JP2014516540A - ２５−ヒドロキシビタミンｄ２およびｄ３に対する抗体ならびにその使用 - Google Patents

２５−ヒドロキシビタミンｄ２およびｄ３に対する抗体ならびにその使用 Download PDF

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JP2014516540A
JP2014516540A JP2014512897A JP2014512897A JP2014516540A JP 2014516540 A JP2014516540 A JP 2014516540A JP 2014512897 A JP2014512897 A JP 2014512897A JP 2014512897 A JP2014512897 A JP 2014512897A JP 2014516540 A JP2014516540 A JP 2014516540A
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hydroxyvitamin
antibody
vitamin
seq
antigen
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JP2014516540A5 (enExample
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キャンベル，ブルース・エー
リン，スペンサー・シャン−シ
リャオ，チム
サハキアン，ニヴァー・パノシアン
フリーマン，ジェームズ・ヴィンセント
エヴァンジェリスタ，ラモン・エイ
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Siemens Healthcare Diagnostics Inc
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Siemens Healthcare Diagnostics Inc
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Publication of JP2014516540A publication Critical patent/JP2014516540A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/02—Nutritional disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2014512897A 2011-05-20 2012-05-18 ２５−ヒドロキシビタミンｄ２およびｄ３に対する抗体ならびにその使用 Pending JP2014516540A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161488630P 2011-05-20 2011-05-20
US61/488,630 2011-05-20
US13/458,847 US8785603B2 (en) 2011-05-20 2012-04-27 Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof
US13/458,847 2012-04-27
PCT/US2012/038637 WO2012162165A2 (en) 2011-05-20 2012-05-18 Antibodies to 25-hydroxyvitamin d2 and d3 and uses thereof

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JP2016191362A Division JP6404876B2 (ja) 2011-05-20 2016-09-29 ２５−ヒドロキシビタミンｄ２およびｄ３に対する抗体ならびにその使用

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JP2014516540A true JP2014516540A (ja) 2014-07-17
JP2014516540A5 JP2014516540A5 (enExample) 2015-07-09

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JP2014512897A Pending JP2014516540A (ja) 2011-05-20 2012-05-18 ２５−ヒドロキシビタミンｄ２およびｄ３に対する抗体ならびにその使用
JP2016191362A Active JP6404876B2 (ja) 2011-05-20 2016-09-29 ２５−ヒドロキシビタミンｄ２およびｄ３に対する抗体ならびにその使用

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US (6) US8785603B2 (enExample)
EP (1) EP2710376B1 (enExample)
JP (2) JP2014516540A (enExample)
KR (1) KR102032531B1 (enExample)
CN (1) CN103857698B (enExample)
AU (2) AU2012259080A1 (enExample)
ES (1) ES2710449T3 (enExample)
WO (1) WO2012162165A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022020884A (ja) * 2020-07-21 2022-02-02 株式会社ファンケル 血清ビタミンｄ代謝物の濃度の推定方法
JP2024535594A (ja) * 2021-10-13 2024-09-30 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド Ｄｈｅａｓアッセイ、そのための試薬、並びにその製造方法及び使用
JP7861111B2 (ja) 2021-10-13 2026-05-18 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド Ｄｈｅａｓアッセイ、そのための試薬、並びにその製造方法及び使用

