HRP20231281T1 - Bispecifična anti-muc16-cd3 antitijela i konjugati anti-muc16 s lijekom - Google Patents

Bispecifična anti-muc16-cd3 antitijela i konjugati anti-muc16 s lijekom Download PDF

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HRP20231281T1
HRP20231281T1 HRP20231281TT HRP20231281T HRP20231281T1 HR P20231281 T1 HRP20231281 T1 HR P20231281T1 HR P20231281T T HRP20231281T T HR P20231281TT HR P20231281 T HRP20231281 T HR P20231281T HR P20231281 T1 HRP20231281 T1 HR P20231281T1
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Croatia
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amino acid
seq
antigen
acid sequence
bispecific antibody
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HRP20231281TT
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Lauric Haber
Eric Smith
Marcus KELLY
Jessica R. Kirshner
Sandra COETZEE
Alison CRAWFORD
Thomas Nittoli
Yashu Liu
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Regeneron Pharmaceuticals, Inc.
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Publication of HRP20231281T1 publication Critical patent/HRP20231281T1/hr

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    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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Claims (14)

1. Bispecifično antitijelo ili njegov fragment za vezanje antigena koji sadrži prvu antigen-vežuću domenu koja specifično veže humani CD3, i drugu antigen vežuću domenu koja specifično veže humani MUC16, pri čemu druga antigen-vežuća domena sadrži domene HCDRI-HCDR2-HCDR3-LCDRI-LCDR2-LCDR3, tim redom, koje sadrže aminokiselinske nizove SEQ ID NOs: 20-22-24-28-30-32.
2. Bispecifično antitijelo ili fragment za vezanje antigena prema zahtjevu 1, koji sadrži varijabilnu regiju teškog lanca koja sadrži aminokiselinski niz SEQ ID NO: 18, i varijabilnu regiju lakog lanca koja sadrži aminokiselinski niz SEQ ID NO: 26.
3. Bispecifično antitijelo ili fragment za vezanje antigena prema zahtjevu 1 ili 2, gdje prva domena za vezanje antigena koja specifično veže humani CD3 sadrži domene HCDRI-HCDR2-HCDR3-LCDRI-LCDR2-LCDR3, tim redom, koje sadrže aminokiselinske nizove koji su odabrani iz grupe koja obuhvaća SEQ ID NOs: 1732-1734-1736-28-30-32, 1764-1766-1768-28-30-32, 1780-1782-1784-28-30-32, 1788-1790-1792-28-30-32, i 1868-1870-1872-28-30-32.
4. Bispecifično antitijelo ili fragment za vezanje antigena prema zahtjevu 3, gdje prva domena za vezanje antigena koja veže humani CD3 sadrži varijabilnu regiju teškog lanca (HCVR) koja sadrži aminokiselinski niz koji je odabran iz grupe koja se sastoji iz SEQ ID NOs: 1730, 1762, 1778, 1786, i 1866, i varijabilna regija lakog lanca (LCVR) koja sadrži aminokiselinski niz SEQ ID NO: 26.
5. Bispecifično antitijelo ili fragment za vezanje antigena prema zahtjevu 3, gdje prva domena za vezanje antigena sadrži domene HCDRI-HCDR2-HCDR3-LCDRI-LCDR2-LCDR3, tim redom, koji sadrže aminokiselinske sekvence SEQ ID NOs: 1732-1734-1736-28-30-32 i druga domena za vezanje antigena sadrži domene HCDR1-HCDR2-HCDR3-LCDR1-LCDR2-LCDR3, tim redom, koji sadrže aminokiselinske sekvence SEQ ID NOs: 20-22-24-28-30-32.
6. Bispecifično antitijelo ili fragment za vezanje antigena prema zahtjevu 3, gdje prva domena za vezanje antigena sadrži domene HCDRI-HCDR2-HCDR3-LCDRI-LCDR2-LCDR3, tim redom, koje sadrže aminokiselinske nizove SEQ ID NOs: 1868-1870-1872-28-30-32 i druge domene za vezanje antigena sadrže domene HCDR1-HCDR2-HCDR3-LCDR1-LCDR2-LCDR3, tim redom, koje sadrže aminokiselinske nizove SEQ ID NOs: 20-22-24-28-30-32.
