JP2016501839A5 - - Google Patents
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- JP2016501839A5 JP2016501839A5 JP2015539954A JP2015539954A JP2016501839A5 JP 2016501839 A5 JP2016501839 A5 JP 2016501839A5 JP 2015539954 A JP2015539954 A JP 2015539954A JP 2015539954 A JP2015539954 A JP 2015539954A JP 2016501839 A5 JP2016501839 A5 JP 2016501839A5
- Authority
- JP
- Japan
- Prior art keywords
- chain
- antibody
- conjugate
- cytolytic
- terminus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000001461 cytolytic effect Effects 0.000 claims 34
- 108090000765 processed proteins & peptides Proteins 0.000 claims 16
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 14
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 13
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 102000005962 receptors Human genes 0.000 claims 6
- 108020003175 receptors Proteins 0.000 claims 6
- 150000008574 D-amino acids Chemical class 0.000 claims 5
- 150000001413 amino acids Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 150000008575 L-amino acids Chemical class 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 229940127121 immunoconjugate Drugs 0.000 claims 3
- 102000001301 EGF receptor Human genes 0.000 claims 2
- 108060006698 EGF receptor Proteins 0.000 claims 2
- 101150029707 ERBB2 gene Proteins 0.000 claims 2
- 102000008238 LHRH Receptors Human genes 0.000 claims 2
- 108010021290 LHRH Receptors Proteins 0.000 claims 2
- 102100024952 Protein CBFA2T1 Human genes 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 102100032937 CD40 ligand Human genes 0.000 claims 1
- 108010065524 CD52 Antigen Proteins 0.000 claims 1
- 102100025221 CD70 antigen Human genes 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 108010051696 Growth Hormone Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000868215 Homo sapiens CD40 ligand Proteins 0.000 claims 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 1
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 1
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims 1
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 102100038803 Somatotropin Human genes 0.000 claims 1
- 102100035721 Syndecan-1 Human genes 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261720257P | 2012-10-30 | 2012-10-30 | |
| US61/720,257 | 2012-10-30 | ||
| PCT/US2013/067621 WO2014070957A1 (en) | 2012-10-30 | 2013-10-30 | Antibody/drug conjugates and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016501839A JP2016501839A (ja) | 2016-01-21 |
| JP2016501839A5 true JP2016501839A5 (enExample) | 2016-12-15 |
| JP6559066B2 JP6559066B2 (ja) | 2019-08-14 |
Family
ID=50622572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015539954A Expired - Fee Related JP6559066B2 (ja) | 2012-10-30 | 2013-10-30 | 抗体／薬剤結合体及び使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US9492563B2 (enExample) |
| EP (2) | EP2914633B1 (enExample) |
| JP (1) | JP6559066B2 (enExample) |
| KR (2) | KR20210090298A (enExample) |
| CN (1) | CN105121472A (enExample) |
| AU (2) | AU2013337926B2 (enExample) |
| BR (1) | BR112015009752A2 (enExample) |
| CA (1) | CA2889475A1 (enExample) |
| DK (1) | DK2914633T3 (enExample) |
| IL (1) | IL238323B2 (enExample) |
| WO (1) | WO2014070957A1 (enExample) |
Families Citing this family (53)
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| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| WO2010009271A2 (en) | 2008-07-15 | 2010-01-21 | Academia Sinica | Glycan arrays on ptfe-like aluminum coated glass slides and related methods |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| AU2011250970B2 (en) | 2010-05-10 | 2016-12-15 | Sinica, Academia | Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| JP6302909B2 (ja) | 2012-08-18 | 2018-03-28 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | シアリダーゼの同定および画像化のための細胞透過性プローブ |
| US9547009B2 (en) | 2012-08-21 | 2017-01-17 | Academia Sinica | Benzocyclooctyne compounds and uses thereof |
| KR20210090298A (ko) | 2012-10-30 | 2021-07-19 | 에스퍼란스 파마슈티컬스, 인코포레이티드 | 항체/약물 컨쥬게이트 및 이의 사용 방법 |
| EP3013365B1 (en) | 2013-06-26 | 2019-06-05 | Academia Sinica | Rm2 antigens and use thereof |
| US9981030B2 (en) | 2013-06-27 | 2018-05-29 | Academia Sinica | Glycan conjugates and use thereof |
| WO2015035337A1 (en) | 2013-09-06 | 2015-03-12 | Academia Sinica | HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS WITH ALTERED GLYCOSYL GROUPS |
