JP2018531914A - CD155/TIGIT経路およびTGF−βのアンタゴニストを介してがんを処置するための組成物および方法 - Google Patents
CD155/TIGIT経路およびTGF−βのアンタゴニストを介してがんを処置するための組成物および方法 Download PDFInfo
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Classifications
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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- Life Sciences & Earth Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
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| US201562218169P | 2015-09-14 | 2015-09-14 | |
| US201562218227P | 2015-09-14 | 2015-09-14 | |
| US62/218,169 | 2015-09-14 | ||
| US62/218,227 | 2015-09-14 | ||
| PCT/US2016/051704 WO2017048824A1 (en) | 2015-09-14 | 2016-09-14 | COMPOSITIONS AND METHODS FOR TREATING CANCER VIA ANTAGONISM OF THE CD155/TIGIT PATHWAY AND TGF-β |
Publications (2)
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| JP2018531914A true JP2018531914A (ja) | 2018-11-01 |
| JP2018531914A5 JP2018531914A5 (enExample) | 2019-10-31 |
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| JP2018513505A Withdrawn JP2018531914A (ja) | 2015-09-14 | 2016-09-14 | CD155/TIGIT経路およびTGF−βのアンタゴニストを介してがんを処置するための組成物および方法 |
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| Country | Link |
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| US (1) | US20180251548A1 (enExample) |
| EP (1) | EP3349792A1 (enExample) |
| JP (1) | JP2018531914A (enExample) |
| AU (1) | AU2016322934A1 (enExample) |
| CA (1) | CA2998589A1 (enExample) |
| WO (1) | WO2017048824A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111763660A (zh) * | 2020-08-07 | 2020-10-13 | 南京大学 | 一种重组溶瘤痘苗病毒及其制备方法和应用 |
| JP2022541654A (ja) * | 2019-07-26 | 2022-09-26 | ボード オブ トラスティーズ オブ ミシガン ステート ユニバーシティ | 骨格筋の脂肪変性を予防または処置する方法 |
| JP2022553129A (ja) * | 2019-10-08 | 2022-12-22 | ネクチン セラピューティクス エルティーディー. | ポリオウイルス受容体(pvr)に対する抗体およびその使用 |
| JP2024532836A (ja) * | 2021-08-20 | 2024-09-10 | 中山康方生物医▲藥▼有限公司 | 抗TIGIT抗体及びTGF-βRを含む融合タンパク質、並びにその医薬組成物及び使用 |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102405286A (zh) | 2008-09-22 | 2012-04-04 | 阿克赛医药公司 | 减小大小的自递送RNAi化合物 |
| CN106074591B (zh) | 2010-03-24 | 2020-01-14 | 菲奥医药公司 | 眼部症候中的rna干扰 |
| US9340786B2 (en) | 2010-03-24 | 2016-05-17 | Rxi Pharmaceuticals Corporation | RNA interference in dermal and fibrotic indications |
| TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Tigit結合劑和彼之用途 |
| US11230596B2 (en) | 2016-11-30 | 2022-01-25 | Mereo Biopharma 5, Inc. | Methods for treatment of cancer comprising TIGIT-binding agents |
| EP3579848B1 (en) | 2017-02-08 | 2024-10-30 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| JP7685821B2 (ja) | 2017-02-20 | 2025-05-30 | ドラゴンフライ セラピューティクス, インコーポレイテッド | Her2、NKG2DおよびCD16に結合するタンパク質 |
| US11760777B2 (en) | 2017-04-26 | 2023-09-19 | Bristol-Myers Squibb Company | Methods of antibody production that minimize disulfide bond reduction |
| EP3618863B1 (en) | 2017-05-01 | 2023-07-26 | Agenus Inc. | Anti-tigit antibodies and methods of use thereof |
| US11845798B2 (en) | 2017-05-02 | 2023-12-19 | Merck Sharp & Dohme Llc | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies |
| US20200354453A1 (en) * | 2017-05-02 | 2020-11-12 | Merck Sharp & Dohme Corp. | Stable formulations of anti-tigit antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| MX2019014265A (es) | 2017-06-01 | 2020-08-03 | Compugen Ltd | Tratamientos conjuntos triples con anticuerpos. |
| WO2018229163A1 (en) | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
| SG11201913137VA (en) | 2017-07-11 | 2020-01-30 | Compass Therapeutics Llc | Agonist antibodies that bind human cd137 and uses thereof |
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- 2016-09-14 JP JP2018513505A patent/JP2018531914A/ja not_active Withdrawn
- 2016-09-14 EP EP16778924.7A patent/EP3349792A1/en not_active Withdrawn
- 2016-09-14 AU AU2016322934A patent/AU2016322934A1/en not_active Abandoned
- 2016-09-14 CA CA2998589A patent/CA2998589A1/en not_active Abandoned
- 2016-09-14 WO PCT/US2016/051704 patent/WO2017048824A1/en not_active Ceased
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| JP2022553129A (ja) * | 2019-10-08 | 2022-12-22 | ネクチン セラピューティクス エルティーディー. | ポリオウイルス受容体(pvr)に対する抗体およびその使用 |
| JP7754506B2 (ja) | 2019-10-08 | 2025-10-15 | ネクチン セラピューティクス エルティーディー. | ポリオウイルス受容体(pvr)に対する抗体およびその使用 |
| CN111763660A (zh) * | 2020-08-07 | 2020-10-13 | 南京大学 | 一种重组溶瘤痘苗病毒及其制备方法和应用 |
| JP2024532836A (ja) * | 2021-08-20 | 2024-09-10 | 中山康方生物医▲藥▼有限公司 | 抗TIGIT抗体及びTGF-βRを含む融合タンパク質、並びにその医薬組成物及び使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017048824A1 (en) | 2017-03-23 |
| US20180251548A1 (en) | 2018-09-06 |
| EP3349792A1 (en) | 2018-07-25 |
| CA2998589A1 (en) | 2017-03-23 |
| AU2016322934A1 (en) | 2018-04-12 |
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