JP2019531084A5 - - Google Patents
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- JP2019531084A5 JP2019531084A5 JP2019521178A JP2019521178A JP2019531084A5 JP 2019531084 A5 JP2019531084 A5 JP 2019531084A5 JP 2019521178 A JP2019521178 A JP 2019521178A JP 2019521178 A JP2019521178 A JP 2019521178A JP 2019531084 A5 JP2019531084 A5 JP 2019531084A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 44
- 210000004027 cell Anatomy 0.000 claims 40
- 239000000427 antigen Substances 0.000 claims 33
- 108091007433 antigens Proteins 0.000 claims 33
- 102000036639 antigens Human genes 0.000 claims 33
- 230000027455 binding Effects 0.000 claims 30
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 27
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 206010028980 Neoplasm Diseases 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 102000002029 Claudin Human genes 0.000 claims 13
- 108050009302 Claudin Proteins 0.000 claims 13
- 210000002865 immune cell Anatomy 0.000 claims 12
- 101000685724 Homo sapiens Protein S100-A4 Proteins 0.000 claims 10
- 102100023087 Protein S100-A4 Human genes 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 8
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 5
- 102000002227 Interferon Type I Human genes 0.000 claims 5
- 108010014726 Interferon Type I Proteins 0.000 claims 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 5
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 5
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 5
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 5
- 201000004101 esophageal cancer Diseases 0.000 claims 5
- 239000013604 expression vector Substances 0.000 claims 5
- 206010017758 gastric cancer Diseases 0.000 claims 5
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- 238000004519 manufacturing process Methods 0.000 claims 5
- 201000002528 pancreatic cancer Diseases 0.000 claims 5
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- 241000700605 Viruses Species 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
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- 206010009944 Colon cancer Diseases 0.000 claims 2
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- 229940124597 therapeutic agent Drugs 0.000 claims 2
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 229940125644 antibody drug Drugs 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000001588 bifunctional effect Effects 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
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- 238000012258 culturing Methods 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
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- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 229960001904 epirubicin Drugs 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
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- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610536449 | 2016-07-08 | ||
| CN201610536449.9 | 2016-07-08 | ||
| CNPCT/CN2017/082024 | 2017-04-26 | ||
| PCT/CN2017/082024 WO2017186121A1 (zh) | 2016-04-26 | 2017-04-26 | 一种改善免疫应答细胞功能的方法 |
| PCT/CN2017/092381 WO2018006882A1 (zh) | 2016-07-08 | 2017-07-10 | 抗密蛋白18a2的抗体及其应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531084A JP2019531084A (ja) | 2019-10-31 |
| JP2019531084A5 true JP2019531084A5 (enExample) | 2020-09-03 |
| JP7587921B2 JP7587921B2 (ja) | 2024-11-21 |
Family
