JP2018531914A5 - - Google Patents
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- JP2018531914A5 JP2018531914A5 JP2018513505A JP2018513505A JP2018531914A5 JP 2018531914 A5 JP2018531914 A5 JP 2018531914A5 JP 2018513505 A JP2018513505 A JP 2018513505A JP 2018513505 A JP2018513505 A JP 2018513505A JP 2018531914 A5 JP2018531914 A5 JP 2018531914A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- tgf
- antagonist
- combination
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000005557 antagonist Substances 0.000 claims description 164
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims description 100
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims description 100
- 206010028980 Neoplasm Diseases 0.000 claims description 81
- 201000011510 cancer Diseases 0.000 claims description 81
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims description 72
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims description 72
- 239000012634 fragment Substances 0.000 claims description 37
- 108091005735 TGF-beta receptors Proteins 0.000 claims description 32
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 claims description 32
- 230000028993 immune response Effects 0.000 claims description 32
- 230000005867 T cell response Effects 0.000 claims description 30
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 30
- 210000004027 cell Anatomy 0.000 claims description 20
- 239000000427 antigen Substances 0.000 claims description 18
- 102000036639 antigens Human genes 0.000 claims description 18
- 108091007433 antigens Proteins 0.000 claims description 18
- 150000001413 amino acids Chemical group 0.000 claims description 15
- 108020001507 fusion proteins Proteins 0.000 claims description 14
- 102000037865 fusion proteins Human genes 0.000 claims description 14
- 230000002708 enhancing effect Effects 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 230000037455 tumor specific immune response Effects 0.000 claims description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
- 102000009027 Albumins Human genes 0.000 claims description 5
- 108010088751 Albumins Proteins 0.000 claims description 5
- 108010002350 Interleukin-2 Proteins 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 102000039446 nucleic acids Human genes 0.000 claims description 5
- 108020004707 nucleic acids Proteins 0.000 claims description 5
- 150000007523 nucleic acids Chemical class 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 229920001184 polypeptide Polymers 0.000 claims description 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
- 210000002966 serum Anatomy 0.000 claims description 5
- 150000003384 small molecules Chemical class 0.000 claims description 5
- 230000035755 proliferation Effects 0.000 claims description 4
- 102000005962 receptors Human genes 0.000 claims 7
- 108020003175 receptors Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 description 60
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562218227P | 2015-09-14 | 2015-09-14 | |
| US201562218169P | 2015-09-14 | 2015-09-14 | |
| US62/218,169 | 2015-09-14 | ||
| US62/218,227 | 2015-09-14 | ||
| PCT/US2016/051704 WO2017048824A1 (en) | 2015-09-14 | 2016-09-14 | COMPOSITIONS AND METHODS FOR TREATING CANCER VIA ANTAGONISM OF THE CD155/TIGIT PATHWAY AND TGF-β |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018531914A JP2018531914A (ja) | 2018-11-01 |
| JP2018531914A5 true JP2018531914A5 (enExample) | 2019-10-31 |
Family
ID=57121497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513505A Withdrawn JP2018531914A (ja) | 2015-09-14 | 2016-09-14 | CD155/TIGIT経路およびTGF−βのアンタゴニストを介してがんを処置するための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20180251548A1 (enExample) |
| EP (1) | EP3349792A1 (enExample) |
| JP (1) | JP2018531914A (enExample) |
| AU (1) | AU2016322934A1 (enExample) |
| CA (1) | CA2998589A1 (enExample) |
