MXPA02007473A - Moleculas activadoras de celulas presentadoras de antigenos (apc) que se unen a cd40. - Google Patents

Moleculas activadoras de celulas presentadoras de antigenos (apc) que se unen a cd40.

Info

Publication number
MXPA02007473A
MXPA02007473A MXPA02007473A MXPA02007473A MXPA02007473A MX PA02007473 A MXPA02007473 A MX PA02007473A MX PA02007473 A MXPA02007473 A MX PA02007473A MX PA02007473 A MXPA02007473 A MX PA02007473A MX PA02007473 A MXPA02007473 A MX PA02007473A
Authority
MX
Mexico
Prior art keywords
activating molecules
binding
apc activating
binding apc
molecules
Prior art date
Application number
MXPA02007473A
Other languages
English (en)
Inventor
David Thomas
Boer Mark De
Pieter C J M Res
Peter J Simons
Original Assignee
Tanox Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanox Inc filed Critical Tanox Inc
Publication of MXPA02007473A publication Critical patent/MXPA02007473A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
MXPA02007473A 2000-02-01 2001-02-01 Moleculas activadoras de celulas presentadoras de antigenos (apc) que se unen a cd40. MXPA02007473A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17893400P 2000-02-01 2000-02-01
PCT/US2001/003378 WO2001056603A1 (en) 2000-02-01 2001-02-01 Cd40-binding apc-activating molecules

Publications (1)

Publication Number Publication Date
MXPA02007473A true MXPA02007473A (es) 2003-09-22

Family

ID=22654507

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02007473A MXPA02007473A (es) 2000-02-01 2001-02-01 Moleculas activadoras de celulas presentadoras de antigenos (apc) que se unen a cd40.

Country Status (9)

