JP2019531084A5 - - Google Patents
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- JP2019531084A5 JP2019531084A5 JP2019521178A JP2019521178A JP2019531084A5 JP 2019531084 A5 JP2019531084 A5 JP 2019531084A5 JP 2019521178 A JP2019521178 A JP 2019521178A JP 2019521178 A JP2019521178 A JP 2019521178A JP 2019531084 A5 JP2019531084 A5 JP 2019531084A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 44
- 210000004027 cell Anatomy 0.000 claims 40
- 239000000427 antigen Substances 0.000 claims 33
- 108091007433 antigens Proteins 0.000 claims 33
- 102000036639 antigens Human genes 0.000 claims 33
- 230000027455 binding Effects 0.000 claims 30
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 27
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 206010028980 Neoplasm Diseases 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 102000002029 Claudin Human genes 0.000 claims 13
- 108050009302 Claudin Proteins 0.000 claims 13
- 210000002865 immune cell Anatomy 0.000 claims 12
- 101000685724 Homo sapiens Protein S100-A4 Proteins 0.000 claims 10
- 102100023087 Protein S100-A4 Human genes 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 8
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 5
- 102000002227 Interferon Type I Human genes 0.000 claims 5
- 108010014726 Interferon Type I Proteins 0.000 claims 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 5
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 5
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 5
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 5
- 201000004101 esophageal cancer Diseases 0.000 claims 5
- 239000013604 expression vector Substances 0.000 claims 5
- 206010017758 gastric cancer Diseases 0.000 claims 5
- 201000005202 lung cancer Diseases 0.000 claims 5
- 208000020816 lung neoplasm Diseases 0.000 claims 5
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 201000002528 pancreatic cancer Diseases 0.000 claims 5
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 5
- 201000011549 stomach cancer Diseases 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 229940075993 receptor modulator Drugs 0.000 claims 3
- 210000004881 tumor cell Anatomy 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 108010083359 Antigen Receptors Proteins 0.000 claims 2
- 102000006306 Antigen Receptors Human genes 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 2
- 208000005016 Intestinal Neoplasms Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 208000008383 Wilms tumor Diseases 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000010175 gallbladder cancer Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 229940127121 immunoconjugate Drugs 0.000 claims 2
- 201000002313 intestinal cancer Diseases 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 208000022013 kidney Wilms tumor Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 201000008026 nephroblastoma Diseases 0.000 claims 2
- 230000009871 nonspecific binding Effects 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 229940125644 antibody drug Drugs 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000001588 bifunctional effect Effects 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002458 cell surface marker Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 229960001904 epirubicin Drugs 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 210000000581 natural killer T-cell Anatomy 0.000 claims 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610536449.9 | 2016-07-08 | ||
