JP2018520993A5 - - Google Patents
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- JP2018520993A5 JP2018520993A5 JP2017557938A JP2017557938A JP2018520993A5 JP 2018520993 A5 JP2018520993 A5 JP 2018520993A5 JP 2017557938 A JP2017557938 A JP 2017557938A JP 2017557938 A JP2017557938 A JP 2017557938A JP 2018520993 A5 JP2018520993 A5 JP 2018520993A5
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- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 120
- 102000050320 human TNFRSF4 Human genes 0.000 claims description 120
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- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 18
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- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 15
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- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 14
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- 102220626433 Methyl-CpG-binding domain protein 2_P93A_mutation Human genes 0.000 claims description 14
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- 102000003814 Interleukin-10 Human genes 0.000 claims description 6
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- ZADWXFSZEAPBJS-SNVBAGLBSA-N (2r)-2-amino-3-(1-methylindol-3-yl)propanoic acid Chemical compound C1=CC=C2N(C)C=C(C[C@@H](N)C(O)=O)C2=C1 ZADWXFSZEAPBJS-SNVBAGLBSA-N 0.000 claims description 3
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- 241000193830 Bacillus <bacterium> Species 0.000 claims description 2
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 2
- 101100348617 Candida albicans (strain SC5314 / ATCC MYA-2876) NIK1 gene Proteins 0.000 claims description 2
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- 101100125027 Dictyostelium discoideum mhsp70 gene Proteins 0.000 claims description 2
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- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 102000016943 Muramidase Human genes 0.000 claims description 2
- 108010014251 Muramidase Proteins 0.000 claims description 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
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- 241000589516 Pseudomonas Species 0.000 claims description 2
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- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- 101100007329 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) COS1 gene Proteins 0.000 claims description 2
- 101100221606 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) COS7 gene Proteins 0.000 claims description 2
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims description 2
- 206010052779 Transplant rejections Diseases 0.000 claims description 2
- 206010046851 Uveitis Diseases 0.000 claims description 2
- 206010047115 Vasculitis Diseases 0.000 claims description 2
- 230000001270 agonistic effect Effects 0.000 claims description 2
- 230000003042 antagnostic effect Effects 0.000 claims description 2
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- 230000010261 cell growth Effects 0.000 claims description 2
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- 238000012258 culturing Methods 0.000 claims description 2
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- 229960000274 lysozyme Drugs 0.000 claims description 2
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- YPBKTZBXSBLTDK-PKNBQFBNSA-N (3e)-3-[(3-bromo-4-fluoroanilino)-nitrosomethylidene]-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole Chemical group NS(=O)(=O)NCCNC1=NON\C1=C(N=O)/NC1=CC=C(F)C(Br)=C1 YPBKTZBXSBLTDK-PKNBQFBNSA-N 0.000 claims 1
- RFMMMVDNIPUKGG-YFKPBYRVSA-N N-acetyl-L-glutamic acid Chemical compound CC(=O)N[C@H](C(O)=O)CCC(O)=O RFMMMVDNIPUKGG-YFKPBYRVSA-N 0.000 claims 1
- 229950006370 epacadostat Drugs 0.000 claims 1
