JP2018520650A5 - - Google Patents
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- Publication number
- JP2018520650A5 JP2018520650A5 JP2017560535A JP2017560535A JP2018520650A5 JP 2018520650 A5 JP2018520650 A5 JP 2018520650A5 JP 2017560535 A JP2017560535 A JP 2017560535A JP 2017560535 A JP2017560535 A JP 2017560535A JP 2018520650 A5 JP2018520650 A5 JP 2018520650A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- cancer
- specific
- bispecific
- polypeptide according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022077013A JP7419434B2 (ja) | 2015-05-21 | 2022-05-09 | 新規のポリペプチド |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1508729.9A GB201508729D0 (en) | 2015-05-21 | 2015-05-21 | Binding molecules |
| GB1508729.9 | 2015-05-21 | ||
| GB1514994.1 | 2015-08-24 | ||
| GBGB1514994.1A GB201514994D0 (en) | 2015-08-24 | 2015-08-24 | Bispecific polypeptide |
| GB1605450.4 | 2016-03-31 | ||
| GB201605450 | 2016-03-31 | ||
| PCT/EP2016/061420 WO2016185016A1 (en) | 2015-05-21 | 2016-05-20 | Novel polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022077013A Division JP7419434B2 (ja) | 2015-05-21 | 2022-05-09 | 新規のポリペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018520650A JP2018520650A (ja) | 2018-08-02 |
| JP2018520650A5 true JP2018520650A5 (enExample) | 2019-06-20 |
Family
ID=56026872
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560535A Pending JP2018520650A (ja) | 2015-05-21 | 2016-05-20 | 新規のポリペプチド |
| JP2022077013A Active JP7419434B2 (ja) | 2015-05-21 | 2022-05-09 | 新規のポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022077013A Active JP7419434B2 (ja) | 2015-05-21 | 2022-05-09 | 新規のポリペプチド |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11008396B2 (enExample) |
| EP (2) | EP3988577A1 (enExample) |
| JP (2) | JP2018520650A (enExample) |
| KR (1) | KR102712820B1 (enExample) |
| CN (2) | CN107709367A (enExample) |
| AU (1) | AU2016265447B2 (enExample) |
| BR (1) | BR112017024770A2 (enExample) |
| IL (1) | IL255767B2 (enExample) |
| MX (1) | MX2017014699A (enExample) |
| RU (1) | RU2017142008A (enExample) |
| WO (1) | WO2016185016A1 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2963268T3 (es) | 2015-07-31 | 2024-03-26 | Immunewalk Therapeutics Inc | Proteína 2 que contiene el dominio de esperma móvil e inflamación |
| GB201519481D0 (en) * | 2015-11-04 | 2015-12-16 | Cancer Rec Tech Ltd | Immunomodulatory antibodies |
| BR112018071612A2 (pt) | 2016-04-22 | 2019-02-19 | Alligator Bioscience Ab | polipeptídeos biespecíficos inovadores contra cd137 |
| SG11201811184UA (en) | 2016-06-20 | 2019-01-30 | F Star Beta Ltd | Lag -3 binding members |
| JP7085709B2 (ja) | 2016-06-20 | 2022-06-17 | エフ－スター セラピューティクス リミテッド | Ｐｄ－ｌ１及びｌａｇ－３に結合する結合分子 |
| US10052215B2 (en) | 2016-06-29 | 2018-08-21 | Globus Medical, Inc. | Expandable fusion device and method of installation thereof |
| US12544236B2 (en) | 2016-06-29 | 2026-02-10 | Globus Medical Inc. | Expandable fusion device and method of installation thereof |
| GB201611530D0 (en) * | 2016-07-01 | 2016-08-17 | Alligator Bioscience Ab | Novel polypeptides |
