ES2547248T3 - Anticuerpos que se unen al dominio extracelular del receptor Tirosina cinasa ALK - Google Patents
Anticuerpos que se unen al dominio extracelular del receptor Tirosina cinasa ALK Download PDFInfo
- Publication number
- ES2547248T3 ES2547248T3 ES07720099.6T ES07720099T ES2547248T3 ES 2547248 T3 ES2547248 T3 ES 2547248T3 ES 07720099 T ES07720099 T ES 07720099T ES 2547248 T3 ES2547248 T3 ES 2547248T3
- Authority
- ES
- Spain
- Prior art keywords
- seq
- antibody
- alk
- scfv antibody
- scfv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 title claims abstract description 25
- 101000779641 Homo sapiens ALK tyrosine kinase receptor Proteins 0.000 title claims abstract description 13
- 150000001413 amino acids Chemical class 0.000 claims abstract description 10
- 206010025323 Lymphomas Diseases 0.000 claims abstract 2
- 101100323015 Mus musculus Alk gene Proteins 0.000 claims abstract 2
- 206010028980 Neoplasm Diseases 0.000 claims description 15
- 210000004027 cell Anatomy 0.000 claims description 13
- 239000013604 expression vector Substances 0.000 claims description 7
- 238000011282 treatment Methods 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 5
- 208000005017 glioblastoma Diseases 0.000 claims description 5
- 239000003053 toxin Substances 0.000 claims description 5
- 206010029260 Neuroblastoma Diseases 0.000 claims description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 201000002528 pancreatic cancer Diseases 0.000 claims description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims description 4
- 231100000765 toxin Toxicity 0.000 claims description 4
- 230000001404 mediated effect Effects 0.000 claims description 3
- 201000001441 melanoma Diseases 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 208000006168 Ewing Sarcoma Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 201000000582 Retinoblastoma Diseases 0.000 claims description 2
- 208000033781 Thyroid carcinoma Diseases 0.000 claims description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 201000008275 breast carcinoma Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 201000002510 thyroid cancer Diseases 0.000 claims description 2
- 208000013077 thyroid gland carcinoma Diseases 0.000 claims description 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 206010024612 Lipoma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 206010024627 liposarcoma Diseases 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 description 23
- 108090000368 Fibroblast growth factor 8 Proteins 0.000 description 8
- 102000005162 pleiotrophin Human genes 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 description 5
- 102000051965 human ALK Human genes 0.000 description 5
- 108091026890 Coding region Proteins 0.000 description 4
- 102100030335 Midkine Human genes 0.000 description 4
- 108010092801 Midkine Proteins 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108700012359 toxins Proteins 0.000 description 3
- 208000005623 Carcinogenesis Diseases 0.000 description 2
- 230000009824 affinity maturation Effects 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000036952 cancer formation Effects 0.000 description 2
- 231100000504 carcinogenesis Toxicity 0.000 description 2
- 238000002703 mutagenesis Methods 0.000 description 2
- 231100000350 mutagenesis Toxicity 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000009465 prokaryotic expression Effects 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 102000053642 Catalytic RNA Human genes 0.000 description 1
- 108090000994 Catalytic RNA Proteins 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 108090000143 Mouse Proteins Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010068771 Soft tissue neoplasm Diseases 0.000 description 1
- 206010064390 Tumour invasion Diseases 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 230000009400 cancer invasion Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000006801 homologous recombination Effects 0.000 description 1
- 238000002744 homologous recombination Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000012744 immunostaining Methods 0.000 description 1
- 210000003000 inclusion body Anatomy 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 150000007523 nucleic acids Chemical group 0.000 description 1