ID=60912336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019521178A Active JP7587921B2 (ja) | 2016-07-08 | 2017-07-10 | 抗クローディンタンパク質１８ａ２の抗体及びその応用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11111295B2 (enExample) |
| EP (1) | EP3483182B1 (enExample) |
| JP (1) | JP7587921B2 (enExample) |
| KR (1) | KR102723896B1 (enExample) |
| CN (1) | CN109790222B (enExample) |
| AU (1) | AU2017294276B2 (enExample) |
| BR (1) | BR112019000327A8 (enExample) |
| CA (1) | CA3030257A1 (enExample) |
| CL (1) | CL2019000061A1 (enExample) |
| ES (1) | ES2979068T3 (enExample) |
| IL (1) | IL264144B2 (enExample) |
| SG (1) | SG11201900171QA (enExample) |
| WO (1) | WO2018006882A1 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109790222B (zh) * | 2016-07-08 | 2022-03-15 | 克莱格医学有限公司 | 抗密蛋白18a2的抗体及其应用 |
| US12178786B2 (en) | 2018-02-02 | 2024-12-31 | Crage Medical Co., Limited | Combination of cellular immunotherapy |
| EP3762031A4 (en) | 2018-03-08 | 2021-12-22 | Phanes Therapeutics, Inc. | ANTI-CLAUDINE ANTIBODIES 18.2 AND THEIR USES |
| KR20210013013A (ko) * | 2018-03-09 | 2021-02-03 | 카르스젠 테라퓨틱스 리미티드 | 종양 치료 방법 및 조성물 |
| CN112166123B (zh) * | 2018-03-14 | 2022-09-30 | 北京轩义医药科技有限公司 | 抗紧密连接蛋白18.2抗体 |
| EP3789486A4 (en) * | 2018-05-03 | 2022-03-30 | Cafa Therapeutics Limited | Immune effector cell and use thereof |
| EP3822345B1 (en) | 2018-05-15 | 2024-10-16 | CRAGE medical Co., Limited | Genetically engineered cell and application thereof |
| CN116178554B (zh) * | 2018-05-18 | 2025-09-09 | 礼新医药科技(上海)有限公司 | 抗密蛋白18.2抗体及其用途 |
| CA3107515A1 (en) | 2018-07-24 | 2020-01-30 | Carsgen Therapeutics Co., Ltd. | Method for tumor treatment with immune effector cells |
| CN112770723B (zh) * | 2018-07-25 | 2024-08-02 | 阿克罗斯生物科学公司 | Cldn 18.2特异性单克隆抗体及其使用方法 |
| CN110857322A (zh) * | 2018-08-22 | 2020-03-03 | 瑞阳(苏州)生物科技有限公司 | 抗人claudin 18.2单克隆抗体及其应用 |
| CN112654638B (zh) * | 2018-08-27 | 2022-12-30 | 南京圣和药业股份有限公司 | 一种抗Claudin18.2抗体及其应用 |
| CN109206524B (zh) * | 2018-09-25 | 2022-04-05 | 山东兴瑞生物科技有限公司 | 抗Claudin18A2嵌合抗原受体、其修饰的T细胞及T细胞制备方法和用途 |
| US20220033491A1 (en) * | 2018-09-30 | 2022-02-03 | Cafa Therapeutics Limited | Combination therapy of cldn18 antibody and chemotherapy drugs |
| AU2019391204A1 (en) * | 2018-12-07 | 2021-06-24 | Zlip Holding Limited | Anti-Claudin antibodies and uses thereof |
| EP3892333A4 (en) | 2018-12-07 | 2022-11-30 | CRAGE medical Co., Limited | Tumor combined immunotherapy |
| JP7562528B2 (ja) * | 2018-12-28 | 2024-10-07 | 四川科倫博泰生物医薬股▲フン▼有限公司 | 抗体及びその用途 |
| CN113227146B (zh) | 2018-12-28 | 2024-03-01 | 南京金斯瑞生物科技有限公司 | 密蛋白18.2结合部分和其用途 |
| US20220152101A1 (en) | 2019-01-07 | 2022-05-19 | Carsgen Therapeutics Co., Ltd. | Cellular immunotherapy combination |
| CN113817061B (zh) * | 2019-01-15 | 2022-11-04 | 浙江道尔生物科技有限公司 | 一种抗cld18a2单域抗体及其抗肿瘤用途 |
| CN109762067B (zh) * | 2019-01-17 | 2020-02-28 | 北京天广实生物技术股份有限公司 | 结合人Claudin 18.2的抗体及其用途 |
| WO2020156554A1 (zh) | 2019-02-01 | 2020-08-06 | 科济生物医药（上海）有限公司 | Tcr融合蛋白及表达tcr融合蛋白的细胞 |
| WO2020160560A2 (en) * | 2019-02-01 | 2020-08-06 | Novarock Biotherapeutics, Ltd. | Anti-claudin 18 antibodies and methods of use thereof |
| SG11202109057XA (en) | 2019-03-05 | 2021-09-29 | Nkarta Inc | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| EP3947471A4 (en) * | 2019-03-27 | 2023-03-15 | The Trustees of The University of Pennsylvania | TN-MUC1 CHIMERIC ANTIGEN RECEPTOR (CAR) T-LYMPHOCYTE THERAPY |