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- 230000035939 shock Effects 0.000 claims 1
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021066377A JP7404303B2 (ja) | 2015-05-07 | 2021-04-09 | 抗ｏｘ４０抗体及びその使用方法 |
| JP2023122389A JP2023156367A (ja) | 2015-05-07 | 2023-07-27 | 抗ｏｘ４０抗体及びその使用方法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562158515P | 2015-05-07 | 2015-05-07 | |
| US62/158,515 | 2015-05-07 | ||
| US201562161198P | 2015-05-13 | 2015-05-13 | |
| US62/161,198 | 2015-05-13 | ||
| US201562262373P | 2015-12-02 | 2015-12-02 | |
| US62/262,373 | 2015-12-02 | ||
| US201662323458P | 2016-04-15 | 2016-04-15 | |
| US62/323,458 | 2016-04-15 | ||
| PCT/US2016/031257 WO2016179517A1 (en) | 2015-05-07 | 2016-05-06 | Anti-ox40 antibodies and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021066377A Division JP7404303B2 (ja) | 2015-05-07 | 2021-04-09 | 抗ｏｘ４０抗体及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018520993A JP2018520993A (ja) | 2018-08-02 |
| JP2018520993A5 true JP2018520993A5 (enExample) | 2019-06-13 |
| JP6867955B2 JP6867955B2 (ja) | 2021-05-12 |
Family
ID=56015132
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557938A Active JP6867955B2 (ja) | 2015-05-07 | 2016-05-06 | 抗ｏｘ４０抗体及びその使用方法 |
| JP2021066377A Active JP7404303B2 (ja) | 2015-05-07 | 2021-04-09 | 抗ｏｘ４０抗体及びその使用方法 |
| JP2023122389A Pending JP2023156367A (ja) | 2015-05-07 | 2023-07-27 | 抗ｏｘ４０抗体及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021066377A Active JP7404303B2 (ja) | 2015-05-07 | 2021-04-09 | 抗ｏｘ４０抗体及びその使用方法 |
| JP2023122389A Pending JP2023156367A (ja) | 2015-05-07 | 2023-07-27 | 抗ｏｘ４０抗体及びその使用方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (8) | US10259882B2 (enExample) |
| EP (1) | EP3292152A1 (enExample) |
| JP (3) | JP6867955B2 (enExample) |
| KR (1) | KR20180015650A (enExample) |
| CN (2) | CN115109158A (enExample) |
| AU (2) | AU2016256911B2 (enExample) |
| BR (1) | BR112017023849A2 (enExample) |
| CA (1) | CA2984794A1 (enExample) |
| EA (1) | EA201792451A1 (enExample) |
| HK (1) | HK1250513A1 (enExample) |
| IL (1) | IL255278A0 (enExample) |
| MA (1) | MA42043A (enExample) |
| MX (1) | MX2017014188A (enExample) |
| MY (1) | MY189692A (enExample) |
| PH (1) | PH12017502013B1 (enExample) |
| SG (1) | SG11201708804WA (enExample) |
| TW (2) | TWI716405B (enExample) |
| WO (1) | WO2016179517A1 (enExample) |
Families Citing this family (131)
| Publication number | Priority date | Publication date | Assignee | Title |
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| LT2609118T (lt) * | 2010-08-23 | 2017-04-25 | Board Of Regents, The University Of Texas System | Anti-ox40 antikūnai ir jų panaudojimo būdai |
| RS57840B1 (sr) | 2013-03-18 | 2018-12-31 | Biocerox Prod Bv | Humanizovana anti-cd 134 (ox40) antitela i njihove upotrebe |
| KR101697473B1 (ko) | 2014-11-26 | 2017-01-18 | 주식회사 녹십자랩셀 | T 세포를 이용한 자연살해세포의 배양방법 |
| US10046047B2 (en) * | 2015-02-06 | 2018-08-14 | Heat Biologics, Inc. | Vector co-expressing vaccine and costimulatory molecules |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| EP3292152A1 (en) | 2015-05-07 | 2018-03-14 | Agenus Inc. | Anti-ox40 antibodies and methods of use thereof |
| JP6869987B2 (ja) | 2015-09-01 | 2021-05-12 | アジェナス インコーポレイテッド | 抗ｐｄ−１抗体及びその使用方法 |
| WO2017063162A1 (zh) | 2015-10-15 | 2017-04-20 | 苏州丁孚靶点生物技术有限公司 | 抗ox40抗体及其应用 |
| WO2017096179A1 (en) | 2015-12-02 | 2017-06-08 | Agenus Inc. | Antibodies and methods of use thereof |
| CA3006963A1 (en) * | 2015-12-03 | 2017-06-08 | Ludwig Institute For Cancer Research Ltd. | Anti-ox40 antibodies and methods of use thereof |
| JP7114477B2 (ja) | 2015-12-16 | 2022-08-08 | グリットストーン バイオ インコーポレイテッド | 新生抗原の特定、製造、および使用 |
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| KR102379464B1 (ko) | 2016-06-20 | 2022-03-29 | 키맵 리미티드 | 항-pd-l1 항체 |
