/ja active Active
- 2015-09-03 CN CN201580051521.2A patent/CN106687584B/zh active Active
- 2015-09-03 DK DK15838102.0T patent/DK3189132T3/da active
- 2015-09-03 US US14/844,717 patent/US10961506B2/en active Active
-
2021
- 2021-03-04 US US17/191,830 patent/US20210189343A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210189343A1 (en) | 2021-06-24 |
| JP2017528133A (ja) | 2017-09-28 |
| ES2808914T3 (es) | 2021-03-02 |
| EP3189132A1 (en) | 2017-07-12 |
| CN106687584B (zh) | 2021-08-13 |
| US20160068811A1 (en) | 2016-03-10 |
| WO2016033690A1 (en) | 2016-03-10 |
| BR112017004270A2 (pt) | 2017-12-12 |
| JP6998763B2 (ja) | 2022-02-04 |
| BR112017004270B1 (pt) | 2023-03-07 |
| EP3189132A4 (en) | 2018-02-28 |
| EP3189132B1 (en) | 2020-06-24 |
| CN106687584A (zh) | 2017-05-17 |
| US10961506B2 (en) | 2021-03-30 |
| CA2996848A1 (en) | 2016-03-10 |
| CA2996848C (en) | 2021-01-05 |
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