SG11202012729YA - Bispecific anti-psma x anti-cd28 antibodies and uses thereof - Google Patents

Bispecific anti-psma x anti-cd28 antibodies and uses thereof

Info

Publication number
SG11202012729YA
SG11202012729YA SG11202012729YA SG11202012729YA SG11202012729YA SG 11202012729Y A SG11202012729Y A SG 11202012729YA SG 11202012729Y A SG11202012729Y A SG 11202012729YA SG 11202012729Y A SG11202012729Y A SG 11202012729YA SG 11202012729Y A SG11202012729Y A SG 11202012729YA
Authority
SG
Singapore
Prior art keywords
psma
antibodies
bispecific
bispecific anti
Prior art date
Application number
SG11202012729YA
Inventor
Andrew Murphy
Dimitris Skokos
Janelle Waite
Erica Ullman
Aynur Hermann
Eric Smith
Lauric Haber
George Yancopoulos
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11202012729YA publication Critical patent/SG11202012729YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
SG11202012729YA 2018-06-21 2019-06-21 Bispecific anti-psma x anti-cd28 antibodies and uses thereof SG11202012729YA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862688227P 2018-06-21 2018-06-21
US201862781930P 2018-12-19 2018-12-19
US201862781980P 2018-12-19 2018-12-19
US201962815878P 2019-03-08 2019-03-08
PCT/US2019/038460 WO2019246514A1 (en) 2018-06-21 2019-06-21 Bispecific anti-psma x anti-cd28 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
SG11202012729YA true SG11202012729YA (en) 2021-01-28

Family

ID=67297279

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202012729YA SG11202012729YA (en) 2018-06-21 2019-06-21 Bispecific anti-psma x anti-cd28 antibodies and uses thereof

Country Status (15)

Country Link
US (3) US11548947B2 (en)
EP (1) EP3810282A1 (en)
JP (1) JP2021527431A (en)
KR (1) KR20210023982A (en)
CN (1) CN112351820A (en)
AU (1) AU2019290198A1 (en)
BR (1) BR112020025926A2 (en)
CA (1) CA3104098A1 (en)
CL (1) CL2020003285A1 (en)
IL (1) IL279354A (en)
MA (1) MA52970A (en)
MX (1) MX2020013804A (en)
PH (1) PH12020552116A1 (en)
SG (1) SG11202012729YA (en)
WO (1) WO2019246514A1 (en)

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JP2016535013A (en) 2013-10-18 2016-11-10 ドイチェス クレブスフォルシュンクスツェントルム Labeled inhibitor of prostate specific membrane antigen (PSMA), imaging agent for the treatment of prostate cancer and its use as a medicament
US20230098279A1 (en) * 2020-02-18 2023-03-30 Endocyte, Inc. Method of treating psma-expressing cancers
KR102607909B1 (en) 2020-08-19 2023-12-01 젠코어 인코포레이티드 Anti-CD28 composition
CA3194771A1 (en) 2020-09-16 2022-03-24 Amgen Inc. Methods for administering therapeutic doses of bispecific t-cell engaging molecules for the treatment of cancer
IL301037A (en) * 2020-09-18 2023-05-01 Regeneron Pharma Antigen-binding molecules that bind cd38 and/or cd28, and uses thereof
JP2023547507A (en) * 2020-11-03 2023-11-10 ドイチェス クレブスフォルシュンクスツェントルム スチフトゥング デス エッフェントリヒェン レヒツ Target cell-restricted and co-stimulatory bispecific and bivalent anti-CD28 antibody
TW202242121A (en) 2021-01-11 2022-11-01 美商薩那生物科技公司 Use of cd8-targeted viral vectors
EP4320156A1 (en) 2021-04-09 2024-02-14 Ose Immunotherapeutics Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains
TW202321457A (en) 2021-08-04 2023-06-01 美商薩那生物科技公司 Use of cd4-targeted viral vectors
WO2023150518A1 (en) 2022-02-01 2023-08-10 Sana Biotechnology, Inc. Cd3-targeted lentiviral vectors and uses thereof
WO2023164510A1 (en) * 2022-02-23 2023-08-31 Xencor, Inc. Anti-cd28 x anti-psma antibodies
WO2023170474A1 (en) 2022-03-07 2023-09-14 Novimmune Sa Cd28 bispecific antibodies for targeted t cell activation
US20230287146A1 (en) 2022-03-14 2023-09-14 LamKap Bio gamma AG BISPECIFIC GPC3xCD28 AND GPC3xCD3 ANTIBODIES AND THEIR COMBINATION FOR TARGETED KILLING OF GPC3 POSITIVE MALIGNANT CELLS
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
WO2023193239A1 (en) 2022-04-08 2023-10-12 Peter Peizhi Luo Anti-cd28 antibodies and methods of use thereof
TW202405015A (en) * 2022-04-11 2024-02-01 大陸商江蘇恆瑞醫藥股份有限公司 Antigen-binding molecules specifically binding to psma and cd28 and their pharmaceutical uses
WO2024018069A1 (en) 2022-07-22 2024-01-25 Philogen S.P.A Anti-cd28 antibodies
WO2024026377A1 (en) 2022-07-27 2024-02-01 Sana Biotechnology, Inc. Methods of transduction using a viral vector and inhibitors of antiviral restriction factors
WO2024030453A1 (en) 2022-08-02 2024-02-08 Regeneron Pharmaceuticals, Inc. Methods of treating metastatic castration-resistant prostate cancer with bispecific anti-psma x anti-cd28 antibodies in combination with anti-pd-1 antibodies
WO2024040195A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
CN117844748A (en) * 2022-09-30 2024-04-09 北京昌平实验室 Identification, in vitro amplification and application method of tumor antigen specific memory CD8T cells
WO2024084052A1 (en) 2022-10-21 2024-04-25 Novimmune Sa Pd-l1xcd28 bispecific antibodies for immune checkpoint-dependent t cell activation