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US8785603B2 (en) 2011-05-20 2014-07-22 Siemens Healthcare Diagnostics Inc. Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof
KR20220051197A (ko) 2012-05-17 2022-04-26 익스텐드 바이오사이언시즈, 인크. 개선된 약물 전달용 캐리어
CN103588872B (zh) * 2012-08-13 2016-01-06 北京博晖创新光电技术股份有限公司 一种维生素d合成抗原、其制备方法及应用
US9618523B2 (en) 2013-02-28 2017-04-11 Siemens Healthcare Diagnostics Inc. Methods and reagents for determining isomeric analytes
US20140273021A1 (en) 2013-03-14 2014-09-18 Enzo Biochem, Inc. Vitamin d assays
US20140308751A1 (en) * 2013-04-12 2014-10-16 Siemens Healthcare Diagnostics Inc. Assays for Analyte Homologs
EP3027226A4 (en) * 2013-08-02 2016-07-27 Siemens Healthcare Diagnostics CELL-BASED CONTROL AND METHOD
CN106661115A (zh) * 2014-06-27 2017-05-10 西门子医疗保健诊断公司 对维生素d差向异构体特异性的结合配偶体
AU2015280290B2 (en) 2014-06-27 2019-09-19 Siemens Healthcare Diagnostics Inc. Compositions relating to vitamin D
KR20180023047A (ko) * 2014-06-27 2018-03-06 지멘스 헬쓰케어 다이아그노스틱스 인크. 비타민 d 에피머에 대한 검정 방법
ES2853525T3 (es) 2014-06-27 2021-09-16 Siemens Healthcare Diagnostics Inc Parejas de unión específicas para epímeros de vitamina D en ensayos de vitamina D
CN104098493A (zh) * 2014-06-30 2014-10-15 湖南华腾制药有限公司 一种维生素d衍生物的制备方法
CN104062440B (zh) * 2014-06-30 2016-05-11 韩雅君 一种快速检测维生素d的试纸条
CN104076155B (zh) * 2014-07-10 2016-08-31 深圳市新产业生物医学工程股份有限公司 用于检测25-羟基维生素d的检测剂及制备方法和应用
US10114030B2 (en) * 2014-07-10 2018-10-30 Shenzhen New Industries Biomedical Engineering Co., Ltd Detection agent for detecting 25-hydroxy vitamin D, preparation method and use
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
JP2019507890A (ja) 2016-01-22 2019-03-22 アフィメディックス， インコーポレイテッド ビタミンｄ代謝産物の検出のためのデバイス
US10338084B2 (en) 2016-04-07 2019-07-02 Quidel Corporation Processing reagent and use thereof in assays for detection of analytes associated with a binding protein
CN107325173A (zh) * 2016-04-28 2017-11-07 上海惠斯生物科技有限公司 一种25羟基维生素d3人工抗原、制备方法及应用
CN106199016A (zh) * 2016-06-30 2016-12-07 深圳市亚辉龙生物科技股份有限公司 25‑羟基维生素d化学发光免疫检测试剂盒及其制备方法
WO2018006264A1 (zh) * 2016-07-05 2018-01-11 深圳市亚辉龙生物科技股份有限公司 吖啶标记结合物及其制备方法、化学发光试剂盒
WO2018006268A1 (zh) * 2016-07-05 2018-01-11 深圳市亚辉龙生物科技股份有限公司 吖啶标记结合物及其制备方法、化学发光试剂盒
CN106501535B (zh) * 2016-11-30 2018-11-09 迪瑞医疗科技股份有限公司 一种ans盐复合释放剂与检测血液中皮质醇的试剂盒
CN108205064B (zh) * 2018-03-28 2020-08-21 北京丹大生物技术有限公司 25ohd3检测试剂、试剂盒及其检测方法
CN108709993B (zh) * 2018-04-02 2021-03-26 深圳上泰生物工程有限公司 一种胶乳增强免疫比浊检测试剂盒及其制备和检测方法
US12509506B2 (en) 2019-08-09 2025-12-30 Siemens Healthcare Diagnostics Inc. Anti-Hog TCN1 monoclonal antibodies and methods of production and use thereof
CN110713533B (zh) * 2019-11-26 2021-03-16 杭州隆基生物技术有限公司 一种25-羟基维生素d3抗原及其制备方法
US20230115540A1 (en) * 2020-03-06 2023-04-13 H. Lee Moffitt Cancer Center And Research Institute, Inc. Tumor targeted fluorescence guidance for intraoperative margin assessment
CN111351945B (zh) * 2020-03-18 2021-04-23 东南大学 维生素d结合蛋白作为标志物在精神疾病抑郁症诊断中的应用
CN113999311B (zh) * 2020-07-28 2022-11-04 东莞市朋志生物科技有限公司 可特异性结合25-羟基维生素d的抗体、其应用以及诊断试剂盒
CN112624947B (zh) * 2021-01-25 2023-09-08 福建万菇生物科技有限公司 一种利用绣球菌子实体提取高含量维生素d2的方法
JP2025532599A (ja) * 2022-09-16 2025-10-01 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 免疫検定における信号対雑音の改善
EP4593867A2 (en) 2022-09-30 2025-08-06 Extend Biosciences, Inc. Long-acting parathyroid hormone
CN119080938B (zh) * 2023-06-05 2025-06-24 东莞市朋志生物科技有限公司 抗25羟维生素d抗体、检测25羟维生素d的试剂和试剂盒
CN117417455B (zh) * 2023-10-30 2024-06-21 江南大学 一种特异性结合25-羟基维生素d3的抗原结合蛋白
CN120137045A (zh) * 2023-12-13 2025-06-13 菲鹏生物股份有限公司 抗25-羟基维生素d抗体及其用途
CN119846235B (zh) * 2025-01-23 2026-04-03 重庆医科大学附属儿童医院 维生素d缺乏所致oab生物标记物及其应用
CN121471307A (zh) * 2025-02-20 2026-02-06 东南大学 一种靶向cldn6蛋白的多肽及其制备方法和应用

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Cited By (4)

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Publication number Priority date Publication date Assignee Title
JP2022020884A (ja) * 2020-07-21 2022-02-02 株式会社ファンケル 血清ビタミンｄ代謝物の濃度の推定方法
JP7413624B2 (ja) 2020-07-21 2024-01-16 株式会社ファンケル 血清ビタミンｄ代謝物の濃度の推定方法
JP2024535594A (ja) * 2021-10-13 2024-09-30 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド Ｄｈｅａｓアッセイ、そのための試薬、並びにその製造方法及び使用
JP7861111B2 (ja) 2021-10-13 2026-05-18 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド Ｄｈｅａｓアッセイ、そのための試薬、並びにその製造方法及び使用

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WO2012162165A3 (en) 2013-01-17
JP6404876B2 (ja) 2018-10-17
WO2012162165A2 (en) 2012-11-29
US20240094227A1 (en) 2024-03-21
EP2710376A4 (en) 2015-04-15
AU2017203779B2 (en) 2019-08-01
US11815517B2 (en) 2023-11-14
EP2710376A2 (en) 2014-03-26
US12379386B2 (en) 2025-08-05
US20140336156A1 (en) 2014-11-13
US10837973B2 (en) 2020-11-17
US8785603B2 (en) 2014-07-22
KR102032531B1 (ko) 2019-11-28
US20130059825A1 (en) 2013-03-07
CN103857698A (zh) 2014-06-11
US20250110139A1 (en) 2025-04-03
ES2710449T3 (es) 2019-04-25
US20180372761A1 (en) 2018-12-27
AU2012259080A1 (en) 2013-10-31
KR20140086925A (ko) 2014-07-08
AU2017203779A1 (en) 2017-06-22
EP2710376B1 (en) 2018-11-14
JP2017040659A (ja) 2017-02-23
CN103857698B (zh) 2016-09-21
US20210055314A1 (en) 2021-02-25

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