JP2014516026A5 - - Google Patents
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- Publication number
- JP2014516026A5 JP2014516026A5 JP2014509820A JP2014509820A JP2014516026A5 JP 2014516026 A5 JP2014516026 A5 JP 2014516026A5 JP 2014509820 A JP2014509820 A JP 2014509820A JP 2014509820 A JP2014509820 A JP 2014509820A JP 2014516026 A5 JP2014516026 A5 JP 2014516026A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- fusion protein
- antibody
- seq
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001507 fusion proteins Proteins 0.000 claims description 26
- 102000037865 fusion proteins Human genes 0.000 claims description 26
- 239000012634 fragment Substances 0.000 claims description 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- 208000002193 Pain Diseases 0.000 claims description 8
- 241000282465 Canis Species 0.000 claims description 6
- 206010061218 Inflammation Diseases 0.000 claims description 4
- 230000004054 inflammatory process Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 7
- 108060003951 Immunoglobulin Proteins 0.000 claims 6
- 102000018358 immunoglobulin Human genes 0.000 claims 6
- 239000012636 effector Substances 0.000 claims 5
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 4
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 210000000987 immune system Anatomy 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 2
- 102000019034 Chemokines Human genes 0.000 claims 2
- 108010012236 Chemokines Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 238000005571 anion exchange chromatography Methods 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 230000024203 complement activation Effects 0.000 claims 2
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 102000006240 membrane receptors Human genes 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
- 206010045171 Tumour pain Diseases 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000001542 size-exclusion chromatography Methods 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 230000002917 arthritic effect Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161483481P | 2011-05-06 | 2011-05-06 | |
| US61/483,481 | 2011-05-06 | ||
| GBGB1114858.2A GB201114858D0 (en) | 2011-08-29 | 2011-08-29 | Anti-nerve growth factor antibodies and methods of using the same |
| GB1114858.2 | 2011-08-29 | ||
| US201161531439P | 2011-09-06 | 2011-09-06 | |
| US61/531,439 | 2011-09-06 | ||
| PCT/GB2012/051008 WO2012153126A1 (en) | 2011-05-06 | 2012-05-08 | Therapeutic canine immunoglobulins and methods of using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015239920A Division JP5969102B2 (ja) | 2011-05-06 | 2015-12-09 | 治療用イヌ免疫グロブリンおよびそれを用いる方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014516026A JP2014516026A (ja) | 2014-07-07 |
| JP2014516026A5 true JP2014516026A5 (enExample) | 2015-10-29 |
| JP5990701B2 JP5990701B2 (ja) | 2016-09-14 |
Family
ID=44838842
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509820A Active JP5990701B2 (ja) | 2011-05-06 | 2012-05-08 | 治療用イヌ免疫グロブリンおよびそれを用いる方法 |
| JP2014509817A Pending JP2014522236A (ja) | 2011-05-06 | 2012-05-08 | 抗神経成長因子抗体並びに前記抗体の製造及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509817A Pending JP2014522236A (ja) | 2011-05-06 | 2012-05-08 | 抗神経成長因子抗体並びに前記抗体の製造及び使用方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10040849B2 (enExample) |
| EP (3) | EP2705057B8 (enExample) |
| JP (2) | JP5990701B2 (enExample) |
| KR (4) | KR20170070271A (enExample) |
| CN (4) | CN103732622A (enExample) |
| AU (2) | AU2012252156B2 (enExample) |
| BR (2) | BR112013028523A8 (enExample) |
| CA (3) | CA2906505C (enExample) |
| DK (1) | DK2705057T3 (enExample) |
| ES (2) | ES2704036T3 (enExample) |
| GB (1) | GB201114858D0 (enExample) |
| HU (1) | HUE030654T2 (enExample) |
| MY (2) | MY161295A (enExample) |
| PL (1) | PL2705057T3 (enExample) |
| PT (1) | PT2705057T (enExample) |
| RU (3) | RU2626527C1 (enExample) |