7. Bispecifično antitijelo prema zahtjevu 5, gdje prva domena za vezanje antigena sadrži HCVR koja sadrži aminokiselinski niz SEQ ID NO: 1730 i LCVR koji sadrži aminokiselinski niz SEQ ID NO: 26, i gdje druga domena za vezanje antigena sadrži HCVR koji sadrži aminokiselinski niz SEQ ID NO: 18 i LCVR koji sadrži aminokiselinski niz SEQ ID NO: 26.
8. Bispecifično antitijelo prema zahtjevu 6, gdje prva domena za vezanje antigena sadrži HCVR koja sadrži aminokiselinski niz SEQ ID NO: 1866 i LCVR koji sadrži aminokiselinski niz SEQ ID NO: 26, i gdje druga domena za vezanje antigena sadrži HCVR koji sadrži aminokiselinski niz SEQ ID NO: 18 i LCVR koji sadrži aminokiselinski niz SEQ ID NO: 26.
9. Bispecifično antitijelo prema zahtjevu 7, koje sadrži prvi vezujući krak koji sadrži težak lanac koji sadrži aminokiselinski niz SEQ ID NO: 1961 i laki lanac koji sadrži aminokiselinski niz SEQ ID NO: 1960, i drugi vezujući krak koji sadrži težak lanac koji sadrži aminokiselinski niz SEQ ID NO: 1959 i laki lanac koji sadrži aminokiselinski niz SEQ ID NO: 1960.
10. Bispecifično antitijelo prema zahtjevu 8, koje sadrži prvi vezujući krak koji sadrži težak lanac koji sadrži aminokiselinski niz SEQ ID NO: 1962 i laki lanac koji sadrži aminokiselinski niz SEQ ID NO: 1960, i drugi vezujući krak koji sadrži težak lanac koji sadrži aminokiselinski niz SEQ ID NO: 1959 i laki lanac koji sadrži aminokiselinski niz SEQ ID NO: 1960.
11. Farmacetuski sastav koji sadrži bispecifično antitijelo ili fragment za vezanje antigena prema bilo kojem od zahtjeva 1-10, i farmaceutski prihvatljiv nosač ili razrjeđivač.
12. Bispecifično antitijelo ili fragment za vezanje antigena prema bilo kojem od zahtjeva 1-10, ili farmaceutski sastav prema zahtjevu 11, za upotrebu u postupku liječenja raka koji eksprimira MUC16.
13. Bispecifično antitijelo ili fragment za vezanje antigena, ili farmaceutski sastav, za upotrebu prema zahtjevu 12, pri čemu je rak odabran iz grupe koja se sastoji iz raka jajnika, raka dojke, raka pankreasa, raka nemalih ćelija pluća, intrahepatičnog holangiokarcinoma-tip koji obrazuje masu, adenokarcinoma cerviksa maternice, i adenokarcinoma želučanog trakta.
14. Bispecifično antitijelo ili fragment za vezanje antigena, ili farmaceutski sastav, za upotrebu prema zahtjevu 12, gdje je rak rak jajnika.