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IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
LU91067I2 (en) 1991-06-14 2004-04-02 Genentech Inc Trastuzumab and its variants and immunochemical derivatives including immotoxins
US7235641B2 (en) * 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
EP1740946B1 (en) 2004-04-20 2013-11-06 Genmab A/S Human monoclonal antibodies against cd20
CA2598522A1 (en) * 2005-02-18 2006-08-24 Medarex, Inc. Human monoclonal antibodies to prostate specific membrane antigen (psma)
ATE537190T1 (en) 2006-06-02 2011-12-15 Regeneron Pharma HIGH AFFINE ANTIBODIES AGAINST THE HUMAN IL-6 RECEPTOR
ES2603559T5 (en) 2010-02-08 2021-02-22 Regeneron Pharma Mouse common light chain
US20150203591A1 (en) 2012-08-02 2015-07-23 Regeneron Pharmaceuticals, Inc. Mutivalent antigen-binding proteins
JOP20200236A1 (en) 2012-09-21 2017-06-16 Regeneron Pharma Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
TWI681969B (en) 2014-01-23 2020-01-11 美商再生元醫藥公司 Human antibodies to pd-1
JOP20160154B1 (en) * 2015-07-31 2021-08-17 Regeneron Pharma Anti-psma antibodies, bispecific antigen-binding molecules that bind psma and cd3, and uses thereof
HRP20220133T8 (en) 2015-09-23 2022-05-13 Regeneron Pharmaceuticals, Inc. Optimized anti-cd3 bispecific antibodies and uses thereof
EP3192810A1 (en) * 2016-01-14 2017-07-19 Deutsches Krebsforschungszentrum Psma binding antibody and uses thereof
EP3484516A4 (en) * 2016-07-14 2020-03-18 Fred Hutchinson Cancer Research Center Multiple bi-specific binding domain constructs with different epitope binding to treat cancer
PT3515487T (en) 2016-09-23 2023-08-24 Regeneron Pharma Bi specific anti-muc16-cd3 antibodies and anti-muc16 drug conjugates
KR102520731B1 (en) 2016-09-23 2023-04-14 리제너론 파아마슈티컬스, 인크. Anti-STEAP2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind to STEAP2 and CD3, and uses thereof
US20220185910A1 (en) * 2018-06-18 2022-06-16 Eureka Therapeutics, Inc. Constructs targeting prostate-specific membrane antigen (psma) and uses thereof
EA202191580A1 (en) * 2018-12-19 2021-11-01 Ридженерон Фармасьютикалз, Инк. SPECIFIC ANTI-CD28 X ANTI-CD22 ANTI-BODIES AND THEIR APPLICATION
SG11202105948TA (en) * 2018-12-19 2021-07-29 Regeneron Pharma Bispecific anti-muc16 x anti-cd28 antibodies and uses thereof
MX2021011500A (en) * 2019-03-22 2021-10-22 Regeneron Pharma EGFR x CD28 MULTISPECIFIC ANTIBODIES.
IL301037A (en) * 2020-09-18 2023-05-01 Regeneron Pharma Antigen-binding molecules that bind cd38 and/or cd28, and uses thereof

Also Published As

Publication number Publication date
CA3104098A1 (en) 2019-12-26
US11548947B2 (en) 2023-01-10
BR112020025926A2 (en) 2021-03-23
IL279354A (en) 2021-01-31
US20190389951A1 (en) 2019-12-26
PH12020552116A1 (en) 2021-07-19
KR20210023982A (en) 2021-03-04
US20230303696A1 (en) 2023-09-28
US20230272078A1 (en) 2023-08-31
WO2019246514A1 (en) 2019-12-26
EP3810282A1 (en) 2021-04-28
JP2021527431A (en) 2021-10-14
CN112351820A (en) 2021-02-09
MX2020013804A (en) 2021-03-31
AU2019290198A1 (en) 2021-01-14
CL2020003285A1 (en) 2021-05-28
MA52970A (en) 2021-04-28

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