| BR112021016673A2 (pt) * | 2019-03-29 | 2021-10-13 | Phanes Therapeutics, Inc. | Receptores de antígeno chiméricos anticlaudina 18.2 humanizados e seus usos |
| CN116063516A (zh) * | 2019-04-01 | 2023-05-05 | 江苏恒瑞医药股份有限公司 | 抗Claudin18.2抗体及其应用 |
| WO2020211792A1 (zh) * | 2019-04-19 | 2020-10-22 | 康诺亚生物医药科技（成都）有限公司 | 肿瘤治疗剂及其应用 |
| BR112021023024A2 (pt) | 2019-05-16 | 2022-01-25 | Qilu Pharmaceutical Co Ltd | Anticorpo contra claudina 18a2 e uso do mesmo |
| CN114206935B (zh) * | 2019-05-24 | 2024-01-12 | 三优生物医药(上海)有限公司 | 新型cldn18.2结合分子 |
| CN111978402B (zh) * | 2019-05-24 | 2022-06-28 | 三优生物医药(上海)有限公司 | 新型cldn18.2结合分子 |
| KR102758039B1 (ko) * | 2019-05-30 | 2025-01-22 | 샨동 보안 바이오테크놀로지 컴퍼니, 리미티드 | 클라우딘(Claudin) 18.2를 표적화하는 항체 또는 키메라 항원 수용체 |
| BR112022000371A2 (pt) * | 2019-07-17 | 2022-05-10 | Univ California | Anticorpos claudin18 e métodos de tratamento contra câncer |
| PE20211147A1 (es) * | 2019-08-12 | 2021-06-28 | I Mab Biopharma Us Ltd | Anticuerpos anti-claudina 18.2 y anti-4-1bb biespecificos y su uso |
| CN112574307B (zh) | 2019-09-29 | 2023-11-28 | 迈威(上海)生物科技股份有限公司 | 抗人Claudin18.2抗体及其应用 |
| CN115920078B (zh) * | 2019-11-05 | 2025-10-17 | 礼新医药科技(上海)有限公司 | 靶向紧密连接蛋白18.2的抗体药物偶联物 |
| CN115666594A (zh) * | 2019-11-29 | 2023-01-31 | 苏州诺沃泰医药科技有限公司 | Cart细胞在制备治疗癌症的药物中的应用 |
| WO2021111003A1 (en) | 2019-12-06 | 2021-06-10 | SOTIO a.s. | Humanized cldn18.2 antibodies |
| MX2022007849A (es) | 2019-12-23 | 2022-07-19 | Sotio Biotech A S | Anticuerpos especificos contra la claudina 18.2 tumoral. |
| CN117343186A (zh) * | 2020-01-03 | 2024-01-05 | 上海恺兴诊断技术有限公司 | 抗Claudin18.2的抗体及其应用 |
| AU2021218927B2 (en) * | 2020-02-10 | 2024-12-19 | Shanghai Escugen Biotechnology Co., Ltd. | Claudin 18.2 antibody and use thereof |
| EP4110820A4 (en) * | 2020-02-25 | 2024-03-27 | Gensun Biopharma Inc. | TRISPECIFIC T CELL CONTACTING AGENTS |
| KR20230012000A (ko) * | 2020-05-15 | 2023-01-25 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 항체 약물 컨쥬게이트, 이의 제조 방법 및 이의 용도 |
| CA3178855A1 (en) * | 2020-06-19 | 2021-12-23 | Innovent Biologics (Suzhou) Co., Ltd. | Anti-claudin18.2 antibody and use thereof |
| CN111704669B (zh) * | 2020-07-13 | 2022-05-13 | 北京凯因科技股份有限公司 | 一种用于治疗晚期胃癌的抗cldn18全人源化抗体 |
| CN111961135B (zh) * | 2020-07-13 | 2022-08-16 | 北京亦庄国际蛋白药物技术有限公司 | 一种用于预防或治疗癌症的抗体 |
| CN113929780A (zh) * | 2020-07-13 | 2022-01-14 | 北京凯因科技股份有限公司 | 一种结合密蛋白的用于治疗癌症的人源化抗体 |
| CN114222761B (zh) * | 2020-07-14 | 2024-02-20 | 浙江道尔生物科技有限公司 | 一种抗cld18a2的单域抗体 |
| CN116194125A (zh) | 2020-08-07 | 2023-05-30 | 克莱格医学有限公司 | 工程化改造的细胞以及工程化改造细胞的方法 |
| WO2022068854A1 (en) * | 2020-09-30 | 2022-04-07 | Nanjing GenScript Biotech Co., Ltd. | Antibodies targeting human claudin 18.2 and uses thereof |
| WO2022122709A1 (en) | 2020-12-07 | 2022-06-16 | Sotio Biotech A.S. | Antibody-drug conjugates based on humanized cldn18.2 antibodies |
| IL303270A (en) | 2020-12-21 | 2023-07-01 | Allogene Therapeutics Inc | The CD45–GATE vehicle activates a protease |
| WO2022136642A1 (en) | 2020-12-23 | 2022-06-30 | Sotio Biotech A.S. | Tumor-specific claudin 18.2 antibody-drug conjugates |
| KR20230142470A (ko) | 2021-01-29 | 2023-10-11 | 알로젠 테라퓨틱스 인코포레이티드 | 동종이계 세포 산물의 T 세포 인식을 완화하기 위한TAP2, NLRC5, β2m, TRAC, RFX5, RFXAP, 및 RFXANK 중 하나 이상의 녹다운 또는 녹아웃 |
| CN117545771A (zh) * | 2021-04-08 | 2024-02-09 | 克莱格医学有限公司 | 细胞免疫治疗的应用 |
| CN117480247A (zh) * | 2021-04-15 | 2024-01-30 | 恺兴生命科技(上海)有限公司 | 嵌合t细胞受体及其应用 |
| CN117460741A (zh) | 2021-06-29 | 2024-01-26 | 科济生物医药（上海）有限公司 | 调控细胞生理活动的嵌合多肽 |