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Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI682941B (zh) 2013-02-01 2020-01-21 美商再生元醫藥公司 含嵌合恆定區之抗體
AU2016242866B2 (en) 2015-03-30 2021-06-03 Regeneron Pharmaceuticals, Inc. Heavy chain constant regions with reduced binding to FC gamma receptors
TWI829617B (zh) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Ｆｌｔ３及ｃｄ３抗體構築體
TWI796283B (zh) 2015-07-31 2023-03-21 德商安美基研究（慕尼黑）公司 Ｍｓｌｎ及ｃｄ３抗體構築體
TWI784917B (zh) * 2015-09-23 2022-11-21 美商再生元醫藥公司 最優化抗ｃｄ３雙特異性抗體及其用途
US11583593B2 (en) 2016-01-14 2023-02-21 Synthis Therapeutics, Inc. Antibody-ALK5 inhibitor conjugates and their uses
EA039859B1 (ru) 2016-02-03 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
HRP20221202T1 (hr) 2016-09-23 2022-12-09 Regeneron Pharmaceuticals, Inc. Anti-muc16 (mucin 16) antitijela
SG11201907208XA (en) * 2017-02-10 2019-09-27 Regeneron Pharma Radiolabeled anti-lag3 antibodies for immuno-pet imaging
RU2747095C2 (ru) * 2018-05-11 2021-04-26 Федеральное государственное бюджетное учреждение "Российский научный центр рентгенорадиологии" Министерства здравоохранения российской федерации (ФГБУ "РНЦРР" Минздрава России) Мономолекулярный химерный т-клеточный рецептор к раковому антигену са125
CN108659131B (zh) * 2018-05-28 2021-09-14 长春力太生物技术有限公司 一种抗ceacam-5的单域抗体及其应用
SG11202012729YA (en) 2018-06-21 2021-01-28 Regeneron Pharma Bispecific anti-psma x anti-cd28 antibodies and uses thereof
TW202005985A (zh) * 2018-06-21 2020-02-01 美商再生元醫藥公司 用雙特異性抗ＣＤ３ｘＭＵＣ１６抗體及抗ＰＤ－１抗體治療癌症的方法
TWI838389B (zh) * 2018-07-19 2024-04-11 美商再生元醫藥公司 雙特異性抗-BCMAｘ抗-CD3抗體及其用途
EA202190601A1 (ru) 2018-08-23 2021-07-14 Ридженерон Фармасьютикалз, Инк. АНТИТЕЛА АНТИ-Fc ЭПСИЛОН-R1 АЛЬФА (FCER1A), БИСПЕЦИФИЧЕСКИЕ АНТИГЕНСВЯЗЫВАЮЩИЕ МОЛЕКУЛЫ, СВЯЗЫВАЮЩИЕ FCΕR1Α И CD3, И ИХ ПРИМЕНЕНИЕ
MA53495A (fr) 2018-08-31 2021-12-08 Regeneron Pharma Stratégie de dosage permettant d'atténuer le syndrome de libération de cytokines pour des anticorps bispécifiques cd3/c20
SG11202103628PA (en) 2018-10-31 2021-05-28 Regeneron Pharma Method and system of identifying and quantifying a protein
BR112021009373A2 (pt) * 2018-11-16 2021-08-17 Memorial Sloan Kettering Cancer Center anticorpos para mucina-16 e métodos de uso dos mesmos
US11249089B2 (en) 2018-12-12 2022-02-15 Regeneron Pharmaceuticals, Inc. System and method of analysis of a protein using liquid chromatography-mass spectrometry
WO2020132066A1 (en) 2018-12-19 2020-06-25 Regeneron Pharmaceuticals, Inc. Bispecific anti-cd28 x anti-cd22 antibodies and uses thereof
BR112021010457A2 (pt) * 2018-12-19 2021-08-24 Regeneron Pharmaceuticals, Inc. Anticorpos biespecíficos anti-muc16 x anti cd28 e usos dos mesmos
EA202192566A1 (ru) 2019-03-22 2021-12-27 Ридженерон Фармасьютикалз, Инк. МУЛЬТИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА К EGFRxCD28
WO2020256721A1 (en) * 2019-06-19 2020-12-24 Synthis, Llc Antib0dy-alk5 inhibitor conjugates and their uses
KR20220024035A (ko) 2019-06-21 2022-03-03 리제너론 파마슈티칼스 인코포레이티드 Muc16 및 cd3에 결합하는 이중 특이적 항원 결합 분자와 4-1bb 공동 자극의 병용
CN114401988A (zh) * 2019-07-09 2022-04-26 国家生物技术研究所公司 具有降低的免疫原性的抗体
WO2021030680A1 (en) * 2019-08-15 2021-02-18 Regeneron Pharmaceuticals, Inc. Multispecific antigen-binding molecules for cell targeting and uses thereof
CN112969715B (zh) * 2019-08-21 2022-03-18 和铂医药(上海)有限责任公司 一种抗cd47抗原结合蛋白及其应用
US11814428B2 (en) * 2019-09-19 2023-11-14 Regeneron Pharmaceuticals, Inc. Anti-PTCRA antibody-drug conjugates and uses thereof
