ES2710449T3 - Anticuerpos para 25-hidroxivitamina D2 y D3 y usos de los mismos - Google Patents

Anticuerpos para 25-hidroxivitamina D2 y D3 y usos de los mismos Download PDF

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Publication number
ES2710449T3
ES2710449T3 ES12789177T ES12789177T ES2710449T3 ES 2710449 T3 ES2710449 T3 ES 2710449T3 ES 12789177 T ES12789177 T ES 12789177T ES 12789177 T ES12789177 T ES 12789177T ES 2710449 T3 ES2710449 T3 ES 2710449T3
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Spain
Prior art keywords
vitamin
seq
hydroxyvitamin
antibody
ans
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ES12789177T
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English (en)
Spanish (es)
Inventor
Bruce Campbell
Spencer Lin
Qimu Liao
Niver Sahakian
James Freeman
Ramon Evangelista
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Siemens Healthcare Diagnostics Inc
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Siemens Healthcare Diagnostics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/02—Nutritional disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES12789177T 2011-05-20 2012-05-18 Anticuerpos para 25-hidroxivitamina D2 y D3 y usos de los mismos Active ES2710449T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161488630P 2011-05-20 2011-05-20
US13/458,847 US8785603B2 (en) 2011-05-20 2012-04-27 Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof
PCT/US2012/038637 WO2012162165A2 (en) 2011-05-20 2012-05-18 Antibodies to 25-hydroxyvitamin d2 and d3 and uses thereof

Publications (1)

Publication Number Publication Date
ES2710449T3 true ES2710449T3 (es) 2019-04-25

Family

ID=47217992

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12789177T Active ES2710449T3 (es) 2011-05-20 2012-05-18 Anticuerpos para 25-hidroxivitamina D2 y D3 y usos de los mismos

Country Status (8)

