JP2019147801A5 - - Google Patents
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- JP2019147801A5 JP2019147801A5 JP2019067955A JP2019067955A JP2019147801A5 JP 2019147801 A5 JP2019147801 A5 JP 2019147801A5 JP 2019067955 A JP2019067955 A JP 2019067955A JP 2019067955 A JP2019067955 A JP 2019067955A JP 2019147801 A5 JP2019147801 A5 JP 2019147801A5
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- Prior art keywords
- seq
- amino acid
- sequence
- acid sequence
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 70
- 239000000427 antigen Substances 0.000 claims 32
- 102000036639 antigens Human genes 0.000 claims 32
- 108091007433 antigens Proteins 0.000 claims 32
- 239000012634 fragment Substances 0.000 claims 32
- 241000282465 Canis Species 0.000 claims 26
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 21
- 102000015336 Nerve Growth Factor Human genes 0.000 claims 21
- 229940053128 nerve growth factor Drugs 0.000 claims 21
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 14
- 241000282472 Canis lupus familiaris Species 0.000 claims 11
- 238000006467 substitution reaction Methods 0.000 claims 10
- 108091008604 NGF receptors Proteins 0.000 claims 9
- 102000007339 Nerve Growth Factor Receptors Human genes 0.000 claims 9
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 8
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 8
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 8
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 8
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 8
- 101150111783 NTRK1 gene Proteins 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 102220645367 Immunoglobulin J chain_V24A_mutation Human genes 0.000 claims 2
- 102220500287 Lysosomal alpha-glucosidase_D10G_mutation Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010036030 Polyarthritis Diseases 0.000 claims 2
- 102220585298 Serine/threonine-protein kinase STK11_E16G_mutation Human genes 0.000 claims 2
- 102220590621 Spindlin-1_T19R_mutation Human genes 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 208000030428 polyarticular arthritis Diseases 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 102200152029 rs2245803 Human genes 0.000 claims 2
- 102220126689 rs886044337 Human genes 0.000 claims 2
- 102220509400 E3 ubiquitin-protein ligase HUWE1_T27V_mutation Human genes 0.000 claims 1
- 102220486979 Sodium-dependent phosphate transport protein 1_S76N_mutation Human genes 0.000 claims 1
- 102220519680 Transcription factor E2F1_E14D_mutation Human genes 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 125000003147 glycosyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 102220281547 rs1555514410 Human genes 0.000 claims 1
- 102220039281 rs199473357 Human genes 0.000 claims 1
- 102220046945 rs267608437 Human genes 0.000 claims 1
- 102200021640 rs2722372 Human genes 0.000 claims 1
- 102220012488 rs397516129 Human genes 0.000 claims 1
- 102200027728 rs62642916 Human genes 0.000 claims 1
- 102220322685 rs777811020 Human genes 0.000 claims 1
- 102220092750 rs876657859 Human genes 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161483481P | 2011-05-06 | 2011-05-06 | |
| US61/483,481 | 2011-05-06 | ||
| GBGB1114858.2A GB201114858D0 (en) | 2011-08-29 | 2011-08-29 | Anti-nerve growth factor antibodies and methods of using the same |
| GB1114858.2 | 2011-08-29 | ||
| US201161531439P | 2011-09-06 | 2011-09-06 | |
| US61/531,439 | 2011-09-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017031939A Division JP2017101064A (ja) | 2011-05-06 | 2017-02-23 | 抗神経成長因子抗体並びに前記抗体の製造及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019147801A JP2019147801A (ja) | 2019-09-05 |
| JP2019147801A5 true JP2019147801A5 (enExample) | 2019-10-24 |
| JP6732990B2 JP6732990B2 (ja) | 2020-07-29 |
Family
ID=50931152
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015239920A Active JP5969102B2 (ja) | 2011-05-06 | 2015-12-09 | 治療用イヌ免疫グロブリンおよびそれを用いる方法 |
| JP2017031939A Pending JP2017101064A (ja) | 2011-05-06 | 2017-02-23 | 抗神経成長因子抗体並びに前記抗体の製造及び使用方法 |
| JP2019067955A Active JP6732990B2 (ja) | 2011-05-06 | 2019-03-29 | 抗神経成長因子抗体並びに前記抗体の製造及び使用方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015239920A Active JP5969102B2 (ja) | 2011-05-06 | 2015-12-09 | 治療用イヌ免疫グロブリンおよびそれを用いる方法 |
| JP2017031939A Pending JP2017101064A (ja) | 2011-05-06 | 2017-02-23 | 抗神経成長因子抗体並びに前記抗体の製造及び使用方法 |
Country Status (3)
| Country | Link |
|---|---|
| US (3) | US9580496B2 (enExample) |
| JP (3) | JP5969102B2 (enExample) |
| GB (1) | GB2528401A (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8587771B2 (en) * | 2010-07-16 | 2013-11-19 | Microsoft Corporation | Method and system for multi-phase dynamic calibration of three-dimensional (3D) sensors in a time-of-flight system |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| PE20160953A1 (es) * | 2013-12-12 | 2016-09-26 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo pd-1, fragmento de union al antigeno de este y uso medico de este |