| BR112019000512A2 (pt) | 2016-07-14 | 2019-04-24 | Genmab A/S | anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, composição, métodos de tratamento de uma doença, para produzir um anticorpo biespecífico e para detectar se a reticulação entre as células que expressam cd40 e cd137 ocorre em uma amostra, uso de um anticorpo multiespecífico, e, kit |
| GB201612520D0 (en) | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
| EP3515951B1 (en) | 2016-09-23 | 2024-02-28 | Merus N.V. | Binding molecules that modulate a biological activity expressed by a cell |
| GB201619652D0 (en) | 2016-11-21 | 2017-01-04 | Alligator Bioscience Ab | Novel polypeptides |
| GB201619648D0 (en) | 2016-11-21 | 2017-01-04 | Alligator Bioscience Ab | Novel antibodies and uses thereof |
| UY37523A (es) * | 2016-12-15 | 2018-07-31 | Abbvie Biotherapeutics Inc | Anticuerpos anti-ox40 y sus usos |
| BR112019017628A2 (pt) * | 2017-02-24 | 2020-07-07 | Macrogenics, Inc. | molécula de ligação a cd137 x ta, composições farmacêuticas, uso da molécula de ligação a cd137 x ta, molécula de ligação a cd137, uso da molécula de ligação a cd137, molécula de ligação a her2/neu, uso da molécula de ligação a her2/neu, e uso de uma composição |
| BR112019017241A2 (pt) | 2017-04-13 | 2020-04-14 | Agenus Inc. | anticorpos anti-cd137 e métodos de uso dos mesmos |
| MX2019012953A (es) * | 2017-05-02 | 2020-02-12 | Alligator Bioscience Ab | Anticuerpo biespecifico contra ox40 y ctla-4. |
| IL270743B2 (en) * | 2017-05-19 | 2024-09-01 | Wuxi Biologics Shanghai Co Ltd | Monoclonal antibodies to cytotoxic t-lymphocyte-associated protein 4 (ctla-4), compositions containing same and uses thereof |
| MX2019015885A (es) * | 2017-06-22 | 2020-09-10 | Novartis Ag | Moleculas de anticuerpo que se unen a cd73 y usos de las mismas. |
| SG10201913147WA (en) | 2017-07-11 | 2020-02-27 | Compass Therapeutics Llc | Agonist antibodies that bind human cd137 and uses thereof |
| US11725060B2 (en) * | 2017-07-20 | 2023-08-15 | Aptevo Reserch and Development LLC | Antigen binding proteins binding to 5T4 and 4-1BB and related compositions and methods |
| KR20250020679A (ko) | 2017-08-04 | 2025-02-11 | 젠맵 에이/에스 | Pd-l1 및 cd137에 결합하는 결합제 및 그의 용도 |
| CN111511762B (zh) * | 2017-08-21 | 2025-05-06 | 天演药业公司 | 抗cd137分子及其用途 |
| US11718679B2 (en) | 2017-10-31 | 2023-08-08 | Compass Therapeutics Llc | CD137 antibodies and PD-1 antagonists and uses thereof |
| EP3713961A2 (en) | 2017-11-20 | 2020-09-30 | Compass Therapeutics LLC | Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof |
| CA3086098A1 (en) | 2017-12-19 | 2019-06-27 | F-Star Beta Limited | Fc binding fragments comprising a pd-l1 antigen-binding site |
| WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
| CN112041336A (zh) * | 2018-03-13 | 2020-12-04 | 脉管生物生长有限公司 | 针对mospd2和t细胞或nk细胞特异性分子的双特异性抗体 |
| CN110467674B (zh) | 2018-05-11 | 2022-05-31 | 同润澳门一人有限公司 | 抗ox40的全人抗体及其制备方法和用途 |
| GB201811403D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Antibody molecules |
| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
| BR112021000394A2 (pt) | 2018-07-12 | 2021-04-06 | F-Star Beta Limited | Moléculas de anticorpo que se ligam a pd-l1 e cd137 |
