JP2018503401A5 - - Google Patents
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- JP2018503401A5 JP2018503401A5 JP2017556795A JP2017556795A JP2018503401A5 JP 2018503401 A5 JP2018503401 A5 JP 2018503401A5 JP 2017556795 A JP2017556795 A JP 2017556795A JP 2017556795 A JP2017556795 A JP 2017556795A JP 2018503401 A5 JP2018503401 A5 JP 2018503401A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 41
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 39
- 102000003390 tumor necrosis factor Human genes 0.000 claims description 39
- 102000005962 receptors Human genes 0.000 claims description 38
- 108020003175 receptors Proteins 0.000 claims description 38
- 239000000427 antigen Substances 0.000 claims description 33
- 102000036639 antigens Human genes 0.000 claims description 33
- 108091007433 antigens Proteins 0.000 claims description 33
- 239000012634 fragment Substances 0.000 claims description 23
- 108091033319 polynucleotide Proteins 0.000 claims description 23
- 102000040430 polynucleotide Human genes 0.000 claims description 23
- 239000002157 polynucleotide Substances 0.000 claims description 23
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 claims description 13
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 claims description 13
- 230000006907 apoptotic process Effects 0.000 claims description 13
- 201000011510 cancer Diseases 0.000 claims description 13
- 229920001184 polypeptide Polymers 0.000 claims description 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 11
- 101000610605 Homo sapiens Tumor necrosis factor receptor superfamily member 10A Proteins 0.000 claims description 11
- 102100040113 Tumor necrosis factor receptor superfamily member 10A Human genes 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 230000001939 inductive effect Effects 0.000 claims description 9
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 8
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 8
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 101000840258 Homo sapiens Immunoglobulin J chain Proteins 0.000 claims description 7
- 101000610602 Homo sapiens Tumor necrosis factor receptor superfamily member 10C Proteins 0.000 claims description 7
- 101000610609 Homo sapiens Tumor necrosis factor receptor superfamily member 10D Proteins 0.000 claims description 7
- 102100029571 Immunoglobulin J chain Human genes 0.000 claims description 7
- 102100040115 Tumor necrosis factor receptor superfamily member 10C Human genes 0.000 claims description 7
- 102100040110 Tumor necrosis factor receptor superfamily member 10D Human genes 0.000 claims description 7
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims description 7
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims description 7
- 239000013598 vector Substances 0.000 claims description 7
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 6
- 238000006467 substitution reaction Methods 0.000 claims description 6
- 230000001404 mediated effect Effects 0.000 claims description 5
- 101150013553 CD40 gene Proteins 0.000 claims description 4
- 101001055311 Equus asinus Immunoglobulin heavy constant alpha Proteins 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 4
- 150000007523 nucleic acids Chemical group 0.000 claims description 4
- 101000648505 Homo sapiens Tumor necrosis factor receptor superfamily member 12A Proteins 0.000 claims description 3
- 101000679907 Homo sapiens Tumor necrosis factor receptor superfamily member 27 Proteins 0.000 claims description 3
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims description 3
- 101000920026 Homo sapiens Tumor necrosis factor receptor superfamily member EDAR Proteins 0.000 claims description 3
- 108060003951 Immunoglobulin Proteins 0.000 claims description 3
- 108010035042 Osteoprotegerin Proteins 0.000 claims description 3
- 102000008108 Osteoprotegerin Human genes 0.000 claims description 3
- 108010014401 TWEAK Receptor Proteins 0.000 claims description 3
- 102000016946 TWEAK Receptor Human genes 0.000 claims description 3
- 102100032236 Tumor necrosis factor receptor superfamily member 11B Human genes 0.000 claims description 3
- 102100028786 Tumor necrosis factor receptor superfamily member 12A Human genes 0.000 claims description 3
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims description 3
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims description 3
- 102100022202 Tumor necrosis factor receptor superfamily member 27 Human genes 0.000 claims description 3
- 102100040403 Tumor necrosis factor receptor superfamily member 6 Human genes 0.000 claims description 3