CN114929343A (zh) * 2019-12-06 2022-08-19 瑞泽恩制药公司 用双特异性抗BCMA x抗CD3抗体治疗多发性骨髓瘤的方法
WO2021112925A1 (en) 2019-12-06 2021-06-10 Regeneron Pharmaceuticals, Inc. Anti-vegf protein compositions and methods for producing the same
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
AU2021268026A1 (en) 2020-05-08 2023-01-19 Regeneron Pharmaceuticals, Inc. VEGF traps and mini-traps and methods for treating ocular disorders and cancer
WO2022165171A1 (en) 2021-01-28 2022-08-04 Regeneron Pharmaceuticals, Inc. Compositions and methods for treating cytokine release syndrome
TW202304507A (zh) * 2021-04-02 2023-02-01 美商再生元醫藥公司 含有抗ｍｕｃ１６ｘ抗ｃｄ３雙特異性抗體之穩定調配物
JP2024523033A (ja) 2021-06-17 2024-06-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の三重特異的結合分子
US20230235089A1 (en) 2021-11-24 2023-07-27 Regeneron Pharmaceuticals, Inc. Methods for Treating Cancer with Bispecific Anti-CD3 x MUC16 Antibodies and Anti-CTLA-4 Antibodies
KR20240130137A (ko) 2022-01-07 2024-08-28 리제너론 파아마슈티컬스, 인크. 이중특이적 항-MUC16 x 항-CD3 항체 단독으로 또는 항-PD-1 항체와의 조합으로 재발성 난소암을 치료하는 방법
TW202334234A (zh) * 2022-01-10 2023-09-01 大陸商南京維立志博生物科技有限公司 一種抗體及其用途
IL314076A (en) * 2022-01-10 2024-09-01 Regeneron Pharma MUC16 chimeric antigen receptors
AU2023236126A1 (en) 2022-03-17 2024-09-19 Regeneron Pharmaceuticals, Inc. Methods of treating recurrent epithelioid sarcoma with bispecific anti-muc16 x anti-cd3 antibodies alone or in combination with anti-pd-1 antibodies
US20230357446A1 (en) 2022-04-11 2023-11-09 Regeneron Pharmaceuticals, Inc. Compositions and methods for universal tumor cell killing
WO2024051752A1 (en) * 2022-09-06 2024-03-14 I-Mab Biopharma Co., Ltd. Multispecific constructs and uses thereof
WO2024123698A1 (en) 2022-12-08 2024-06-13 Regeneron Pharmaceuticals, Inc. Methods to characterizing a fragment crystallizable domain of a bispecific antibody
WO2024173830A2 (en) 2023-02-17 2024-08-22 Regeneron Pharmaceuticals, Inc. Induced nk cells responsive to cd3/taa bispecific antibodies
WO2024191983A1 (en) 2023-03-13 2024-09-19 Regeneron Pharmaceuticals, Inc. Methods of treating cancer with bispecific anti-cd22 x anti-cd28 molecules
CN117024596B (zh) * 2023-08-18 2024-02-27 镜像绮点(上海)细胞技术有限公司 肿瘤原代细胞特异性标记与活体成像

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US20070258987A1 (en) 2000-11-28 2007-11-08 Seattle Genetics, Inc. Recombinant Anti-Cd30 Antibodies and Uses Thereof
AU2002254615A1 (en) * 2001-04-17 2002-10-28 The Board Of Trustees Of The University Of Arkansas Repeat sequences of the ca125 gene and their use for diagnostic and therapeutic interventions
EP1318402B1 (de) 2001-12-04 2005-04-20 B.R.A.H.M.S Aktiengesellschaft Verfahren zur Diagnose von Sepsis unter Bestimmung von CA 125
ES2535742T3 (es) 2002-10-16 2015-05-14 Purdue Pharma L.P. Anticuerpos que se unen a CA 125/0722P asociado a células y métodos de uso de los mismos
CA2523716C (en) 2003-05-31 2014-11-25 Micromet Ag Human anti-human cd3 binding molecules
AU2005216251B2 (en) 2004-02-23 2011-03-10 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
TW200539855A (en) 2004-03-15 2005-12-16 Wyeth Corp Calicheamicin conjugates
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
RS52176B (en) 2006-06-02 2012-08-31 Regeneron Pharmaceuticals Inc. HIGH AFINITY ANTIBODIES TO THE HUMAN IL-6 RECEPTOR
RU2448979C2 (ru) 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
