JP2019530640A5 - - Google Patents
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- JP2019530640A5 JP2019530640A5 JP2019502573A JP2019502573A JP2019530640A5 JP 2019530640 A5 JP2019530640 A5 JP 2019530640A5 JP 2019502573 A JP2019502573 A JP 2019502573A JP 2019502573 A JP2019502573 A JP 2019502573A JP 2019530640 A5 JP2019530640 A5 JP 2019530640A5
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- JP
- Japan
- Prior art keywords
- seq
- sequence number
- binding molecule
- binding
- multimer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 43
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 41
- 210000004027 cell Anatomy 0.000 claims description 27
- 239000012634 fragment Substances 0.000 claims description 23
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 21
- 239000000427 antigen Substances 0.000 claims description 18
- 102000036639 antigens Human genes 0.000 claims description 18
- 108091007433 antigens Proteins 0.000 claims description 18
- 108091033319 polynucleotide Proteins 0.000 claims description 14
- 102000040430 polynucleotide Human genes 0.000 claims description 14
- 239000002157 polynucleotide Substances 0.000 claims description 14
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 12
- 230000001404 mediated effect Effects 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 230000011664 signaling Effects 0.000 claims description 8
- 101000840258 Homo sapiens Immunoglobulin J chain Proteins 0.000 claims description 6
- 102100029571 Immunoglobulin J chain Human genes 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 229920001184 polypeptide Polymers 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 210000003162 effector t lymphocyte Anatomy 0.000 claims description 5
- 230000001939 inductive effect Effects 0.000 claims description 5
- 239000000178 monomer Substances 0.000 claims description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
- 210000003289 regulatory T cell Anatomy 0.000 claims description 5
- 230000004044 response Effects 0.000 claims description 5
- 230000002476 tumorcidal effect Effects 0.000 claims description 5
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims description 4
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims description 4
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 4
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 4
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000000977 initiatory effect Effects 0.000 claims description 4
- 238000006467 substitution reaction Methods 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 3
- 238000004132 cross linking Methods 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 150000007523 nucleic acids Chemical group 0.000 claims description 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 claims description 2
- 230000005809 anti-tumor immunity Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 230000035755 proliferation Effects 0.000 claims description 2
- 210000004881 tumor cell Anatomy 0.000 claims description 2
- 230000005909 tumor killing Effects 0.000 claims description 2
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 101001055311 Equus asinus Immunoglobulin heavy constant alpha Proteins 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102400001107 Secretory component Human genes 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662364763P | 2016-07-20 | 2016-07-20 | |
| US62/364,763 | 2016-07-20 | ||
| PCT/US2017/043165 WO2018017888A1 (en) | 2016-07-20 | 2017-07-20 | Multimeric ox40 binding molecules and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019530640A JP2019530640A (ja) | 2019-10-24 |
| JP2019530640A5 true JP2019530640A5 (enExample) | 2020-08-13 |
Family
ID=60996094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019502573A Withdrawn JP2019530640A (ja) | 2016-07-20 | 2017-07-20 | 多量体ｏｘ４０結合分子及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190330374A1 (enExample) |
| EP (1) | EP3487533A4 (enExample) |
| JP (1) | JP2019530640A (enExample) |
| CN (1) | CN109562165A (enExample) |
| AU (1) | AU2017298483A1 (enExample) |
