JP2019531084A5 - - Google Patents

Download PDF

Info

Publication number
JP2019531084A5
JP2019531084A5 JP2019521178A JP2019521178A JP2019531084A5 JP 2019531084 A5 JP2019531084 A5 JP 2019531084A5 JP 2019521178 A JP2019521178 A JP 2019521178A JP 2019521178 A JP2019521178 A JP 2019521178A JP 2019531084 A5 JP2019531084 A5 JP 2019531084A5
Authority
JP
Japan
Prior art keywords
seq
antibody
chain variable
variable region
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019521178A
Other languages
English (en)
Japanese (ja)
Other versions
JP7587921B2 (ja
JP2019531084A (ja
Filing date
Publication date
Priority claimed from PCT/CN2017/082024 external-priority patent/WO2017186121A1/zh
Application filed filed Critical
Priority claimed from PCT/CN2017/092381 external-priority patent/WO2018006882A1/zh
Publication of JP2019531084A publication Critical patent/JP2019531084A/ja
Publication of JP2019531084A5 publication Critical patent/JP2019531084A5/ja
Application granted granted Critical
Publication of JP7587921B2 publication Critical patent/JP7587921B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019521178A 2016-07-08 2017-07-10 抗クローディンタンパク質18a2の抗体及びその応用 Active JP7587921B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201610536449.9 2016-07-08
CN201610536449 2016-07-08
CNPCT/CN2017/082024 2017-04-26
PCT/CN2017/082024 WO2017186121A1 (zh) 2016-04-26 2017-04-26 一种改善免疫应答细胞功能的方法
PCT/CN2017/092381 WO2018006882A1 (zh) 2016-07-08 2017-07-10 抗密蛋白18a2的抗体及其应用

Publications (3)

Publication Number Publication Date
JP2019531084A JP2019531084A (ja) 2019-10-31
JP2019531084A5 true JP2019531084A5 (enExample) 2020-09-03
JP7587921B2 JP7587921B2 (ja) 2024-11-21

Family

ID=60912336

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019521178A Active JP7587921B2 (ja) 2016-07-08 2017-07-10 抗クローディンタンパク質18a2の抗体及びその応用

Country Status (13)