| SG (5) | SG10201500954WA (enExample) |
| WO (2) | WO2012153121A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9498530B2 (en) * | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| CN101014364B (zh) | 2002-12-24 | 2012-01-18 | 里纳特神经系统学公司 | 抗ngf抗体及其使用方法 |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| CA2932515C (en) * | 2013-12-20 | 2023-08-01 | Intervet International B.V. | Caninized antibodies |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| ES2853823T3 (es) | 2014-09-30 | 2021-09-17 | Intervet Int Bv | Anticuerpos de PD-L1 que se unen a PD-L1 canino |
| WO2016156588A1 (en) | 2015-04-02 | 2016-10-06 | Intervet International B.V. | Antibodies to canine interleukin-4 receptor alpha |
| US9758575B2 (en) | 2015-04-06 | 2017-09-12 | Yung Shin Pharmaceutical Industrial Co. Ltd. | Antibodies which specifically bind to canine vascular endothelial growth factor and uses thereof |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| BR112017025029A2 (pt) * | 2015-05-22 | 2018-08-07 | Astellas Pharma Inc. | ?novo fragmento fab de anticorpo ngf anti- humano?. |
| US20190292250A1 (en) * | 2015-08-31 | 2019-09-26 | The Trustees Of The University Of Pennsylvania | Aav-anti-vegf for treating cancer in companion animals |
| JP7008020B2 (ja) | 2015-12-18 | 2022-01-25 | インターベット インターナショナル ベー． フェー． | ヒトおよびイヌｉｌ－４ｒアルファに対するイヌ化ヒト抗体 |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| EP3401331B1 (en) * | 2016-01-06 | 2022-04-06 | Order-Made Medical Research Inc. | High-affinity anti-vegf antibody |
| KR102293753B1 (ko) | 2016-01-06 | 2021-08-24 | 오더-메이드 메디컬 리서치 인코포레이티드 | Vegf 와 nrp1 의 결합을 저해하는 항체 |
| EP3416984B1 (en) * | 2016-02-18 | 2021-03-31 | Elanco US Inc. | Chimeric canine anti-cd20 antibody |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| CA3093772C (en) | 2018-03-12 | 2024-04-16 | Zoetis Services Llc | Anti-ngf antibodies and methods thereof |
| GB2578867A (en) * | 2018-10-09 | 2020-06-03 | Genome Res Ltd | Animal models and therapeutic molecules |
| MX2021007680A (es) * | 2018-12-27 | 2021-10-13 | Kindred Biosciences Inc | Variantes de igg fc para uso veterinario. |
| CA3145345A1 (en) | 2019-07-15 | 2021-01-21 | Intervet International B.V. | Caninized antibodies against canine ctla-4 |
| US20230348577A1 (en) | 2020-02-19 | 2023-11-02 | Adivo Gmbh | Modified fc regions |
| WO2021176362A1 (en) * | 2020-03-03 | 2021-09-10 | Scout Bio, Inc. | Antigen-binding molecules and uses thereof |
| CN116568708A (zh) * | 2020-10-07 | 2023-08-08 | 硕腾服务有限责任公司 | 抗ngf抗体和其使用方法 |
| TW202306990A (zh) | 2021-05-12 | 2023-02-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 特異性結合ｒａｎｋｌ和ｎｇｆ的抗原結合分子及其醫藥用途 |
| KR20240107201A (ko) | 2021-08-31 | 2024-07-08 | 스카우트 바이오, 인코포레이티드 | 항원-결합 분자 및 이의 용도 |
| EP4642795A2 (en) | 2022-12-27 | 2025-11-05 | Invetx, Inc. | Polypeptides with altered binding to neonatal fc receptor (fcrn) and methods of use |
| WO2024155982A2 (en) | 2023-01-20 | 2024-07-25 | Invetx, Inc. | Bispecific binding agents for use in companion animals |
| FR3148027A1 (fr) * | 2023-04-24 | 2024-10-25 | Peptinov | Composition vaccinale anti-ngf |
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| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| JP2837240B2 (ja) * | 1990-06-07 | 1998-12-14 | 財団法人化学及血清療法研究所 | イヌ免疫グロブリンγ鎖の定常領域をコードする遺伝子断片およびマウス×イヌキメラ抗体 |
| AU640397B2 (en) | 1989-08-25 | 1993-08-26 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Dog-mouse heterohybridoma and gene fragment coding for constant region of canine immunoglobulin |
| WO1992022324A1 (en) | 1991-06-14 | 1992-12-23 | Xoma Corporation | Microbially-produced antibody fragments and their conjugates |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| GB9202796D0 (en) | 1992-02-11 | 1992-03-25 | Wellcome Found | Antiviral antibody |
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| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
