HUE051013T2 - Tumor nekrózis faktor (TNF) szupercsalád receptor kötõ molekulák és ezek alkalmazása - Google Patents
Tumor nekrózis faktor (TNF) szupercsalád receptor kötõ molekulák és ezek alkalmazásaInfo
- Publication number
- HUE051013T2 HUE051013T2 HUE16740686A HUE16740686A HUE051013T2 HU E051013 T2 HUE051013 T2 HU E051013T2 HU E16740686 A HUE16740686 A HU E16740686A HU E16740686 A HUE16740686 A HU E16740686A HU E051013 T2 HUE051013 T2 HU E051013T2
- Authority
- HU
- Hungary
- Prior art keywords
- tnf
- receptor binding
- necrosis factor
- tumor necrosis
- binding molecules
- Prior art date
Links
- 108060008682 Tumor Necrosis Factor Proteins 0.000 title 1
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
- 102000003390 tumor necrosis factor Human genes 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562105323P | 2015-01-20 | 2015-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE051013T2 true HUE051013T2 (hu) | 2021-01-28 |
Family
ID=56417700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE16740686A HUE051013T2 (hu) | 2015-01-20 | 2016-01-20 | Tumor nekrózis faktor (TNF) szupercsalád receptor kötõ molekulák és ezek alkalmazása |
Country Status (17)
Country | Link |
---|---|
US (4) | US10689449B2 (hu) |
EP (2) | EP3750918A1 (hu) |
JP (3) | JP7179464B2 (hu) |
KR (1) | KR102435324B1 (hu) |
CN (1) | CN107207601A (hu) |
AU (2) | AU2016209324B2 (hu) |
CA (1) | CA2972990A1 (hu) |
DK (1) | DK3247728T3 (hu) |
ES (1) | ES2806500T3 (hu) |
HU (1) | HUE051013T2 (hu) |
IL (3) | IL284430B2 (hu) |
NZ (1) | NZ732922A (hu) |
PL (1) | PL3247728T3 (hu) |
PT (1) | PT3247728T (hu) |
SG (2) | SG11201705116SA (hu) |
SI (1) | SI3247728T1 (hu) |
WO (1) | WO2016118641A1 (hu) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015053887A1 (en) | 2013-09-05 | 2015-04-16 | Igm Biosciences, Inc. | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
BR112016018313A8 (pt) | 2014-02-10 | 2018-06-12 | Igm Biosciences Inc | Moléculas de ligação multiespecíficas iga |
PL3560954T3 (pl) | 2014-04-03 | 2021-12-13 | Igm Biosciences, Inc. | Zmodyfikowany łańcuch J |
SG11201705116SA (en) | 2015-01-20 | 2017-08-30 | Igm Biosciences Inc | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
ES2874558T3 (es) | 2015-03-04 | 2021-11-05 | Igm Biosciences Inc | Moléculas de unión a CD20 y usos de las mismas |
JP6882184B2 (ja) | 2015-03-25 | 2021-06-02 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多価b型肝炎ウイルス抗原結合分子およびその使用 |
AU2016249404B2 (en) | 2015-04-17 | 2021-01-21 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
CA2999284C (en) | 2015-09-30 | 2023-06-13 | Igm Biosciences A/S | Binding molecules with modified j-chain |
DK3356401T3 (da) | 2015-09-30 | 2020-09-07 | Igm Biosciences Inc | Bindingsmolekyler med modificeret j-kæde |
IL262295B2 (en) | 2016-05-09 | 2023-09-01 | Igm Biosciences Inc | Antibodies against pd–l1 |
JP2019528683A (ja) * | 2016-07-20 | 2019-10-17 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多量体gitr結合分子及びその使用 |
MA45941A (fr) * | 2016-08-12 | 2019-06-19 | Janssen Biotech Inc | Anticorps de membres de la superfamille anti-tnfr modifiés par fc ayant une activité agoniste améliorée et leurs procédés d'utilisation |
