DK3189132T3 - Opløselige antistofkomplekser til T-celle- eller NK-celle-aktivering og -ekspansion - Google Patents
Opløselige antistofkomplekser til T-celle- eller NK-celle-aktivering og -ekspansion Download PDFInfo
- Publication number
- DK3189132T3 DK3189132T3 DK15838102.0T DK15838102T DK3189132T3 DK 3189132 T3 DK3189132 T3 DK 3189132T3 DK 15838102 T DK15838102 T DK 15838102T DK 3189132 T3 DK3189132 T3 DK 3189132T3
- Authority
- DK
- Denmark
- Prior art keywords
- cell
- expansion
- antibody complexes
- soluble antibody
- cell activation
- Prior art date
Links
- 230000006051 NK cell activation Effects 0.000 title 1
- 230000006044 T cell activation Effects 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/53—CD2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045591P | 2014-09-04 | 2014-09-04 | |
| PCT/CA2015/050846 WO2016033690A1 (en) | 2014-09-04 | 2015-09-03 | Soluble antibody complexes for t cell or nk cell activation and expansion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3189132T3 true DK3189132T3 (da) | 2020-08-10 |
Family
ID=55436953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15838102.0T DK3189132T3 (da) | 2014-09-04 | 2015-09-03 | Opløselige antistofkomplekser til T-celle- eller NK-celle-aktivering og -ekspansion |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10961506B2 (da) |
| EP (1) | EP3189132B1 (da) |
| JP (1) | JP6998763B2 (da) |
| CN (1) | CN106687584B (da) |
| BR (1) | BR112017004270B1 (da) |
| CA (1) | CA2996848C (da) |
| DK (1) | DK3189132T3 (da) |
| ES (1) | ES2808914T3 (da) |
| WO (1) | WO2016033690A1 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014117121A1 (en) | 2013-01-28 | 2014-07-31 | St. Jude Children's Research Hospital, Inc. | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| EP3097187B1 (en) * | 2014-01-21 | 2018-07-04 | Stemcell Technologies Inc. | Method for separating target entities from a sample using a composition of mono-specific tetrameric antibody complexes coupled to a surface |
| CN106459914B (zh) | 2014-05-15 | 2020-11-06 | 新加坡国立大学 | 经修饰的自然杀伤细胞及其用途 |
| EP3819310A1 (en) | 2015-10-25 | 2021-05-12 | Sanofi | Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection |
| KR101683614B1 (ko) * | 2016-02-15 | 2016-12-07 | 신동혁 | Nk세포배양용 배지첨가키트 및 상기 키트를 이용한 nk세포배양방법 |
| MY192090A (en) | 2016-04-13 | 2022-07-26 | Sanofi Sa | Trispecific and/or trivalent binding proteins |
| WO2018005712A1 (en) * | 2016-06-28 | 2018-01-04 | Geneius Biotechnology, Inc. | T cell compositions for immunotherapy |
| CN109789092A (zh) * | 2016-07-13 | 2019-05-21 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
| CN106222140A (zh) * | 2016-08-04 | 2016-12-14 | 英普乐孚生物技术(上海)有限公司 | 一种nk细胞无血清培养基及其配制方法 |
| US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
| KR102588469B1 (ko) * | 2016-09-30 | 2023-10-11 | 포세이다 테라퓨틱스, 인크. | 변형된 줄기세포 기억 t 세포, 이의 제조 방법 및 사용 방법 |
| US20190119636A1 (en) | 2017-10-23 | 2019-04-25 | Poseida Therapeutics, Inc. | Modified stem cell memory t cells, methods of making and methods of using same |
| EA201892312A1 (ru) | 2017-03-17 | 2019-04-30 | Санофи | Триспецифические и/или тривалентные связывающие белки |
| CN110494557A (zh) | 2017-03-27 | 2019-11-22 | 新加坡国立大学 | 用于离体扩增和活化自然杀伤细胞的刺激细胞系 |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| WO2019068066A1 (en) * | 2017-09-29 | 2019-04-04 | National Health Research Institutes | METHODS AND COMPOSITIONS FOR IMPROVING THE SURVIVAL AND FUNCTIONALITY OF ANTI-TUMOR AND ANTI-VIRAL CELL LYMPHOCYTES |
| EP4249068A3 (en) | 2017-10-10 | 2023-11-22 | Sanofi | Anti-cd38 antibodies and combinations with anti-cd3 and anti-cd28 antibodies |
| EP3818083A2 (en) | 2018-07-03 | 2021-05-12 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| JP7462621B2 (ja) | 2018-10-09 | 2024-04-05 | サノフイ | 三重特異性抗ｃｄ３８、抗ｃｄ２８、および抗ｃｄ３結合タンパク質ならびにウイルス感染を処置するための使用方法 |