Country Link
US (3) US7172759B2 (es)
EP (2) EP1975182A1 (es)
JP (1) JP2003524644A (es)
CN (2) CN100490895C (es)
AU (2) AU3662101A (es)
BR (1) BR0108001A (es)
CA (1) CA2398998C (es)
MX (1) MXPA02007473A (es)
WO (1) WO2001056603A1 (es)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6407218B1 (en) * 1997-11-10 2002-06-18 Cytimmune Sciences, Inc. Method and compositions for enhancing immune response and for the production of in vitro mabs
CA2223225A1 (en) * 1997-11-28 1999-05-28 Canadian Red Cross Society Method for inhibiting in vivo immune response
US20110041190A1 (en) * 2002-10-31 2011-02-17 Tykocinski Mark L Novel chimeric proteins
EP1975182A1 (en) * 2000-02-01 2008-10-01 PanGenetics B.V. CD40-binding APC-activating molecules
US7063845B2 (en) 2000-04-28 2006-06-20 Gemini Science, Inc. Human anti-CD40 antibodies
CA2658221C (en) 2001-04-27 2012-11-27 Kyowa Hakko Kirin Co., Ltd. Anti-cd40 monoclonal antibody
US20030091593A1 (en) * 2001-09-14 2003-05-15 Cytos Biotechnology Ag In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
AU2002339224B2 (en) 2001-09-14 2008-10-09 Kuros Us Llc Packaging of immunostimulatory substances into virus-like particles: method of preparation and use
AR039067A1 (es) * 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
EP1605973B1 (en) 2003-03-26 2012-09-26 Cytos Biotechnology AG Packaging of immunostimulatory oligonucleotides into virus-like particles: methods of preparation and uses
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
JP2008504216A (ja) * 2003-12-02 2008-02-14 サイトイミューン サイエンシズ インコーポレイテッド モノクローナル抗体の生成のための方法および組成物
US20050136055A1 (en) 2003-12-22 2005-06-23 Pfizer Inc CD40 antibody formulation and methods
US20070184068A1 (en) 2005-12-14 2007-08-09 Cytos Biotechnology Ag Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
MX2008013993A (es) 2006-05-03 2009-05-11 Univ Colorado Combinación adyuvante sinergistica de anticuerpo agonista de cd40/interferona tipo 1, conjugados que la contienen y uso de los mismos como un terapeutico para aumentar la inmunidad celular.
PL2032592T3 (pl) 2006-06-12 2013-11-29 Kuros Biosciences Ag Sposoby pakowania oligonukleotydów do cząstek wirusopodobnych z bakteriofagów RNA
US20090074711A1 (en) * 2006-09-07 2009-03-19 University Of Southhampton Human therapies using chimeric agonistic anti-human cd40 antibody
CA2706700A1 (en) * 2007-11-08 2009-05-14 Cytimmune Sciences, Inc. Compositions and methods for generating antibodies
WO2012042480A1 (en) 2010-09-28 2012-04-05 Kahr Medical Ltd. Compositions and methods for treatment of hematological malignancies
CA3122934A1 (en) 2011-03-11 2012-09-20 Beth Israel Deaconess Medical Center, Inc. Fusion protein comprising a fragment of cd40 and method of producing same
MX339239B (es) 2011-04-29 2016-05-18 Apexigen Inc Anticuerpos anti-cd40 y metodos de uso.
CN104918957B (zh) 2012-10-30 2018-11-16 埃派斯进有限公司 抗-cd40抗体及其使用方法
CN103793594A (zh) * 2013-12-30 2014-05-14 上海交通大学医学院附属瑞金医院 一种构建肠道-胰岛调控轴相关功能评估模型的方法与应用
WO2016033690A1 (en) * 2014-09-04 2016-03-10 Stemcell Technologies Inc. Soluble antibody complexes for t cell or nk cell activation and expansion
KR102656470B1 (ko) 2014-12-10 2024-04-09 리전츠 오브 더 유니버스티 오브 미네소타 질환을 치료하기 위한 유전적으로 변형된 세포, 조직 및 장기
US20170316176A1 (en) * 2014-12-25 2017-11-02 Hitachi, Ltd. Device for analyzing insulin secretion ability, system for analyzing insulin secretion ability provided with same, and method for analyzing insulin secretion ability
MA41459A (fr) 2015-02-03 2017-12-12 Als Therapy Development Inst Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l
WO2016130667A1 (en) 2015-02-10 2016-08-18 Ohio State Innovation Foundation Chlamydia-activated b cell platforms and methods thereof
WO2016166568A1 (en) 2015-04-16 2016-10-20 Juno Therapeutics Gmbh Methods, kits and apparatus for expanding a population of cells
JP2018521983A (ja) 2015-07-16 2018-08-09 バイオカイン セラピューティックス リミテッド がんを治療するための組成物および方法
SI3307322T1 (sl) 2015-09-04 2021-08-31 Primatope Therapeutics Inc. Humanizirana protitelesa proti CD40 in njihove uporabe
EP3355921A4 (en) 2015-09-30 2019-05-22 Janssen Biotech, Inc. ANTAGONIST ANTIBODIES SPECIFICALLY BINDING TO HUMAN CD40 AND METHODS OF USE
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
MA45488A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés, kits et appareil de culture de cellules
BR112018008891A8 (pt) 2015-11-03 2019-02-26 Janssen Biotech Inc anticorpos que se ligam especificamente a pd-1 e tim-3 e seus usos
US10835601B2 (en) 2015-11-10 2020-11-17 Ohio State Innovation Foundation Methods and compositions related to accelerated humoral affinity
EP3426271A4 (en) 2016-03-10 2019-10-16 Cold Genesys, Inc. METHODS OF TREATING SOLID OR LYMPHATIC TUMORS BY POLYTHERAPY
KR102426765B1 (ko) * 2016-04-22 2022-07-29 엘리게이터 바이오사이언스 에이비 Cd137에 대한 신규한 이중특이성 폴리펩타이드
AU2017271601A1 (en) 2016-05-27 2018-12-13 Abbvie Biotherapeutics Inc. Bispecific binding proteins binding an immunomodulatory protein and a tumor antigen
MX2018014630A (es) 2016-05-27 2019-06-10 Abbvie Biotherapeutics Inc Anticuerpos anti-cd40 y sus usos.
US11091557B2 (en) 2016-07-14 2021-08-17 Genmab A/S Methods of producing multispecific antibodies against CD40 and CD137
AU2017308734A1 (en) 2016-08-12 2019-02-14 Janssen Biotech, Inc. Fc engineered anti-TNFR superfamily member antibodies having enhanced agonistic activity and methods of using them
SG11201900746RA (en) 2016-08-12 2019-02-27 Janssen Biotech Inc Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions
JP7305538B2 (ja) 2016-09-23 2023-07-10 メルス ナムローゼ フェンノートシャップ 細胞によって発現される生物活性を調節する結合分子
CA3055433A1 (en) * 2017-03-29 2018-10-04 Glycotope Gmbh Humanized anti-cd40 antibodies
KR102606210B1 (ko) 2017-04-27 2023-11-24 주노 테라퓨틱스 게엠베하 올리고머 입자 시약 및 이의 사용 방법
WO2018217918A2 (en) 2017-05-24 2018-11-29 Als Therapy Development Institute Therapeutic anti-cd40 ligand antibodies
WO2019016402A1 (en) 2017-07-20 2019-01-24 Aptevo Research And Development Llc BINDING PROTEINS BINDING AT 5T4 AND 4-1BB, COMPOSITIONS AND METHODS RELATED THERETO
JP2022512872A (ja) 2018-10-31 2022-02-07 ジュノ セラピューティクス ゲーエムベーハー 細胞の選択および刺激のための方法ならびにそのための装置
CA3117720A1 (en) 2018-11-06 2020-05-14 Juno Therapeutics, Inc. Process for producing genetically engineered t cells
CN109912717B (zh) * 2019-03-04 2020-05-26 北京天广实生物技术股份有限公司 结合cd40的抗体及其用途
AU2020377043A1 (en) 2019-10-30 2022-06-02 Juno Therapeutics Gmbh Cell selection and/or stimulation devices and methods of use
CA3164129A1 (en) 2019-12-20 2021-06-24 Amgen Inc. Mesothelin-targeted cd40 agonistic multispecific antibody constructs for the treatment of solid tumors
CN111235208B (zh) * 2020-02-28 2022-10-28 江苏大学 一种离子液体对糖代谢影响的评估方法
WO2021231661A2 (en) 2020-05-13 2021-11-18 Juno Therapeutics, Inc. Process for producing donor-batched cells expressing a recombinant receptor
WO2022036495A1 (en) 2020-08-17 2022-02-24 Utc Therapeutics Inc. Lymphocytes-antigen presenting cells co-stimulators and uses thereof
CN117916256A (zh) 2021-05-06 2024-04-19 朱诺治疗学有限公司 用于刺激和转导t细胞的方法
WO2023213969A1 (en) 2022-05-05 2023-11-09 Juno Therapeutics Gmbh Viral-binding protein and related reagents, articles, and methods of use