- 210000001322 periplasm Anatomy 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 238000002626 targeted therapy Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000005747 tumor angiogenesis Effects 0.000 description 1
- 239000000439 tumor marker Substances 0.000 description 1
- 238000010396 two-hybrid screening Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79583106P | 2006-04-28 | 2006-04-28 | |
| US795831P | 2006-04-28 | ||
| PCT/CH2007/000202 WO2007124610A1 (en) | 2006-04-28 | 2007-04-27 | Antibodies binding to the extracellular domain of the receptor tyrosine kinase alk |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2547248T3 true ES2547248T3 (es) | 2015-10-02 |
Family
ID=38515389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07720099.6T Active ES2547248T3 (es) | 2006-04-28 | 2007-04-27 | Anticuerpos que se unen al dominio extracelular del receptor Tirosina cinasa ALK |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7902340B2 (enExample) |
| EP (2) | EP2604627A1 (enExample) |
| JP (2) | JP5431920B2 (enExample) |
| KR (1) | KR101457228B1 (enExample) |
| CN (1) | CN101443361B (enExample) |
| AU (1) | AU2007246144B2 (enExample) |
| BR (1) | BRPI0710971A2 (enExample) |
| CA (1) | CA2650822C (enExample) |
| DK (1) | DK2013236T3 (enExample) |
| ES (1) | ES2547248T3 (enExample) |
| IL (1) | IL194752A0 (enExample) |
| MX (1) | MX2008013705A (enExample) |
| NZ (1) | NZ572248A (enExample) |
| PL (1) | PL2013236T3 (enExample) |
| RU (1) | RU2460540C2 (enExample) |
| WO (1) | WO2007124610A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007246144B2 (en) * | 2006-04-28 | 2012-12-06 | Delenex Therapeutics Ag | Antibodies binding to the extracellular domain of the Receptor Tyrosine Kinase ALK |
| WO2008131575A2 (en) * | 2007-04-27 | 2008-11-06 | Esbatech Ag | Anti-alk antibodies suitable for treating metastatic cancers or tumors |
| US20110206691A1 (en) * | 2008-02-15 | 2011-08-25 | Mosse Yael P | Methods and Compositions for Treating Neuroblastoma |
| WO2009103061A2 (en) * | 2008-02-15 | 2009-08-20 | The Children's Hospital Of Philadelphia | Methods and compositions for identifying, diagnosing, and treating neuroblastoma |
| MX345395B (es) | 2008-06-25 | 2017-01-30 | Esbatech Alcon Biomed Res Unit | Humanizacion de anticuerpos de conejos usando una estructura de anticuerpos universal. |
| WO2009155723A2 (en) | 2008-06-25 | 2009-12-30 | Esbatech, An Alcon Biomedical Research Unit Llc | STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFα |
| UY33679A (es) | 2010-10-22 | 2012-03-30 | Esbatech | Anticuerpos estables y solubles |
| JP2015527869A (ja) | 2011-08-26 | 2015-09-24 | メリマック ファーマシューティカルズ インコーポレーティッド | タンデムＦｃ二重特異性抗体 |
| WO2013067492A1 (en) | 2011-11-03 | 2013-05-10 | The Trustees Of The University Of Pennsylvania | Isolated b7-h4 specific compositions and methods of use thereof |
| WO2014138449A1 (en) | 2013-03-06 | 2014-09-12 | Merrimack Pharmaceuticals, Inc. | Anti-c-met tandem fc bispecific antibodies |
| CN104861069B (zh) * | 2014-02-21 | 2018-12-18 | 无锡傲锐东源生物科技有限公司 | 针对间变性淋巴瘤激酶的单克隆抗体1a4及其用途 |
| WO2015184231A2 (en) * | 2014-05-30 | 2015-12-03 | Kolltan Pharmaceuticals, Inc. | Regulators of anaplastic lymphoma kinase and uses thereof |
| EP3341021A4 (en) | 2015-08-27 | 2019-03-13 | Celldex Therapeutics, Inc. | ANTI-ALK ANTIBODIES AND METHOD OF USE THEREOF |
| CA2940470C (en) | 2015-09-18 | 2019-08-20 | Signpath Pharma Inc. | Treatment for glioblastoma |
| JP7017015B2 (ja) | 2015-10-13 | 2022-02-08 | エウレカ セラピューティクス インコーポレイテッド | ヒトｃｄ１９に特異的な抗体剤及びその使用 |
| RU2767209C2 (ru) | 2015-10-23 | 2022-03-16 | Еурека Терапьютикс, Инк. | Химерные конструкции антитело/т-клеточный рецептор и их применения |
| WO2017147408A1 (en) * | 2016-02-25 | 2017-08-31 | The Regents Of The University Of California | Methods for the treatment of hematologic cancer |
| IL310182A (en) | 2017-04-26 | 2024-03-01 | Eureka Therapeutics Inc ׂ A Delaware Corp | Structures of chimeric antibody/T-cell receptor and uses thereof |
| EP3749682B1 (en) * | 2018-02-09 | 2025-09-24 | Acceleron Pharma Inc. | Treating heterotopic ossification |
| IT201800009282A1 (it) * | 2018-10-09 | 2020-04-09 | Metis Prec Medicine Sb Srl | Nuovo agente terapeutico per il trattamento di un tumore e/o metastasi |
