JP2014522236A5 - - Google Patents
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- JP2014522236A5 JP2014522236A5 JP2014509817A JP2014509817A JP2014522236A5 JP 2014522236 A5 JP2014522236 A5 JP 2014522236A5 JP 2014509817 A JP2014509817 A JP 2014509817A JP 2014509817 A JP2014509817 A JP 2014509817A JP 2014522236 A5 JP2014522236 A5 JP 2014522236A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- antibody
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 70
- 239000000427 antigen Substances 0.000 claims 25
- 102000036639 antigens Human genes 0.000 claims 25
- 108091007433 antigens Proteins 0.000 claims 25
- 239000012634 fragment Substances 0.000 claims 25
- 241000282465 Canis Species 0.000 claims 15
- 102000015336 Nerve Growth Factor Human genes 0.000 claims 12
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 12
- 229940053128 nerve growth factor Drugs 0.000 claims 12
- 238000006467 substitution reaction Methods 0.000 claims 10
- 241000282472 Canis lupus familiaris Species 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 108091008604 NGF receptors Proteins 0.000 claims 3
- 101150111783 NTRK1 gene Proteins 0.000 claims 3
- 102000007339 Nerve Growth Factor Receptors Human genes 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 102220645367 Immunoglobulin J chain_V24A_mutation Human genes 0.000 claims 2
- 102220500287 Lysosomal alpha-glucosidase_D10G_mutation Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010036030 Polyarthritis Diseases 0.000 claims 2
- 102220585298 Serine/threonine-protein kinase STK11_E16G_mutation Human genes 0.000 claims 2
- 102220590621 Spindlin-1_T19R_mutation Human genes 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 208000030428 polyarticular arthritis Diseases 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 102200152029 rs2245803 Human genes 0.000 claims 2
- 102220126689 rs886044337 Human genes 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102220509400 E3 ubiquitin-protein ligase HUWE1_T27V_mutation Human genes 0.000 claims 1
- 102220486979 Sodium-dependent phosphate transport protein 1_S76N_mutation Human genes 0.000 claims 1
- 102220519680 Transcription factor E2F1_E14D_mutation Human genes 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 125000003147 glycosyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 102220281547 rs1555514410 Human genes 0.000 claims 1
- 102220039281 rs199473357 Human genes 0.000 claims 1
- 102220046945 rs267608437 Human genes 0.000 claims 1
- 102200021640 rs2722372 Human genes 0.000 claims 1
- 102220012488 rs397516129 Human genes 0.000 claims 1
- 102200027728 rs62642916 Human genes 0.000 claims 1
- 102220322685 rs777811020 Human genes 0.000 claims 1
- 102220092750 rs876657859 Human genes 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161483481P | 2011-05-06 | 2011-05-06 | |
| US61/483,481 | 2011-05-06 | ||
| GBGB1114858.2A GB201114858D0 (en) | 2011-08-29 | 2011-08-29 | Anti-nerve growth factor antibodies and methods of using the same |
| GB1114858.2 | 2011-08-29 | ||
| US201161531439P | 2011-09-06 | 2011-09-06 | |
| US61/531,439 | 2011-09-06 | ||
| PCT/GB2012/051002 WO2012153121A1 (en) | 2011-05-06 | 2012-05-08 | Anti-nerve growth factor antibodies and methods of preparing and using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017031939A Division JP2017101064A (ja) | 2011-05-06 | 2017-02-23 | 抗神経成長因子抗体並びに前記抗体の製造及び使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014522236A JP2014522236A (ja) | 2014-09-04 |
| JP2014522236A5 true JP2014522236A5 (enExample) | 2015-05-07 |
Family
ID=44838842
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509817A Pending JP2014522236A (ja) | 2011-05-06 | 2012-05-08 | 抗神経成長因子抗体並びに前記抗体の製造及び使用方法 |
| JP2014509820A Active JP5990701B2 (ja) | 2011-05-06 | 2012-05-08 | 治療用イヌ免疫グロブリンおよびそれを用いる方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509820A Active JP5990701B2 (ja) | 2011-05-06 | 2012-05-08 | 治療用イヌ免疫グロブリンおよびそれを用いる方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10040849B2 (enExample) |