| CN201610536449 | 2016-07-08 | ||
| PCT/CN2017/082024 WO2017186121A1 (zh) | 2016-04-26 | 2017-04-26 | 一种改善免疫应答细胞功能的方法 |
| CNPCT/CN2017/082024 | 2017-04-26 | ||
| PCT/CN2017/092381 WO2018006882A1 (zh) | 2016-07-08 | 2017-07-10 | 抗密蛋白18a2的抗体及其应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531084A JP2019531084A (ja) | 2019-10-31 |
| JP2019531084A5 true JP2019531084A5 (enExample) | 2020-09-03 |
| JP7587921B2 JP7587921B2 (ja) | 2024-11-21 |
Family
ID=60912336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019521178A Active JP7587921B2 (ja) | 2016-07-08 | 2017-07-10 | 抗クローディンタンパク質１８ａ２の抗体及びその応用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11111295B2 (enExample) |
| EP (1) | EP3483182B1 (enExample) |
| JP (1) | JP7587921B2 (enExample) |
| KR (1) | KR102723896B1 (enExample) |
| CN (1) | CN109790222B (enExample) |
| AU (1) | AU2017294276B2 (enExample) |
| BR (1) | BR112019000327A8 (enExample) |
| CA (1) | CA3030257A1 (enExample) |
| CL (1) | CL2019000061A1 (enExample) |
| ES (1) | ES2979068T3 (enExample) |
| IL (1) | IL264144B2 (enExample) |
| SG (1) | SG11201900171QA (enExample) |
| WO (1) | WO2018006882A1 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019000327A8 (pt) * | 2016-07-08 | 2022-10-18 | Carsgen Therapeutics Co Ltd | Anticorpo para anticlaudina 18a2 e uso do mesmo |
| WO2019149279A1 (zh) | 2018-02-02 | 2019-08-08 | 科济生物医药（上海）有限公司 | 细胞免疫治疗的组合 |
| IL276830B2 (en) | 2018-03-08 | 2025-08-01 | Phanes Therapeutics Inc | Anti-claudin 18.2 antibodies and uses thereof |
| CN119770648A (zh) * | 2018-03-09 | 2025-04-08 | 克莱格医学有限公司 | 用于治疗肿瘤的方法和组合物 |
| TW202003562A (zh) * | 2018-03-14 | 2020-01-16 | 中國大陸商北京軒義醫藥科技有限公司 | 抗密連蛋白18.2(cldn18.2)抗體 |
| US20220127570A1 (en) * | 2018-05-03 | 2022-04-28 | Cafa Therapeutics Limited | Immune effector cell and use thereof |
| SG11202011392VA (en) | 2018-05-15 | 2020-12-30 | Carsgen Therapeutics Co Ltd | Genetically engineered cell and application thereof |
| KR102421427B1 (ko) * | 2018-05-18 | 2022-07-18 | 라노바 메디신즈 리미티드 컴파니 | 항-클라우딘 18.2 항체 및 이의 사용 |
| EP3834849A4 (en) | 2018-07-24 | 2022-08-03 | CRAGE medical Co., Limited | Method for treating tumor using immune effector cell |
| CN112770723B (zh) * | 2018-07-25 | 2024-08-02 | 阿克罗斯生物科学公司 | Cldn 18.2特异性单克隆抗体及其使用方法 |
| CN110857322A (zh) * | 2018-08-22 | 2020-03-03 | 瑞阳(苏州)生物科技有限公司 | 抗人claudin 18.2单克隆抗体及其应用 |
| WO2020043044A1 (zh) * | 2018-08-27 | 2020-03-05 | 南京圣和药业股份有限公司 | 一种抗Claudin18.2抗体及其应用 |
| CN109206524B (zh) * | 2018-09-25 | 2022-04-05 | 山东兴瑞生物科技有限公司 | 抗Claudin18A2嵌合抗原受体、其修饰的T细胞及T细胞制备方法和用途 |
| EP3858384A4 (en) * | 2018-09-30 | 2022-07-06 | CRAGE medical Co., Limited | COMBINATION THERAPY OF CLDN18 ANTIBODY AND CHEMOTHERAPEUTICS |
| US20210380680A1 (en) * | 2018-12-07 | 2021-12-09 | ZLlP HOLDING LIMITED | Anti-claudin antibodies and uses thereof |
| JP2022517301A (ja) | 2018-12-07 | 2022-03-08 | カファ セラピューティクス リミテッド | 腫瘍併用免疫療法 |
| CN113166246B (zh) * | 2018-12-28 | 2024-10-18 | 四川科伦博泰生物医药股份有限公司 | 一种抗体及其用途 |
