CN103857698B - 针对25-羟基维生素d2和d3的抗体及其用途 - Google Patents

针对25-羟基维生素d2和d3的抗体及其用途 Download PDF

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Publication number
CN103857698B
CN103857698B CN201280024421.7A CN201280024421A CN103857698B CN 103857698 B CN103857698 B CN 103857698B CN 201280024421 A CN201280024421 A CN 201280024421A CN 103857698 B CN103857698 B CN 103857698B
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antibody
vitamin
seq
antigen
hydroxyvitamin
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CN103857698A (zh
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布鲁斯·A·坎贝尔
林相喜
廖起牧
N.P.萨哈基安
J.V.弗里曼
R.A.埃文格利斯塔
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Siemens Healthcare Diagnostics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/02—Nutritional disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280024421.7A 2011-05-20 2012-05-18 针对25-羟基维生素d2和d3的抗体及其用途 Active CN103857698B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161488630P 2011-05-20 2011-05-20
US61/488630 2011-05-20
US13/458847 2012-04-27
US13/458,847 US8785603B2 (en) 2011-05-20 2012-04-27 Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof
PCT/US2012/038637 WO2012162165A2 (en) 2011-05-20 2012-05-18 Antibodies to 25-hydroxyvitamin d2 and d3 and uses thereof

Publications (2)

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CN103857698A CN103857698A (zh) 2014-06-11
CN103857698B true CN103857698B (zh) 2016-09-21

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US (6) US8785603B2 (enExample)
EP (1) EP2710376B1 (enExample)
JP (2) JP2014516540A (enExample)
KR (1) KR102032531B1 (enExample)
CN (1) CN103857698B (enExample)
AU (2) AU2012259080A1 (enExample)
ES (1) ES2710449T3 (enExample)
WO (1) WO2012162165A2 (enExample)

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US12509506B2 (en) 2020-08-07 2025-12-30 Siemens Healthcare Diagnostics Inc. Anti-Hog TCN1 monoclonal antibodies and methods of production and use thereof