| CN113960313B (zh) * | 2021-12-22 | 2022-04-12 | 上海思路迪医学检验所有限公司 | 一种外泌体alk融合蛋白磁免疫化学发光检测试剂盒 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US21505A (en) * | 1858-09-14 | Improvement in bullet-machines | ||
| US5529925A (en) * | 1993-12-03 | 1996-06-25 | St. Jude Children's Research Hospital | Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma |
| US6696548B2 (en) * | 1993-12-03 | 2004-02-24 | St. Jude Children's Research Hospital | Antibodies for recognition of alk protein tyrosine/kinase receptor |
| CA2229043C (en) | 1995-08-18 | 2016-06-07 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
| EP0938506B1 (en) | 1996-07-16 | 2003-11-05 | Plückthun, Andreas, Prof. Dr. | Immunoglobulin superfamily domains and fragments with increased solubility |
| JPH1116250A (ja) * | 1997-06-20 | 1999-01-22 | Pioneer Electron Corp | 情報再生システム |
| DK1242457T3 (da) * | 1999-12-28 | 2004-12-20 | Esbatech Ag | Intracellulære antistoffer [intracellulære antistoffer] med defineret struktur, der er stabil i et reducerende miljö, og anvendelse deraf |
| DE60141518D1 (de) * | 2000-06-14 | 2010-04-22 | Univ Georgetown | Pleiotrophin wachstumfaktor rezeptor alk zur behandlung von proliferativen, gefässer- und neurologischen erkrankungen |
| US7417130B2 (en) | 2000-09-08 | 2008-08-26 | University Of Zurich | Collection of repeat proteins comprising repeat modules |
| CN105175535A (zh) | 2002-05-22 | 2015-12-23 | 艾斯巴技术-诺华有限责任公司 | 在胞内环境中表现出增强的稳定性的免疫球蛋白构架及其鉴定方法 |
| US7888485B2 (en) | 2003-03-26 | 2011-02-15 | Georgetown University | Anti-pleiotrophin antibodies and methods of use thereof |
| AU2005272920B2 (en) | 2004-08-10 | 2011-05-12 | Institute For Multiple Myeloma And Bone Cancer Research | Methods of regulating differentiation and treating of multiple myeloma |
| AU2007246144B2 (en) * | 2006-04-28 | 2012-12-06 | Delenex Therapeutics Ag | Antibodies binding to the extracellular domain of the Receptor Tyrosine Kinase ALK |
-
2007
- 2007-04-27 AU AU2007246144A patent/AU2007246144B2/en not_active Ceased
- 2007-04-27 CA CA2650822A patent/CA2650822C/en not_active Expired - Fee Related
- 2007-04-27 DK DK07720099.6T patent/DK2013236T3/en active
- 2007-04-27 PL PL07720099T patent/PL2013236T3/pl unknown
- 2007-04-27 EP EP13000844.4A patent/EP2604627A1/en not_active Withdrawn
- 2007-04-27 RU RU2008146922/10A patent/RU2460540C2/ru not_active IP Right Cessation
- 2007-04-27 MX MX2008013705A patent/MX2008013705A/es active IP Right Grant
- 2007-04-27 CN CN200780017546.6A patent/CN101443361B/zh not_active Expired - Fee Related
- 2007-04-27 US US11/796,549 patent/US7902340B2/en not_active Expired - Fee Related
- 2007-04-27 ES ES07720099.6T patent/ES2547248T3/es active Active
- 2007-04-27 JP JP2009506889A patent/JP5431920B2/ja not_active Expired - Fee Related
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- 2007-04-27 EP EP07720099.6A patent/EP2013236B1/en active Active
- 2007-04-27 KR KR1020087026220A patent/KR101457228B1/ko not_active Expired - Fee Related
- 2007-04-27 BR BRPI0710971-7A patent/BRPI0710971A2/pt not_active IP Right Cessation
- 2007-04-27 WO PCT/CH2007/000202 patent/WO2007124610A1/en not_active Ceased
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2008
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101443361A (zh) | 2009-05-27 |
| EP2013236B1 (en) | 2015-06-17 |
| AU2007246144A1 (en) | 2007-11-08 |
| JP5431920B2 (ja) | 2014-03-05 |
| CA2650822C (en) | 2017-03-14 |
| RU2460540C2 (ru) | 2012-09-10 |
| US8945563B2 (en) | 2015-02-03 |
| KR20080113261A (ko) | 2008-12-29 |
| EP2013236A1 (en) | 2009-01-14 |
| US7902340B2 (en) | 2011-03-08 |
| EP2604627A1 (en) | 2013-06-19 |
| IL194752A0 (en) | 2011-08-01 |
| AU2007246144B2 (en) | 2012-12-06 |
| JP2013226144A (ja) | 2013-11-07 |
| MX2008013705A (es) | 2008-11-06 |
| CA2650822A1 (en) | 2007-11-08 |
| WO2007124610A1 (en) | 2007-11-08 |
| JP2009535021A (ja) | 2009-10-01 |
| US20110159008A1 (en) | 2011-06-30 |
| HK1124619A1 (en) | 2009-07-17 |
| US20080118512A1 (en) | 2008-05-22 |
| DK2013236T3 (en) | 2015-09-21 |
| RU2008146922A (ru) | 2010-06-10 |
| CN101443361B (zh) | 2015-08-19 |
| JP5911821B2 (ja) | 2016-04-27 |
| NZ572248A (en) | 2011-08-26 |
| US20150203829A1 (en) | 2015-07-23 |
| KR101457228B1 (ko) | 2014-11-04 |
| US9512411B2 (en) | 2016-12-06 |
| PL2013236T3 (pl) | 2015-12-31 |
| BRPI0710971A2 (pt) | 2011-05-31 |
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