ES2710449T3 - Anticuerpos para 25-hidroxivitamina D2 y D3 y usos de los mismos - Google Patents

Anticuerpos para 25-hidroxivitamina D2 y D3 y usos de los mismos Download PDF

Info

Publication number
ES2710449T3
ES2710449T3 ES12789177T ES12789177T ES2710449T3 ES 2710449 T3 ES2710449 T3 ES 2710449T3 ES 12789177 T ES12789177 T ES 12789177T ES 12789177 T ES12789177 T ES 12789177T ES 2710449 T3 ES2710449 T3 ES 2710449T3
Authority
ES
Spain
Prior art keywords
vitamin
seq
hydroxyvitamin
antibody
ans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12789177T
Other languages
English (en)
Spanish (es)
Inventor
Bruce Campbell
Spencer Lin
Qimu Liao
Niver Sahakian
James Freeman
Ramon Evangelista
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Siemens Healthcare Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Inc filed Critical Siemens Healthcare Diagnostics Inc
Application granted granted Critical
Publication of ES2710449T3 publication Critical patent/ES2710449T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/02—Nutritional disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES12789177T 2011-05-20 2012-05-18 Anticuerpos para 25-hidroxivitamina D2 y D3 y usos de los mismos Active ES2710449T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161488630P 2011-05-20 2011-05-20
US13/458,847 US8785603B2 (en) 2011-05-20 2012-04-27 Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof
PCT/US2012/038637 WO2012162165A2 (en) 2011-05-20 2012-05-18 Antibodies to 25-hydroxyvitamin d2 and d3 and uses thereof

Publications (1)

Publication Number Publication Date
ES2710449T3 true ES2710449T3 (es) 2019-04-25

Family

ID=47217992

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12789177T Active ES2710449T3 (es) 2011-05-20 2012-05-18 Anticuerpos para 25-hidroxivitamina D2 y D3 y usos de los mismos

Country Status (8)