| KR20210110339A (ko) * | 2018-12-28 | 2021-09-07 | 난징 진스크립트 바이오테크 컴퍼니 리미티드 | 클라우딘18.2 결합 모이어티 및 그 용도 |
| CN113271953A (zh) * | 2019-01-07 | 2021-08-17 | 科济生物医药（上海）有限公司 | 细胞免疫治疗的组合 |
| CN113817061B (zh) * | 2019-01-15 | 2022-11-04 | 浙江道尔生物科技有限公司 | 一种抗cld18a2单域抗体及其抗肿瘤用途 |
| CN109762067B (zh) * | 2019-01-17 | 2020-02-28 | 北京天广实生物技术股份有限公司 | 结合人Claudin 18.2的抗体及其用途 |
| CN113490689B (zh) * | 2019-02-01 | 2024-06-04 | 恺兴生命科技(上海)有限公司 | Tcr融合蛋白及表达tcr融合蛋白的细胞 |
| US11407828B2 (en) | 2019-02-01 | 2022-08-09 | Novarock Biotherapeutics, Ltd. | Anti-CLauDiN 18 antibodies and methods of use thereof |
| WO2020180882A1 (en) | 2019-03-05 | 2020-09-10 | Nkarta, Inc. | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| CN113661180B (zh) * | 2019-03-27 | 2025-08-26 | 宾夕法尼亚大学董事会 | Tn-MUC1嵌合抗原受体(CAR)T细胞疗法 |
| MX2021011887A (es) * | 2019-03-29 | 2021-10-26 | Phanes Therapeutics Inc | Receptores de antigeno quimerico humanizados anti-claudin 18.2 y usos de los mismos. |
| US12428478B2 (en) * | 2019-04-01 | 2025-09-30 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-Claudin 18.2 antibody and application thereof |
| CN119613553A (zh) * | 2019-04-19 | 2025-03-14 | 康诺亚生物医药科技（成都）有限公司 | 肿瘤治疗剂及其应用 |
| JP7407841B2 (ja) | 2019-05-16 | 2024-01-04 | 斉魯制薬有限公司 | クローディン１８ａ２に対する抗体及びその応用 |
| CN111978402B (zh) * | 2019-05-24 | 2022-06-28 | 三优生物医药(上海)有限公司 | 新型cldn18.2结合分子 |
| EP3978532A4 (en) * | 2019-05-24 | 2023-10-18 | Sanyou Biopharmaceuticals Co., Ltd. | Novel cldn18.2 binding molecule |
| US12312402B2 (en) | 2019-05-30 | 2025-05-27 | Shandong Boan Biotechnology Co., Ltd. | Antibody or chimeric antigen receptor which targets Claudin 18.2 |
| US12345709B2 (en) * | 2019-07-17 | 2025-07-01 | The Regents Of The University Of California | CLAUDIN18 antibodies and methods of treating cancer |
| EP3853257A4 (en) * | 2019-08-12 | 2022-06-29 | I-Mab Biopharma US Limited | Anti-claudin 18.2 and anti-4-1bb bispecific antibodies and uses thereof |
| CN112574307B (zh) | 2019-09-29 | 2023-11-28 | 迈威(上海)生物科技股份有限公司 | 抗人Claudin18.2抗体及其应用 |
| PE20221459A1 (es) | 2019-11-05 | 2022-09-21 | Lanova Medicines Ltd | Conjugados anticuerpo-farmaco dirigido a claudina 18.2 |
| WO2021104511A1 (zh) * | 2019-11-29 | 2021-06-03 | 苏州诺沃泰医药科技有限公司 | Cart细胞在制备治疗癌症的药物中的应用 |
| WO2021111003A1 (en) | 2019-12-06 | 2021-06-10 | SOTIO a.s. | Humanized cldn18.2 antibodies |
| CN114901365B (zh) | 2019-12-23 | 2025-07-15 | 斯迪安生物技术公司 | 肿瘤特异性密蛋白18.2抗体 |
| EP4086287A4 (en) * | 2020-01-03 | 2024-03-06 | CRAGE medical Co., Limited | ANTI-CLAUDIN 18.2 ANTIBODIES AND USE THEREOF |
| JP7522482B2 (ja) * | 2020-02-10 | 2024-07-25 | 上海詩健生物科技有限公司 | クローディン１８．２の抗体及びその使用 |
| CN116096751A (zh) * | 2020-02-25 | 2023-05-09 | 璟尚生物制药公司 | 三特异性t细胞接合器 |
| KR20230012000A (ko) * | 2020-05-15 | 2023-01-25 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 항체 약물 컨쥬게이트, 이의 제조 방법 및 이의 용도 |
| AU2021291259B2 (en) * | 2020-06-19 | 2025-07-31 | Fortvita Biologics (Singapore) Pte.Ltd. | Anti-Claudin18.2 antibody and use thereof |
| CN111961135B (zh) * | 2020-07-13 | 2022-08-16 | 北京亦庄国际蛋白药物技术有限公司 | 一种用于预防或治疗癌症的抗体 |
| CN111704669B (zh) * | 2020-07-13 | 2022-05-13 | 北京凯因科技股份有限公司 | 一种用于治疗晚期胃癌的抗cldn18全人源化抗体 |
| CN113929780A (zh) * | 2020-07-13 | 2022-01-14 | 北京凯因科技股份有限公司 | 一种结合密蛋白的用于治疗癌症的人源化抗体 |
| CN114222761B (zh) * | 2020-07-14 | 2024-02-20 | 浙江道尔生物科技有限公司 | 一种抗cld18a2的单域抗体 |
