|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US5892019A
(en)
|
1987-07-15 |
1999-04-06 |
The United States Of America, As Represented By The Department Of Health And Human Services |
Production of a single-gene-encoded immunoglobulin
|
|
GB8719963D0
(en)
|
1987-08-24 |
1987-09-30 |
Cattaneo A |
Recombinant dna products
|
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE69133566T2
(de)
|
1990-01-12 |
2007-12-06 |
Amgen Fremont Inc. |
Bildung von xenogenen Antikörpern
|
|
US6476198B1
(en)
|
1993-07-13 |
2002-11-05 |
The Scripps Research Institute |
Multispecific and multivalent antigen-binding polypeptide molecules
|
|
UA40577C2
(uk)
|
1993-08-02 |
2001-08-15 |
Мерк Патент Гмбх |
Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин
|
|
AU697387C
(en)
|
1994-09-16 |
2006-03-02 |
Austin Research Institute Cancer and Anti-inflammatory Syndicate No 1 |
Polypeptides with Fc binding ability
|
|
US6808709B1
(en)
|
1994-12-30 |
2004-10-26 |
The Regents Of The University Of California |
Immunoglobulins containing protection proteins and their use
|
|
US6165463A
(en)
|
1997-10-16 |
2000-12-26 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
|
US20050003431A1
(en)
|
1996-08-16 |
2005-01-06 |
Wucherpfennig Kai W. |
Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor
|
|
US8212004B2
(en)
|
1999-03-02 |
2012-07-03 |
Human Genome Sciences, Inc. |
Neutrokine-alpha fusion proteins
|
|
EP1015493A1
(en)
*
|
1997-01-10 |
2000-07-05 |
EPIcyte Pharmaceutical, Inc. |
Novel epithelial tissue targeting agent
|
|
US6045774A
(en)
|
1997-01-10 |
2000-04-04 |
Epicyte Pharmaceutical Inc. |
J chain polypeptide targeting molecule linked to an imaging agent
|
|
US6284536B1
(en)
|
1998-04-20 |
2001-09-04 |
The Regents Of The University Of California |
Modified immunoglobin molecules and methods for use thereof
|
|
WO2000074718A1
(en)
|
1999-06-09 |
2000-12-14 |
Immunomedics, Inc. |
Immunotherapy of autoimmune disorders using antibodies which target b-cells
|
|
DK1272647T3
(en)
|
2000-04-11 |
2014-12-15 |
Genentech Inc |
Multivalent antibodies and uses thereof
|
|
ES2332872T3
(es)
|
2000-04-28 |
2010-02-15 |
Planet Biotechnology, Inc. |
Inmunoadhesina para la prevencion de la infeccion por rinovirus.
|
|
AU2001272908A1
(en)
|
2000-05-10 |
2001-11-20 |
David A. Sirbasku |
Compositions and methods for the diagnosis, treatment and prevention of steroid hormone responsive cancers
|
|
US7138496B2
(en)
|
2002-02-08 |
2006-11-21 |
Genetastix Corporation |
Human monoclonal antibodies against human CXCR4
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
US7402312B2
(en)
|
2001-04-13 |
2008-07-22 |
Human Genome Sciences, Inc. |
Antibodies to vascular endothelial growth factor 2 (VEGF-2)
|
|
US20050129616A1
(en)
|
2001-05-25 |
2005-06-16 |
Human Genome Sciences, Inc. |
Antibodies that immunospecifically bind to TRAIL receptors