Country Link
US (6) US8785603B2 (enExample)
EP (1) EP2710376B1 (enExample)
JP (2) JP2014516540A (enExample)
KR (1) KR102032531B1 (enExample)
CN (1) CN103857698B (enExample)
AU (2) AU2012259080A1 (enExample)
ES (1) ES2710449T3 (enExample)
WO (1) WO2012162165A2 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8785603B2 (en) * 2011-05-20 2014-07-22 Siemens Healthcare Diagnostics Inc. Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof
MX349035B (es) 2012-05-17 2017-07-07 Extend Biosciences Inc Portadores para el suministro mejorado de farmaco.
CN103588872B (zh) * 2012-08-13 2016-01-06 北京博晖创新光电技术股份有限公司 一种维生素d合成抗原、其制备方法及应用
US9618523B2 (en) 2013-02-28 2017-04-11 Siemens Healthcare Diagnostics Inc. Methods and reagents for determining isomeric analytes
US20140273021A1 (en) 2013-03-14 2014-09-18 Enzo Biochem, Inc. Vitamin d assays
US20140308751A1 (en) * 2013-04-12 2014-10-16 Siemens Healthcare Diagnostics Inc. Assays for Analyte Homologs
EP3027226A4 (en) * 2013-08-02 2016-07-27 Siemens Healthcare Diagnostics CELL-BASED CONTROL AND METHOD
KR20180021934A (ko) * 2014-06-27 2018-03-05 지멘스 헬쓰케어 다이아그노스틱스 인크. 비타민 d 검정에서 비타민 d 에피머에 특이적인 결합 파트너
KR102309377B1 (ko) * 2014-06-27 2021-10-05 지멘스 헬쓰케어 다이아그노스틱스 인크. 비타민 d 에피머에 특이적인 결합 파트너
BR122022025940B1 (pt) * 2014-06-27 2023-11-28 Siemens Healthcare Diagnostics Inc Kit para determinação da presença e/ou quantidade de analitos de vitamina d
AU2015280288B2 (en) * 2014-06-27 2019-07-11 Siemens Healthcare Diagnostics Inc. Assays for vitamin D epimers
CN104098493A (zh) * 2014-06-30 2014-10-15 湖南华腾制药有限公司 一种维生素d衍生物的制备方法
CN104062440B (zh) * 2014-06-30 2016-05-11 韩雅君 一种快速检测维生素d的试纸条
EP3168619B1 (en) * 2014-07-10 2021-10-20 Shenzhen New Industries Biomedical Engineering Co., Ltd. Detection agent for detecting 25-hydroxy vitamin d, preparation method and use
CN104076155B (zh) * 2014-07-10 2016-08-31 深圳市新产业生物医学工程股份有限公司 用于检测25-羟基维生素d的检测剂及制备方法和应用
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
AU2017209523A1 (en) 2016-01-22 2018-08-09 Affimedix, Inc. Device for detection of vitamin D metabolites
US10338084B2 (en) 2016-04-07 2019-07-02 Quidel Corporation Processing reagent and use thereof in assays for detection of analytes associated with a binding protein
CN107325173A (zh) * 2016-04-28 2017-11-07 上海惠斯生物科技有限公司 一种25羟基维生素d3人工抗原、制备方法及应用
CN106199016A (zh) * 2016-06-30 2016-12-07 深圳市亚辉龙生物科技股份有限公司 25‑羟基维生素d化学发光免疫检测试剂盒及其制备方法
WO2018006268A1 (zh) * 2016-07-05 2018-01-11 深圳市亚辉龙生物科技股份有限公司 吖啶标记结合物及其制备方法、化学发光试剂盒
US20190309030A1 (en) * 2016-07-05 2019-10-10 Shenzhen Yhlo Biotech Co., Ltd. Acridine labelled conjugates and preparation methods therefor and chemiluminescent kits
CN106501535B (zh) * 2016-11-30 2018-11-09 迪瑞医疗科技股份有限公司 一种ans盐复合释放剂与检测血液中皮质醇的试剂盒
CN108205064B (zh) * 2018-03-28 2020-08-21 北京丹大生物技术有限公司 25ohd3检测试剂、试剂盒及其检测方法
CN108709993B (zh) * 2018-04-02 2021-03-26 深圳上泰生物工程有限公司 一种胶乳增强免疫比浊检测试剂盒及其制备和检测方法
CN114206367B (zh) * 2019-08-09 2024-07-19 美国西门子医学诊断股份有限公司 抗猪tcn1单克隆抗体及其生产和使用方法
CN110713533B (zh) * 2019-11-26 2021-03-16 杭州隆基生物技术有限公司 一种25-羟基维生素d3抗原及其制备方法
US20230115540A1 (en) * 2020-03-06 2023-04-13 H. Lee Moffitt Cancer Center And Research Institute, Inc. Tumor targeted fluorescence guidance for intraoperative margin assessment
CN111351945B (zh) * 2020-03-18 2021-04-23 东南大学 维生素d结合蛋白作为标志物在精神疾病抑郁症诊断中的应用
JP7413624B2 (ja) * 2020-07-21 2024-01-16 株式会社ファンケル 血清ビタミンｄ代謝物の濃度の推定方法
CN113999311B (zh) * 2020-07-28 2022-11-04 东莞市朋志生物科技有限公司 可特异性结合25-羟基维生素d的抗体、其应用以及诊断试剂盒
CN112624947B (zh) * 2021-01-25 2023-09-08 福建万菇生物科技有限公司 一种利用绣球菌子实体提取高含量维生素d2的方法
WO2023064670A1 (en) * 2021-10-13 2023-04-20 Siemens Healthcare Diagnostics Inc. Dheas assay, reagents for same, and methods of production and use thereof
WO2024059707A2 (en) 2022-09-16 2024-03-21 Siemens Healthcare Diagnostics Inc. Improving signal to noise in immunoassays
US12233115B2 (en) 2022-09-30 2025-02-25 Extend Biosciences, Inc. Long-acting parathyroid hormone
CN119080938B (zh) * 2023-06-05 2025-06-24 东莞市朋志生物科技有限公司 抗25羟维生素d抗体、检测25羟维生素d的试剂和试剂盒
CN117417455B (zh) * 2023-10-30 2024-06-21 江南大学 一种特异性结合25-羟基维生素d3的抗原结合蛋白
