JP2014516540A5 - - Google Patents
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- JP2014516540A5 JP2014516540A5 JP2014512897A JP2014512897A JP2014516540A5 JP 2014516540 A5 JP2014516540 A5 JP 2014516540A5 JP 2014512897 A JP2014512897 A JP 2014512897A JP 2014512897 A JP2014512897 A JP 2014512897A JP 2014516540 A5 JP2014516540 A5 JP 2014516540A5
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- JP
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- Prior art keywords
- seq
- antibody
- amino acid
- acid sequence
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 18
- 102000014914 Carrier Proteins Human genes 0.000 claims 10
- 108010078791 Carrier Proteins Proteins 0.000 claims 10
- 230000002163 immunogen Effects 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 10
- 239000002157 polynucleotide Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 239000011782 vitamin Substances 0.000 claims 8
- 229940088594 vitamin Drugs 0.000 claims 8
- 229930003231 vitamin Natural products 0.000 claims 8
- 235000013343 vitamin Nutrition 0.000 claims 8
- 150000003722 vitamin derivatives Chemical class 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 5
- 229940098773 bovine serum albumin Drugs 0.000 claims 5
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 5
- JWUBBDSIWDLEOM-UHFFFAOYSA-N 25-Hydroxycholecalciferol Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CCC1=C JWUBBDSIWDLEOM-UHFFFAOYSA-N 0.000 claims 4
- JWUBBDSIWDLEOM-DCHLRESJSA-N 25-Hydroxyvitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C/C=C1\C[C@@H](O)CCC1=C JWUBBDSIWDLEOM-DCHLRESJSA-N 0.000 claims 4
- JWUBBDSIWDLEOM-NQZHSCJISA-N 25-hydroxy-3 epi cholecalciferol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@H](O)CCC1=C JWUBBDSIWDLEOM-NQZHSCJISA-N 0.000 claims 4
- KJKIIUAXZGLUND-ICCVIKJNSA-N 25-hydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C KJKIIUAXZGLUND-ICCVIKJNSA-N 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 210000004408 hybridoma Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 0 CCN(*1)C1NC=O Chemical compound CCN(*1)C1NC=O 0.000 description 1
- DTOGLPYSKCDHJO-TWGQIWQCSA-N N/C1=C/C(C2)CC2CCCN1 Chemical compound N/C1=C/C(C2)CC2CCCN1 DTOGLPYSKCDHJO-TWGQIWQCSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161488630P | 2011-05-20 | 2011-05-20 | |
| US61/488,630 | 2011-05-20 | ||
| US13/458,847 US8785603B2 (en) | 2011-05-20 | 2012-04-27 | Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof |
| US13/458,847 | 2012-04-27 | ||
| PCT/US2012/038637 WO2012162165A2 (en) | 2011-05-20 | 2012-05-18 | Antibodies to 25-hydroxyvitamin d2 and d3 and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016191362A Division JP6404876B2 (ja) | 2011-05-20 | 2016-09-29 | ２５−ヒドロキシビタミンｄ２およびｄ３に対する抗体ならびにその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014516540A JP2014516540A (ja) | 2014-07-17 |
| JP2014516540A5 true JP2014516540A5 (enExample) | 2015-07-09 |
Family
ID=47217992
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512897A Pending JP2014516540A (ja) | 2011-05-20 | 2012-05-18 | ２５−ヒドロキシビタミンｄ２およびｄ３に対する抗体ならびにその使用 |
