JP2018512379A5 - - Google Patents

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JP2018512379A5
JP2018512379A5 JP2017542004A JP2017542004A JP2018512379A5 JP 2018512379 A5 JP2018512379 A5 JP 2018512379A5 JP 2017542004 A JP2017542004 A JP 2017542004A JP 2017542004 A JP2017542004 A JP 2017542004A JP 2018512379 A5 JP2018512379 A5 JP 2018512379A5
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antibody
seq
variable region
heavy chain
light chain
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JP2017542004A
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JP6895890B2 (ja
JP2018512379A (ja
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Priority claimed from PCT/US2016/017422 external-priority patent/WO2016130726A1/en
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Publication of JP2018512379A5 publication Critical patent/JP2018512379A5/ja
Priority to JP2021021535A priority Critical patent/JP7324789B2/ja
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Publication of JP6895890B2 publication Critical patent/JP6895890B2/ja
Priority to JP2023124894A priority patent/JP2023162180A/ja
Priority to JP2025091489A priority patent/JP2025148326A/ja
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JP2017542004A 2015-02-10 2016-02-10 ヒト化抗muc1* 抗体 Active JP6895890B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021021535A JP7324789B2 (ja) 2015-02-10 2021-02-15 ヒト化抗muc1* 抗体
JP2023124894A JP2023162180A (ja) 2015-02-10 2023-07-31 ヒト化抗muc1*抗体
JP2025091489A JP2025148326A (ja) 2015-02-10 2025-05-30 ヒト化抗muc1*抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562114526P 2015-02-10 2015-02-10
US62/114,526 2015-02-10
PCT/US2016/017422 WO2016130726A1 (en) 2015-02-10 2016-02-10 Humanized anti-muc1* antibodies

Related Child Applications (1)

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JP2021021535A Division JP7324789B2 (ja) 2015-02-10 2021-02-15 ヒト化抗muc1* 抗体

Publications (3)

Publication Number Publication Date
JP2018512379A JP2018512379A (ja) 2018-05-17
JP2018512379A5 true JP2018512379A5 (enExample) 2019-03-14
JP6895890B2 JP6895890B2 (ja) 2021-06-30

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ID=56615670

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017542004A Active JP6895890B2 (ja) 2015-02-10 2016-02-10 ヒト化抗muc1* 抗体
JP2021021535A Active JP7324789B2 (ja) 2015-02-10 2021-02-15 ヒト化抗muc1* 抗体
JP2023124894A Pending JP2023162180A (ja) 2015-02-10 2023-07-31 ヒト化抗muc1*抗体
JP2025091489A Pending JP2025148326A (ja) 2015-02-10 2025-05-30 ヒト化抗muc1*抗体

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021021535A Active JP7324789B2 (ja) 2015-02-10 2021-02-15 ヒト化抗muc1* 抗体
JP2023124894A Pending JP2023162180A (ja) 2015-02-10 2023-07-31 ヒト化抗muc1*抗体
JP2025091489A Pending JP2025148326A (ja) 2015-02-10 2025-05-30 ヒト化抗muc1*抗体

Country Status (8)