| CA3041340A1 (en) * | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof |
| CN110300599B (zh) | 2016-12-07 | 2024-07-02 | 艾吉纳斯公司 | 抗体和其使用方法 |
| UY37523A (es) * | 2016-12-15 | 2018-07-31 | Abbvie Biotherapeutics Inc | Anticuerpos anti-ox40 y sus usos |
| AU2017384528A1 (en) | 2016-12-19 | 2019-07-04 | Ichnos Sciences SA | Novel TNFR agonists and uses thereof |
| CN108623686A (zh) * | 2017-03-25 | 2018-10-09 | 信达生物制药(苏州)有限公司 | 抗ox40抗体及其用途 |
| WO2018193102A1 (en) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
| CA3057744A1 (en) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy with an anti-cd25 antibody-drug conjugate |
| EP3633029A4 (en) | 2017-05-26 | 2021-06-09 | Green Cross Lab Cell Corporation | METHOD OF DEVELOPING A NATURAL KILLER CELL USING A T-CELL |
| KR102442736B1 (ko) | 2017-06-14 | 2022-09-16 | 에이디씨 테라퓨틱스 에스에이 | 항-cd19 adc의 투여를 위한 투약량 체제 |
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| CN111465989B (zh) | 2017-10-10 | 2024-06-25 | 磨石生物公司 | 使用热点进行的新抗原鉴别 |
| AU2018373154B2 (en) | 2017-11-22 | 2025-08-07 | Seattle Project Corp. | Reducing junction epitope presentation for neoantigens |
| CN109970864A (zh) * | 2017-12-28 | 2019-07-05 | 上海细胞治疗研究院 | 一种双向激活共刺激分子受体及其用途 |
| CN108218990B (zh) | 2017-12-29 | 2021-03-02 | 南京优迈生物科技有限公司 | 分离的抗体或其抗原结合片段及其在肿瘤治疗中的应用 |
| CN110467674B (zh) * | 2018-05-11 | 2022-05-31 | 同润澳门一人有限公司 | 抗ox40的全人抗体及其制备方法和用途 |
| CA3098103A1 (en) | 2018-05-23 | 2019-11-28 | Adc Therapeutics Sa | Molecular adjuvant |
| IL317993B2 (en) | 2018-07-03 | 2025-11-01 | Gilead Sciences Inc | Antibodies directed against HIV gp120 and methods of use |
| WO2020014583A1 (en) | 2018-07-13 | 2020-01-16 | Bristol-Myers Squibb Company | Ox-40 agonist, pd-1 pathway inhibitor and ctla-4 inhibitor combination for use in a mehtod of treating a cancer or a solid tumor |
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| CA3113541A1 (en) * | 2018-09-26 | 2020-04-02 | Jiangsu Hengrui Medicine Co., Ltd. | An anti-ox40 antibody, antigen-binding fragment thereof, and the pharmaceutical use |
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| JP7179986B2 (ja) * | 2018-11-14 | 2022-11-29 | グリーン クロス ラボ セル コーポレーション | 形質転換されたｔ細胞を用いた臍帯血由来のナチュラルキラー細胞の培養方法 |
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| TWI762925B (zh) | 2019-05-21 | 2022-05-01 | 美商基利科學股份有限公司 | 鑑別對使用gp120 v3聚醣導向之抗體的治療敏感之hiv病患的方法 |
| CN114245807B (zh) | 2019-06-25 | 2025-05-02 | 吉利德科学公司 | Flt3l-fc融合蛋白和使用方法 |
| WO2020259667A1 (zh) * | 2019-06-28 | 2020-12-30 | 江苏恒瑞医药股份有限公司 | Tlr激动剂与抗ox40抗体或其抗原结合片段联合在制备治疗肿瘤的药物中的用途 |
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2016
- 2016-05-06 EP EP16723616.5A patent/EP3292152A1/en active Pending
- 2016-05-06 KR KR1020177035013A patent/KR20180015650A/ko not_active Ceased
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- 2016-05-06 BR BR112017023849-7A patent/BR112017023849A2/en not_active IP Right Cessation
- 2016-05-06 AU AU2016256911A patent/AU2016256911B2/en active Active
- 2016-05-06 CN CN202210581278.7A patent/CN115109158A/zh active Pending
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- 2016-05-06 CN CN201680039426.5A patent/CN108137686B/zh active Active
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- 2016-05-06 MA MA042043A patent/MA42043A/fr unknown
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- 2016-05-06 TW TW110100363A patent/TWI820377B/zh not_active IP Right Cessation
- 2016-05-06 WO PCT/US2016/031257 patent/WO2016179517A1/en not_active Ceased
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2017
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2019
- 2019-02-25 US US16/284,811 patent/US11136404B2/en active Active
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2023
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