| JP2016191362A Active JP6404876B2 (ja) | 2011-05-20 | 2016-09-29 | ２５−ヒドロキシビタミンｄ２およびｄ３に対する抗体ならびにその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016191362A Active JP6404876B2 (ja) | 2011-05-20 | 2016-09-29 | ２５−ヒドロキシビタミンｄ２およびｄ３に対する抗体ならびにその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US8785603B2 (enExample) |
| EP (1) | EP2710376B1 (enExample) |
| JP (2) | JP2014516540A (enExample) |
| KR (1) | KR102032531B1 (enExample) |
| CN (1) | CN103857698B (enExample) |
| AU (2) | AU2012259080A1 (enExample) |
| ES (1) | ES2710449T3 (enExample) |
| WO (1) | WO2012162165A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8785603B2 (en) | 2011-05-20 | 2014-07-22 | Siemens Healthcare Diagnostics Inc. | Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof |
| WO2013172967A1 (en) | 2012-05-17 | 2013-11-21 | Extend Biosciences, Inc | Carriers for improved drug delivery |
| CN103588872B (zh) * | 2012-08-13 | 2016-01-06 | 北京博晖创新光电技术股份有限公司 | 一种维生素d合成抗原、其制备方法及应用 |
| US9618523B2 (en) * | 2013-02-28 | 2017-04-11 | Siemens Healthcare Diagnostics Inc. | Methods and reagents for determining isomeric analytes |
| US20140273021A1 (en) | 2013-03-14 | 2014-09-18 | Enzo Biochem, Inc. | Vitamin d assays |
| US20140308751A1 (en) * | 2013-04-12 | 2014-10-16 | Siemens Healthcare Diagnostics Inc. | Assays for Analyte Homologs |
| EP3027226A4 (en) * | 2013-08-02 | 2016-07-27 | Siemens Healthcare Diagnostics | CELL-BASED CONTROL AND METHOD |
| KR102528381B1 (ko) * | 2014-06-27 | 2023-05-02 | 지멘스 헬쓰케어 다이아그노스틱스 인크. | 비타민 d에 관한 조성물 |
| CN106661114B (zh) * | 2014-06-27 | 2019-01-29 | 西门子医疗保健诊断公司 | 维生素d测定法中对维生素d差向异构体特异性的结合配偶体 |
| KR20170015527A (ko) * | 2014-06-27 | 2017-02-08 | 지멘스 헬쓰케어 다이아그노스틱스 인크. | 비타민 d 에피머에 대한 검정 방법 |
| WO2015200182A1 (en) * | 2014-06-27 | 2015-12-30 | Siemens Healthcare Diagnostics Inc. | Binding partners specific for vitamin d epimers |
| CN104098493A (zh) * | 2014-06-30 | 2014-10-15 | 湖南华腾制药有限公司 | 一种维生素d衍生物的制备方法 |
| CN104062440B (zh) * | 2014-06-30 | 2016-05-11 | 韩雅君 | 一种快速检测维生素d的试纸条 |
| US10114030B2 (en) * | 2014-07-10 | 2018-10-30 | Shenzhen New Industries Biomedical Engineering Co., Ltd | Detection agent for detecting 25-hydroxy vitamin D, preparation method and use |
| CN104076155B (zh) * | 2014-07-10 | 2016-08-31 | 深圳市新产业生物医学工程股份有限公司 | 用于检测25-羟基维生素d的检测剂及制备方法和应用 |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| KR20180104080A (ko) | 2016-01-22 | 2018-09-19 | 아피메딕스, 인코포레이티드 | 비타민 d 대사산물 검출용 장치 |
| US10338084B2 (en) | 2016-04-07 | 2019-07-02 | Quidel Corporation | Processing reagent and use thereof in assays for detection of analytes associated with a binding protein |
| CN107325173A (zh) * | 2016-04-28 | 2017-11-07 | 上海惠斯生物科技有限公司 | 一种25羟基维生素d3人工抗原、制备方法及应用 |
| CN106199016A (zh) * | 2016-06-30 | 2016-12-07 | 深圳市亚辉龙生物科技股份有限公司 | 25‑羟基维生素d化学发光免疫检测试剂盒及其制备方法 |
| WO2018006264A1 (zh) * | 2016-07-05 | 2018-01-11 | 深圳市亚辉龙生物科技股份有限公司 | 吖啶标记结合物及其制备方法、化学发光试剂盒 |
| EP3483172B1 (en) * | 2016-07-05 | 2022-01-26 | Shenzhen Yhlo Biotech Co., Ltd | Acridine-marker conjugate and preparation method thereof, and chemiluminescence kit |
| CN106501535B (zh) * | 2016-11-30 | 2018-11-09 | 迪瑞医疗科技股份有限公司 | 一种ans盐复合释放剂与检测血液中皮质醇的试剂盒 |
| CN108205064B (zh) * | 2018-03-28 | 2020-08-21 | 北京丹大生物技术有限公司 | 25ohd3检测试剂、试剂盒及其检测方法 |
| CN108709993B (zh) * | 2018-04-02 | 2021-03-26 | 深圳上泰生物工程有限公司 | 一种胶乳增强免疫比浊检测试剂盒及其制备和检测方法 |