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US6106835A (en) * 1991-04-19 2000-08-22 Tanox, Inc. Modified binding molecules specific for T or B lymphocytes and their use as in vivo immune modulators
US5637481A (en) * 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
DE69334255D1 (de) 1992-02-06 2009-02-12 Novartis Vaccines & Diagnostic Marker für Krebs und biosynthetisches Bindeprotein dafür
ES2211884T3 (es) 1993-10-01 2004-07-16 Immunex Corporation Anticuerpos contra el cd40.
ATE267607T1 (de) 1993-12-23 2004-06-15 Immunex Corp Verwendung von löslichen oligomerischen cd40 liganden oder monoklonalen antikörpern zur herstellung eines arzneimitells zur vorbeugung oder behandlung von neoplastischen krankheiten
US5463564A (en) 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US5504004A (en) 1994-12-20 1996-04-02 Michigan Biotechnology Institute Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms
WO1998001473A1 (en) 1996-07-05 1998-01-15 Novo Nordisk A/S Method for the production of precursors of insulin, precursors of insulin analogues, and insulin like peptides
DE29611914U1 (de) 1996-07-09 1997-11-06 Bosch Gmbh Robert Zündspule für eine Brennkraftmaschine
NZ333607A (en) * 1996-07-10 2000-08-25 Immunex Corp Method of stimulating the immune system by transfecting dendritic cells
WO1999061057A2 (en) * 1998-05-23 1999-12-02 Tanox, Inc. Molecules targeting cd40 and tumor cells
EP1082141B1 (en) * 1998-05-23 2005-09-14 Leiden university medical center Cd40 binding antibodies and ctl peptides for treating tumors
US6946129B1 (en) * 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
EP1975182A1 (en) * 2000-02-01 2008-10-01 PanGenetics B.V. CD40-binding APC-activating molecules
AU2001259106A1 (en) 2000-04-19 2002-02-18 Tanox, Inc. CD40 antagonists for use in treating psoriasis and other inflammatory skin conditions
JP4483043B2 (ja) * 2000-07-19 2010-06-16 ヤマハ株式会社 楽曲データ提供装置、方法、及び記録媒体