| AU2019301206B2 (en) * | 2018-07-12 | 2025-10-30 | Invox Pharma Limited | Antibody molecules that bind CD137 and OX40 |
| GB201811404D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-CD137 Antibodies |
| GB201811415D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-Mesothelin Anti bodies |
| GB201811408D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | CD137 Binding Molecules |
| GB201811450D0 (en) | 2018-07-12 | 2018-08-29 | F Star Delta Ltd | Mesothelin and CD137 binding molecules |
| JP2022510218A (ja) * | 2018-11-30 | 2022-01-26 | メモリアル スローン ケタリング キャンサー センター | ヘテロ二量体四価特異性抗体およびこれらの使用 |
| WO2020127374A2 (en) * | 2018-12-17 | 2020-06-25 | Alligator Bioscience Ab | Novel polypeptides |
| BR112021012631A2 (pt) | 2018-12-26 | 2021-12-14 | Xilio Dev Inc | Anticorpos anti-ctla4 e métodos de uso dos mesmos |
| WO2020216947A1 (en) | 2019-04-24 | 2020-10-29 | Heidelberg Pharma Research Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
| MX2022001882A (es) | 2019-08-12 | 2022-05-30 | Aptevo Res & Development Llc | Proteinas de union a 4-1bb y ox40 y composiciones y metodos relacionados anticuerpos contra 4-1bb, anticuerpos contra ox40. |
| JP7634001B2 (ja) * | 2019-10-11 | 2025-02-20 | ナンチン リーズ バイオラブス カンパニー，リミティド | ４－１ｂｂに結合する抗体およびその用途 |
| JP7702954B2 (ja) * | 2019-12-27 | 2025-07-04 | ハイファイバイオ， インコーポレイテッド | 抗ｏｘ４０抗体およびその使用 |
| US20230151102A1 (en) | 2020-01-13 | 2023-05-18 | Aptevo Research And Development Llc | Methods and compositions for preventing adsorption of therapeutic proteins to drug delivery system components |
| CN115279406A (zh) | 2020-01-13 | 2022-11-01 | 阿帕特夫研究和发展有限公司 | 蛋白质治疗剂的调配物 |
| JP2023504675A (ja) | 2020-05-19 | 2023-02-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ガンの処置のための結合分子 |
| US11919958B2 (en) | 2020-08-19 | 2024-03-05 | Xencor, Inc. | Anti-CD28 compositions |
| IL301202A (en) | 2020-09-10 | 2023-05-01 | Vascular Biogenics Ltd | Antibodies against MOTILE SPERM DOMAIN CONTAINING PROTEIN 2 and methods of using them |
| WO2022094299A2 (en) * | 2020-10-30 | 2022-05-05 | Janux Therapeutics, Inc. | Multispecific antibodies for targeting cd28 and pd-l1 and methods of use thereof |
| KR20230167025A (ko) * | 2021-02-17 | 2023-12-07 | 압테보 리서치 앤드 디벨롭먼트 엘엘씨 | 4-1bb 및 ox40 결합 단백질을 포함하는 조성물 및 이의 용도 |
| US20240262920A1 (en) | 2021-05-21 | 2024-08-08 | Aptevo Research And Development Llc | Dosing regimens for protein therapeutics |
| IL314993A (en) | 2022-02-23 | 2024-10-01 | Xencor Inc | Anti-cd28 x anti-psma antibodies |
| US12195546B2 (en) | 2022-12-19 | 2025-01-14 | Sanofi | CD28/OX40 bispecific antibodies |
| US20250043001A1 (en) * | 2023-03-14 | 2025-02-06 | Xencor, Inc. | Anti-cd28 compositions |
| CN121231764A (zh) * | 2024-06-28 | 2025-12-30 | 江苏三联生物工程股份有限公司 | 蛋白芯片、基于多肽编码微阵列芯片的检测试剂盒及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| KR100452954B1 (ko) * | 2002-02-26 | 2004-10-14 | 주식회사 엘지생명과학 | 가변영역 아미노산 치환을 통한 인간 4-1비비분자에 대한결합 특이성이 증가된 변형 인간화 항체의 제조방법 |
| CA2515100A1 (en) * | 2003-02-06 | 2004-08-19 | Micromet Ag | Trimeric polypeptide construct to induce an enduring t cell response |