WO2008122039A2 (en) 2007-04-02 2008-10-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selenocysteine mediated hybrid antibody molecules
PE20090245A1 (es) * 2007-05-08 2009-03-17 Genentech Inc Anticuerpos anti-muc16 disenados con cisteina y conjugados de anticuerpos y farmacos
EP3561513A1 (en) 2007-05-23 2019-10-30 Ventana Medical Systems, Inc. Polymeric carriers for immunohistochemistry and in situ hybridization
US8187801B2 (en) * 2008-04-24 2012-05-29 Wisconsin Alumni Research Foundation Methods and kits to detect and monitor ovarian cancer and preeclampsia
SG189817A1 (en) 2008-04-30 2013-05-31 Immunogen Inc Potent conjugates and hydrophilic linkers
PL2326349T3 (pl) 2008-07-21 2015-08-31 Polytherics Ltd Nowe reagenty i sposób sprzęgania cząsteczek biologicznych
DK2975051T3 (da) 2009-06-26 2021-04-26 Regeneron Pharma Let-at-isolere bispecifikke antistoffer med nativt immunoglobulinformat
JO3182B1 (ar) 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
WO2011018611A1 (en) 2009-08-10 2011-02-17 Ucl Business Plc Reversible covalent linkage of functional molecules
RS59001B1 (sr) 2010-02-08 2019-08-30 Regeneron Pharma Miš sa zajedničkim lakim lancem
CA3002192C (en) * 2010-03-26 2023-03-07 Memorial Sloan-Kettering Cancer Center Antibodies to muc16 and methods of use thereof
MX2012011901A (es) 2010-04-15 2012-11-29 Spirogen Sarl Pirrolobenzodiacepinas y conjugados de las mismas.
WO2012005982A2 (en) 2010-07-06 2012-01-12 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Reporter for rna polymerase ii termination
EP2642979A4 (en) * 2010-11-26 2014-09-17 Univ Witwatersrand Jhb PHARMACEUTICAL COMPOSITION
US20150080559A1 (en) 2011-05-27 2015-03-19 Ambrx, Inc. Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acid Linked Dolastatin Derivatives
US8815226B2 (en) 2011-06-10 2014-08-26 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
KR101891859B1 (ko) 2011-10-14 2018-08-24 메디뮨 리미티드 피롤로벤조디아제핀
CA2850373C (en) 2011-10-14 2019-07-16 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
BR112014009070B1 (pt) 2011-10-14 2021-11-23 Medimmune Limited Método de síntese e intermediários úteis na preparação de pirrolobenzo-diazepinas
EA036202B1 (ru) 2011-10-14 2020-10-14 Сиэтл Дженетикс, Инк. Пирролбензодиазепины и конъюгаты направленного действия
WO2013068874A1 (en) 2011-11-11 2013-05-16 Pfizer Inc. Antibody-drug conjugates
IN2014CN04961A (hr) 2011-12-05 2015-09-18 Igenica Biotherapeutics Inc
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
TWI682941B (zh) 2013-02-01 2020-01-21 美商再生元醫藥公司 含嵌合恆定區之抗體
KR102306490B1 (ko) 2013-03-15 2021-09-28 리제너론 파아마슈티컬스, 인크. 생물학적 활성 분자, 그의 접합체 및 치료 용도
CA2921412C (en) 2013-08-26 2024-05-28 Regeneron Pharmaceuticals, Inc. Pharmaceutical compositions comprising macrolide diastereomers, methods of their synthesis and therapeutic uses
LT3083689T (lt) * 2013-12-17 2020-08-10 Genentech, Inc. Anti-cd3 antikūnai ir jų panaudojimo būdai
TWI754319B (zh) * 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
RU2758113C2 (ru) * 2015-03-17 2021-10-26 Мемориал Слоан-Кеттеринг Кэнсер Сентер Антитела к muc16 и их применение
MX2017012380A (es) 2015-03-27 2018-04-11 Regeneron Pharma Derivados de maitansinoide, conjugados de los mismos, y metodos de uso.
TWI784917B (zh) * 2015-09-23 2022-11-21 美商再生元醫藥公司 最優化抗ｃｄ３雙特異性抗體及其用途
HRP20221202T1 (hr) 2016-09-23 2022-12-09 Regeneron Pharmaceuticals, Inc. Anti-muc16 (mucin 16) antitijela

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