| WO2021030166A1 (en) | 2019-08-09 | 2021-02-18 | Siemens Healthcare Diagnostics Inc. | Anti-hog tcn1 monoclonal antibodies and methods of production and use thereof |
| CN110713533B (zh) * | 2019-11-26 | 2021-03-16 | 杭州隆基生物技术有限公司 | 一种25-羟基维生素d3抗原及其制备方法 |
| US20230115540A1 (en) * | 2020-03-06 | 2023-04-13 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Tumor targeted fluorescence guidance for intraoperative margin assessment |
| CN111351945B (zh) * | 2020-03-18 | 2021-04-23 | 东南大学 | 维生素d结合蛋白作为标志物在精神疾病抑郁症诊断中的应用 |
| JP7413624B2 (ja) * | 2020-07-21 | 2024-01-16 | 株式会社ファンケル | 血清ビタミンｄ代謝物の濃度の推定方法 |
| CN113999311B (zh) * | 2020-07-28 | 2022-11-04 | 东莞市朋志生物科技有限公司 | 可特异性结合25-羟基维生素d的抗体、其应用以及诊断试剂盒 |
| CN112624947B (zh) * | 2021-01-25 | 2023-09-08 | 福建万菇生物科技有限公司 | 一种利用绣球菌子实体提取高含量维生素d2的方法 |
| CN118103706A (zh) * | 2021-10-13 | 2024-05-28 | 美国西门子医学诊断股份有限公司 | Dheas测定、用于dheas测定的试剂及其生产和使用方法 |
| JP2025532599A (ja) * | 2022-09-16 | 2025-10-01 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 免疫検定における信号対雑音の改善 |
| US12233115B2 (en) | 2022-09-30 | 2025-02-25 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
| CN119080938B (zh) * | 2023-06-05 | 2025-06-24 | 东莞市朋志生物科技有限公司 | 抗25羟维生素d抗体、检测25羟维生素d的试剂和试剂盒 |
| CN117417455B (zh) * | 2023-10-30 | 2024-06-21 | 江南大学 | 一种特异性结合25-羟基维生素d3的抗原结合蛋白 |
| CN120137045A (zh) * | 2023-12-13 | 2025-06-13 | 菲鹏生物股份有限公司 | 抗25-羟基维生素d抗体及其用途 |
| CN120025402B (zh) * | 2025-02-20 | 2026-02-13 | 东南大学 | 一种靶向cldn6蛋白的多肽及其制备方法和应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0092004B1 (en) | 1982-04-20 | 1985-10-30 | Teijin Limited | Novel vitamin d3 derivatives, processes for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom |
| US4456553A (en) | 1982-05-07 | 1984-06-26 | Teijin Limited | Vitamin D3 derivatives, process for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom |
| JPH02274A (ja) | 1987-10-14 | 1990-01-05 | Toyo Jozo Co Ltd | 新規な２５−ヒドロキシビタミンｄ↓３誘導体およびその製造法およびそれを用いた定量法 |
| FR2631025B1 (fr) | 1988-05-04 | 1991-04-12 | Ire Medgenix Sa | Nouveaux derives de la vitamine d3 et application aux dosages des metabolites de la vitamine d3 |
| GB9325415D0 (en) | 1993-12-13 | 1994-02-16 | Res Inst Medicine Chem | Chemical compounds |
| US5821020A (en) | 1995-07-14 | 1998-10-13 | Nhh Biologics | Vitamin D assay |
| CA2279590A1 (en) | 1997-02-13 | 1998-08-20 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin d compounds |
| WO1999055369A1 (en) | 1998-04-28 | 1999-11-04 | Smithkline Beecham Corporation | Monoclonal antibodies with reduced immunogenicity |
| DE19981132D2 (de) | 1998-06-25 | 2001-10-18 | Immundiagnostik Ges Fuer Produ | Funktionelle Vitamin-D-Derivate und Verfahren zur Bestimmung von 25-Hydroxy- und 1alpha,25-Dihydroxy-Vitamin-D |
| JP3589912B2 (ja) | 1999-09-03 | 2004-11-17 | 泰久 福井 | ホスファチジルイノシトール−３，４−二リン酸を認識するモノクローナル抗体 |
| GB0029729D0 (en) * | 2000-12-06 | 2001-01-17 | Ids Ltd | Method for detection of vitamin D metabolites |
| US7087395B1 (en) | 2001-01-16 | 2006-08-08 | Quest Diagnostics Investments Incorporated | Vitamin D assay |