CN120137045B (zh) * 2023-12-13 2026-06-19 菲鹏生物股份有限公司 抗25-羟基维生素d抗体及其用途
WO2026128231A1 (en) * 2024-12-09 2026-06-18 Siemens Healthcare Diagnostics Inc. Compositions, kits, and systems for performing vitamin d assays and methods of producing and using same
WO2026128233A1 (en) * 2024-12-10 2026-06-18 Siemens Healthcare Diagnostics Inc. Compositions, kits, and systems for performing vitamin d assays and methods of producing and using same
CN119846235B (zh) * 2025-01-23 2026-04-03 重庆医科大学附属儿童医院 维生素d缺乏所致oab生物标记物及其应用
CN121471306A (zh) * 2025-02-20 2026-02-06 东南大学 一种靶向cldn6蛋白的多肽及其制备方法和应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092004B1 (en) 1982-04-20 1985-10-30 Teijin Limited Novel vitamin d3 derivatives, processes for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom
US4456553A (en) 1982-05-07 1984-06-26 Teijin Limited Vitamin D3 derivatives, process for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom
JPH02274A (ja) 1987-10-14 1990-01-05 Toyo Jozo Co Ltd 新規な２５−ヒドロキシビタミンｄ↓３誘導体およびその製造法およびそれを用いた定量法
FR2631025B1 (fr) 1988-05-04 1991-04-12 Ire Medgenix Sa Nouveaux derives de la vitamine d3 et application aux dosages des metabolites de la vitamine d3
GB9325415D0 (en) 1993-12-13 1994-02-16 Res Inst Medicine Chem Chemical compounds
US5821020A (en) 1995-07-14 1998-10-13 Nhh Biologics Vitamin D assay
NZ336924A (en) 1997-02-13 2001-06-29 Bone Care Int Inc Targeted therapeutic delivery of vitamin D compounds via a Vitamin D conjugate
WO1999055369A1 (en) 1998-04-28 1999-11-04 Smithkline Beecham Corporation Monoclonal antibodies with reduced immunogenicity
AU763458B2 (en) 1998-06-25 2003-07-24 Biomedica Gmbh Functional vitamin D derivatives and a method for determining 25-hydroxy-vitamin D and 1alpha,25-dihydroxy-vitamin D
JP3589912B2 (ja) 1999-09-03 2004-11-17 泰久 福井 ホスファチジルイノシトール−３，４−二リン酸を認識するモノクローナル抗体
GB0029729D0 (en) 2000-12-06 2001-01-17 Ids Ltd Method for detection of vitamin D metabolites
US7087395B1 (en) 2001-01-16 2006-08-08 Quest Diagnostics Investments Incorporated Vitamin D assay
US7630836B2 (en) 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
USH2220H1 (en) 2001-08-10 2008-07-01 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
ES2382627T3 (es) 2004-06-29 2012-06-12 B.R.A.H.M.S Gmbh Nuevos anticuerpos monoclonales estimuladores o bloqueadores de la tiroides, secuencias peptídicas que corresponden a sus regiones variables, y sus usos en medicina diagnóstica, preventiva y terapéutica
US20080148432A1 (en) 2005-12-21 2008-06-19 Mark Scott Abad Transgenic plants with enhanced agronomic traits
CA2624124A1 (en) * 2005-09-29 2007-04-12 F. Hoffmann-La Roche Ag Antibodies against 25-hydroxyvitamin d
ES2374942T3 (es) 2005-09-29 2012-02-23 F. Hoffmann-La Roche Ag Reactivo de liberación para compuestos de vitamina d.
US8603466B2 (en) 2006-03-29 2013-12-10 King's College London Agonist antibodies against TSHR
DE602007003833D1 (de) 2006-06-06 2010-01-28 Roche Diagnostics Gmbh Verbesserte vitamin-d-messung
US20080148421A1 (en) 2006-12-14 2008-06-19 Monsanto Technology Llc Plants and seeds of corn variety lh361
ES2348126T3 (es) 2007-02-01 2010-11-30 Immundiagnostik Ag Determinación directa de la vitamina d en suero o plasma.
WO2009079922A1 (en) 2007-12-13 2009-07-02 Shanghai Guojian Bio-Tech Institute Humanized anti-cd34 monoclonal antibody, the preparation and uses thereof
PL2246427T3 (pl) 2008-02-08 2017-06-30 Immunas Pharma, Inc. Przeciwciała zdolne do wiązania się swoiście do oligomerów amyloidu beta i ich stosowanie
US20110212534A1 (en) 2008-08-11 2011-09-01 Taylor Robert L Methods for determining levels of 1,25 dihydroxy vitamin d2 and d3
US8580714B2 (en) 2009-10-14 2013-11-12 Janssen Biotech, Inc. Methods of affinity maturing antibodies
RS57966B1 (sr) 2009-10-16 2019-01-31 Progastrine Et Cancers S A R L Monoklonska antitela na progastrin i njihova upotreba
US20110097733A1 (en) 2009-10-27 2011-04-28 Michel Anciaux Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite
US8785603B2 (en) * 2011-05-20 2014-07-22 Siemens Healthcare Diagnostics Inc. Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof

Also Published As

Publication number Publication date
CN103857698B (zh) 2016-09-21
JP2017040659A (ja) 2017-02-23
WO2012162165A3 (en) 2013-01-17
EP2710376A4 (en) 2015-04-15
WO2012162165A2 (en) 2012-11-29
CN103857698A (zh) 2014-06-11
EP2710376A2 (en) 2014-03-26
US20130059825A1 (en) 2013-03-07
AU2012259080A1 (en) 2013-10-31
AU2017203779A1 (en) 2017-06-22
JP6404876B2 (ja) 2018-10-17
US20140336156A1 (en) 2014-11-13
US10837973B2 (en) 2020-11-17
KR20140086925A (ko) 2014-07-08
KR102032531B1 (ko) 2019-11-28
JP2014516540A (ja) 2014-07-17
US12379386B2 (en) 2025-08-05
US20240094227A1 (en) 2024-03-21
AU2017203779B2 (en) 2019-08-01
US20250110139A1 (en) 2025-04-03
EP2710376B1 (en) 2018-11-14
US8785603B2 (en) 2014-07-22
US20210055314A1 (en) 2021-02-25
US20180372761A1 (en) 2018-12-27
US11815517B2 (en) 2023-11-14

Similar Documents

Publication Publication Date Title
US12379386B2 (en) Antibodies to 25-hydroxyvitamin D2 and D3 for detecting total 25-hydroxyvitamin D
CN112533958B (zh) 识别抗体-药物缀合物的药物部分的蛋白
ES2717535T3 (es) Procedimiento para la medición de vitamina D
WO2022176959A1 (en) Anti-pt217 tau antibody
EP3947452A1 (en) Anti-nmda receptor antibodies and methods of use
BR112019011131A2 (pt) anticorpo monoclonal, métodos para medir um analito em uma amostra e para produzir um anticorpo, uso de um anticorpo, kit de teste de imunoensaio e imunógeno
WO2020247920A1 (en) Compositions and methods for detecting autoantibodies
ES2561984T3 (es) Anticuerpo anticomplejo heparina/FP4 modificado y patrón de anticuerpo TIH
US12129310B2 (en) Materials and methods for enhanced linker targeting
CN111154000A (zh) 一种抗西马特罗单克隆抗体及其应用
BR122026005537A2 (pt) Anticorpos monoclonais isolados de coelho para imunoglobulinas g humanas, método de produção dos mesmos, composição ou kit, molécula de ácido nucleico isolada, construto de expressão, e método de detecção de imunoglobulina g humana
JP2011160696A (ja) 修飾ヒトｉｇｆ−１／ｅペプチドに対する抗体
WO2012077643A1 (ja) ｃｏｆｉｌｉｎ１タンパク質の免疫学的測定方法
JP2020186175A (ja) 免疫グロブリンａに結合しているペリオスチン並びに免疫グロブリンａに結合しているペリオスチンに結合する抗体、ペリオスチンの測定方法、ペリオスチンの測定試薬及びペリオスチン測定の正確性の改善方法
BR112017008985B1 (pt) Método in vitro para a determinação da concentração de 25-hidroxivitamina d, uso de um método in vitro, uso de um primeiro agente de ligação e kit