HRP20201785T1 - Multivalentni i multispecifični fuzijski proteini koji vežu dr5 - Google Patents

Multivalentni i multispecifični fuzijski proteini koji vežu dr5 Download PDF

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Publication number
HRP20201785T1
HRP20201785T1 HRP20201785TT HRP20201785T HRP20201785T1 HR P20201785 T1 HRP20201785 T1 HR P20201785T1 HR P20201785T T HRP20201785T T HR P20201785TT HR P20201785 T HRP20201785 T HR P20201785T HR P20201785 T1 HRP20201785 T1 HR P20201785T1
Authority
HR
Croatia
Prior art keywords
polypeptide
isolated polypeptide
dr5bd
polypeptide according
seq
Prior art date
Application number
HRP20201785TT
Other languages
English (en)
Croatian (hr)
Inventor
John C. Timmer
Kyle S. JONES
Amir S. RAZAI
Abrahim HUSSAIN
Katelyn M. WILLIS
Quinn Deveraux
Brendan P. Eckelman
Original Assignee
Inhibrx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhibrx, Inc. filed Critical Inhibrx, Inc.
Publication of HRP20201785T1 publication Critical patent/HRP20201785T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001136—Cytokines
    • A61K39/001138—Tumor necrosis factors [TNF] or CD70
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HRP20201785TT 2015-07-16 2016-07-18 Multivalentni i multispecifični fuzijski proteini koji vežu dr5 HRP20201785T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562193309P 2015-07-16 2015-07-16
PCT/US2016/042862 WO2017011837A2 (en) 2015-07-16 2016-07-18 Multivalent and multispecific dr5-binding fusion proteins
EP16825315.1A EP3322734B1 (en) 2015-07-16 2016-07-18 Multivalent and multispecific dr5-binding fusion proteins

Publications (1)

Publication Number Publication Date
HRP20201785T1 true HRP20201785T1 (hr) 2021-01-22

Family

ID=57757772

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20201785TT HRP20201785T1 (hr) 2015-07-16 2016-07-18 Multivalentni i multispecifični fuzijski proteini koji vežu dr5

Country Status (25)

Country Link
US (4) US10308720B2 (enExample)
EP (2) EP3322734B1 (enExample)
JP (4) JP6807606B2 (enExample)
KR (2) KR20250017305A (enExample)
CN (2) CN107922491B (enExample)
AU (2) AU2016291701B2 (enExample)
CA (1) CA2991634A1 (enExample)
CY (1) CY1123615T1 (enExample)
DK (1) DK3322734T3 (enExample)
ES (1) ES2833773T3 (enExample)
HR (1) HRP20201785T1 (enExample)
HU (1) HUE051896T2 (enExample)
IL (3) IL307994A (enExample)
LT (1) LT3322734T (enExample)
MX (2) MX2018000523A (enExample)
NZ (1) NZ777930A (enExample)
PL (1) PL3322734T3 (enExample)
PT (1) PT3322734T (enExample)
RS (1) RS61062B1 (enExample)
RU (2) RU2748620C2 (enExample)
SG (1) SG10201912410TA (enExample)
SI (1) SI3322734T1 (enExample)
SM (1) SMT202100066T1 (enExample)
WO (1) WO2017011837A2 (enExample)
ZA (1) ZA201800238B (enExample)

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IL316085A (en) * 2022-04-08 2024-12-01 Inhibrx Biosciences Inc Dr5 agonist and plk1 inhibitor or cdk inhibitor combination therapy
US20250302948A1 (en) * 2022-05-23 2025-10-02 Inhibrx Biosciences, Inc. DR5 Agonist and IAP Antagonist Combination Therapy
CN117285644A (zh) * 2022-06-16 2023-12-26 清华大学 一种相变调节元件及其用途
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Publication number Publication date
JP2023022214A (ja) 2023-02-14
US20240376220A1 (en) 2024-11-14
AU2016291701B2 (en) 2022-09-29
AU2016291701A1 (en) 2018-01-25
PT3322734T (pt) 2020-11-30
EP3322734A2 (en) 2018-05-23
ES2833773T3 (es) 2021-06-15
IL307994A (en) 2023-12-01
JP2025084923A (ja) 2025-06-03
MX2018000523A (es) 2018-04-13
US11976126B2 (en) 2024-05-07
CN114106178A (zh) 2022-03-01
KR20250017305A (ko) 2025-02-04
CA2991634A1 (en) 2017-01-19
MX2023002379A (es) 2023-03-21
CN107922491B (zh) 2021-09-28
KR102760380B1 (ko) 2025-01-31
HK1254433A1 (en) 2019-07-19
RU2018102803A3 (enExample) 2019-12-27
JP6807606B2 (ja) 2021-01-06
DK3322734T3 (da) 2020-10-26
US20220064318A1 (en) 2022-03-03
IL256772A (en) 2018-03-29
NZ777930A (en) 2025-05-02
PL3322734T3 (pl) 2021-05-04
RU2748620C2 (ru) 2021-05-28
CN107922491A (zh) 2018-04-17
RU2021111382A (ru) 2021-05-21
KR20180030518A (ko) 2018-03-23
LT3322734T (lt) 2021-02-10
US11117973B2 (en) 2021-09-14
WO2017011837A2 (en) 2017-01-19
US20190309083A1 (en) 2019-10-10
ZA201800238B (en) 2021-07-28
EP3322734A4 (en) 2019-04-17
SMT202100066T1 (it) 2021-03-15
SG10201912410TA (en) 2020-02-27
SI3322734T1 (sl) 2021-02-26
US20170015753A1 (en) 2017-01-19
EP3322734B1 (en) 2020-09-09
HUE051896T2 (hu) 2021-03-29
US10308720B2 (en) 2019-06-04
JP2018522888A (ja) 2018-08-16
BR112018000584A2 (pt) 2018-09-11
IL292037A (en) 2022-06-01
WO2017011837A3 (en) 2017-03-02
JP7244938B2 (ja) 2023-03-23
RU2018102803A (ru) 2019-08-19
RS61062B1 (sr) 2020-12-31
AU2022291498A1 (en) 2023-02-02
EP3798232A1 (en) 2021-03-31
NZ738850A (en) 2024-11-29
CY1123615T1 (el) 2022-03-24
IL256772B (en) 2022-05-01
JP2021046414A (ja) 2021-03-25

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