JP2020504723A5 - - Google Patents
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- JP2020504723A5 JP2020504723A5 JP2019533085A JP2019533085A JP2020504723A5 JP 2020504723 A5 JP2020504723 A5 JP 2020504723A5 JP 2019533085 A JP2019533085 A JP 2019533085A JP 2019533085 A JP2019533085 A JP 2019533085A JP 2020504723 A5 JP2020504723 A5 JP 2020504723A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 42
- 230000027455 binding Effects 0.000 claims 32
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 26
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 26
- 239000000427 antigen Substances 0.000 claims 24
- 102000036639 antigens Human genes 0.000 claims 24
- 108091007433 antigens Proteins 0.000 claims 24
- 239000003814 drug Substances 0.000 claims 21
- 239000000556 agonist Substances 0.000 claims 13
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 7
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 6
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 6
- 208000017604 Hodgkin disease Diseases 0.000 claims 6
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 6
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 6
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 6
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 6
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 6
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 6
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 6
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 6
- 201000003444 follicular lymphoma Diseases 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 6
- 208000021937 marginal zone lymphoma Diseases 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 108010082808 4-1BB Ligand Proteins 0.000 claims 3
- 102000002627 4-1BB Ligand Human genes 0.000 claims 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 3
- 208000034578 Multiple myelomas Diseases 0.000 claims 3
- 238000002648 combination therapy Methods 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 201000000050 myeloid neoplasm Diseases 0.000 claims 3
- 230000009870 specific binding Effects 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 229960003347 obinutuzumab Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16205493.6 | 2016-12-20 | ||
| EP16205493 | 2016-12-20 | ||
| PCT/EP2017/083222 WO2018114748A1 (en) | 2016-12-20 | 2017-12-18 | Combination therapy of anti-cd20/anti-cd3 bispecific antibodies and 4-1bb (cd137) agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020504723A JP2020504723A (ja) | 2020-02-13 |
| JP2020504723A5 true JP2020504723A5 (enExample) | 2021-02-04 |
| JP7247091B2 JP7247091B2 (ja) | 2023-03-28 |
Family
ID=57609723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533085A Active JP7247091B2 (ja) | 2016-12-20 | 2017-12-18 | 抗ｃｄ２０／抗ｃｄ３二重特異性抗体と４－１ｂｂ（ｃｄ１３７）アゴニストの併用療法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11718680B2 (enExample) |
| EP (1) | EP3559034B1 (enExample) |
| JP (1) | JP7247091B2 (enExample) |
| KR (1) | KR102692708B1 (enExample) |
| CN (1) | CN110088135A (enExample) |
| AU (1) | AU2017384126B2 (enExample) |
| BR (1) | BR112019007267A2 (enExample) |
| CA (1) | CA3039446A1 (enExample) |
| ES (1) | ES2847973T3 (enExample) |
| IL (1) | IL267406B2 (enExample) |
| MX (1) | MX2019006954A (enExample) |
| PL (1) | PL3559034T3 (enExample) |
| TW (1) | TWI773712B (enExample) |
| WO (1) | WO2018114748A1 (enExample) |
Families Citing this family (46)
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| TWI736437B (zh) * | 2010-11-30 | 2021-08-11 | 日商中外製藥股份有限公司 | 細胞傷害誘導治療劑 |
| CA2963718A1 (en) | 2014-11-14 | 2016-05-19 | F. Hoffmann-La Roche Ag | Antigen binding molecules comprising a tnf family ligand trimer |
| CN114751989B (zh) | 2015-03-31 | 2025-03-14 | 豪夫迈·罗氏有限公司 | 包含三聚体tnf家族配体的抗原结合分子 |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| CN108602887B (zh) | 2015-10-02 | 2022-06-21 | 豪夫迈·罗氏有限公司 | 对共刺激性tnf受体特异性的双特异性抗体 |
| KR102692708B1 (ko) | 2016-12-20 | 2024-08-07 | 에프. 호프만-라 로슈 아게 | 항-cd20/항-cd3 이중특이성 항체 및 4-1bb(cd137) 작용물질의 병용 요법 |
| KR20190099527A (ko) | 2017-01-03 | 2019-08-27 | 에프. 호프만-라 로슈 아게 | 항-4-1bb 클론 20h4.9를 포함하는 이중특이성 항원 결합 분자 |
| WO2018178055A1 (en) | 2017-03-29 | 2018-10-04 | F. Hoffmann-La Roche Ag | Bispecific antigen binding molecule for a costimulatory tnf receptor |
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| US12227567B2 (en) | 2017-07-25 | 2025-02-18 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| EP3720963A4 (en) | 2017-12-05 | 2021-12-08 | Chugai Seiyaku Kabushiki Kaisha | ANTIGEN BINDING MOLECULE INCLUDING A VARIABLE REGION OF MODIFIED ANTIBODIES BINDING TO CD3 AND CD137 |
| TWI841551B (zh) | 2018-03-13 | 2024-05-11 | 瑞士商赫孚孟拉羅股份公司 | 使用靶向4-1bb (cd137)之促效劑的組合療法 |