| CA (1) | CA3030647A1 (enExample) |
| IL (1) | IL263799A (enExample) |
| MX (1) | MX2019000796A (enExample) |
| WO (1) | WO2018017888A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3041862T3 (da) | 2013-09-05 | 2020-07-27 | Igm Biosciences Inc | Modificerede bispecifikke, penta- og hexavalente ig-m-antistoffer med konstant kæde |
| DK3105250T3 (da) | 2014-02-10 | 2020-09-28 | Igm Biosciences Inc | Multispecifikke iga-bindingsmolekyler |
| IL292311A (en) | 2014-04-03 | 2022-06-01 | Igm Biosciences Inc | J-chain qualified |
| JP7179464B2 (ja) | 2015-01-20 | 2022-11-29 | アイジーエム バイオサイエンシズ インコーポレイテッド | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| SG11201707144VA (en) | 2015-03-04 | 2017-09-28 | Igm Biosciences Inc | Cd20 binding molecules and uses thereof |
| AU2016238246B2 (en) | 2015-03-25 | 2021-05-13 | Igm Biosciences, Inc. | Multi-valent hepatitis B virus antigen binding molecules and uses thereof |
| JP6811723B2 (ja) | 2015-04-17 | 2021-01-13 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多価ヒト免疫不全ウイルス抗原結合分子およびその使用方法 |
| US11639389B2 (en) | 2015-09-30 | 2023-05-02 | Igm Biosciences, Inc. | Binding molecules with modified J-chain |
| CA2999284C (en) | 2015-09-30 | 2023-06-13 | Igm Biosciences A/S | Binding molecules with modified j-chain |
| DK3455257T3 (da) | 2016-05-09 | 2021-11-01 | Igm Biosciences Inc | Anti-pd-l1-antistoffer |
| KR102696143B1 (ko) | 2017-04-07 | 2024-08-21 | 아이쥐엠 바이오사이언스 인코포레이티드 | 보체-의존성 세포용해 효과기 기능의 조정을 위한 변형된 인간 IgM 불변 영역 |
| EP3758752A4 (en) | 2018-03-01 | 2021-12-15 | IGM Biosciences Inc. | IGM-FC AND J-CHAIN MUTATIONS AFFECTING IGM SERUM HALF-LIFE |
| TWI726426B (zh) * | 2018-09-25 | 2021-05-01 | 大陸商信達生物製藥（蘇州）有限公司 | 包含抗ｏｘ４０抗體的製劑、其製備方法及其用途 |
| JP2022505663A (ja) * | 2018-10-23 | 2022-01-14 | アイジーエム バイオサイエンシズ インコーポレイテッド | ＩｇＭ－Ｆｃベース及びＩｇＡ－Ｆｃベースの多価結合分子 |
| CN110172090B (zh) * | 2019-06-03 | 2020-04-03 | 中山标佳生物科技有限公司 | Cd134单克隆抗体及其制备方法和癌症治疗中的应用 |
| AU2020329301A1 (en) | 2019-08-15 | 2022-02-17 | Igm Biosciences, Inc. | Immunostimulatory multimeric binding molecules |
| BR112022021392A2 (pt) | 2020-04-22 | 2022-12-06 | Igm Biosciences Inc | Moléculas de ligação multiméricas de agonista de pd-1 |
| CN112957475B (zh) * | 2021-02-04 | 2022-07-22 | 李文峰 | 一种预防和或治疗肿瘤的组合物及应用 |
| US20220332837A1 (en) * | 2021-04-08 | 2022-10-20 | Colorado State University Research Foundation | Methods and compositions for ox40 activation in treatment of canine cancer |
| US12600801B2 (en) | 2022-07-11 | 2026-04-14 | Fred Hutchinson Cancer Center | Single-domain antibodies that bind ROR1 |
| WO2025160083A1 (en) * | 2024-01-22 | 2025-07-31 | Onko-Innate Pty Ltd | Targeted low potency il-12 fc fusion proteins and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116092D0 (en) * | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| US9382319B2 (en) * | 2011-09-26 | 2016-07-05 | Jn Biosciences Llc | Hybrid constant regions |
| US9828432B2 (en) * | 2012-02-06 | 2017-11-28 | Providence Health & Services—Oregon | Cancer treatment and monitoring methods using OX40 agonists |
| WO2015153514A1 (en) * | 2014-03-31 | 2015-10-08 | Genentech, Inc. | Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists |
| TW201619200A (zh) * | 2014-10-10 | 2016-06-01 | 麥迪紐有限責任公司 | 人類化抗－ｏｘ４０抗體及其用途 |
| IL298686A (en) * | 2016-01-11 | 2023-01-01 | Inhibrx Inc | Multivalent and multispecific ox40-binding fusion proteins |
-
2017
- 2017-07-20 EP EP17831908.3A patent/EP3487533A4/en not_active Withdrawn
- 2017-07-20 CN CN201780044931.3A patent/CN109562165A/zh active Pending
- 2017-07-20 AU AU2017298483A patent/AU2017298483A1/en not_active Abandoned
- 2017-07-20 JP JP2019502573A patent/JP2019530640A/ja not_active Withdrawn
- 2017-07-20 CA CA3030647A patent/CA3030647A1/en not_active Abandoned
- 2017-07-20 MX MX2019000796A patent/MX2019000796A/es unknown
- 2017-07-20 US US16/317,814 patent/US20190330374A1/en not_active Abandoned
- 2017-07-20 WO PCT/US2017/043165 patent/WO2018017888A1/en not_active Ceased
-
2018
- 2018-12-18 IL IL263799A patent/IL263799A/en unknown
-
2022
- 2022-02-17 US US17/673,864 patent/US20220169751A1/en not_active Abandoned