|
|
CN100522999C
(zh)
|
2002-02-14 |
2009-08-05 |
免疫医疗公司 |
抗cd20抗体及其融合蛋白和使用方法
|
|
WO2003074567A2
(en)
|
2002-03-01 |
2003-09-12 |
Immunomedics, Inc. |
Internalizing anti-cd74 antibodies and methods of use
|
|
NZ536420A
(en)
|
2002-04-12 |
2008-04-30 |
Medarex Inc |
Methods of treatment using CTLA-4 antibodies
|
|
EP1519958B1
(en)
|
2002-06-14 |
2014-10-15 |
Immunomedics, Inc. |
Humanized monoclonal antibody hpam4
|
|
SI1523496T1
(sl)
|
2002-07-18 |
2011-11-30 |
Merus B V |
Rekombinantno proizvajanje zmesi protiteles
|
|
WO2004035607A2
(en)
*
|
2002-10-17 |
2004-04-29 |
Genmab A/S |
Human monoclonal antibodies against cd20
|
|
US20050014932A1
(en)
|
2003-05-15 |
2005-01-20 |
Iogenetics, Llc |
Targeted biocides
|
|
AR044388A1
(es)
|
2003-05-20 |
2005-09-07 |
Applied Molecular Evolution |
Moleculas de union a cd20
|
|
DK1626992T3
(da)
|
2003-05-23 |
2010-09-20 |
Crucell Holland Bv |
Produktion af rekombinant IgM i PER.C6-celler
|
|
EP1652925B1
(en)
|
2003-07-15 |
2010-12-08 |
Chugai Seiyaku Kabushiki Kaisha |
IgM PRODUCTION BY TRANSFORMED CELLS AND METHODS FOR QUANTIFYING SAID IgM PRODUCTION
|
|
EP1648512A4
(en)
|
2003-07-31 |
2009-01-21 |
Immunomedics Inc |
ANTI-CD19 ANTIBODIES
|
|
US8147832B2
(en)
|
2003-08-14 |
2012-04-03 |
Merck Patent Gmbh |
CD20-binding polypeptide compositions and methods
|
|
JP4671864B2
(ja)
|
2003-10-09 |
2011-04-20 |
中外製薬株式会社 |
タンパク質溶液の安定化方法
|
|
KR101229731B1
(ko)
|
2003-10-16 |
2013-03-07 |
암젠 리서치 (뮌헨) 게엠베하 |
다중특이적 탈면역화된 ｃｄ3-바인더
|
|
FR2861255B1
(fr)
|
2003-10-24 |
2006-02-17 |
Centre Nat Rech Scient |
Mammifere non-humain transgenique pour la region constante de la chaine lourde des immunoglobulines humaines de classe a et ses applications.
|
|
WO2005077981A2
(en)
*
|
2003-12-22 |
2005-08-25 |
Xencor, Inc. |
Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES
|
|
EP1740946B1
(en)
|
2004-04-20 |
2013-11-06 |
Genmab A/S |
Human monoclonal antibodies against cd20
|
|
JP2008519030A
(ja)
|
2004-11-05 |
2008-06-05 |
パリンゲン インコーポレーテッド |
抗体で誘導される細胞膜損傷
|
|
EP3332808B1
(en)
|
2005-03-03 |
2020-09-09 |
Immunomedics Inc. |
Humanized l243 antibodies
|
|
US8349332B2
(en)
*
|
2005-04-06 |
2013-01-08 |
Ibc Pharmaceuticals, Inc. |
Multiple signaling pathways induced by hexavalent, monospecific and bispecific antibodies for enhanced toxicity to B-cell lymphomas and other diseases
|
|
US20110129412A1
(en)
|
2005-06-02 |
2011-06-02 |
Astrazeneca Ab |
Antibodies Directed to CD20 and Uses Thereof
|
|
CN102443058A
(zh)
*
|
2005-08-03 |
2012-05-09 |
人类多克隆治疗股份有限公司 |
表达人源化免疫球蛋白的转基因动物中b细胞凋亡的抑制
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
CN105709237A
(zh)
*
|
2005-12-16 |
2016-06-29 |
Ibc 医药公司 |
基于免疫球蛋白的多价生物活性装配体
|
|
KR20080090441A
(ko)
|
2005-12-21 |
2008-10-08 |
메디뮨 엘엘씨 |
Ｅｐｈａ２ ｂｉｔｅ 분자 및 이의 용도
|
|
CN105837690A
(zh)
|
2006-06-12 |
2016-08-10 |