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| JP2021528988A (ja) * | 2018-07-04 | 2021-10-28 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 新規の二重特異性アゴニスト４−１ｂｂ抗原結合分子 |
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| EP3856785A4 (en) * | 2018-09-28 | 2022-07-06 | Chugai Seiyaku Kabushiki Kaisha | ANTIGEN-BINDING MOLECULES THAT CAN BIND CD3 AND CD137 BUT NOT SIMULTANEOUSLY |
| UA126188C2 (uk) | 2018-10-01 | 2022-08-25 | Ф. Хоффманн-Ля Рош Аг | Біспецифічна антигензв'язувальна молекула, яка містить домен зв'язування з fap та домен зв'язування з сd40 |
| SG11202103568PA (en) * | 2018-10-23 | 2021-05-28 | Magenta Therapeutics Inc | Fc silenced antibody drug conjugates (adcs) and uses thereof |
| WO2020127628A1 (en) * | 2018-12-21 | 2020-06-25 | F. Hoffmann-La Roche Ag | Tumor-targeted superagonistic cd28 antigen binding molecules |
| WO2020127618A1 (en) * | 2018-12-21 | 2020-06-25 | F. Hoffmann-La Roche Ag | Tumor-targeted agonistic cd28 antigen binding molecules |
| CN114025802B (zh) * | 2019-06-21 | 2024-04-23 | 瑞泽恩制药公司 | 结合psma和cd3的双特异性抗原结合分子与4-1bb共刺激组合的用途 |
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| EP3990477A1 (en) * | 2019-06-26 | 2022-05-04 | F. Hoffmann-La Roche AG | Fusion of an antibody binding cea and 4-1bbl |
| MY207446A (en) * | 2019-08-12 | 2025-02-27 | Abl Bio Inc | Anti-claudin 18.2 and anti-4-1bb bispecific antibodies and uses thereof |
| CN112390882A (zh) * | 2019-08-19 | 2021-02-23 | 杨洋 | 靶向cd3和cd20的双特异性抗体及其应用 |
| CR20250287A (es) | 2020-03-31 | 2025-08-28 | Chugai Pharmaceutical Co Ltd | Moléculas de unión al antígeno multiespecíficas dirigidas a ligando de tipo delta (dll3) y sus usos (divisional exp. 2022-0541) |
| AR121706A1 (es) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
| CA3185040A1 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| BR112022025856A2 (pt) | 2020-06-19 | 2023-01-10 | Hoffmann La Roche | Anticorpo que se liga a cd3 e cd19, polinucleotídeo isolado, célula hospedeira, método de produção de um anticorpo que se liga a cd3 e cd19, composição farmacêutica, uso do anticorpo, método para tratar uma doença em um indivíduo e invenção |
| CN112062855B (zh) * | 2020-08-26 | 2024-08-30 | 北京天诺健成医药科技有限公司 | 一种含有衔接器的药物治疗剂的开发和应用 |
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| CA3213632A1 (en) | 2021-04-30 | 2022-11-03 | F. Hoffmann-La Roche Ag | Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate |
| IL307821A (en) * | 2021-04-30 | 2023-12-01 | Hoffmann La Roche | Dosage for treatment with BISPIFIC ANTI-CD20/ANTI-CD3 antibody |
| CN118139641A (zh) * | 2021-06-04 | 2024-06-04 | Xencor股份有限公司 | 结合cd20和cd3的双重特异性抗体的剂量施用 |
| EP4467571A1 (en) * | 2022-01-20 | 2024-11-27 | Shanghai Junshi Biosciences Co., Ltd. | Anti-cd3 and anti-cd20 bispecific antibody and use thereof |
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| CA3247475A1 (en) | 2022-04-11 | 2023-10-19 | Regeneron Pharma | COMPOSITIONS AND METHODS FOR THE DESTRUCTION OF UNIVERSAL TUMOR CELLS |
| CA3255366A1 (en) * | 2022-04-13 | 2023-10-19 | Hoffmann La Roche | Pharmaceutical compositions based on bispecific anti-CD20/anti-CD3 antibodies and methods of use |
| EP4565620A1 (en) * | 2022-08-05 | 2025-06-11 | Shanghai Kaijin Biotechnology , Ltd | Multi-specific polypeptide complexes |
| CN120152989A (zh) * | 2022-11-03 | 2025-06-13 | 豪夫迈·罗氏有限公司 | 抗cd19/抗cd28双特异性抗体的组合疗法 |
| KR20250151441A (ko) | 2023-02-17 | 2025-10-21 | 리제너론 파마슈티칼스 인코포레이티드 | Cd3/taa 이중특이적 항체에 대해 반응성인 유도된 nk 세포 |
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2017
- 2017-12-18 KR KR1020197017459A patent/KR102692708B1/ko active Active
- 2017-12-18 CA CA3039446A patent/CA3039446A1/en active Pending
- 2017-12-18 AU AU2017384126A patent/AU2017384126B2/en active Active
- 2017-12-18 EP EP17829176.1A patent/EP3559034B1/en active Active
- 2017-12-18 BR BR112019007267A patent/BR112019007267A2/pt unknown
- 2017-12-18 PL PL17829176T patent/PL3559034T3/pl unknown
- 2017-12-18 IL IL267406A patent/IL267406B2/en unknown
- 2017-12-18 ES ES17829176T patent/ES2847973T3/es active Active
- 2017-12-18 JP JP2019533085A patent/JP7247091B2/ja active Active
- 2017-12-18 MX MX2019006954A patent/MX2019006954A/es unknown
- 2017-12-18 CN CN201780078372.8A patent/CN110088135A/zh active Pending
- 2017-12-18 WO PCT/EP2017/083222 patent/WO2018114748A1/en not_active Ceased
- 2017-12-19 TW TW106144582A patent/TWI773712B/zh active
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2020
- 2020-03-16 US US16/820,504 patent/US11718680B2/en active Active
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2023
- 2023-06-13 US US18/334,228 patent/US20240109976A1/en active Pending
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