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US8785603B2 (en) * 2011-05-20 2014-07-22 Siemens Healthcare Diagnostics Inc. Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof
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CN103588872B (zh) * 2012-08-13 2016-01-06 北京博晖创新光电技术股份有限公司 一种维生素d合成抗原、其制备方法及应用
US9618523B2 (en) * 2013-02-28 2017-04-11 Siemens Healthcare Diagnostics Inc. Methods and reagents for determining isomeric analytes
US20140273021A1 (en) 2013-03-14 2014-09-18 Enzo Biochem, Inc. Vitamin d assays
US20140308751A1 (en) * 2013-04-12 2014-10-16 Siemens Healthcare Diagnostics Inc. Assays for Analyte Homologs
EP3027226A4 (en) * 2013-08-02 2016-07-27 Siemens Healthcare Diagnostics CELL-BASED CONTROL AND METHOD
AU2015280290B2 (en) * 2014-06-27 2019-09-19 Siemens Healthcare Diagnostics Inc. Compositions relating to vitamin D
EP3172239A4 (en) * 2014-06-27 2017-06-21 Siemens Healthcare Diagnostics Inc. Binding partners specific for vitamin d epimers
ES2731254T3 (es) * 2014-06-27 2019-11-14 Siemens Healthcare Diagnostics Inc Ensayos para epímeros de vitamina D
WO2015200186A1 (en) * 2014-06-27 2015-12-30 Siemens Healthcare Diagnostics Inc. Binding partners specific for vitamin d epimers in vitamin d assays
CN104062440B (zh) * 2014-06-30 2016-05-11 韩雅君 一种快速检测维生素d的试纸条
CN104098493A (zh) * 2014-06-30 2014-10-15 湖南华腾制药有限公司 一种维生素d衍生物的制备方法
WO2016004613A1 (zh) * 2014-07-10 2016-01-14 深圳市新产业生物医学工程股份有限公司 用于检测25-羟基维生素d的检测剂及制备方法和应用
CN104076155B (zh) * 2014-07-10 2016-08-31 深圳市新产业生物医学工程股份有限公司 用于检测25-羟基维生素d的检测剂及制备方法和应用
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
JP6946182B2 (ja) 2014-10-22 2021-10-06 エクステンド バイオサイエンシズ インコーポレーテッドＥｘｔｅｎｄ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ 治療用ビタミンｄコンジュゲート
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
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CN107325173A (zh) * 2016-04-28 2017-11-07 上海惠斯生物科技有限公司 一种25羟基维生素d3人工抗原、制备方法及应用
CN106199016A (zh) * 2016-06-30 2016-12-07 深圳市亚辉龙生物科技股份有限公司 25‑羟基维生素d化学发光免疫检测试剂盒及其制备方法
US20190309030A1 (en) * 2016-07-05 2019-10-10 Shenzhen Yhlo Biotech Co., Ltd. Acridine labelled conjugates and preparation methods therefor and chemiluminescent kits
WO2018006268A1 (zh) * 2016-07-05 2018-01-11 深圳市亚辉龙生物科技股份有限公司 吖啶标记结合物及其制备方法、化学发光试剂盒
CN106501535B (zh) * 2016-11-30 2018-11-09 迪瑞医疗科技股份有限公司 一种ans盐复合释放剂与检测血液中皮质醇的试剂盒
CN108205064B (zh) * 2018-03-28 2020-08-21 北京丹大生物技术有限公司 25ohd3检测试剂、试剂盒及其检测方法
CN108709993B (zh) * 2018-04-02 2021-03-26 深圳上泰生物工程有限公司 一种胶乳增强免疫比浊检测试剂盒及其制备和检测方法
WO2021030166A1 (en) * 2019-08-09 2021-02-18 Siemens Healthcare Diagnostics Inc. Anti-hog tcn1 monoclonal antibodies and methods of production and use thereof
CN110713533B (zh) * 2019-11-26 2021-03-16 杭州隆基生物技术有限公司 一种25-羟基维生素d3抗原及其制备方法
WO2021178951A1 (en) * 2020-03-06 2021-09-10 H. Lee Moffitt Cancer Center And Research Institute, Inc. Tumor targeted fluorescence guidance for intraoperative margin assessment
CN111351945B (zh) * 2020-03-18 2021-04-23 东南大学 维生素d结合蛋白作为标志物在精神疾病抑郁症诊断中的应用
JP7413624B2 (ja) * 2020-07-21 2024-01-16 株式会社ファンケル 血清ビタミンｄ代謝物の濃度の推定方法
CN113999311B (zh) * 2020-07-28 2022-11-04 东莞市朋志生物科技有限公司 可特异性结合25-羟基维生素d的抗体、其应用以及诊断试剂盒
CN112624947B (zh) * 2021-01-25 2023-09-08 福建万菇生物科技有限公司 一种利用绣球菌子实体提取高含量维生素d2的方法
US20240410906A1 (en) * 2021-10-13 2024-12-12 Siemens Healthcare Diagnostics Inc. Dheas assay, reagents for same, and methods of production and use thereof
JP2025534350A (ja) 2022-09-30 2025-10-15 エクステンド バイオサイエンシズ インコーポレーテッド 長時間作用型副甲状腺ホルモン
CN119080938B (zh) * 2023-06-05 2025-06-24 东莞市朋志生物科技有限公司 抗25羟维生素d抗体、检测25羟维生素d的试剂和试剂盒
CN117417455B (zh) * 2023-10-30 2024-06-21 江南大学 一种特异性结合25-羟基维生素d3的抗原结合蛋白
CN120137045A (zh) * 2023-12-13 2025-06-13 菲鹏生物股份有限公司 抗25-羟基维生素d抗体及其用途
CN120025402A (zh) * 2025-02-20 2025-05-23 东南大学 一种靶向cldn6蛋白的多肽及其制备方法和应用

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US20130059825A1 (en) 2013-03-07
JP6404876B2 (ja) 2018-10-17
US11815517B2 (en) 2023-11-14
KR20140086925A (ko) 2014-07-08
US12379386B2 (en) 2025-08-05
JP2017040659A (ja) 2017-02-23
WO2012162165A3 (en) 2013-01-17
US20180372761A1 (en) 2018-12-27
AU2017203779A1 (en) 2017-06-22
AU2012259080A1 (en) 2013-10-31
JP2014516540A (ja) 2014-07-17
KR102032531B1 (ko) 2019-11-28
US20140336156A1 (en) 2014-11-13
US20250110139A1 (en) 2025-04-03
US8785603B2 (en) 2014-07-22
WO2012162165A2 (en) 2012-11-29
CN103857698A (zh) 2014-06-11
US20210055314A1 (en) 2021-02-25
ES2710449T3 (es) 2019-04-25
EP2710376A4 (en) 2015-04-15
AU2017203779B2 (en) 2019-08-01
US10837973B2 (en) 2020-11-17
US20240094227A1 (en) 2024-03-21
EP2710376B1 (en) 2018-11-14
EP2710376A2 (en) 2014-03-26

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