Country Link
US (2) US11111295B2 (enExample)
EP (1) EP3483182B1 (enExample)
JP (1) JP7587921B2 (enExample)
KR (1) KR102723896B1 (enExample)
CN (1) CN109790222B (enExample)
AU (1) AU2017294276B2 (enExample)
BR (1) BR112019000327A8 (enExample)
CA (1) CA3030257A1 (enExample)
CL (1) CL2019000061A1 (enExample)
ES (1) ES2979068T3 (enExample)
IL (1) IL264144B2 (enExample)
SG (1) SG11201900171QA (enExample)
WO (1) WO2018006882A1 (enExample)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2979068T3 (es) * 2016-07-08 2024-09-24 Crage Medical Co Ltd Anticuerpos para anti-claudina 18A2 y utilización de los mismos
CN110123837A (zh) 2018-02-02 2019-08-16 科济生物医药(上海)有限公司 细胞免疫治疗的组合
CA3089653A1 (en) * 2018-03-08 2019-09-12 Phanes Therapeutics, Inc. Anti-claudin 18.2 antibodies and uses thereof
KR20210013013A (ko) * 2018-03-09 2021-02-03 카르스젠 테라퓨틱스 리미티드 종양 치료 방법 및 조성물
TW202003562A (zh) * 2018-03-14 2020-01-16 中國大陸商北京軒義醫藥科技有限公司 抗密連蛋白18.2(cldn18.2)抗體
CN112074600A (zh) * 2018-05-03 2020-12-11 科济生物医药(上海)有限公司 免疫效应细胞及其应用
SG11202011392VA (en) 2018-05-15 2020-12-30 Carsgen Therapeutics Co Ltd Genetically engineered cell and application thereof
SG11202007074PA (en) * 2018-05-18 2020-08-28 Lanova Medicines Ltd Company Anti-claudin 18.2 antibodies and uses thereof
US20210292427A1 (en) 2018-07-24 2021-09-23 Cafa Therapeutics Limited Method for treating tumor using immune effector cell
CN112770723B (zh) * 2018-07-25 2024-08-02 阿克罗斯生物科学公司 Cldn 18.2特异性单克隆抗体及其使用方法
CN110857322A (zh) * 2018-08-22 2020-03-03 瑞阳(苏州)生物科技有限公司 抗人claudin 18.2单克隆抗体及其应用
EP3878863A4 (en) * 2018-08-27 2022-06-22 Nanjing Sanhome Pharmaceutical Co., Ltd. ANTI-CLAUDIN18.2 ANTIBODIES AND ITS USE
CN109206524B (zh) * 2018-09-25 2022-04-05 山东兴瑞生物科技有限公司 抗Claudin18A2嵌合抗原受体、其修饰的T细胞及T细胞制备方法和用途
JP2022511394A (ja) * 2018-09-30 2022-01-31 カファ セラピューティクス リミテッド Cldn18の抗体及び化学療法薬の併用療法
SG11202105885WA (en) * 2018-12-07 2021-07-29 Zlip Holding Ltd Anti-claudin antibodies and uses thereof
JP2022517301A (ja) 2018-12-07 2022-03-08 カファ セラピューティクス リミテッド 腫瘍併用免疫療法
MX2021007939A (es) 2018-12-28 2021-10-22 Nanjing Genscript Biotech Co Ltd Porciones de union a claudina 18.2 y usos de estas.
WO2020135201A1 (zh) * 2018-12-28 2020-07-02 四川科伦博泰生物医药股份有限公司 一种抗体及其用途
WO2020143631A1 (zh) 2019-01-07 2020-07-16 科济生物医药(上海)有限公司 细胞免疫治疗的组合
CN114106183B (zh) * 2019-01-15 2023-06-23 浙江道尔生物科技有限公司 抗cld18a2纳米抗体及其应用
CN109762067B (zh) * 2019-01-17 2020-02-28 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途
KR20210134321A (ko) * 2019-02-01 2021-11-09 노바록 바이오테라퓨틱스 리미티드 항-클라우딘 18 항체 및 이의 이용 방법
EP3919517A4 (en) 2019-02-01 2023-03-15 CRAGE medical Co., Limited TCR FUSION PROTEIN AND CELL WITH TCR FUSION PROTEIN EXPRESSION
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
CN120944827A (zh) * 2019-03-27 2025-11-14 宾夕法尼亚大学董事会 Tn-MUC1嵌合抗原受体(CAR)T细胞疗法
SG11202109052YA (en) * 2019-03-29 2021-10-28 Phanes Therapeutics Inc Humanized anti-claudin 18.2 chimeric antigen receptors and uses thereof
MY208022A (en) * 2019-04-01 2025-04-08 Shanghai hengrui pharmaceutical co ltd Anti-claudin 18.2 antibody and application thereof
EP3960766A4 (en) * 2019-04-19 2022-12-07 Keymed Biosciences Co.,Ltd. ANTI-TUMOR THERAPEUTIC AGENT AND USE THEREOF
WO2020228806A1 (zh) 2019-05-16 2020-11-19 齐鲁制药有限公司 针对密蛋白18a2的抗体及其应用
CN111978402B (zh) * 2019-05-24 2022-06-28 三优生物医药(上海)有限公司 新型cldn18.2结合分子
KR20220012262A (ko) * 2019-05-24 2022-02-03 산유 바이오파마슈티컬스 씨오., 엘티디. 신형 cldn18.2 결합분자
WO2020239005A1 (zh) * 2019-05-30 2020-12-03 山东博安生物技术有限公司 靶向Claudin18.2的抗体或嵌合抗原受体
JP2022541435A (ja) * 2019-07-17 2022-09-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア クローディン18抗体及びがんを処置する方法
MY207446A (en) 2019-08-12 2025-02-27 Abl Bio Inc Anti-claudin 18.2 and anti-4-1bb bispecific antibodies and uses thereof