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US (4) US11746159B2 (enExample)
EP (1) EP3256494A4 (enExample)
JP (4) JP6895890B2 (enExample)
CN (2) CN107660213B (enExample)
AU (3) AU2016219350A1 (enExample)
CA (2) CA2976089C (enExample)
IL (1) IL253909B (enExample)
WO (1) WO2016130726A1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012504961A (ja) * 2008-10-06 2012-03-01 ミネルバ バイオテクノロジーズ コーポレーション Muc1*抗体
EP4050103A1 (en) 2014-04-07 2022-08-31 Minerva Biotechnologies Corporation Anti-nme antibody
EP3256494A4 (en) * 2015-02-10 2018-12-05 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies
CA3039797A1 (en) * 2016-10-11 2018-04-19 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies and use of cleavage enzyme
CN108003237B (zh) * 2016-11-01 2023-03-10 中国科学院广州生物医药与健康研究院 高稳定性的人源化抗人cd3单链抗体及其制法和应用
WO2018092885A1 (ja) * 2016-11-18 2018-05-24 アステラス製薬株式会社 新規な抗ヒトMUC1抗体Fabフラグメント
CN110300603B (zh) 2017-02-14 2023-04-14 亘喜生物科技(上海)有限公司 Cd47-car-t细胞
CN109790518A (zh) * 2017-05-08 2019-05-21 中国科学院动物研究所 经修饰的t细胞、其制备方法及用途
TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類CEACAM5抗體Fab片段
WO2019094360A1 (en) * 2017-11-07 2019-05-16 The Board Of Regents Of The University Of Texas System Targeting lilrb4 with car-t or car-nk cells in the treatment of cancer
WO2019104306A1 (en) * 2017-11-27 2019-05-31 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies and direct use of cleavage enzyme
WO2019165421A1 (en) * 2018-02-26 2019-08-29 Minerva Biotechnologies Corporation Diagnostic methods using anti-muc1* antibodies
US20200405832A1 (en) * 2018-03-09 2020-12-31 Minerva Biotechnologies Corporation Method for anti-muc1* car t cell stimulation
US12202908B2 (en) 2018-05-17 2025-01-21 Astellas Pharma Inc. Complex having anti-human MUC1 antibody Fab fragment, peptide linker and/or ligand
MX2021004146A (es) 2018-10-10 2021-06-08 Astellas Pharma Inc Composicion farmaceutica que contiene complejo de fragmento fab de anticuerpo antihumano con sitio marcado.
BR112021008486A2 (pt) 2018-11-01 2021-10-26 Shandong New Time Pharmaceutical Co., Ltd Anticorpo biespecífico e seu uso
WO2020146902A2 (en) * 2019-01-11 2020-07-16 Minerva Biotechnologies Corporation Anti-variable muc1* antibodies and uses thereof
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
WO2020188836A1 (ja) * 2019-03-15 2020-09-24 公益財団法人がん研究会 抗ポドプラニン抗体
WO2020227446A1 (en) * 2019-05-07 2020-11-12 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of polypeptides and chimeric antigen receptors via hinge domains
CN114174325A (zh) * 2019-06-04 2022-03-11 恩卡尔塔公司 用于免疫疗法的工程化自然杀伤细胞和工程化t细胞的组合
KR20220054579A (ko) * 2019-06-26 2022-05-03 더 존스 홉킨스 유니버시티 면역 효과기 세포의 표적화된 확장을 위한 방법 및 재료
EP3990004A4 (en) * 2019-06-26 2023-06-07 The Johns Hopkins University Methods and materials for targeted expansion of regulatory t cells
WO2021013479A1 (en) * 2019-07-19 2021-01-28 Universiteit Antwerpen Mucin isoforms in diseases characterized by barrier dysfunction
WO2021081232A1 (en) 2019-10-23 2021-04-29 Cue Biopharma, Inc. Modified cytotoxic t cells and methods of use thereof
JP2023530039A (ja) * 2020-06-08 2023-07-12 ミネルバ バイオテクノロジーズ コーポレーション 抗nme抗体および癌または癌転移の治療方法
MX2022015586A (es) 2020-06-12 2023-03-15 Nkarta Inc Linfocitos citolíticos naturales modificados genéticamente para inmunoterapia de cáncer dirigida a cd70.
CA3183682A1 (en) 2020-06-26 2021-12-30 Minerva Biotechnologies Corporation Anti-nme antibody and method of treating cancer or cancer metastasis
CN116802493A (zh) * 2020-06-30 2023-09-22 安特卫普大学 以屏障功能障碍为特征的疾病中的黏蛋白及其同种型
CN116234828A (zh) * 2020-07-29 2023-06-06 米纳瓦生物技术公司 抗可变muc1*抗体及其用途
TW202241935A (zh) 2020-12-18 2022-11-01 美商世紀治療股份有限公司 具有可調適受體專一性之嵌合抗原受體系統
KR20240035506A (ko) * 2021-07-16 2024-03-15 노일 이뮨 바이오테크 가부시키가이샤 키메라 항원 수용체, 상기 수용체를 발현하는 세포, 상기 세포를 포함하는 의약 조성물, 상기 세포의 제조 방법, 및 상기 키메라 항원 수용체를 코딩하는 염기서열을 포함하는 폴리뉴클레오티드 또는 벡터
MX2024003779A (es) 2021-09-29 2024-04-19 Kisoji Biotechnology Inc Agentes de union dirigidos a celulas tumorales que expresan trop2.
CA3248038A1 (en) * 2022-04-12 2023-10-19 Minerva Biotechnologies Corporation ANTI-MUC1* VARIABLE ANTIBODIES AND RELATED USES
IL316918A (en) * 2022-05-09 2025-01-01 Minerva Biotechnologies Corp Chimeric antigen receptor and IL-18 receptor compositions and methods of using them
US20240261406A1 (en) * 2023-02-02 2024-08-08 Minerva Biotechnologies Corporation Chimeric antigen receptor compositions and methods for treating muc1* diseases
CN121620592A (zh) * 2023-05-01 2026-03-06 西雅图儿童医院d/b/a西雅图儿童研究所 表达突变体白细胞介素15的免疫细胞
WO2025250739A1 (en) * 2024-05-31 2025-12-04 Janssen Biotech, Inc. Chimeric antigen receptor with spacer domains derived from human igg

