JP2017525343A5 - - Google Patents
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- JP2017525343A5 JP2017525343A5 JP2017501280A JP2017501280A JP2017525343A5 JP 2017525343 A5 JP2017525343 A5 JP 2017525343A5 JP 2017501280 A JP2017501280 A JP 2017501280A JP 2017501280 A JP2017501280 A JP 2017501280A JP 2017525343 A5 JP2017525343 A5 JP 2017525343A5
- Authority
- JP
- Japan
- Prior art keywords
- hil
- antigen
- binding
- nmol
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14176619.6 | 2014-07-10 | ||
| EP14176619 | 2014-07-10 | ||
| PCT/IB2015/055226 WO2016005950A1 (en) | 2014-07-10 | 2015-07-10 | Immune-stimulating monoclonal antibodies against human interleukin-2 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525343A JP2017525343A (ja) | 2017-09-07 |
| JP2017525343A5 true JP2017525343A5 (enExample) | 2018-08-16 |
| JP7209464B2 JP7209464B2 (ja) | 2023-01-20 |
Family
ID=51162588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017501280A Active JP7209464B2 (ja) | 2014-07-10 | 2015-07-10 | ヒトインターロイキン－２に対する免疫刺激性モノクローナル抗体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10894828B2 (enExample) |
| EP (2) | EP3693389B1 (enExample) |
| JP (1) | JP7209464B2 (enExample) |
| CN (1) | CN106604932B (enExample) |
| AU (1) | AU2015287227B2 (enExample) |
| CA (1) | CA2954476C (enExample) |
| DK (1) | DK3166973T3 (enExample) |
| ES (2) | ES2989669T3 (enExample) |
| WO (1) | WO2016005950A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1257518A1 (zh) | 2016-01-11 | 2019-10-25 | Novartis Ag | 针对人白介素-2的免疫刺激性人源化单克隆抗体及其融合蛋白 |
| CN110087681A (zh) | 2016-09-28 | 2019-08-02 | 佐马美国有限公司 | 结合白细胞介素-2的抗体和其用途 |
| GB201621806D0 (en) * | 2016-12-21 | 2017-02-01 | Philogen Spa | Immunocytokines with progressive activation mechanism |
| WO2018156955A1 (en) * | 2017-02-23 | 2018-08-30 | City Of Hope | Methods for in vivo expansion of cd8+ t cells and prevention or treatment of gvhd |
| US11274146B2 (en) | 2017-03-23 | 2022-03-15 | The Trustees Of The University Of Pennsylvania | Anti-C5a antibodies and uses thereof |
| US11117958B2 (en) | 2017-05-25 | 2021-09-14 | Institute For Basic Science | Anti-human interleukin-2 antibodies and uses thereof |
| KR20200135986A (ko) | 2018-03-19 | 2020-12-04 | 멀티비르 인코포레이티드 | 종양 억제인자 유전자 치료 및 cd122/cd132 작용제를 포함하는 암 치료를 위한 방법 및 조성물 |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| CN115768483A (zh) | 2020-01-13 | 2023-03-07 | 西纳福克斯股份有限公司 | 抗体与免疫细胞衔接器的缀合物 |
| MX2022010034A (es) | 2020-02-16 | 2022-12-13 | Aulos Bioscience Inc | Anticuerpos anti-il-2 diseñados. |
| PH12022552719A1 (en) * | 2020-04-22 | 2024-02-05 | Merck Sharp & Dohme Llc | HUMAN INTERLEUKIN-2 CONJUGATES BIASED FOR THE INTERLEUKIN-2 RECEPTOR BETA GAMMAc DIMER AND CONJUGATED TO A NONPEPTIDIC, WATER-SOLUBLE POLYMER |
| CN116783213A (zh) * | 2020-08-18 | 2023-09-19 | 苏黎世大学 | Cd25偏向的抗il‐2抗体 |
| CA3189257A1 (en) * | 2020-08-18 | 2022-02-24 | Universitat Zurich | A cd25-biased anti-il-2 antibody |
| JP2024506022A (ja) | 2021-02-08 | 2024-02-08 | シンアフィックス ビー．ブイ． | 多機能性抗体 |
| CA3234995A1 (en) | 2021-10-14 | 2023-04-20 | Latticon (Suzhou) Biopharmaceuticals Co., Ltd. | Novel antibody-cytokine fusion protein, preparation method therefor and use thereof |
