CN115052893A - 抗tigit抗体和使用方法 - Google Patents

抗tigit抗体和使用方法 Download PDF

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CN115052893A
CN115052893A CN202180008448.6A CN202180008448A CN115052893A CN 115052893 A CN115052893 A CN 115052893A CN 202180008448 A CN202180008448 A CN 202180008448A CN 115052893 A CN115052893 A CN 115052893A
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heavy chain
seq
chain variable
variable region
amino acids
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杨明
许文峰
姜伟东
薛杰
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Shanghai Henlius Biotech Inc
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Shanghai Henlius Biotech Inc
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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Abstract

本发明提供了与“具有Ig和ITIM结构域的T细胞免疫受体（TIGIT）”结合的抗TIGIT抗体，这些抗体包括对TIGIT和一种或多种另外的抗原具有结合特异性的多特异性抗TIGIT抗体；以及其使用方法。这些抗TIGIT抗体包含与TIGIT结合的单结构域抗体。

Description

PCT国内申请，说明书已公开。

Claims (107)

  1. PCT国内申请，权利要求书已公开。
CN202180008448.6A 2020-01-10 2021-01-08 抗tigit抗体和使用方法 Pending CN115052893A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202010024565.9A CN110818795B (zh) 2020-01-10 2020-01-10 抗tigit抗体和使用方法
PCT/CN2021/070903 WO2021139777A1 (zh) 2020-01-10 2021-01-08 抗tigit抗体和使用方法

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CN115052893A true CN115052893A (zh) 2022-09-13

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CN202180008448.6A Pending CN115052893A (zh) 2020-01-10 2021-01-08 抗tigit抗体和使用方法

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US (1) US20230134580A1 (zh)
EP (1) EP4089115A4 (zh)
JP (1) JP2023509196A (zh)
KR (1) KR20220131258A (zh)
CN (2) CN110818795B (zh)
AU (1) AU2021206420A1 (zh)
BR (1) BR112022013545A2 (zh)
CA (1) CA3164281A1 (zh)
WO (1) WO2021139777A1 (zh)
ZA (1) ZA202208807B (zh)

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WO2022152245A1 (zh) * 2021-01-14 2022-07-21 上海君实生物医药科技股份有限公司 抗tigit抗体药物组合物及其用途
CN114790241A (zh) * 2021-01-26 2022-07-26 北京免疫方舟医药科技有限公司 抗tigit抗体及其应用
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