| CA2932515C (en) | 2013-12-20 | 2023-08-01 | Intervet International B.V. | Caninized antibodies |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| ES2853823T3 (es) | 2014-09-30 | 2021-09-17 | Intervet Int Bv | Anticuerpos de PD-L1 que se unen a PD-L1 canino |
| US9758575B2 (en) * | 2015-04-06 | 2017-09-12 | Yung Shin Pharmaceutical Industrial Co. Ltd. | Antibodies which specifically bind to canine vascular endothelial growth factor and uses thereof |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US20190292250A1 (en) * | 2015-08-31 | 2019-09-26 | The Trustees Of The University Of Pennsylvania | Aav-anti-vegf for treating cancer in companion animals |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| JP7008020B2 (ja) | 2015-12-18 | 2022-01-25 | インターベット インターナショナル ベー． フェー． | ヒトおよびイヌｉｌ－４ｒアルファに対するイヌ化ヒト抗体 |
| KR102293753B1 (ko) | 2016-01-06 | 2021-08-24 | 오더-메이드 메디컬 리서치 인코포레이티드 | Vegf 와 nrp1 의 결합을 저해하는 항체 |
| EP3401331B1 (en) | 2016-01-06 | 2022-04-06 | Order-Made Medical Research Inc. | High-affinity anti-vegf antibody |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| US10928489B2 (en) * | 2017-04-06 | 2021-02-23 | Microsoft Technology Licensing, Llc | Time of flight camera |
| US10215856B1 (en) | 2017-11-27 | 2019-02-26 | Microsoft Technology Licensing, Llc | Time of flight camera |
| US10901087B2 (en) | 2018-01-15 | 2021-01-26 | Microsoft Technology Licensing, Llc | Time of flight camera |
| US10942274B2 (en) | 2018-04-11 | 2021-03-09 | Microsoft Technology Licensing, Llc | Time of flight and picture camera |
| US10895925B2 (en) | 2018-10-03 | 2021-01-19 | Microsoft Technology Licensing, Llc | Touch display alignment |
| US11435476B2 (en) | 2018-10-12 | 2022-09-06 | Microsoft Technology Licensing, Llc | Time-of-flight RGB-IR image sensor |
| JP2021059499A (ja) | 2019-10-03 | 2021-04-15 | 日本全薬工業株式会社 | イヌｃｄ２０に対するモノクローナル抗体又は抗体フラグメント |
| US11079515B2 (en) | 2019-12-18 | 2021-08-03 | Microsoft Technology Licensing, Llc | Micro lens time-of-flight sensor having micro lens heights that vary based on image height |
| US20240018481A1 (en) | 2021-07-30 | 2024-01-18 | Chengdu Unovel Biopharma Co., Ltd. | Recombinant cho cell, construction method therefor, and detection system and method using same |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2837240B2 (ja) * | 1990-06-07 | 1998-12-14 | 財団法人化学及血清療法研究所 | イヌ免疫グロブリンγ鎖の定常領域をコードする遺伝子断片およびマウス×イヌキメラ抗体 |
| GB9202796D0 (en) | 1992-02-11 | 1992-03-25 | Wellcome Found | Antiviral antibody |
| EP1268794A2 (en) * | 2000-04-07 | 2003-01-02 | Heska Corporation | Compositions and methods related to canine igg and canine il-13 receptors |
| US7321026B2 (en) | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
| US20030190705A1 (en) | 2001-10-29 | 2003-10-09 | Sunol Molecular Corporation | Method of humanizing immune system molecules |
| US7261890B2 (en) | 2001-12-21 | 2007-08-28 | Idexx Laboratories, Inc. | Methods for using canine immunoglobulin variable domains and caninized antibodies |
| PL379983A1 (pl) * | 2003-02-19 | 2006-11-27 | Rinat Neuroscience Corp. | Sposoby leczenia bólu polegające na podaniu antagonisty czynnika wzrostu nerwów i niesteroidowego leku przeciwzapalnego oraz zawierające je kompozycje |
| JP2005104936A (ja) * | 2003-10-01 | 2005-04-21 | Nippon Zenyaku Kogyo Kk | イヌｔａｒｃ抗体 |
| JP2005143436A (ja) * | 2003-11-18 | 2005-06-09 | Nippon Zenyaku Kogyo Kk | イヌｍｄｃ |
| ITRM20030601A1 (it) | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| US7462697B2 (en) * | 2004-11-08 | 2008-12-09 | Epitomics, Inc. | Methods for antibody engineering |
| ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| EP2185589B1 (en) * | 2007-06-01 | 2016-01-06 | University of Maryland, Baltimore | Immunoglobulin constant region fc receptor binding agents |
| US8337842B2 (en) | 2008-09-04 | 2012-12-25 | Vet Therapeutics, Inc. | Monoclonal antibodies |
| US8569460B2 (en) | 2009-03-25 | 2013-10-29 | Vet Therapeutics, Inc. | Antibody constant domain regions and uses thereof |
| WO2010117448A2 (en) * | 2009-04-05 | 2010-10-14 | Provenance Biopharmaceuticals Corp. | Chimeric immunocytokines and methods of use thereof |
| CA2808577C (en) | 2010-08-19 | 2018-09-25 | Abbott Laboratories | Anti-ngf antibodies and their use |
| KR20170070272A (ko) | 2011-05-06 | 2017-06-21 | 넥스베트 오스트레일리아 피티와이 리미티드 | 항신경성 성장 인자 항체 및 그의 제조방법과 이용방법 |
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2012
- 2012-05-08 GB GB1517547.4A patent/GB2528401A/en not_active Withdrawn
- 2012-05-08 US US14/115,779 patent/US9580496B2/en active Active
-
2015
- 2015-12-09 JP JP2015239920A patent/JP5969102B2/ja active Active
-
2017
- 2017-01-24 US US15/413,808 patent/US20170369565A1/en not_active Abandoned
- 2017-02-23 JP JP2017031939A patent/JP2017101064A/ja active Pending
-
2018
- 2018-06-28 US US16/022,405 patent/US20190161540A1/en not_active Abandoned
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2019
- 2019-03-29 JP JP2019067955A patent/JP6732990B2/ja active Active