CN112574307B (zh) 2019-09-29 2023-11-28 迈威(上海)生物科技股份有限公司 抗人Claudin18.2抗体及其应用
EP4054648A4 (en) 2019-11-05 2023-12-27 LaNova Medicines Limited ANTIBODY DRUG CONJUGATES DIRECTED AGAINST CLAUDIN 18.2
EP4066842A4 (en) * 2019-11-29 2023-01-25 Suzhou Nova Therapeutics Co. Ltd APPLICATION OF CAR-T CELLS IN MANUFACTURE OF DRUG FOR TREATMENT OF CANCER
CN114901696B (zh) 2019-12-06 2025-08-05 斯迪安生物技术公司 人源化cldn18.2抗体
BR112022012327A2 (pt) 2019-12-23 2022-10-18 Sotio Biotech A S Anticorpos ou fragmentos dos mesmos, ácido nucleico, vetor e célula hospedeira
KR20220121873A (ko) * 2020-01-03 2022-09-01 크라제 메디컬 씨오 리미티드 항-클라우딘 18.2 항체 및 그 용도
KR102929927B1 (ko) 2020-02-10 2026-02-25 상하이 에스쿠겐 바이오테크놀로지 컴퍼니 리미티드 클라우딘18.2 항체 및 그것의 사용
WO2021173307A1 (en) * 2020-02-25 2021-09-02 Gensun Biopharma Inc. Trispecific t cell engagers
EP4151235A4 (en) * 2020-05-15 2025-08-06 Sichuan Kelun Biotech Biopharmaceutical Co Ltd ANTIBODY-DRUG CONJUGATE, ITS PREPARATION METHOD AND ITS USE
TWI809426B (zh) * 2020-06-19 2023-07-21 大陸商信達生物製藥(蘇州)有限公司 抗Claudin18.2抗體以及其用途
CN111704669B (zh) * 2020-07-13 2022-05-13 北京凯因科技股份有限公司 一种用于治疗晚期胃癌的抗cldn18全人源化抗体
CN111961135B (zh) * 2020-07-13 2022-08-16 北京亦庄国际蛋白药物技术有限公司 一种用于预防或治疗癌症的抗体
CN111808194B (zh) * 2020-07-13 2021-04-20 北京凯因科技股份有限公司 一种结合密蛋白的用于治疗癌症的人源化抗体
CN114222761B (zh) * 2020-07-14 2024-02-20 浙江道尔生物科技有限公司 一种抗cld18a2的单域抗体
CN116194125A (zh) 2020-08-07 2023-05-30 克莱格医学有限公司 工程化改造的细胞以及工程化改造细胞的方法
US20240034784A1 (en) * 2020-09-30 2024-02-01 Nanjing GenScript Biotech Co., Ltd. Antibodies targeting human claudin 18.2 and uses thereof
WO2022122709A1 (en) 2020-12-07 2022-06-16 Sotio Biotech A.S. Antibody-drug conjugates based on humanized cldn18.2 antibodies
WO2022140388A1 (en) 2020-12-21 2022-06-30 Allogene Therapeutics, Inc. Protease-activating cd45-gate car
PE20231561A1 (es) 2020-12-23 2023-10-03 Sotio Biotech A S Conjugados anticuerpo-farmaco especificos para tumores con claudina 18.2
EP4284918A1 (en) 2021-01-29 2023-12-06 Allogene Therapeutics, Inc. Knockdown or knockout of one or more of tap2, nlrc5, beta2m, trac, rfx5, rfxap and rfxank to mitigate t cell recognition of allogeneic cell products
EP4299593A4 (en) * 2021-04-02 2025-12-10 Oricell Therapeutics Co Ltd CLDN18.2 ANTIGEN-BINDING PROTEIN AND ITS USE
CN117545771A (zh) * 2021-04-08 2024-02-09 克莱格医学有限公司 细胞免疫治疗的应用
WO2022218375A1 (zh) * 2021-04-15 2022-10-20 克莱格医学有限公司 嵌合t细胞受体及其应用
US12577320B2 (en) 2021-05-08 2026-03-17 Remegen Co., Ltd. Anti-Claudin 18.2 antibody and antibody-drug conjugate thereof
EP4365193A4 (en) 2021-06-29 2024-12-25 Carsgen Therapeutics Co., Ltd. Chimeric polypeptide for regulating cell physiological activity
CN115057930B (zh) * 2021-09-03 2022-11-29 深圳市先康达生命科学有限公司 靶向人Claudin18.2蛋白的单克隆抗体及其应用
WO2023078386A1 (zh) * 2021-11-05 2023-05-11 正大天晴药业集团股份有限公司 抗cldn18.2抗体及其用途
CN119677781A (zh) * 2022-05-06 2025-03-21 上海先博生物科技有限公司 靶向cldn18.2的嵌合抗原t细胞受体及其应用
WO2024022495A1 (en) * 2022-07-28 2024-02-01 Concept To Medicine Biotech Co., Ltd. Anti-MerTK ANTIBODIES AND USES THEREOF
CN119654406A (zh) 2022-07-29 2025-03-18 艾洛基治疗公司 具有降低的基因表达以减轻免疫细胞识别的经工程化的细胞
TW202434307A (zh) 2023-01-18 2024-09-01 大陸商泰勵生物科技(上海)有限公司 抗體偶聯藥物及其用途
CN121620529A (zh) * 2023-07-31 2026-03-06 南京传奇生物科技有限公司 嵌合细胞因子受体及其使用方法
WO2025076127A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
WO2025096560A1 (en) 2023-10-30 2025-05-08 Allogene Therapeutics, Inc. Engineered cells
CN117430708B (zh) * 2023-12-21 2024-04-09 苏州近岸蛋白质科技股份有限公司 一种抗Claudin18.2抗体
WO2025217454A2 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles
WO2025217452A1 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
CN120005046B (zh) * 2025-04-18 2025-09-02 深锐(天津)生物医学有限公司 双靶点嵌合抗原受体联合pd-1与il-21融合蛋白