| EP (3) | EP2705054B1 (enExample) |
| JP (2) | JP2014522236A (enExample) |
| KR (4) | KR101637502B1 (enExample) |
| CN (4) | CN105999261A (enExample) |
| AU (2) | AU2012252156B2 (enExample) |
| BR (2) | BR112013028654A2 (enExample) |
| CA (3) | CA2906505C (enExample) |
| CY (1) | CY2022007I1 (enExample) |
| DK (1) | DK2705057T3 (enExample) |
| ES (2) | ES2704036T3 (enExample) |
| GB (1) | GB201114858D0 (enExample) |
| HU (1) | HUE030654T2 (enExample) |
| MY (2) | MY161295A (enExample) |
| PL (1) | PL2705057T3 (enExample) |
| PT (1) | PT2705057T (enExample) |
| RU (3) | RU2627191C2 (enExample) |
| SG (5) | SG194796A1 (enExample) |
| WO (2) | WO2012153121A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1575517T3 (da) | 2002-12-24 | 2012-05-14 | Rinat Neuroscience Corp | Anti-ngf-antistoffer og fremgangsmåder til anvendelse af samme |
| US9498530B2 (en) * | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| AU2014368453B2 (en) * | 2013-12-20 | 2020-04-16 | Intervet International B.V. | Caninized murine anti-canine PD-1 antibodies |
| CN105939767B (zh) | 2014-01-08 | 2018-04-06 | 弗洛设计声能学公司 | 具有双声电泳腔的声电泳装置 |
| ES2853823T3 (es) | 2014-09-30 | 2021-09-17 | Intervet Int Bv | Anticuerpos de PD-L1 que se unen a PD-L1 canino |
| EP3954710A3 (en) | 2015-04-02 | 2022-07-20 | Intervet International B.V. | Antibodies to canine interleukin-4 receptor alpha |
| US9758575B2 (en) | 2015-04-06 | 2017-09-12 | Yung Shin Pharmaceutical Industrial Co. Ltd. | Antibodies which specifically bind to canine vascular endothelial growth factor and uses thereof |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| WO2016190263A1 (ja) * | 2015-05-22 | 2016-12-01 | アステラス製薬株式会社 | 新規抗ヒトＮＧＦ抗体Ｆａｂフラグメント |
| EP3344294A4 (en) * | 2015-08-31 | 2019-03-20 | The Trustees Of The University Of Pennsylvania | CHIMERIC AAV ANTI-VEGF FOR THE TREATMENT OF CANCER IN DOGS |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| ES3014160T3 (en) | 2015-12-18 | 2025-04-21 | Intervet Int Bv | Caninized human antibodies to human and canine il-4r alpha |
| WO2017119434A1 (ja) | 2016-01-06 | 2017-07-13 | 株式会社オーダーメードメディカルリサーチ | Ｖｅｇｆとｎｒｐ１との結合を阻害する抗体 |
| EP3401331B1 (en) * | 2016-01-06 | 2022-04-06 | Order-Made Medical Research Inc. | High-affinity anti-vegf antibody |
| CA3014461C (en) * | 2016-02-18 | 2023-02-28 | Elanco Us Inc. | Chimeric canine anti-cd20 antibody |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| BR112020017701A2 (pt) * | 2018-03-12 | 2020-12-29 | Zoetis Services Llc | Anticorpos anti-ngf e métodos dos mesmos |
| GB2578867A (en) * | 2018-10-09 | 2020-06-03 | Genome Res Ltd | Animal models and therapeutic molecules |
| WO2020139984A1 (en) * | 2018-12-27 | 2020-07-02 | Kindred Biosciences, Inc. | Igg fc variants for veterinary use |
| AU2020312686B2 (en) | 2019-07-15 | 2026-07-30 | Intervet International B.V. | Caninized antibodies against canine CTLA-4 |
| CN115135669B (zh) | 2020-02-19 | 2026-05-19 | 硕腾服务有限责任公司 | 修饰的Fc区 |
| EP4114856A4 (en) * | 2020-03-03 | 2023-11-22 | Scout Bio, Inc. | ANTIGEN BINDING MOLECULES AND USES THEREOF |
| KR20230104157A (ko) * | 2020-10-07 | 2023-07-07 | 조에티스 서비시즈 엘엘씨 | 항-ngf 항체 및 그의 사용 방법 |
| US20230391862A1 (en) * | 2020-10-22 | 2023-12-07 | Scout Bio, Inc. | Method of suppressing immune response to vector-delivered therapeutic protein |
| US20240254245A1 (en) | 2021-05-12 | 2024-08-01 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Antigen binding molecule specifically binding to rankl and ngf, and medical use thereof |
| KR20240107201A (ko) | 2021-08-31 | 2024-07-08 | 스카우트 바이오, 인코포레이티드 | 항원-결합 분자 및 이의 용도 |
| KR20250137204A (ko) | 2022-12-27 | 2025-09-17 | 인베티엑스 인코포레이티드 | 신생아 fc 수용체(fcrn)에 대한 결합이 변경된 폴리펩타이드 및 사용 방법 |
| CN121002059A (zh) | 2023-01-20 | 2025-11-21 | 因外泰克斯公司 | 用于伴侣动物的双特异性结合剂 |
| FR3148027A1 (fr) * | 2023-04-24 | 2024-10-25 | Peptinov | Composition vaccinale anti-ngf |
