JP2018520650A5 - - Google Patents
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- Publication number
- JP2018520650A5 JP2018520650A5 JP2017560535A JP2017560535A JP2018520650A5 JP 2018520650 A5 JP2018520650 A5 JP 2018520650A5 JP 2017560535 A JP2017560535 A JP 2017560535A JP 2017560535 A JP2017560535 A JP 2017560535A JP 2018520650 A5 JP2018520650 A5 JP 2018520650A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- cancer
- specific
- bispecific
- polypeptide according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022077013A JP7419434B2 (ja) | 2015-05-21 | 2022-05-09 | 新規のポリペプチド |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1508729.9 | 2015-05-21 | ||
| GBGB1508729.9A GB201508729D0 (en) | 2015-05-21 | 2015-05-21 | Binding molecules |
| GB1514994.1 | 2015-08-24 | ||
| GBGB1514994.1A GB201514994D0 (en) | 2015-08-24 | 2015-08-24 | Bispecific polypeptide |
| GB1605450.4 | 2016-03-31 | ||
| GB201605450 | 2016-03-31 | ||
| PCT/EP2016/061420 WO2016185016A1 (en) | 2015-05-21 | 2016-05-20 | Novel polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022077013A Division JP7419434B2 (ja) | 2015-05-21 | 2022-05-09 | 新規のポリペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018520650A JP2018520650A (ja) | 2018-08-02 |
| JP2018520650A5 true JP2018520650A5 (enExample) | 2019-06-20 |
Family
ID=56026872
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560535A Pending JP2018520650A (ja) | 2015-05-21 | 2016-05-20 | 新規のポリペプチド |
| JP2022077013A Active JP7419434B2 (ja) | 2015-05-21 | 2022-05-09 | 新規のポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022077013A Active JP7419434B2 (ja) | 2015-05-21 | 2022-05-09 | 新規のポリペプチド |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11008396B2 (enExample) |
| EP (2) | EP3988577A1 (enExample) |
| JP (2) | JP2018520650A (enExample) |
| KR (1) | KR102712820B1 (enExample) |
| CN (2) | CN114181309B (enExample) |
| AU (1) | AU2016265447B2 (enExample) |
| BR (1) | BR112017024770A2 (enExample) |
| CA (1) | CA2986415A1 (enExample) |
| IL (1) | IL255767B2 (enExample) |
| MX (1) | MX2017014699A (enExample) |
| RU (1) | RU2017142008A (enExample) |
| WO (1) | WO2016185016A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2963268T3 (es) | 2015-07-31 | 2024-03-26 | Immunewalk Therapeutics Inc | Proteína 2 que contiene el dominio de esperma móvil e inflamación |
| GB201519481D0 (en) | 2015-11-04 | 2015-12-16 | Cancer Rec Tech Ltd | Immunomodulatory antibodies |
| US20190169308A1 (en) * | 2016-04-22 | 2019-06-06 | Alligator Bioscience Ab | Novel bispecific polypeptides against cd137 |
| JP7085708B2 (ja) | 2016-06-20 | 2022-06-17 | エフ－スター セラピューティクス リミテッド | Ｌａｇ－３結合要素 |
| PL3472207T3 (pl) | 2016-06-20 | 2021-07-12 | F-Star Delta Limited | Wiążące cząsteczki wiążące się z PD-L1 i LAG-3 |
| GB201611530D0 (en) * | 2016-07-01 | 2016-08-17 | Alligator Bioscience Ab | Novel polypeptides |
| EA201990293A1 (ru) | 2016-07-14 | 2019-07-31 | Генмаб А/С | Мультиспецифичные антитела против cd40 и cd137 |
| GB201612520D0 (en) | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
| UA127449C2 (uk) * | 2016-09-23 | 2023-08-30 | Мерус Н.В. | Зв'язувальна молекула, яка модулює біологічну активність, що експресується клітиною |
| GB201619652D0 (en) | 2016-11-21 | 2017-01-04 | Alligator Bioscience Ab | Novel polypeptides |
| GB201619648D0 (en) | 2016-11-21 | 2017-01-04 | Alligator Bioscience Ab | Novel antibodies and uses thereof |
| TWI734879B (zh) * | 2016-12-15 | 2021-08-01 | 美商艾伯維生物醫療股份有限公司 | 抗ox40抗體及其用途 |
| KR102585848B1 (ko) * | 2017-02-24 | 2023-10-11 | 마크로제닉스, 인크. | Cd137 및 종양 항원에 결합할 수 있는 이중특이적 결합 분자, 및 그것의 용도 |
| WO2018191502A2 (en) | 2017-04-13 | 2018-10-18 | Agenus Inc. | Anti-cd137 antibodies and methods of use thereof |
| CN110709421A (zh) * | 2017-05-02 | 2020-01-17 | 鳄鱼生物科学公司 | 针对ox40和ctla-4的双特异性抗体 |