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4452775A (en) 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US5108933A (en) 1988-09-16 1992-04-28 Immunicon Corporation Manipulation of colloids for facilitating magnetic separations
CA2003211A1 (en) 1988-11-17 1990-05-17 Pei-Xiang Xing Monoclonal antibodies
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
EP0505566A1 (en) 1989-12-15 1992-09-30 Takeda Chemical Industries, Ltd. Biospecific antibody to cancer cell and enzyme with prodrug-activating characteristics
FR2668064B1 (fr) 1990-10-23 1994-12-16 Transgene Sa Composition pharmaceutique pour le traitement ou la prevention d'une tumeur maligne.
US5407686A (en) 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
US5342947A (en) 1992-10-09 1994-08-30 Glaxo Inc. Preparation of water soluble camptothecin derivatives
EP0804249A2 (en) 1994-03-15 1997-11-05 Brown University Research Foundation Polymeric gene delivery system
GB9412230D0 (en) 1994-06-17 1994-08-10 Celltech Ltd Interleukin-5 specific recombiant antibodies
IL110464A0 (en) 1994-07-26 1994-10-21 Univ Ramot Novel proteins for the diagnosis, imaging, and therapy of human cancer
US5874540A (en) 1994-10-05 1999-02-23 Immunomedics, Inc. CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies
US6548643B1 (en) 1994-11-16 2003-04-15 Austin Research Institute Antigen carbohydrate compounds and their use in immunotherapy
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US5767135A (en) 1995-12-29 1998-06-16 Fernandez-Pol; Jose Alberto Antiviral agent
US6127393A (en) 1995-12-29 2000-10-03 Novactyl, Inc. Antiproliferative, antiinfective, antiinflammatory, autologous immunization agent and method
US20020136725A1 (en) 1996-01-17 2002-09-26 Smithkline Beecham Corporation Antithrombotic agents
FR2746016B1 (fr) 1996-03-15 1998-04-17 Combinaisons d'enzymes pour la destruction de cellules proliferatives
DE69837754T2 (de) 1997-02-18 2008-02-07 Canji, Inc., San Diego Kombinierte tumor suppressor-gen-therapie und chemotherapie bei der neoplasmabehandlung
TWI242563B (en) 1998-04-30 2005-11-01 Tanox Inc Monoclonal agonist antibodies which specifically bind to or interact with human G-CSF receptor
CA2348781A1 (en) 1998-11-12 2000-05-25 Novolytics Inc. Compositions and methods for producing vascular occlusion
WO2000034783A1 (en) 1998-12-08 2000-06-15 Smithkline Beecham Corporation Methods of screening for agonists and antagonists of the hdpxu17 receptor
CA2360927C (en) 1999-01-23 2018-03-06 Minerva Biotechnologies Corporation Interaction of colloid-immobilized species with species on non-colloidal structures
JP5122705B2 (ja) 1999-01-25 2013-01-16 ミナーヴァ・バイオテクノロジーズ・コーポレーション 神経変性疾患における異常型タンパク質凝集の迅速かつ高感度の検出
US20020064528A1 (en) 2000-01-28 2002-05-30 Zhenping Zhu Antibodies specific to KDR and uses thereof
US20020052311A1 (en) 1999-09-03 2002-05-02 Beka Solomon Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders
DE60028996T2 (de) 1999-11-12 2007-02-08 The Johns Hopkins University School Of Medicine Behandlung von krebs durch erhöhung des malonyl-coa-spiegels
WO2002022685A2 (en) 2000-09-11 2002-03-21 Kufe Donald W Muc1 extracellular domain and cancer treatment compositions and methods derived therefrom
AU2002248909A1 (en) 2000-11-15 2002-05-27 Minerva Biotechnologies Corporation Use of suramine, l-histidine, quisqualic acid or d-cycloserine for angiogenesis inhibition
US7700715B2 (en) 2000-11-27 2010-04-20 Minerva Biotechnologies Corporation Diagnostic tumor markers, drug screening for tumorigenesis inhibition, and compositions and methods for treatment of cancer
WO2002078598A2 (en) 2001-03-29 2002-10-10 Ramot University Authority For Applied Research & Industrial Development Ltd. Peptides and antibodies to muc 1 proteins
US7630836B2 (en) 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
CA2459584A1 (en) 2001-09-05 2003-03-13 Cynthia C. Bamdad Compositions and use thereof in the treatment of cancer
EP1425016B1 (en) 2001-09-05 2010-06-02 Minerva Biotechnologies Corporation Compositions and methods of treatment of cancer
US6716627B2 (en) 2001-12-20 2004-04-06 Isis Pharmaceuticals, Inc. Antisense modulation of mucin 1, transmembrane expression
CA2478047C (en) 2002-03-01 2014-01-21 Immunomedics, Inc. Rs7 antibodies
EP1497649A4 (en) 2002-04-22 2006-03-22 Dyax Corp FOR MUCIN POLYPEPTIDE SPECIFIC ANTIBODIES
WO2003091447A2 (en) * 2002-04-26 2003-11-06 California Institute Of Technology D1-1 nucleic acids, polypeptides and related methods
JP2006502110A (ja) * 2002-07-03 2006-01-19 イミュノジェン・インコーポレーテッド 非放出Muc1およびMuc16に対する抗体、およびその使用
JP2007531505A (ja) 2002-11-27 2007-11-08 ミネルバ バイオオテクノロジーズ コーポレーション 癌(muc1)の診断および治療のための技術および組成物
US7101978B2 (en) 2003-01-08 2006-09-05 Applied Molecular Evolution TNF-α binding molecules
US20060173171A1 (en) 2003-08-26 2006-08-03 Bamdad Cynthia C Techniques and compositions for diagnosis and treatment of cancer (muci)
US20130266551A1 (en) 2003-11-05 2013-10-10 St. Jude Children's Research Hospital, Inc. Chimeric receptors with 4-1bb stimulatory signaling domain
EP2168986A3 (en) 2004-02-19 2010-07-28 Genentech, Inc. CDR-repaired antibodies
CA2579391C (en) * 2004-09-06 2010-10-26 Kirin Beer Kabushiki Kaisha Anti-a33 antibody
CN101035810B (zh) 2004-10-04 2011-04-06 健泰科生物技术公司 肝细胞生长因子激活剂的调控物
US8859495B2 (en) 2005-03-30 2014-10-14 Minerva Biotechnologies Corporation Methods for stimulating or enhancing proliferation of non-tumorous cells expressing MUC1 receptors
PE20070374A1 (es) * 2005-07-08 2007-05-12 Pfizer Ltd ANTICUERPOS ANTI-MAdCAM
US7825092B2 (en) 2006-08-08 2010-11-02 University Of South Florida Dendroaspis natriuretic peptide for treatment of cancer
US20090075926A1 (en) 2006-12-06 2009-03-19 Bamdad Cynthia C Method for identifying and manipulating cells