| SG11202109057XA (en) | 2019-03-05 | 2021-09-29 | Nkarta Inc | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| WO2020210392A1 (en) * | 2019-04-09 | 2020-10-15 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| CN115003387A (zh) * | 2019-11-25 | 2022-09-02 | Ksq治疗公司 | 用于活化和扩增肿瘤浸润淋巴细胞的方法 |
| US20210324331A1 (en) * | 2020-04-15 | 2021-10-21 | Amgen Inc. | Process for generating genetically engineered autologous t cells |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| NL8501219A (nl) | 1985-04-29 | 1986-11-17 | Stichting Vrienden Van De Stic | Immunologisch complex, de bereiding en toepassing daarvan. |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US6352694B1 (en) * | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| CA2191586A1 (en) * | 1994-06-03 | 1995-12-14 | Carl H. June | Methods for selectively stimulating proliferation of t cells |
| DE60039354D1 (de) | 1999-04-09 | 2008-08-14 | Univ Zuerich | Verfahren zur Stabilisierung von chimären Immunoglobulinen oder Immunoglobulinfragmenten und stabilisiertes Anti-EGP-2-scFv-Fragment |
| AU769903B2 (en) * | 1999-05-28 | 2004-02-05 | Stemcell Technologies Canada Inc. | Method for separating cells using immunorosettes |
| AU3662101A (en) * | 2000-02-01 | 2001-08-14 | Tanox Inc | Cd40-binding apc-activating molecules |
| US20030235908A1 (en) | 2000-02-24 | 2003-12-25 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| AU4328801A (en) * | 2000-02-24 | 2001-09-03 | Xcyte Therapies Inc | Simultaneous stimulation and concentration of cells |
| CA2411392C (en) | 2001-11-07 | 2012-10-16 | Stemcell Technologies Inc. | Tetrameric antibody complexes for blocking non-specific binding of antigens |
| US7592431B2 (en) | 2004-02-26 | 2009-09-22 | Immunovative Therapies, Ltd. | Biodegradable T-cell Activation device |
| AU2006224313B2 (en) * | 2005-03-17 | 2011-08-11 | Ucl Biomedica Plc | Method for actvating Natural Killer cells by tumor cell preparation in vitro |
| JP2006345852A (ja) | 2005-06-16 | 2006-12-28 | Virxsys Corp | 抗体複合体 |
| KR101525199B1 (ko) * | 2012-09-13 | 2015-06-04 | (주)케이셀바이오 | 100㎖ 이하 말초혈액으로부터 ｎｋ세포의 대량 증식 방법 |
| EP2711418B1 (en) | 2012-09-25 | 2017-08-23 | Miltenyi Biotec GmbH | Method for polyclonal stimulation of T cells by flexible nanomatrices |
-
2015
- 2015-09-03 DK DK15838102.0T patent/DK3189132T3/da active
- 2015-09-03 CN CN201580051521.2A patent/CN106687584B/zh active Active
- 2015-09-03 WO PCT/CA2015/050846 patent/WO2016033690A1/en active Application Filing
- 2015-09-03 CA CA2996848A patent/CA2996848C/en active Active
- 2015-09-03 ES ES15838102T patent/ES2808914T3/es active Active
- 2015-09-03 BR BR112017004270-3A patent/BR112017004270B1/pt active IP Right Grant
- 2015-09-03 JP JP2017512742A patent/JP6998763B2/ja active Active
- 2015-09-03 EP EP15838102.0A patent/EP3189132B1/en active Active
- 2015-09-03 US US14/844,717 patent/US10961506B2/en active Active
-
2021
- 2021-03-04 US US17/191,830 patent/US20210189343A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210189343A1 (en) | 2021-06-24 |
| BR112017004270A2 (pt) | 2017-12-12 |
| US20160068811A1 (en) | 2016-03-10 |
| CA2996848A1 (en) | 2016-03-10 |
| WO2016033690A1 (en) | 2016-03-10 |
| EP3189132B1 (en) | 2020-06-24 |
| EP3189132A4 (en) | 2018-02-28 |
| JP6998763B2 (ja) | 2022-02-04 |
| CN106687584B (zh) | 2021-08-13 |
| EP3189132A1 (en) | 2017-07-12 |
| US10961506B2 (en) | 2021-03-30 |
| JP2017528133A (ja) | 2017-09-28 |
| CA2996848C (en) | 2021-01-05 |
| BR112017004270B1 (pt) | 2023-03-07 |
| CN106687584A (zh) | 2017-05-17 |
| ES2808914T3 (es) | 2021-03-02 |
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