| WO (1) | WO2017048824A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108165548B (zh) | 2008-09-22 | 2022-10-14 | 菲奥医药公司 | 减小大小的自递送RNAi化合物 |
| KR102453078B1 (ko) | 2010-03-24 | 2022-10-11 | 피오 파마슈티칼스 코프. | 진피 및 섬유증성 적응증에서의 rna 간섭 |
| CN103200945B (zh) | 2010-03-24 | 2016-07-06 | 雷克西制药公司 | 眼部症候中的rna干扰 |
| TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Tigit結合劑和彼之用途 |
| US11230596B2 (en) | 2016-11-30 | 2022-01-25 | Mereo Biopharma 5, Inc. | Methods for treatment of cancer comprising TIGIT-binding agents |
| CN110944651A (zh) | 2017-02-08 | 2020-03-31 | 蜻蜓疗法股份有限公司 | 用于自然杀伤细胞激活的多特异性结合蛋白及其治疗癌症的治疗性用途 |
| ES2955074T3 (es) | 2017-02-20 | 2023-11-28 | Dragonfly Therapeutics Inc | Proteínas que se unen a HER2, NKG2D Y CD16 |
| WO2018200430A1 (en) | 2017-04-26 | 2018-11-01 | Bristol-Myers Squibb Company | Methods of antibody production that minimize disulfide bond reduction |
| TW202402800A (zh) | 2017-05-01 | 2024-01-16 | 美商艾吉納斯公司 | 抗tigit抗體類和使用彼等之方法 |
| US20200354453A1 (en) * | 2017-05-02 | 2020-11-12 | Merck Sharp & Dohme Corp. | Stable formulations of anti-tigit antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| SG11201909955XA (en) | 2017-05-02 | 2019-11-28 | Merck Sharp & Dohme | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| CN110799213A (zh) | 2017-06-01 | 2020-02-14 | 康姆普根有限公司 | 三联组合抗体疗法 |
| WO2018229163A1 (en) | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
| EP3652209A2 (en) | 2017-07-11 | 2020-05-20 | Compass Therapeutics LLC | Agonist antibodies that bind human cd137 and uses thereof |
| AU2018313149B2 (en) * | 2017-08-07 | 2024-11-14 | Phio Pharmaceuticals Corp. | Chemically modified oligonucleotides |
| WO2019037052A1 (zh) * | 2017-08-24 | 2019-02-28 | 深圳市博奥康生物科技有限公司 | 靶向沉默wucam的shrna |
| CN108558997B (zh) * | 2017-10-20 | 2021-10-08 | 中国人民解放军第四军医大学 | 一种重组融合蛋白TIGIT-Fc及其抗移植排斥反应的应用 |
| WO2019089753A2 (en) | 2017-10-31 | 2019-05-09 | Compass Therapeutics Llc | Cd137 antibodies and pd-1 antagonists and uses thereof |
| US11851497B2 (en) | 2017-11-20 | 2023-12-26 | Compass Therapeutics Llc | CD137 antibodies and tumor antigen-targeting antibodies and uses thereof |
| SG11202007482WA (en) | 2018-02-08 | 2020-09-29 | Dragonfly Therapeutics Inc | Antibody variable domains targeting the nkg2d receptor |
| CA3090236A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells |
| KR102832460B1 (ko) | 2018-02-20 | 2025-07-11 | 드래곤플라이 쎄라퓨틱스, 인크. | Cd33, nkg2d, 및 cd16에 결합하는 다중-특이적 결합 단백질, 및 이의 사용 방법 |
| MX2020008795A (es) | 2018-02-28 | 2020-10-08 | Yuhan Corp | Anti cuerpos anti tigit y usos de los mismos. |
| WO2019178356A1 (en) * | 2018-03-14 | 2019-09-19 | Dana-Farber Cancer Institute, Inc. | Engineered cells, t cell immune modulating antibodies and methods for using the same |
| MX2021001527A (es) | 2018-08-08 | 2021-06-15 | Dragonfly Therapeutics Inc | Proteínas de unión a nkg2d, cd16 y a un antígeno asociado a tumor. |
| MA53293A (fr) | 2018-08-08 | 2021-11-17 | Dragonfly Therapeutics Inc | Protéines de liaison multi-spécifiques se liant à bcma, nkg2d et cd16, et méthodes d'utilisation |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| AU2019324170A1 (en) | 2018-08-23 | 2021-02-18 | Seagen, Inc. | Anti-TIGIT antibodies |
| KR102084196B1 (ko) * | 2018-08-29 | 2020-03-03 | 연세대학교 산학협력단 | 면역 항암 요법의 치료 반응에 관한 정보 제공 방법 및 이를 이용한 키트 |
| EP3876990A4 (en) | 2018-11-07 | 2023-09-06 | Merck Sharp & Dohme LLC | CO-FORMULATIONS OF ANTI-LAG3 ANTIBODIES AND ANTI-PD-1 ANTIBODIES |
| MX2021005594A (es) | 2018-11-13 | 2021-10-22 | Compass Therapeutics Llc | Constructos multiespecificos de union contra moleculas de puntos de control y usos de los mismos. |
| WO2021021528A1 (en) * | 2019-07-26 | 2021-02-04 | Board Of Trustees Of Michigan State University | Methods of preventing or treating fatty degeneration of skeletal muscle |