| CN114751984B (zh) * | 2021-09-03 | 2023-02-14 | 深圳市先康达生命科学有限公司 | 靶向人Claudin18.2蛋白的单克隆抗体及其应用 |
| CN118139888A (zh) * | 2021-11-05 | 2024-06-04 | 正大天晴药业集团股份有限公司 | 抗cldn18.2抗体及其用途 |
| WO2023213280A1 (zh) * | 2022-05-06 | 2023-11-09 | 上海先博生物科技有限公司 | 靶向cldn18.2的嵌合抗原t细胞受体及其应用 |
| CN120484126B (zh) * | 2022-07-28 | 2025-11-18 | 乐普创一生物科技（上海）有限公司 | 抗MerTK抗体及其用途 |
| CN119654406A (zh) | 2022-07-29 | 2025-03-18 | 艾洛基治疗公司 | 具有降低的基因表达以减轻免疫细胞识别的经工程化的细胞 |
| WO2024153127A1 (zh) | 2023-01-18 | 2024-07-25 | 泰励生物科技（上海）有限公司 | 抗体偶联药物及其用途 |
| WO2025026347A1 (en) * | 2023-07-31 | 2025-02-06 | Nanjing Legend Biotech Co., Ltd. | Chimeric cytokine receptors and methods of use thereof |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025076127A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025096560A1 (en) | 2023-10-30 | 2025-05-08 | Allogene Therapeutics, Inc. | Engineered cells |
| CN117430708B (zh) * | 2023-12-21 | 2024-04-09 | 苏州近岸蛋白质科技股份有限公司 | 一种抗Claudin18.2抗体 |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
| CN120005046B (zh) * | 2025-04-18 | 2025-09-02 | 深锐(天津)生物医学有限公司 | 双靶点嵌合抗原受体联合pd-1与il-21融合蛋白 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
| WO2014127785A1 (en) * | 2013-02-20 | 2014-08-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2014146672A1 (en) | 2013-03-18 | 2014-09-25 | Ganymed Pharmaceuticals Ag | Therapy involving antibodies against claudin 18.2 for treatment of cancer |
| CN105315375B (zh) * | 2014-07-17 | 2021-04-23 | 恺兴生命科技(上海)有限公司 | 靶向cld18a2的t淋巴细胞及其制备方法和应用 |
| CN105331585A (zh) * | 2015-11-13 | 2016-02-17 | 科济生物医药（上海）有限公司 | 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞 |
| SG11201804673WA (en) | 2015-12-04 | 2018-06-28 | Abbvie Stemcentrx Llc | Novel anti-claudin antibodies and methods of use |
| CN108884459B (zh) * | 2016-04-26 | 2024-04-02 | 科济生物医药（上海）有限公司 | 一种改善免疫应答细胞功能的方法 |
| CN109790222B (zh) * | 2016-07-08 | 2022-03-15 | 克莱格医学有限公司 | 抗密蛋白18a2的抗体及其应用 |
| KR20210013013A (ko) * | 2018-03-09 | 2021-02-03 | 카르스젠 테라퓨틱스 리미티드 | 종양 치료 방법 및 조성물 |
| US20220033491A1 (en) * | 2018-09-30 | 2022-02-03 | Cafa Therapeutics Limited | Combination therapy of cldn18 antibody and chemotherapy drugs |
| US20220152101A1 (en) * | 2019-01-07 | 2022-05-19 | Carsgen Therapeutics Co., Ltd. | Cellular immunotherapy combination |
| US20230272341A1 (en) * | 2020-08-10 | 2023-08-31 | Crage Medical Co., Limited | Multifunctional immune effector cell and use thereof |
-
2017
- 2017-07-10 CN CN201780042611.4A patent/CN109790222B/zh active Active
- 2017-07-10 US US16/316,331 patent/US11111295B2/en active Active
- 2017-07-10 AU AU2017294276A patent/AU2017294276B2/en active Active
- 2017-07-10 BR BR112019000327A patent/BR112019000327A8/pt unknown
- 2017-07-10 JP JP2019521178A patent/JP7587921B2/ja active Active
- 2017-07-10 IL IL264144A patent/IL264144B2/en unknown
- 2017-07-10 KR KR1020197003874A patent/KR102723896B1/ko active Active
- 2017-07-10 ES ES17823694T patent/ES2979068T3/es active Active
- 2017-07-10 SG SG11201900171QA patent/SG11201900171QA/en unknown
- 2017-07-10 EP EP17823694.9A patent/EP3483182B1/en active Active
- 2017-07-10 WO PCT/CN2017/092381 patent/WO2018006882A1/zh not_active Ceased
- 2017-07-10 CA CA3030257A patent/CA3030257A1/en active Pending
-
2019
- 2019-01-08 CL CL2019000061A patent/CL2019000061A1/es unknown
-
2021
- 2021-08-05 US US17/395,223 patent/US20220185880A1/en not_active Abandoned
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