| US11773160B1 (en) | 2022-08-05 | 2023-10-03 | Anaveon AG | Immune-stimulating IL-2 fusion proteins |
| CN119912559B (zh) * | 2025-01-22 | 2025-12-26 | 贵州中医药大学 | 一种新冠病毒变异株jn.1刺突s蛋白的单链抗体及其应用 |
| CN119775409B (zh) * | 2025-03-05 | 2025-07-11 | 深圳真实生物医药科技有限公司 | 靶向sost的抗体及其用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ210634A (en) * | 1983-12-23 | 1989-05-29 | Hoffmann La Roche | Purification of recombinant human interleukin - 2; pharmaceutical compositions |
| DK134487A (da) * | 1986-03-17 | 1987-09-18 | Hoffmann La Roche | Monoklonalt antistof med affinitet for humant interleukin-2 |
| US6111090A (en) | 1996-08-16 | 2000-08-29 | Schering Corporation | Mammalian cell surface antigens; related reagents |
| DE69738749D1 (de) | 1996-08-16 | 2008-07-17 | Schering Corp | Zelloberflächen-antigen aus säugetieren und verwandte reagenzien |
| JP3614866B2 (ja) | 1997-06-12 | 2005-01-26 | リサーチ コーポレイション テクノロジーズ，インコーポレイティド | 人工抗体ポリペプチド |
| EP2572714A1 (en) | 2002-12-30 | 2013-03-27 | 3M Innovative Properties Company | Immunostimulatory Combinations |
| US20060002932A1 (en) | 2004-06-04 | 2006-01-05 | Duke University | Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity |
| EP1888644A1 (en) * | 2005-06-01 | 2008-02-20 | Micromet AG | Anti-il2 antibodies |
| CN102875681A (zh) * | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
| CN101573139A (zh) * | 2006-02-16 | 2009-11-04 | 纳森特生物制剂公司 | 在哺乳动物个体中改善免疫功能的方法以及预防或治疗疾病的方法 |
| CN101045923B (zh) * | 2006-03-31 | 2011-11-23 | 沈阳三生制药有限责任公司 | 生产一种白细胞介素类似物的方法 |
| RU2531758C2 (ru) | 2008-02-11 | 2014-10-27 | Куретек Лтд. | Моноклональные антитела для лечения опухолей |
| DK3339323T3 (da) * | 2010-08-12 | 2020-01-20 | Lilly Co Eli | Anti-n3pglu-amyloid-beta-peptid-antistoffer og anvendelser deraf |
| HUE029139T2 (hu) | 2011-02-10 | 2017-02-28 | Roche Glycart Ag | Mutáns interleukin-2 polipeptidek |
| WO2013157105A1 (ja) | 2012-04-18 | 2013-10-24 | 公立大学法人大阪市立大学 | ムチンサブタイプ５ａｃ特異的ヒト化抗体およびその利用 |
| CN103566377A (zh) | 2012-07-18 | 2014-02-12 | 上海博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| WO2015109212A1 (en) * | 2014-01-17 | 2015-07-23 | Pfizer Inc. | Anti-il-2 antibodies and compositions and uses thereof |
-
2015
- 2015-07-10 CA CA2954476A patent/CA2954476C/en active Active
- 2015-07-10 EP EP20158066.9A patent/EP3693389B1/en active Active
- 2015-07-10 US US15/324,468 patent/US10894828B2/en active Active
- 2015-07-10 ES ES20158066T patent/ES2989669T3/es active Active
- 2015-07-10 AU AU2015287227A patent/AU2015287227B2/en not_active Ceased
- 2015-07-10 CN CN201580048027.0A patent/CN106604932B/zh active Active
- 2015-07-10 JP JP2017501280A patent/JP7209464B2/ja active Active
- 2015-07-10 DK DK15759938.2T patent/DK3166973T3/da active
- 2015-07-10 EP EP15759938.2A patent/EP3166973B1/en active Active
- 2015-07-10 WO PCT/IB2015/055226 patent/WO2016005950A1/en not_active Ceased
- 2015-07-10 ES ES15759938T patent/ES2779977T3/es active Active
-
2020
- 2020-12-22 US US17/131,221 patent/US20210230269A1/en not_active Abandoned
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