- 102100030810 Tumor necrosis factor receptor superfamily member EDAR Human genes 0.000 claims description 3
- 230000001640 apoptogenic effect Effects 0.000 claims description 3
- 102000018358 immunoglobulin Human genes 0.000 claims description 3
- 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 claims description 2
- 101000679903 Homo sapiens Tumor necrosis factor receptor superfamily member 25 Proteins 0.000 claims description 2
- 101000597785 Homo sapiens Tumor necrosis factor receptor superfamily member 6B Proteins 0.000 claims description 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 2
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 2
- 102400001107 Secretory component Human genes 0.000 claims description 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims description 2
- 102100022203 Tumor necrosis factor receptor superfamily member 25 Human genes 0.000 claims description 2
- 102100035284 Tumor necrosis factor receptor superfamily member 6B Human genes 0.000 claims description 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims description 2
- 230000011664 signaling Effects 0.000 claims 5
- 230000019552 anatomical structure morphogenesis Effects 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 230000019491 signal transduction Effects 0.000 claims 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 22
- 210000003494 hepatocyte Anatomy 0.000 description 3
- 241001024304 Mino Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562105323P | 2015-01-20 | 2015-01-20 | |
| US62/105,323 | 2015-01-20 | ||
| PCT/US2016/014153 WO2016118641A1 (en) | 2015-01-20 | 2016-01-20 | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020158581A Division JP2021006044A (ja) | 2015-01-20 | 2020-09-23 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503401A JP2018503401A (ja) | 2018-02-08 |
| JP2018503401A5 true JP2018503401A5 (enExample) | 2019-02-28 |
| JP7179464B2 JP7179464B2 (ja) | 2022-11-29 |
Family
ID=56417700
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556795A Active JP7179464B2 (ja) | 2015-01-20 | 2016-01-20 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| JP2020158581A Pending JP2021006044A (ja) | 2015-01-20 | 2020-09-23 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| JP2022142258A Active JP7499813B2 (ja) | 2015-01-20 | 2022-09-07 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| JP2024090474A Withdrawn JP2024113039A (ja) | 2015-01-20 | 2024-06-04 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020158581A Pending JP2021006044A (ja) | 2015-01-20 | 2020-09-23 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| JP2022142258A Active JP7499813B2 (ja) | 2015-01-20 | 2022-09-07 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| JP2024090474A Withdrawn JP2024113039A (ja) | 2015-01-20 | 2024-06-04 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US10689449B2 (enExample) |
| EP (2) | EP3750918A1 (enExample) |
| JP (4) | JP7179464B2 (enExample) |
| KR (1) | KR102435324B1 (enExample) |
| CN (1) | CN107207601A (enExample) |
| AU (2) | AU2016209324B2 (enExample) |
| CA (1) | CA2972990A1 (enExample) |
| DK (1) | DK3247728T3 (enExample) |
| ES (1) | ES2806500T3 (enExample) |
| HU (1) | HUE051013T2 (enExample) |
| IL (3) | IL284430B2 (enExample) |
| NZ (1) | NZ732922A (enExample) |
| PL (1) | PL3247728T3 (enExample) |
| PT (1) | PT3247728T (enExample) |
| SG (2) | SG11201705116SA (enExample) |
| SI (1) | SI3247728T1 (enExample) |
| WO (1) | WO2016118641A1 (enExample) |
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| CN105722855B (zh) | 2013-09-05 | 2021-04-23 | Igm生物科学股份有限公司 | 恒定链经修饰的双特异性五价和六价Ig-M抗体 |
| KR102378289B1 (ko) | 2014-02-10 | 2022-03-23 | 아이쥐엠 바이오사이언스 인코포레이티드 | IgA 다중-특이적 결합 분자 |
| CN112759650B (zh) | 2014-04-03 | 2024-10-01 | Igm生物科学股份有限公司 | 修饰的j链 |
| CA2972990A1 (en) | 2015-01-20 | 2016-07-28 | Beatrice Tien-Yi WANG | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
| NZ762365A (en) | 2015-03-04 | 2024-11-29 | Igm Biosciences Inc | Cd20 binding molecules and uses thereof |
| WO2016154593A1 (en) | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| CN107847591B (zh) | 2015-04-17 | 2023-07-28 | Igm生物科学股份有限公司 | 多价人免疫缺陷病毒抗原结合分子及其应用 |
| WO2017059387A1 (en) | 2015-09-30 | 2017-04-06 | Igm Biosciences, Inc. | Binding molecules with modified j-chain |
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| CA3058825A1 (en) * | 2017-04-06 | 2018-10-11 | Universitat Stuttgart | Tumor necrosis factor receptor (tnfr) binding protein complex with improved binding and bioactivity |
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