Also Published As

Publication number Publication date
US7547438B2 (en) 2009-06-16
BR0108001A (pt) 2004-01-06
EP1253942A4 (en) 2004-06-16
US20010026932A1 (en) 2001-10-04
US7172759B2 (en) 2007-02-06
US7820807B2 (en) 2010-10-26
JP2003524644A (ja) 2003-08-19
AU3662101A (en) 2001-08-14
CA2398998C (en) 2014-04-22
WO2001056603A1 (en) 2001-08-09
CN100490895C (zh) 2009-05-27
US20070098720A1 (en) 2007-05-03
US20090311268A1 (en) 2009-12-17
EP1253942A1 (en) 2002-11-06
EP1975182A1 (en) 2008-10-01
CA2398998A1 (en) 2001-08-09
CN1443077A (zh) 2003-09-17
AU2001236621B2 (en) 2006-06-15
CN1942767A (zh) 2007-04-04

Similar Documents

Publication Publication Date Title
MXPA02007473A (es) Moleculas activadoras de celulas presentadoras de antigenos (apc) que se unen a cd40.
ZA200205479B (en) Novel biarylcarboxamides.
AU2001291200A1 (en) Micro-laser
MXPA03002410A (es) 4-amino-quinazolinas.
AU2002239660A1 (en) Watermaking holograms
MXPA03005445A (es) Barra colectora 12c para aislar los circuitos integrados seleccionados para una comunicacion rapida de barra colectora 12c.
MXPA03007197A (es) Moleculas de enlace terapeuticas.
EG23262A (en) Delta -pyrrolines.
AUPQ632300A0 (en) Bactericidal solution
HK1056872A1 (en) Indoloquinazolinones.
MXPA03001877A (es) 2-guanidin-4-arilquinazolinas.
MXPA03001591A (es) Derivados y analogos de 10-aril-11-h-benzo(b) fluorena para uso medicinal.
ZA200205389B (en) Booklet.
MXPA03002668A (es) Guanidinas de sulfonilo.
MXPA03001991A (es) Novedosas arilalcano-sulfonamidas.
MXPA03005714A (es) Sulfamidotienopirimidinas.
MXPA03002411A (es) 4-amino-quinazolinas.
AU6594401A (en) 6-heterocyclyl-3-oxo-3,4-dihydro-quinoxalines
AU2001259434A1 (en) Calcitonin-related molecules
MXPA03005494A (es) Benzoilpiridazinas.
AU2002210379A1 (en) Subtilase variants
HK1061560A1 (en) Triazolo-epothilones.
MXPA03004202A (es) Producto celulosico entrelazado.
GB0022670D0 (en) Molecules
GB0002625D0 (en) Dendroaspin molecules