| US11643463B2 (en) | 2017-05-19 | 2023-05-09 | Wuxi Biologics (Shanghai) Co., Ltd. | Monoclonal antibodies to cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) |
| CA3066774A1 (en) * | 2017-06-22 | 2018-12-27 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| KR20240147708A (ko) | 2017-07-11 | 2024-10-08 | 콤파스 테라퓨틱스 엘엘씨 | 인간 cd137에 결합하는 작동자 항체 및 이의 용도 |
| US11725060B2 (en) | 2017-07-20 | 2023-08-15 | Aptevo Reserch and Development LLC | Antigen binding proteins binding to 5T4 and 4-1BB and related compositions and methods |
| CN111511762B (zh) * | 2017-08-21 | 2025-05-06 | 天演药业公司 | 抗cd137分子及其用途 |
| WO2019089753A2 (en) | 2017-10-31 | 2019-05-09 | Compass Therapeutics Llc | Cd137 antibodies and pd-1 antagonists and uses thereof |
| EP3713961A2 (en) | 2017-11-20 | 2020-09-30 | Compass Therapeutics LLC | Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof |
| EP3728316B1 (en) | 2017-12-19 | 2025-02-26 | invoX Pharma Limited | Fc binding fragments comprising a pd-l1 antigen-binding site |
| WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
| JP2021517153A (ja) * | 2018-03-13 | 2021-07-15 | バスキュラー バイオジェニックス リミテッド | Ｍｏｓｐｄ２およびｔ細胞またはｎｋ細胞特異的分子に対する二重特異性抗体 電子出願された配列表の参照 |
| BR112020023026A2 (pt) | 2018-05-11 | 2021-02-09 | WuXi Biologics Ireland Limited | anticorpos completamente humanos contra ox40, método para a sua preparação e sua utilização |
| US12344672B2 (en) | 2018-07-12 | 2025-07-01 | Invox Pharma Limited | Antibody molecules that bind PD-L1 and CD137 |
| EP3820898B1 (en) * | 2018-07-12 | 2025-09-03 | invoX Pharma Limited | Antibody molecules that bind cd137 and ox40 |
| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
| GB201811415D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-Mesothelin Anti bodies |
| GB201811408D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | CD137 Binding Molecules |
| GB201811403D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Antibody molecules |
| GB201811450D0 (en) | 2018-07-12 | 2018-08-29 | F Star Delta Ltd | Mesothelin and CD137 binding molecules |
| CA3121168A1 (en) * | 2018-11-30 | 2020-06-04 | Memorial Sloan Kettering Cancer Center | Heterodimeric tetravalency and specificity antibody compositions and uses thereof |
| EP3898679A2 (en) * | 2018-12-17 | 2021-10-27 | Alligator Bioscience AB | Polypeptides |
| JP7680954B2 (ja) | 2018-12-26 | 2025-05-21 | シティ・オブ・ホープ | 活性化可能なマスクされた抗ｃｔｌａ４結合タンパク質 |
| CA3137373A1 (en) | 2019-04-24 | 2020-10-29 | Heidelberg Pharma Research Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
| WO2021030488A1 (en) | 2019-08-12 | 2021-02-18 | Bienvenue David Leonard | 4-1bb and ox40 binding proteins and related compositions and methods, antibodies against 4-1bb, antibodies against ox40 |
| CN114555638B (zh) * | 2019-10-11 | 2023-08-22 | 南京维立志博生物科技有限公司 | 结合4-1bb的抗体及其用途 |
| CN113045655A (zh) * | 2019-12-27 | 2021-06-29 | 高诚生物医药(香港)有限公司 | 抗ox40抗体及其用途 |
| IL294461A (en) | 2020-01-13 | 2022-09-01 | Aptevo Res & Development Llc | Methods and compositions for preventing adsorption of therapeutic proteins to drug delivery system components |
| EP4090367A1 (en) | 2020-01-13 | 2022-11-23 | T-Mobile USA, Inc. | Pattern recognition based on millimeter wave transmission in wireless communication networks |
| US12146000B2 (en) | 2020-05-19 | 2024-11-19 | Boehringer Ingelheim International Gmbh | Bispecific and tetravalent CD137 and FAP molecules for the treatment of cancer |
| US11697682B2 (en) | 2020-09-10 | 2023-07-11 | Vascular Biogenics Ltd. | Motile sperm domain containing protein 2 antibodies and methods of use thereof |
| CA3208339A1 (en) * | 2021-02-17 | 2022-08-25 | David Leonard BIENVENUE | Compositions comprising 4-1bb and ox40 binding proteins and methods of use |
| JP2024519964A (ja) | 2021-05-21 | 2024-05-21 | アプティーボ リサーチ アンド デベロップメント エルエルシー | タンパク質治療薬のための投薬レジメン |