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| PL379983A1 (pl) * | 2003-02-19 | 2006-11-27 | Rinat Neuroscience Corp. | Sposoby leczenia bólu polegające na podaniu antagonisty czynnika wzrostu nerwów i niesteroidowego leku przeciwzapalnego oraz zawierające je kompozycje |
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| JP2005104936A (ja) * | 2003-10-01 | 2005-04-21 | Nippon Zenyaku Kogyo Kk | イヌｔａｒｃ抗体 |
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| US8569460B2 (en) * | 2009-03-25 | 2013-10-29 | Vet Therapeutics, Inc. | Antibody constant domain regions and uses thereof |
| EP2413969A4 (en) | 2009-03-30 | 2012-09-05 | Boehringer Ingelheim Int | FUSION PROTEINS WITH DOG FC ELEMENTS |
| WO2010117448A2 (en) * | 2009-04-05 | 2010-10-14 | Provenance Biopharmaceuticals Corp. | Chimeric immunocytokines and methods of use thereof |
| CA2808577C (en) | 2010-08-19 | 2018-09-25 | Abbott Laboratories | Anti-ngf antibodies and their use |
| WO2012129330A1 (en) | 2011-03-23 | 2012-09-27 | Option Pharmaceutical, Llc | Targeted cytokine for treatment of musculoskeletal diseases |
| KR20170070272A (ko) | 2011-05-06 | 2017-06-21 | 넥스베트 오스트레일리아 피티와이 리미티드 | 항신경성 성장 인자 항체 및 그의 제조방법과 이용방법 |
-
2011
- 2011-08-29 GB GBGB1114858.2A patent/GB201114858D0/en not_active Ceased
-
2012
- 2012-05-08 KR KR1020177016065A patent/KR20170070271A/ko not_active Ceased
- 2012-05-08 AU AU2012252156A patent/AU2012252156B2/en active Active
- 2012-05-08 WO PCT/GB2012/051002 patent/WO2012153121A1/en not_active Ceased
- 2012-05-08 SG SG10201500954WA patent/SG10201500954WA/en unknown
- 2012-05-08 SG SG2013081922A patent/SG194796A1/en unknown
- 2012-05-08 AU AU2012252151A patent/AU2012252151B2/en active Active
- 2012-05-08 EP EP12723733.7A patent/EP2705057B8/en active Active
- 2012-05-08 ES ES12723730T patent/ES2704036T3/es active Active
- 2012-05-08 EP EP12723730.3A patent/EP2705054B1/en active Active
- 2012-05-08 PL PL12723733T patent/PL2705057T3/pl unknown
- 2012-05-08 CA CA2906505A patent/CA2906505C/en active Active
- 2012-05-08 CN CN201280033616.8A patent/CN103732622A/zh active Pending
- 2012-05-08 ES ES12723733.7T patent/ES2601400T3/es active Active
- 2012-05-08 JP JP2014509820A patent/JP5990701B2/ja active Active
- 2012-05-08 CN CN201280033531.XA patent/CN103732620B/zh active Active
- 2012-05-08 BR BR112013028523A patent/BR112013028523A8/pt not_active Application Discontinuation
- 2012-05-08 BR BR112013028654A patent/BR112013028654A2/pt not_active Application Discontinuation
- 2012-05-08 HU HUE12723733A patent/HUE030654T2/en unknown
- 2012-05-08 CA CA2835092A patent/CA2835092C/en active Active
- 2012-05-08 EP EP18205440.3A patent/EP3502137A1/en active Pending
- 2012-05-08 SG SG10201500960TA patent/SG10201500960TA/en unknown
- 2012-05-08 RU RU2016102995A patent/RU2626527C1/ru active
- 2012-05-08 KR KR1020167017621A patent/KR20160079939A/ko not_active Ceased
- 2012-05-08 SG SG2013081906A patent/SG194794A1/en unknown
- 2012-05-08 CN CN201610287357.1A patent/CN105999261A/zh active Pending
- 2012-05-08 CA CA2834992A patent/CA2834992C/en active Active
- 2012-05-08 WO PCT/GB2012/051008 patent/WO2012153126A1/en not_active Ceased
- 2012-05-08 KR KR1020137032543A patent/KR101783398B1/ko active Active
- 2012-05-08 MY MYPI2013702079A patent/MY161295A/en unknown
- 2012-05-08 JP JP2014509817A patent/JP2014522236A/ja active Pending
- 2012-05-08 PT PT127237337T patent/PT2705057T/pt unknown
- 2012-05-08 CN CN201610180304.XA patent/CN105833268A/zh active Pending
- 2012-05-08 MY MYPI2013702082A patent/MY161724A/en unknown
- 2012-05-08 DK DK12723733.7T patent/DK2705057T3/en active
- 2012-05-08 SG SG10201607259TA patent/SG10201607259TA/en unknown
- 2012-05-08 KR KR1020137032546A patent/KR101637502B1/ko active Active
- 2012-05-08 US US14/115,784 patent/US10040849B2/en active Active
- 2012-05-08 RU RU2013154302A patent/RU2627191C2/ru active
- 2012-05-08 RU RU2013154304A patent/RU2644235C2/ru active
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