Country Link
US (6) US8785603B2 (enExample)
EP (1) EP2710376B1 (enExample)
JP (2) JP2014516540A (enExample)
KR (1) KR102032531B1 (enExample)
CN (1) CN103857698B (enExample)
AU (2) AU2012259080A1 (enExample)
ES (1) ES2710449T3 (enExample)
WO (1) WO2012162165A2 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8785603B2 (en) 2011-05-20 2014-07-22 Siemens Healthcare Diagnostics Inc. Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof
CN108524919A (zh) 2012-05-17 2018-09-14 延伸生物科学股份有限公司 用于改进的药物递送的载体
CN103588872B (zh) * 2012-08-13 2016-01-06 北京博晖创新光电技术股份有限公司 一种维生素d合成抗原、其制备方法及应用
US9618523B2 (en) * 2013-02-28 2017-04-11 Siemens Healthcare Diagnostics Inc. Methods and reagents for determining isomeric analytes
US20140273021A1 (en) 2013-03-14 2014-09-18 Enzo Biochem, Inc. Vitamin d assays
US20140308751A1 (en) * 2013-04-12 2014-10-16 Siemens Healthcare Diagnostics Inc. Assays for Analyte Homologs
WO2015017535A2 (en) * 2013-08-02 2015-02-05 Siemens Healthcare Diagnostics Inc. Cell-based control and method
KR102309377B1 (ko) * 2014-06-27 2021-10-05 지멘스 헬쓰케어 다이아그노스틱스 인크. 비타민 d 에피머에 특이적인 결합 파트너
AU2015280290B2 (en) 2014-06-27 2019-09-19 Siemens Healthcare Diagnostics Inc. Compositions relating to vitamin D
KR20170015527A (ko) * 2014-06-27 2017-02-08 지멘스 헬쓰케어 다이아그노스틱스 인크. 비타민 d 에피머에 대한 검정 방법
KR20170016009A (ko) * 2014-06-27 2017-02-10 지멘스 헬쓰케어 다이아그노스틱스 인크. 비타민 d 검정에서 비타민 d 에피머에 특이적인 결합 파트너
CN104098493A (zh) * 2014-06-30 2014-10-15 湖南华腾制药有限公司 一种维生素d衍生物的制备方法
CN104062440B (zh) * 2014-06-30 2016-05-11 韩雅君 一种快速检测维生素d的试纸条
CN104076155B (zh) * 2014-07-10 2016-08-31 深圳市新产业生物医学工程股份有限公司 用于检测25-羟基维生素d的检测剂及制备方法和应用
US10114030B2 (en) * 2014-07-10 2018-10-30 Shenzhen New Industries Biomedical Engineering Co., Ltd Detection agent for detecting 25-hydroxy vitamin D, preparation method and use
WO2016065042A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
KR20180104080A (ko) 2016-01-22 2018-09-19 아피메딕스, 인코포레이티드 비타민 d 대사산물 검출용 장치
US10338084B2 (en) 2016-04-07 2019-07-02 Quidel Corporation Processing reagent and use thereof in assays for detection of analytes associated with a binding protein
CN107325173A (zh) * 2016-04-28 2017-11-07 上海惠斯生物科技有限公司 一种25羟基维生素d3人工抗原、制备方法及应用
CN106199016A (zh) * 2016-06-30 2016-12-07 深圳市亚辉龙生物科技股份有限公司 25‑羟基维生素d化学发光免疫检测试剂盒及其制备方法
WO2018006268A1 (zh) * 2016-07-05 2018-01-11 深圳市亚辉龙生物科技股份有限公司 吖啶标记结合物及其制备方法、化学发光试剂盒
US20190309030A1 (en) * 2016-07-05 2019-10-10 Shenzhen Yhlo Biotech Co., Ltd. Acridine labelled conjugates and preparation methods therefor and chemiluminescent kits
CN106501535B (zh) * 2016-11-30 2018-11-09 迪瑞医疗科技股份有限公司 一种ans盐复合释放剂与检测血液中皮质醇的试剂盒
CN108205064B (zh) * 2018-03-28 2020-08-21 北京丹大生物技术有限公司 25ohd3检测试剂、试剂盒及其检测方法
CN108709993B (zh) * 2018-04-02 2021-03-26 深圳上泰生物工程有限公司 一种胶乳增强免疫比浊检测试剂盒及其制备和检测方法
JP7496411B2 (ja) 2019-08-09 2024-06-06 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 抗ブタｔｃｎ１モノクローナル抗体ならびにその作製方法および使用方法
CN110713533B (zh) * 2019-11-26 2021-03-16 杭州隆基生物技术有限公司 一种25-羟基维生素d3抗原及其制备方法
US20230115540A1 (en) * 2020-03-06 2023-04-13 H. Lee Moffitt Cancer Center And Research Institute, Inc. Tumor targeted fluorescence guidance for intraoperative margin assessment
CN111351945B (zh) * 2020-03-18 2021-04-23 东南大学 维生素d结合蛋白作为标志物在精神疾病抑郁症诊断中的应用
JP7413624B2 (ja) * 2020-07-21 2024-01-16 株式会社ファンケル 血清ビタミンｄ代謝物の濃度の推定方法
CN113999311B (zh) * 2020-07-28 2022-11-04 东莞市朋志生物科技有限公司 可特异性结合25-羟基维生素d的抗体、其应用以及诊断试剂盒
CN112624947B (zh) * 2021-01-25 2023-09-08 福建万菇生物科技有限公司 一种利用绣球菌子实体提取高含量维生素d2的方法
CN118103706A (zh) * 2021-10-13 2024-05-28 美国西门子医学诊断股份有限公司 Dheas测定、用于dheas测定的试剂及其生产和使用方法
AU2023342054A1 (en) * 2022-09-16 2025-01-23 Siemens Healthcare Diagnostics Inc. Improving signal to noise in immunoassays
AU2023353057A1 (en) 2022-09-30 2025-05-01 Extend Biosciences, Inc. Long-acting parathyroid hormone
CN119080938B (zh) * 2023-06-05 2025-06-24 东莞市朋志生物科技有限公司 抗25羟维生素d抗体、检测25羟维生素d的试剂和试剂盒
CN117417455B (zh) * 2023-10-30 2024-06-21 江南大学 一种特异性结合25-羟基维生素d3的抗原结合蛋白
CN120137045A (zh) * 2023-12-13 2025-06-13 菲鹏生物股份有限公司 抗25-羟基维生素d抗体及其用途
CN120025402A (zh) * 2025-02-20 2025-05-23 东南大学 一种靶向cldn6蛋白的多肽及其制备方法和应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092004B1 (en) 1982-04-20 1985-10-30 Teijin Limited Novel vitamin d3 derivatives, processes for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom
US4456553A (en) 1982-05-07 1984-06-26 Teijin Limited Vitamin D3 derivatives, process for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom
JPH02274A (ja) 1987-10-14 1990-01-05 Toyo Jozo Co Ltd 新規な２５−ヒドロキシビタミンｄ↓３誘導体およびその製造法およびそれを用いた定量法
FR2631025B1 (fr) 1988-05-04 1991-04-12 Ire Medgenix Sa Nouveaux derives de la vitamine d3 et application aux dosages des metabolites de la vitamine d3
GB9325415D0 (en) 1993-12-13 1994-02-16 Res Inst Medicine Chem Chemical compounds
US5821020A (en) 1995-07-14 1998-10-13 Nhh Biologics Vitamin D assay
PL336231A1 (en) 1997-02-13 2000-06-19 Bone Care International System for aimed therapeutic delivery of vitamin d compounds
CA2327505A1 (en) 1998-04-28 1999-11-04 Smithkline Beecham Corporation Monoclonal antibodies with reduced immunogenicity
EP1097132B1 (de) 1998-06-25 2003-12-17 Immundiagnostik Gesellschaft für Produktion und Vertrieb von Labordiagnostika mbH Funktionelle vitamin-d-derivate und verfahren zur bestimmung von 25-hydroxy- und 1alpha,25-dihydroxy-vitamin-d
JP3589912B2 (ja) 1999-09-03 2004-11-17 泰久 福井 ホスファチジルイノシトール−３，４−二リン酸を認識するモノクローナル抗体
GB0029729D0 (en) * 2000-12-06 2001-01-17 Ids Ltd Method for detection of vitamin D metabolites
US7087395B1 (en) 2001-01-16 2006-08-08 Quest Diagnostics Investments Incorporated Vitamin D assay
US7630836B2 (en) 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
USH2220H1 (en) 2001-08-10 2008-07-01 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
EP1612224B1 (en) 2004-06-29 2012-03-07 B.R.A.H.M.S GmbH Novel monoclonal thyroid stimulating or blocking antibodies, peptide sequences corresponding to their variable regions, and their uses in diagnostic, preventive and therapeutic medicine
US20080148432A1 (en) 2005-12-21 2008-06-19 Mark Scott Abad Transgenic plants with enhanced agronomic traits
CN101273272B (zh) 2005-09-29 2012-11-07 霍夫曼-拉罗奇有限公司 维生素d化合物的释放试剂
DE602006006200D1 (de) * 2005-09-29 2009-05-20 Roche Diagnostics Gmbh Antikörper gegen 25-hydroxyvitamin d
WO2007110648A1 (en) 2006-03-29 2007-10-04 King's College London Agonist antibodies against tshr
ATE452343T1 (de) 2006-06-06 2010-01-15 Hoffmann La Roche Verbesserte vitamin-d-messung
US20080148421A1 (en) 2006-12-14 2008-06-19 Monsanto Technology Llc Plants and seeds of corn variety lh361
HRP20100532T1 (hr) 2007-02-01 2010-11-30 Immundiagnostik Ag Izravno određivanje vitamina d u serumu ili plazmi
JP2011505810A (ja) 2007-12-13 2011-03-03 シャンハイ グオジアン バイオ−テック インスティチュート ヒト化抗ヒトｃｄ３４抗体、その調製方法および使用
WO2009099176A1 (ja) 2008-02-08 2009-08-13 Immunas Pharma, Inc. Aβオリゴマーに特異的に結合する抗体およびその利用
US20110212534A1 (en) 2008-08-11 2011-09-01 Taylor Robert L Methods for determining levels of 1,25 dihydroxy vitamin d2 and d3
US8580714B2 (en) 2009-10-14 2013-11-12 Janssen Biotech, Inc. Methods of affinity maturing antibodies
EP2488551B1 (en) 2009-10-16 2018-07-25 Progastrine et Cancers S.à r.l. Monoclonal antibodies to progastrin and their uses
US20110097733A1 (en) 2009-10-27 2011-04-28 Michel Anciaux Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite
US8785603B2 (en) * 2011-05-20 2014-07-22 Siemens Healthcare Diagnostics Inc. Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof

Also Published As

Publication number Publication date
EP2710376B1 (en) 2018-11-14
US12379386B2 (en) 2025-08-05
EP2710376A4 (en) 2015-04-15
AU2017203779B2 (en) 2019-08-01
US20140336156A1 (en) 2014-11-13
AU2012259080A1 (en) 2013-10-31
KR20140086925A (ko) 2014-07-08
US11815517B2 (en) 2023-11-14
US8785603B2 (en) 2014-07-22
CN103857698A (zh) 2014-06-11
US20130059825A1 (en) 2013-03-07
AU2017203779A1 (en) 2017-06-22
WO2012162165A3 (en) 2013-01-17
JP6404876B2 (ja) 2018-10-17
JP2017040659A (ja) 2017-02-23
EP2710376A2 (en) 2014-03-26
WO2012162165A2 (en) 2012-11-29
JP2014516540A (ja) 2014-07-17
US20210055314A1 (en) 2021-02-25
US20180372761A1 (en) 2018-12-27
CN103857698B (zh) 2016-09-21
KR102032531B1 (ko) 2019-11-28
US20250110139A1 (en) 2025-04-03
US10837973B2 (en) 2020-11-17
US20240094227A1 (en) 2024-03-21

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