| WO2023164510A1 (en) | 2022-02-23 | 2023-08-31 | Xencor, Inc. | Anti-cd28 x anti-psma antibodies |
| US12195546B2 (en) | 2022-12-19 | 2025-01-14 | Sanofi | CD28/OX40 bispecific antibodies |
| US20250043001A1 (en) * | 2023-03-14 | 2025-02-06 | Xencor, Inc. | Anti-cd28 compositions |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| KR100452954B1 (ko) * | 2002-02-26 | 2004-10-14 | 주식회사 엘지생명과학 | 가변영역 아미노산 치환을 통한 인간 4-1비비분자에 대한결합 특이성이 증가된 변형 인간화 항체의 제조방법 |
| JP2007523602A (ja) * | 2003-02-06 | 2007-08-23 | マイクロメット アクツィエン ゲゼルシャフト | 持続的なｔ細胞応答方法 |
| CN1894413A (zh) * | 2003-03-26 | 2007-01-10 | 特鲁比昂药品公司 | 识别cd3或4－1bb的抗体或基因介导的肿瘤反应性淋巴细胞活化 |
| AR046094A1 (es) * | 2003-10-10 | 2005-11-23 | Bristol Myers Squibb Co | Anticuerpos completamente humanos contra 4-1bb humano |
| US20070253961A1 (en) * | 2004-06-09 | 2007-11-01 | Ulsan Industrial Education Foundation | Pharmaceutical Composition Comprising the Anti-4-1Bb Antibody for Treating or Preventing Rheumatoid Arthritis |
| EP2399935A3 (en) | 2005-02-15 | 2012-02-22 | GTC Biotherapeutics, Inc. | An anti-CD137 antibody as an agent in the treatment of cancer and glycosylation variants thereof |
| CN101802015B (zh) | 2007-03-29 | 2015-05-06 | 根马布股份公司 | 双特异性抗体及其制造方法 |
| US7960515B2 (en) * | 2007-12-14 | 2011-06-14 | Bristol-Myers Squibb Company | Binding molecules to the human OX40 receptor |
| US9931386B2 (en) * | 2008-06-16 | 2018-04-03 | Atsuo Ochi | Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of antigen-specific immunity |
| PL2560993T3 (pl) | 2010-04-20 | 2024-11-04 | Genmab A/S | Heterodimeryczne białka zawierające region FC przeciwciała i sposoby ich wytwarzania |
| RU2551963C2 (ru) * | 2010-09-09 | 2015-06-10 | Пфайзер Инк. | Молекулы, связывающиеся с 4-1вв |
| WO2012145183A2 (en) | 2011-04-19 | 2012-10-26 | Pfizer Inc. | Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer |
| EP2900061B1 (en) * | 2012-09-17 | 2020-01-22 | Galectin Therapeutics Inc. | Method for enhancing specific immunotherapies in cancer treatment |
| GB201311475D0 (en) | 2013-06-27 | 2013-08-14 | Alligator Bioscience Ab | Polypeptides |
| GB201311487D0 (en) * | 2013-06-27 | 2013-08-14 | Alligator Bioscience Ab | Bispecific molecules |
| MX2016007965A (es) * | 2013-12-17 | 2016-10-28 | Genentech Inc | Terapia de combinacion que comprende agonistas de union a ox40 y antagonistas de union al eje pd-1. |
| US10233251B2 (en) * | 2015-02-22 | 2019-03-19 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind CD137 |
-
2016
- 2016-05-20 EP EP21202262.8A patent/EP3988577A1/en active Pending
- 2016-05-20 RU RU2017142008A patent/RU2017142008A/ru unknown
- 2016-05-20 CN CN202111495490.3A patent/CN114181309B/zh active Active
- 2016-05-20 KR KR1020177033709A patent/KR102712820B1/ko active Active
- 2016-05-20 CN CN201680028916.5A patent/CN107709367A/zh active Pending
- 2016-05-20 CA CA2986415A patent/CA2986415A1/en active Pending
- 2016-05-20 EP EP16724036.5A patent/EP3298045A1/en not_active Withdrawn
- 2016-05-20 IL IL255767A patent/IL255767B2/en unknown
- 2016-05-20 WO PCT/EP2016/061420 patent/WO2016185016A1/en not_active Ceased
- 2016-05-20 JP JP2017560535A patent/JP2018520650A/ja active Pending
- 2016-05-20 US US15/567,163 patent/US11008396B2/en not_active Expired - Fee Related
- 2016-05-20 MX MX2017014699A patent/MX2017014699A/es unknown
- 2016-05-20 BR BR112017024770A patent/BR112017024770A2/pt not_active IP Right Cessation
- 2016-05-20 AU AU2016265447A patent/AU2016265447B2/en active Active
-
2020
- 2020-02-03 US US16/780,401 patent/US10774150B2/en not_active Expired - Fee Related
-
2021
- 2021-04-13 US US17/229,130 patent/US11780928B2/en active Active
-
2022
- 2022-05-09 JP JP2022077013A patent/JP7419434B2/ja active Active
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