新兴产品开发西雅图有限公司 |
具有效应功能的单链多价结合蛋白
|
|
US9382327B2
(en)
*
|
2006-10-10 |
2016-07-05 |
Vaccinex, Inc. |
Anti-CD20 antibodies and methods of use
|
|
US20080145420A1
(en)
|
2006-12-13 |
2008-06-19 |
Simon Michael R |
HUMAN SECRETORY IgA FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASES
|
|
EP2087111A2
(en)
|
2007-03-19 |
2009-08-12 |
Medimmune Limited |
Polypeptide variants
|
|
US20100298223A1
(en)
|
2007-05-02 |
2010-11-25 |
Dietmar Rudolf Fries |
Fibrinogen for treatment of bleeding in trauma and platelet disorders
|
|
CN201229536Y
(zh)
|
2008-07-03 |
2009-04-29 |
鸿富锦精密工业（深圳）有限公司 |
电脑机箱
|
|
US20120269830A1
(en)
|
2009-12-07 |
2012-10-25 |
Lawrence Horowitz |
Conjugates with improved pharmacokinetic properties
|
|
EP2519544A1
(en)
|
2009-12-29 |
2012-11-07 |
Emergent Product Development Seattle, LLC |
Polypeptide heterodimers and uses thereof
|
|
US9173961B2
(en)
|
2010-02-10 |
2015-11-03 |
Immunogen, Inc. |
CD20 antibodies and uses thereof
|
|
MX2012009321A
(es)
|
2010-02-11 |
2012-11-21 |
Alexion Pharma Inc |
Metodos terapeuticos que utilizan anticuerpos anti-cd200.
|
|
CN103429260B
(zh)
|
2010-10-19 |
2016-08-10 |
梅奥医学教育和研究基金会 |
用于治疗神经疾病的人抗体及其诊断和治疗用途
|
|
WO2012088290A2
(en)
|
2010-12-22 |
2012-06-28 |
Abbott Laboratories |
Tri-variable domain binding proteins and uses thereof
|
|
US9253965B2
(en)
|
2012-03-28 |
2016-02-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
GB201122047D0
(en)
|
2011-12-21 |
2012-02-01 |
Kymab Ltd |
Transgenic animals
|
|
WO2013087911A1
(en)
|
2011-12-16 |
2013-06-20 |
Synthon Biopharmaceuticals B.V. |
Compounds and methods for treating inflammatory diseases
|
|
MX363819B
(es)
|
2012-02-08 |
2019-04-03 |
Igm Biosciences Inc |
Uniones a cdim y sus usos.
|
|
CA2869023A1
(en)
*
|
2012-04-05 |
2013-10-10 |
Gottfried Himmler |
Secretory immunoglobulin complex
|
|
CN108285483B
(zh)
|
2012-04-17 |
2022-04-26 |
梅奥医学教育和研究基金会 |
用于中风和缺血或缺血性病况的人抗体及其特异性结合序列
|
|
WO2013188870A2
(en)
|
2012-06-15 |
2013-12-19 |
Beth Israel Deaconess Medical Center, Inc. |
IgA CD4i ANTIBODIES AND METHODS OF TREATMENT USING SAME
|
|
EP2880057A4
(en)
*
|
2012-08-02 |
2016-03-23 |
Jn Biosciences Llc |
MULTIMERIZED FUSION ANTIBODIES OR PROTEINS THROUGH THE MUTATION OF A CYSTEINE AND A PIECE OF TAIL
|
|
JOP20200236A1
(ar)
*
|
2012-09-21 |
2017-06-16 |
Regeneron Pharma |
الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
|
|
WO2014124457A1
(en)
|
2013-02-11 |
2014-08-14 |
University Of Louisville Research Foundation, Inc. |
Methods for producing antibodies
|
|
US9487773B2
(en)
|
2013-03-01 |
2016-11-08 |
Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa |
Cell-based methods for coupling protein interactions and binding molecule selection
|
|
GB201311487D0
(en)
|
2013-06-27 |
2013-08-14 |
Alligator Bioscience Ab |
Bispecific molecules
|
|
US20150038682A1
(en)
|
2013-08-02 |