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
WO2013167153A1 (en) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Antibodies useful in cancer diagnosis
WO2014127785A1 (en) * 2013-02-20 2014-08-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2014146672A1 (en) 2013-03-18 2014-09-25 Ganymed Pharmaceuticals Ag Therapy involving antibodies against claudin 18.2 for treatment of cancer
CN120137056A (zh) 2014-07-17 2025-06-13 恺兴生命科技(上海)有限公司 靶向cld18a2的t淋巴细胞及其制备方法和应用
CN105331585A (zh) * 2015-11-13 2016-02-17 科济生物医药(上海)有限公司 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞
CR20180348A (es) 2015-12-04 2018-08-23 Abbvie Stemcentrx Llc Nuevos anticuerpos anti-claudina y sus métodos de uso
CN118165113B (zh) * 2016-04-26 2025-10-28 恺兴生命科技(上海)有限公司 一种改善免疫应答细胞功能的方法
ES2979068T3 (es) * 2016-07-08 2024-09-24 Crage Medical Co Ltd Anticuerpos para anti-claudina 18A2 y utilización de los mismos
KR20210013013A (ko) * 2018-03-09 2021-02-03 카르스젠 테라퓨틱스 리미티드 종양 치료 방법 및 조성물
JP2022511394A (ja) * 2018-09-30 2022-01-31 カファ セラピューティクス リミテッド Cldn18の抗体及び化学療法薬の併用療法
WO2020143631A1 (zh) * 2019-01-07 2020-07-16 科济生物医药(上海)有限公司 细胞免疫治疗的组合
CN116348604A (zh) * 2020-08-10 2023-06-27 克莱格医学有限公司 多功能的免疫效应细胞及其应用

Similar Documents

Publication Publication Date Title
JP2019531084A5 (enExample)
JP2020510422A5 (enExample)
JP2017519759A5 (enExample)
JP2022093564A5 (enExample)
JP2020501531A5 (enExample)
JP2017535257A5 (enExample)
JP2019532625A5 (enExample)
RU2014101669A (ru) Агенты, связывающие белки r-спондины (rspo), и способы их применения
JP2018527919A5 (enExample)
JP2013527762A5 (enExample)
JP2018532383A5 (enExample)
HRP20231281T1 (hr) Bispecifična anti-muc16-cd3 antitijela i konjugati anti-muc16 s lijekom
JP2018529327A5 (enExample)
JP2018506961A5 (enExample)
JP2013506428A5 (enExample)
JP2013527761A5 (enExample)
JP2020529835A5 (enExample)
JP2014522850A5 (enExample)
JP2010535713A5 (enExample)
JP2017526339A5 (enExample)
JP2019512207A5 (enExample)
JP2013519364A5 (enExample)
RU2018122629A (ru) Антитела против 5t4 и конъюгаты антитело-лекарственное средство
JP2020534012A5 (enExample)
JP2017521054A5 (enExample)