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| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| FI903489A7 (fi) | 1988-11-11 | 1990-07-10 | Medical Res Council | Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| JP2837240B2 (ja) * | 1990-06-07 | 1998-12-14 | 財団法人化学及血清療法研究所 | イヌ免疫グロブリンγ鎖の定常領域をコードする遺伝子断片およびマウス×イヌキメラ抗体 |
| AU640397B2 (en) | 1989-08-25 | 1993-08-26 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Dog-mouse heterohybridoma and gene fragment coding for constant region of canine immunoglobulin |
| JPH07503124A (ja) | 1991-06-14 | 1995-04-06 | ゾーマ・コーポレーション | 微生物によって生産される抗体断片とそれらの複合体 |
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| ES2665954T3 (es) | 2010-08-19 | 2018-04-30 | Zoetis Belgium S.A. | Anticuerpos anti-NGF y su uso |
| US9289513B2 (en) | 2011-03-23 | 2016-03-22 | Option Pharmaceuticals, Llc | Targeted cytokine for treatment of musculoskeletal diseases |
| AU2012252152B2 (en) | 2011-05-06 | 2016-07-07 | Zoetis Services Llc | Anti-nerve growth factor antibodies and methods of preparing and using the same |
-
2011
- 2011-08-29 GB GBGB1114858.2A patent/GB201114858D0/en not_active Ceased
-
2012
- 2012-05-08 KR KR1020137032546A patent/KR101637502B1/ko active Active
- 2012-05-08 BR BR112013028654A patent/BR112013028654A2/pt not_active Application Discontinuation
- 2012-05-08 ES ES12723730T patent/ES2704036T3/es active Active
- 2012-05-08 EP EP12723730.3A patent/EP2705054B1/en active Active
- 2012-05-08 CA CA2906505A patent/CA2906505C/en active Active
- 2012-05-08 AU AU2012252156A patent/AU2012252156B2/en active Active
- 2012-05-08 RU RU2013154302A patent/RU2627191C2/ru active
- 2012-05-08 SG SG2013081922A patent/SG194796A1/en unknown
- 2012-05-08 KR KR1020137032543A patent/KR101783398B1/ko active Active
- 2012-05-08 CA CA2834992A patent/CA2834992C/en active Active
- 2012-05-08 EP EP18205440.3A patent/EP3502137A1/en active Pending
- 2012-05-08 CN CN201610287357.1A patent/CN105999261A/zh active Pending
- 2012-05-08 AU AU2012252151A patent/AU2012252151B2/en active Active
- 2012-05-08 WO PCT/GB2012/051002 patent/WO2012153121A1/en not_active Ceased
- 2012-05-08 CA CA2835092A patent/CA2835092C/en active Active
- 2012-05-08 PT PT127237337T patent/PT2705057T/pt unknown
- 2012-05-08 RU RU2016102995A patent/RU2626527C1/ru active
- 2012-05-08 ES ES12723733.7T patent/ES2601400T3/es active Active
- 2012-05-08 BR BR112013028523A patent/BR112013028523A8/pt not_active Application Discontinuation
- 2012-05-08 RU RU2013154304A patent/RU2644235C2/ru active
- 2012-05-08 SG SG2013081906A patent/SG194794A1/en unknown
- 2012-05-08 CN CN201280033531.XA patent/CN103732620B/zh active Active
- 2012-05-08 KR KR1020167017621A patent/KR20160079939A/ko not_active Ceased
- 2012-05-08 SG SG10201607259TA patent/SG10201607259TA/en unknown
- 2012-05-08 CN CN201610180304.XA patent/CN105833268A/zh active Pending
- 2012-05-08 SG SG10201500954WA patent/SG10201500954WA/en unknown
- 2012-05-08 WO PCT/GB2012/051008 patent/WO2012153126A1/en not_active Ceased
- 2012-05-08 JP JP2014509817A patent/JP2014522236A/ja active Pending
- 2012-05-08 US US14/115,784 patent/US10040849B2/en active Active
- 2012-05-08 KR KR1020177016065A patent/KR20170070271A/ko not_active Ceased
- 2012-05-08 MY MYPI2013702079A patent/MY161295A/en unknown
- 2012-05-08 SG SG10201500960TA patent/SG10201500960TA/en unknown
- 2012-05-08 MY MYPI2013702082A patent/MY161724A/en unknown
- 2012-05-08 CN CN201280033616.8A patent/CN103732622A/zh active Pending
- 2012-05-08 DK DK12723733.7T patent/DK2705057T3/en active
- 2012-05-08 JP JP2014509820A patent/JP5990701B2/ja active Active
- 2012-05-08 HU HUE12723733A patent/HUE030654T2/en unknown
- 2012-05-08 PL PL12723733T patent/PL2705057T3/pl unknown
- 2012-05-08 EP EP12723733.7A patent/EP2705057B8/en active Active
-
2022
- 2022-04-05 CY CY2022007C patent/CY2022007I1/el unknown
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