2015-02-05 |
Jn Biosciences Llc |
Antibodies or fusion proteins multimerized via homomultimerizing peptide
|
|
EP3041862B1
(en)
|
2013-09-05 |
2020-05-06 |
IGM Biosciences, Inc. |
Constant chain modified bispecific, penta- and hexavalent ig-m antibodies
|
|
WO2015037000A1
(en)
|
2013-09-11 |
2015-03-19 |
Compugen Ltd |
Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases
|
|
ES2923641T3
(es)
|
2013-12-30 |
2022-09-29 |
Epimab Biotherapeutics Inc |
Inmunoglobulina con Fabs en tándem y usos de la misma
|
|
AU2015206002B2
(en)
|
2014-01-16 |
2020-06-11 |
Mario Umberto Francesco MONDELLI |
Neutralizing human monoclonal antibodies against Hepatitis B Virus surface antigen
|
|
WO2015120474A1
(en)
|
2014-02-10 |
2015-08-13 |
Igm Biosciences, Inc. |
Iga multi-specific binding molecules
|
|
ME03558B
(me)
|
2014-03-14 |
2020-07-20 |
Novartis Ag |
Molekuli anti-lag-3 antiтela i njihove upotrebe
|
|
CA2944647C
(en)
|
2014-04-03 |
2025-07-08 |
Igm Biosciences Inc |
MODIFIED J STRING
|
|
US10689449B2
(en)
|
2015-01-20 |
2020-06-23 |
Igm Biosciences, Inc. |
Multimeric death domain-containing receptor-5 (DR5) antibodies and uses thereof
|
|
WO2016154593A1
(en)
|
2015-03-25 |
2016-09-29 |
Igm Biosciences, Inc. |
Multi-valent hepatitis b virus antigen binding molecules and uses thereof
|
|
CA2983034A1
(en)
|
2015-04-17 |
2016-10-20 |
Igm Biosciences, Inc. |
Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof
|
|
NZ739830A
(en)
|
2015-07-12 |
2021-12-24 |
Hangzhou Dac Biotech Co Ltd |
Bridge linkers for conjugation of cell-binding molecules
|
|
US11639389B2
(en)
|
2015-09-30 |
2023-05-02 |
Igm Biosciences, Inc. |
Binding molecules with modified J-chain
|
|
HUE069387T2
(hu)
*
|
2015-09-30 |
2025-03-28 |
Igm Biosciences Inc |
Módosított J-lánccal rendelkezõ kötõmolekulák
|
|
WO2017196867A1
(en)
|
2016-05-09 |
2017-11-16 |
Igm Biosciences, Inc. |
Anti-pd-l1 antibodies
|
|
CN109561681A
(zh)
|
2016-07-20 |
2019-04-02 |
Igm生物科学股份有限公司 |
多聚gitr结合分子及其用途
|
|
WO2018017761A1
(en)
|
2016-07-20 |
2018-01-25 |
Igm Biosciences, Inc. |
Multimeric cd137/4-1bb binding molecules and uses thereof
|
|
CA3030647A1
(en)
|
2016-07-20 |
2018-01-25 |
Igm Biosciences, Inc. |
Multimeric ox40 binding molecules and uses thereof
|
|
AU2017299610B2
(en)
|
2016-07-20 |
2022-09-29 |
Igm Biosciences, Inc. |
Multimeric CD40 binding molecules and uses thereof
|
|
US11401337B2
(en)
|
2017-04-07 |
2022-08-02 |
Igm Biosciences, Inc. |
Modified human IgM constant regions for modulation of complement-dependent cytolysis effector function
|
|
CN111757941A
(zh)
|
2018-02-26 |
2020-10-09 |
Igm生物科学股份有限公司 |
多聚体抗dr5结合分子与化学治疗剂联合用于治疗癌症的用途
|
|
CN111787951B
(zh)
|
2018-03-01 |
2025-06-17 |
Igm生物科学股份有限公司 |
影响IgM血清半衰期的IgM Fc和J链突变
|
|
CA3113268A1
(en)
|
2018-10-23 |
2020-04-30 |
Igm Biosciences, Inc. |
Multivalent igm- and iga-fc-based binding molecules
|