WO2008073817A2 (en) 2006-12-08 2008-06-19 Dana-Farber Cancer Institute, Inc. Muc1 and galectin-3
US20100104626A1 (en) 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
WO2008119565A2 (en) 2007-04-03 2008-10-09 Micromet Ag Cross-species-specific binding domain
EP2145901B1 (en) * 2008-07-18 2012-11-14 Technische Universität Braunschweig Recombinant anti-MUC1 antibodies
JP2012504961A (ja) 2008-10-06 2012-03-01 ミネルバ バイオテクノロジーズ コーポレーション Muc1*抗体
KR20160017117A (ko) 2008-10-09 2016-02-15 미네르바 바이오테크놀로지 코포레이션 세포내에서 다능성을 유도하기 위한 방법
CA2741798A1 (en) * 2008-10-28 2010-05-06 Shionogi & Co., Ltd. Anti-muc1 antibody
JP5549848B2 (ja) 2008-12-25 2014-07-16 東ソー株式会社 ルテニウム化合物、その製法及びそれを用いた成膜法
MX2011013385A (es) 2009-06-11 2012-05-29 Minerva Biotechnologies Corp Metodos para cultivar celulas madre y celulas progenitoras.
EP2281844A1 (en) * 2009-07-31 2011-02-09 Glycotope GmbH MUC 1 antibodies
JP2013537416A (ja) 2010-08-13 2013-10-03 メディミューン リミテッド 変異型Fc領域を含むモノマーポリペプチド及び使用方法
EP2768945B1 (en) * 2011-10-17 2022-01-05 Minerva Biotechnologies Corporation Media for stem cell proliferation and induction
WO2013157102A1 (ja) * 2012-04-18 2013-10-24 公立大学法人大阪市立大学 ムチンサブタイプ5ac特異的ヒト化抗体およびその利用
CA2880010A1 (en) * 2012-07-24 2014-01-30 Minerva Biotechnologies Corporation Nme variant species expression and suppression
AU2013302620B2 (en) 2012-08-14 2018-08-02 Minerva Biotechnologies Corporation Stem cell enhancing therapeutics
US10117896B2 (en) * 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
US9562110B2 (en) 2012-11-21 2017-02-07 Wuhan Yzy Biopharma Co., Ltd. Bispecific antibody
KR20210082547A (ko) 2013-02-20 2021-07-05 미네르바 바이오테크놀로지 코포레이션 Nme 저해제 및 nme 저해제의 사용 방법
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
CN106132992B (zh) * 2014-01-29 2020-08-07 达娜-法勃肿瘤研究所公司 针对muc1-c/胞外结构域(muc1-c/ecd)的抗体
CN103880956B (zh) * 2014-03-10 2015-12-30 中国人民解放军第四军医大学 抗muc1单克隆抗体及其轻链和重链可变区
EP4050103A1 (en) * 2014-04-07 2022-08-31 Minerva Biotechnologies Corporation Anti-nme antibody
WO2015166056A1 (en) * 2014-05-02 2015-11-05 Cellectis Cs1 specific multi-chain chimeric antigen receptor
EP3169703B2 (en) * 2014-07-16 2023-12-13 Hinrich Abken Chimeric antigen receptor and its use
WO2016126608A1 (en) 2015-02-02 2016-08-11 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
EP3256494A4 (en) * 2015-02-10 2018-12-05 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies
CN109312954B (zh) 2016-02-17 2020-10-16 齐鲁工业大学 一种等离子体加热器
CA3039797A1 (en) * 2016-10-11 2018-04-19 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies and use of cleavage enzyme
WO2019104306A1 (en) * 2017-11-27 2019-05-31 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies and direct use of cleavage enzyme
WO2020146902A2 (en) 2019-01-11 2020-07-16 Minerva Biotechnologies Corporation Anti-variable muc1* antibodies and uses thereof

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