| MX2022004194A (es) * | 2019-10-08 | 2022-05-02 | Nectin Therapeutics Ltd | Anticuerpos contra el receptor de virus de la polio (pvr) y usos de los mismos. |
| BR112022008295A2 (pt) * | 2019-11-05 | 2022-07-26 | Merck Patent Gmbh | Inibição combinada de pd-1, tgfbeta e tigit para o tratamento de câncer |
| US20230057899A1 (en) | 2019-12-05 | 2023-02-23 | Compugen Ltd. | Anti-pvrig and anti-tigit antibodies for enhanced nk-cell based tumor killing |
| US20230037966A1 (en) * | 2020-01-07 | 2023-02-09 | The Trustees Of The University Of Pennsylvania | Source specific exosomes for determining avoidance of cancer treatment and avoidance of checkpoint inhibitor therapies |
| CN115916247B (zh) * | 2020-04-19 | 2025-04-01 | 奥美药业有限公司 | 人tigit特异性单域抗体及其应用 |
| MX2022013944A (es) | 2020-05-06 | 2022-11-30 | Dragonfly Therapeutics Inc | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a). |
| US20210395366A1 (en) | 2020-06-18 | 2021-12-23 | Genentech, Inc. | Treatment with anti-tigit antibodies and pd-1 axis binding antagonists |
| CN111763660A (zh) * | 2020-08-07 | 2020-10-13 | 南京大学 | 一种重组溶瘤痘苗病毒及其制备方法和应用 |
| TW202246242A (zh) | 2021-01-15 | 2022-12-01 | 美商西健公司 | 免疫調節抗體藥物結合物 |
| CA3206244A1 (en) | 2021-02-03 | 2022-08-11 | Kung-Pern WANG | Immunostimulatory compounds and conjugates |
| WO2022187539A1 (en) | 2021-03-03 | 2022-09-09 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen |
| CN113030487B (zh) * | 2021-03-31 | 2023-11-10 | 山东大学齐鲁医院 | Cd155在宫颈癌诊治中的应用 |
| AR125753A1 (es) | 2021-05-04 | 2023-08-09 | Agenus Inc | Anticuerpos anti-tigit, anticuerpos anti-cd96 y métodos de uso de estos |
| JP2024527049A (ja) | 2021-07-28 | 2024-07-19 | ジェネンテック, インコーポレイテッド | がんを治療するための方法及び組成物 |
| US20250319169A2 (en) * | 2021-08-20 | 2025-10-16 | Akeso Biopharma, Inc. | FUSION PROTEIN CONTAINING ANTI-TIGIT ANTIBODY AND TGF-ßR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF |
| TW202321308A (zh) | 2021-09-30 | 2023-06-01 | 美商建南德克公司 | 使用抗tigit抗體、抗cd38抗體及pd—1軸結合拮抗劑治療血液癌症的方法 |
| KR102680316B1 (ko) * | 2021-11-01 | 2024-07-01 | 오토텔릭바이오 주식회사 | 안티센스 올리고뉴클레오타이드 |
| JP2025509832A (ja) | 2022-03-15 | 2025-04-11 | コンピュジェン リミテッド | Il-18bpアンタゴニスト抗体、並びに癌の治療での単剤療法及び併用療法におけるそれらの使用 |
| CN115043910B (zh) * | 2022-03-25 | 2023-04-07 | 湖南中晟全肽生化有限公司 | 抑制tigit与cd155结合的多肽及其应用 |
| WO2023215740A1 (en) | 2022-05-06 | 2023-11-09 | Seagen Inc. | Immunomodulatory antibody-drug conjugates |
| JP2025523387A (ja) | 2022-06-07 | 2025-07-23 | ジェネンテック, インコーポレイテッド | 抗pd-l1アンタゴニストおよび抗tigitアンタゴニスト抗体を含む、肺がん治療の有効性を判定するための方法 |
| AR130111A1 (es) | 2022-08-03 | 2024-11-06 | Seagen Inc | Conjugados de anticuerpo y fármaco inmunoestimuladores |
| EP4321522A1 (en) | 2022-08-12 | 2024-02-14 | Seagen Inc. | Cytotoxic compounds and conjugates thereof |
| CN116284395B (zh) * | 2022-12-12 | 2024-11-08 | 合肥天港免疫药物有限公司 | 抗cd155的抗体及其应用 |
| TW202515608A (zh) | 2023-06-26 | 2025-04-16 | 以色列商坎布根有限公司 | Il—18bp拮抗抗體及其於癌症治療之單一療法及組合療法的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| MX2010011088A (es) * | 2008-04-09 | 2010-11-05 | Genentech Inc | Composiciones y metodos novedosos para el tratamiento de las enfermedades relacionadas con la inmunidad. |
| IL300733B1 (en) * | 2010-03-05 | 2025-10-01 | Univ Johns Hopkins | Compositions and methods for antibodies and fusion proteins targeted for immune modulation |
| US8478258B2 (en) * | 2010-03-05 | 2013-07-02 | Intel Corporation | Techniques to reduce false detection of control channel messages in a wireless network |
-
2016
- 2016-09-14 AU AU2016322934A patent/AU2016322934A1/en not_active Abandoned
- 2016-09-14 JP JP2018513505A patent/JP2018531914A/ja not_active Withdrawn
- 2016-09-14 WO PCT/US2016/051704 patent/WO2017048824A1/en not_active Ceased
- 2016-09-14 US US15/758,090 patent/US20180251548A1/en not_active Abandoned
- 2016-09-14 CA CA2998589A patent/CA2998589A1/en not_active Abandoned
- 2016-09-14 EP EP16778924.7A patent/EP3349792A1/en not_active Withdrawn
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