| CN1894413A (zh) * | 2003-03-26 | 2007-01-10 | 特鲁比昂药品公司 | 识别cd3或4－1bb的抗体或基因介导的肿瘤反应性淋巴细胞活化 |
| AR046094A1 (es) * | 2003-10-10 | 2005-11-23 | Bristol Myers Squibb Co | Anticuerpos completamente humanos contra 4-1bb humano |
| US20070253961A1 (en) * | 2004-06-09 | 2007-11-01 | Ulsan Industrial Education Foundation | Pharmaceutical Composition Comprising the Anti-4-1Bb Antibody for Treating or Preventing Rheumatoid Arthritis |
| WO2006088447A1 (en) | 2005-02-15 | 2006-08-24 | Gtc Biotherapeutics, Inc. | An anti-cd137 antibody as an agent in the treatement of cancer and glycosylation variants thereof |
| EP2626372B1 (en) | 2007-03-29 | 2018-03-21 | Genmab A/S | Bispecific antibodies and methods for production thereof |
| SI2242771T1 (sl) * | 2007-12-14 | 2013-09-30 | Bristol-Myers Squibb Company | Vezane molekule k humanemu ox40 receptorju |
| US9931386B2 (en) * | 2008-06-16 | 2018-04-03 | Atsuo Ochi | Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of antigen-specific immunity |
| PT2560993T (pt) | 2010-04-20 | 2024-09-16 | Genmab As | Proteínas contendo anticorpo heterodimérico fc e métodos para a produção das mesmas |
| NZ729044A (en) * | 2010-09-09 | 2020-07-31 | Pfizer | 4-1bb binding molecules |
| US20140178368A1 (en) | 2011-04-19 | 2014-06-26 | Leslie Lynne SHARP | Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer |
| JP6415437B2 (ja) | 2012-09-17 | 2018-10-31 | ガレクティン・セラピューティクス・インコーポレイテッドＧａｌｅｃｔｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 癌の処置における特異的免疫療法を向上する方法 |
| GB201311487D0 (en) | 2013-06-27 | 2013-08-14 | Alligator Bioscience Ab | Bispecific molecules |
| GB201311475D0 (en) | 2013-06-27 | 2013-08-14 | Alligator Bioscience Ab | Polypeptides |
| MX2016007965A (es) | 2013-12-17 | 2016-10-28 | Genentech Inc | Terapia de combinacion que comprende agonistas de union a ox40 y antagonistas de union al eje pd-1. |
| TW201632559A (zh) * | 2015-02-22 | 2016-09-16 | 索倫多醫療公司 | 結合ｃｄ１３７之抗體治療劑 |
-
2016
- 2016-05-20 BR BR112017024770A patent/BR112017024770A2/pt not_active IP Right Cessation
- 2016-05-20 AU AU2016265447A patent/AU2016265447B2/en active Active
- 2016-05-20 US US15/567,163 patent/US11008396B2/en not_active Expired - Fee Related
- 2016-05-20 WO PCT/EP2016/061420 patent/WO2016185016A1/en not_active Ceased
- 2016-05-20 CN CN201680028916.5A patent/CN107709367A/zh active Pending
- 2016-05-20 KR KR1020177033709A patent/KR102712820B1/ko active Active
- 2016-05-20 RU RU2017142008A patent/RU2017142008A/ru unknown
- 2016-05-20 JP JP2017560535A patent/JP2018520650A/ja active Pending
- 2016-05-20 MX MX2017014699A patent/MX2017014699A/es unknown
- 2016-05-20 CN CN202111495490.3A patent/CN114181309B/zh active Active
- 2016-05-20 EP EP21202262.8A patent/EP3988577A1/en active Pending
- 2016-05-20 IL IL255767A patent/IL255767B2/en unknown
- 2016-05-20 EP EP16724036.5A patent/EP3298045A1/en not_active Withdrawn
-
2020
- 2020-02-03 US US16/780,401 patent/US10774150B2/en not_active Expired - Fee Related
-
2021
- 2021-04-13 US US17/229,130 patent/US11780928B2/en active Active
-
2022
- 2022-05-09 JP JP2022077013A patent/JP7419434B2/ja active Active
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