| KR20160104727A (ko) | 2014-01-16 | 2016-09-05 | 아카데미아 시니카 | 암의 치료 및 검출을 위한 조성물 및 방법 |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| CN106415244B (zh) | 2014-03-27 | 2020-04-24 | 中央研究院 | 反应性标记化合物及其用途 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| KR20220151036A (ko) * | 2014-05-27 | 2022-11-11 | 아카데미아 시니카 | 항-ｃｄ20 글리코항체 및 이의 용도 |
| TWI654202B (zh) | 2014-05-27 | 2019-03-21 | 中央研究院 | 增進抗體功效之通用糖型之組合物及方法 |
| CA2950440A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-her2 glycoantibodies and uses thereof |
| TWI732738B (zh) | 2014-05-28 | 2021-07-11 | 中央研究院 | 抗TNF-α醣抗體及其用途 |
| KR102422375B1 (ko) | 2014-09-08 | 2022-07-18 | 아카데미아 시니카 | 당지질을 사용한 인간 iNKT 세포 활성화 |
| CA2959772A1 (en) * | 2014-09-12 | 2016-03-17 | Biogen Ma Inc. | Humanized anti-alpha v beta 5 antibodies and uses thereof |
| CN113968913A (zh) * | 2014-12-08 | 2022-01-25 | 美国卫生和人力服务部 | 抗cd70嵌合抗原受体 |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| EP3789766A1 (en) | 2015-01-24 | 2021-03-10 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| US10744205B2 (en) * | 2015-06-23 | 2020-08-18 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with anti-CD123-antibodies |
| US11197934B2 (en) * | 2015-09-17 | 2021-12-14 | The Scripps Research Institute | Dual variable domain immunoconjugates and uses thereof |
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| EP3411393B1 (en) | 2016-02-05 | 2021-04-07 | City of Hope | Administration of engineered t cells for treatment of cancers in the central nervous system |
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| CN106248971B (zh) * | 2016-08-19 | 2017-10-03 | 合肥瀚科迈博生物技术有限公司 | 用于检测人血清中her2含量的elisa试剂盒、使用方法及用途 |
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| US20230182041A1 (en) * | 2018-04-25 | 2023-06-15 | Medimmune, Llc | Purification of antibodies |
| BR112021026663A2 (pt) * | 2019-07-02 | 2022-04-12 | Telix Int Pty Ltd | Anticorpos para ligação a psma com afinidade reduzida para o receptor fc neonatal |
| CN111100204B (zh) * | 2019-11-26 | 2022-03-11 | 山东立菲生物产业有限公司 | 靶向cd20的抗体、其制备方法和应用 |
| EP4096713A1 (en) * | 2020-01-31 | 2022-12-07 | Seagen Inc. | Anti-cd30 antibody-drug conjugates and their use for the treatment of non-hodgkin lymphoma |
| MX2022011778A (es) * | 2020-03-26 | 2023-01-19 | A28 Therapeutics Inc | Construcciones de fusion de dominios liticos, inhibidores de puntos de control y metodos de fabricacion utilizando el mismo. |
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| US11617767B2 (en) | 2020-11-20 | 2023-04-04 | Simcere Innovation, Inc. | Armed dual CAR-T compositions and methods for cancer immunotherapy |
| CN113326087B (zh) * | 2021-05-19 | 2023-01-24 | 翱捷科技股份有限公司 | 一种lvgl上的中文字库处理方法及装置 |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| EP4460564A2 (en) * | 2022-01-08 | 2024-11-13 | Carogen Corporation | Multi-antigen therapeutic vaccines to treat or prevent chronic hepatitis b virus infection |
| JP2025528832A (ja) * | 2022-08-15 | 2025-09-02 | ナヴロジェン インコーポレイテッド | 腫瘍免疫抑制性ＩＣＡＭ－１／ＣＤ５４に対し抵抗性のＦｃ改変モノクローナル抗体 |
| CN116514998B (zh) * | 2023-05-12 | 2023-09-15 | 再少年(北京)生物科技有限公司 | 一种嵌合抗原受体、嵌合抗原受体-自然杀伤细胞及其在制备抗肿瘤药物中的应用 |
| CN116593716B (zh) * | 2023-07-11 | 2023-10-13 | 军科正源（北京）药物研究有限责任公司 | 检测抗PEG-rhGH中和抗体的方法 |
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2013
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- 2013-10-30 IL IL238323A patent/IL238323B2/en unknown
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- 2013-10-30 DK DK13850731.4T patent/DK2914633T3/da active
- 2013-10-30 AU AU2013337926A patent/AU2013337926B2/en not_active Ceased
- 2013-10-30 EP EP21212744.3A patent/EP4035685A1/en not_active Withdrawn
- 2013-10-30 KR KR1020157014177A patent/KR102460297B1/ko active Active
- 2013-10-30 US US14/067,819 patent/US9492563B2/en active Active
- 2013-10-30 CN CN201380069036.9A patent/CN105121472A/zh active Pending
- 2013-10-30 BR BR112015009752A patent/BR112015009752A2/pt not_active Application Discontinuation
- 2013-10-30 WO PCT/US2013/067621 patent/WO2014070957A1/en not_active Ceased
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2016
- 2016-11-14 US US15/350,924 patent/US10233214B2/en active Active
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2018
- 2018-03-21 AU AU2018201996A patent/AU2018201996B2/en not_active Ceased
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2019
- 2019-01-11 US US16/246,189 patent/US20190367558A1/en not_active Abandoned
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2021
- 2021-10-15 US US17/503,127 patent/US20220048951A1/en not_active Abandoned
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2024
- 2024-04-08 US US18/629,543 patent/US20250092092A1/en active Pending