| CN116194125A (zh) | 2020-08-07 | 2023-05-30 | 克莱格医学有限公司 | 工程化改造的细胞以及工程化改造细胞的方法 |
| KR20230078701A (ko) * | 2020-09-30 | 2023-06-02 | 난징 진스크립트 바이오테크 컴퍼니 리미티드 | 인간 클라우딘 18.2를 표적화하는 항체 및 이의 용도 |
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| CN117545771A (zh) * | 2021-04-08 | 2024-02-09 | 克莱格医学有限公司 | 细胞免疫治疗的应用 |
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| CN120484126B (zh) * | 2022-07-28 | 2025-11-18 | 乐普创一生物科技（上海）有限公司 | 抗MerTK抗体及其用途 |
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| TW202434307A (zh) | 2023-01-18 | 2024-09-01 | 大陸商泰勵生物科技（上海）有限公司 | 抗體偶聯藥物及其用途 |
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| CN117430708B (zh) * | 2023-12-21 | 2024-04-09 | 苏州近岸蛋白质科技股份有限公司 | 一种抗Claudin18.2抗体 |
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| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
| WO2014127785A1 (en) * | 2013-02-20 | 2014-08-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2014146672A1 (en) | 2013-03-18 | 2014-09-25 | Ganymed Pharmaceuticals Ag | Therapy involving antibodies against claudin 18.2 for treatment of cancer |
| CN112979828B (zh) * | 2014-07-17 | 2025-04-29 | 恺兴生命科技(上海)有限公司 | 靶向cld18a2的t淋巴细胞及其制备方法和应用 |
| CN105331585A (zh) * | 2015-11-13 | 2016-02-17 | 科济生物医药（上海）有限公司 | 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞 |
| AU2016364853A1 (en) | 2015-12-04 | 2018-06-21 | Abbvie Stemcentrx Llc | Novel anti-claudin antibodies and methods of use |
| WO2017186121A1 (zh) * | 2016-04-26 | 2017-11-02 | 科济生物医药（上海）有限公司 | 一种改善免疫应答细胞功能的方法 |
| BR112019000327A8 (pt) * | 2016-07-08 | 2022-10-18 | Carsgen Therapeutics Co Ltd | Anticorpo para anticlaudina 18a2 e uso do mesmo |
| CN119770648A (zh) * | 2018-03-09 | 2025-04-08 | 克莱格医学有限公司 | 用于治疗肿瘤的方法和组合物 |
| EP3858384A4 (en) * | 2018-09-30 | 2022-07-06 | CRAGE medical Co., Limited | COMBINATION THERAPY OF CLDN18 ANTIBODY AND CHEMOTHERAPEUTICS |
| CN113271953A (zh) * | 2019-01-07 | 2021-08-17 | 科济生物医药（上海）有限公司 | 细胞免疫治疗的组合 |
| CN116348604A (zh) * | 2020-08-10 | 2023-06-27 | 克莱格医学有限公司 | 多功能的免疫效应细胞及其应用 |
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2017
- 2017-07-10 BR BR112019000327A patent/BR112019000327A8/pt active Search and Examination
- 2017-07-10 CN CN201780042611.4A patent/CN109790222B/zh active Active
- 2017-07-10 EP EP17823694.9A patent/EP3483182B1/en active Active
- 2017-07-10 WO PCT/CN2017/092381 patent/WO2018006882A1/zh not_active Ceased
- 2017-07-10 CA CA3030257A patent/CA3030257A1/en active Pending
- 2017-07-10 AU AU2017294276A patent/AU2017294276B2/en active Active
- 2017-07-10 IL IL264144A patent/IL264144B2/en unknown
- 2017-07-10 KR KR1020197003874A patent/KR102723896B1/ko active Active
- 2017-07-10 ES ES17823694T patent/ES2979068T3/es active Active
- 2017-07-10 SG SG11201900171QA patent/SG11201900171QA/en unknown
- 2017-07-10 JP JP2019521178A patent/JP7587921B2/ja active Active
- 2017-07-10 US US16/316,331 patent/US11111295B2/en active Active
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2019
- 2019-01-08 CL CL2019000061A patent/CL2019000061A1/es unknown
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2021
- 2021-08-05 US US17/395,223 patent/US20220185880A1/en not_active Abandoned
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