| US7630836B2 (en) | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| USH2220H1 (en) | 2001-08-10 | 2008-07-01 | Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| ES2382627T3 (es) | 2004-06-29 | 2012-06-12 | B.R.A.H.M.S Gmbh | Nuevos anticuerpos monoclonales estimuladores o bloqueadores de la tiroides, secuencias peptídicas que corresponden a sus regiones variables, y sus usos en medicina diagnóstica, preventiva y terapéutica |
| US20080148432A1 (en) | 2005-12-21 | 2008-06-19 | Mark Scott Abad | Transgenic plants with enhanced agronomic traits |
| WO2007039194A1 (en) | 2005-09-29 | 2007-04-12 | Roche Diagnostics Gmbh | Release reagent for vitamin d compounds |
| ATE427965T1 (de) * | 2005-09-29 | 2009-04-15 | Hoffmann La Roche | Antikírper gegen 25-hydroxyvitamin d |
| EP1999153B1 (en) | 2006-03-29 | 2014-04-23 | King's College London | Agonist antibodies against tshr |
| CA2649338C (en) | 2006-06-06 | 2011-07-12 | F.Hoffman-La Roche Ag | Improved measurement of vitamin d |
| US20080148421A1 (en) | 2006-12-14 | 2008-06-19 | Monsanto Technology Llc | Plants and seeds of corn variety lh361 |
| PT2126586E (pt) | 2007-02-01 | 2010-09-17 | Immundiagnostik Ag | Determinação directa de vitamina d no soro ou plasma |
| JP2011505810A (ja) | 2007-12-13 | 2011-03-03 | シャンハイ グオジアン バイオ−テック インスティチュート | ヒト化抗ヒトｃｄ３４抗体、その調製方法および使用 |
| EP3121277B1 (en) | 2008-02-08 | 2018-04-11 | Immunas Pharma, Inc. | Antibody capable of binding specifically to ab-oligomer, and use thereof |
| US20110212534A1 (en) | 2008-08-11 | 2011-09-01 | Taylor Robert L | Methods for determining levels of 1,25 dihydroxy vitamin d2 and d3 |
| US8580714B2 (en) | 2009-10-14 | 2013-11-12 | Janssen Biotech, Inc. | Methods of affinity maturing antibodies |
| AU2010306119A1 (en) | 2009-10-16 | 2012-05-03 | Centre National De La Recherche Scientifique (Cnrs) | Monoclonal antibodies to progastrin and their uses |
| US20110097733A1 (en) * | 2009-10-27 | 2011-04-28 | Michel Anciaux | Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite |
| US8785603B2 (en) * | 2011-05-20 | 2014-07-22 | Siemens Healthcare Diagnostics Inc. | Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof |
-
2012
- 2012-04-27 US US13/458,847 patent/US8785603B2/en active Active
- 2012-05-18 ES ES12789177T patent/ES2710449T3/es active Active
- 2012-05-18 KR KR1020137033893A patent/KR102032531B1/ko active Active
- 2012-05-18 JP JP2014512897A patent/JP2014516540A/ja active Pending
- 2012-05-18 EP EP12789177.8A patent/EP2710376B1/en active Active
- 2012-05-18 CN CN201280024421.7A patent/CN103857698B/zh active Active
- 2012-05-18 WO PCT/US2012/038637 patent/WO2012162165A2/en not_active Ceased
- 2012-05-18 AU AU2012259080A patent/AU2012259080A1/en not_active Abandoned
-
2014
- 2014-07-18 US US14/335,686 patent/US20140336156A1/en not_active Abandoned
-
2016
- 2016-09-29 JP JP2016191362A patent/JP6404876B2/ja active Active
-
2017
- 2017-06-05 AU AU2017203779A patent/AU2017203779B2/en active Active
-
2018
- 2018-03-07 US US15/915,001 patent/US10837973B2/en active Active
-
2020
- 2020-11-03 US US17/087,914 patent/US11815517B2/en active Active
-
2023
- 2023-10-12 US US18/486,137 patent/US12379386B2/en active Active
-
2024
- 2024-12-11 US US18/976,830 patent/US20250110139A1/en active Pending
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