EP3360898A1 (en) | 2017-02-14 | 2018-08-15 | Boehringer Ingelheim International GmbH | Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer |
AU2018247931B2 (en) * | 2017-04-06 | 2022-03-03 | Universität Stuttgart | Tumor necrosis factor receptor (TNFR) binding protein complex with improved binding and bioactivity |
JP2020512820A (ja) | 2017-04-07 | 2020-04-30 | アイジーエム バイオサイエンシズ インコーポレイテッド | 補体依存性細胞溶解のエフェクター機能の調節のための修飾されたヒトIgM定常領域 |
WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
CN108251443A (zh) * | 2018-01-23 | 2018-07-06 | 深圳市人民医院 | 一种tnfrsf10c重组质粒、制备方法及其应用 |
WO2019157772A1 (zh) * | 2018-02-13 | 2019-08-22 | 和元生物技术(上海)股份有限公司 | 抗trailr2抗体-毒素-偶联物及其在抗肿瘤治疗中的药物用途 |
US20200392239A1 (en) * | 2018-02-26 | 2020-12-17 | Igm Biosciences, Inc. | Use of a multimeric anti-dr5 binding molecule in combination with a chemotherapeutic agent for treating cancer |
CA3091144A1 (en) | 2018-03-01 | 2019-09-06 | Igm Biosciences, Inc. | Igm fc and j-chain mutations that affect igm serum half-life |
US11845797B2 (en) | 2018-07-03 | 2023-12-19 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
US20220017630A1 (en) * | 2019-08-02 | 2022-01-20 | Jiangsu Simcere Pharmaceutical Co., Ltd. | Anti-tnfr2 antibody and use thereof |
CN115443140A (zh) * | 2020-04-02 | 2022-12-06 | 苏州恒康生命科学有限公司 | 人ror-1抗体和抗ror-1-car-t细胞 |
JP2023522962A (ja) | 2020-04-22 | 2023-06-01 | アイジーエム バイオサイエンシズ インコーポレイテッド | Pd-1アゴニスト多量体結合分子 |
WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
JP7203870B2 (ja) | 2021-01-18 | 2023-01-13 | イビデン株式会社 | 組電池用熱伝達抑制シート及び組電池 |
GB2623199A (en) | 2021-04-08 | 2024-04-10 | Marengo Therapeutics Inc | Multifunctional molecules binding to TCR and uses thereof |
Family Cites Families (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DK0710719T3 (da) | 1990-01-12 | 2007-07-09 | Amgen Fremont Inc | Frembringelse af xenogene antistoffer |
GB9015908D0 (en) | 1990-07-19 | 1990-09-05 | Celltech Ltd | Multivalent immunoglobulin |
US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
EP0642585B1 (en) | 1992-05-18 | 2005-12-28 | Genentech, Inc. | Activation of oligomerizing receptors by using fused receptor ligands |
ATE204299T1 (de) | 1993-03-05 | 2001-09-15 | Bayer Ag | Humane monoklonale anti-tnf alpha antikörper |
CA2139385C (en) | 1994-02-04 | 2001-12-25 | Gottfried Alber | Products containing g-csf and tnf binding protein |
AU697387C (en) | 1994-09-16 | 2006-03-02 | Austin Research Institute Cancer and Anti-inflammatory Syndicate No 1 | Polypeptides with Fc binding ability |
US8791237B2 (en) | 1994-11-08 | 2014-07-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of non-hodgkins lymphoma |
CN1146442C (zh) | 1995-01-26 | 2004-04-21 | 拜奥根有限公司 | 作为抗肿瘤剂的淋巴毒素-α/β复合体和抗淋巴毒素-β受体抗体 |
IL116784A (en) | 1996-01-16 | 2000-01-31 | Hadasit Med Res Service | Device for examining viscoelasticity of a living or artificial tissue |
US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
US20060269558A1 (en) | 1998-04-27 | 2006-11-30 | Murphy Gerald P | Nr-CAM gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors |
CN101518648A (zh) | 1999-01-07 | 2009-09-02 | 津莫吉尼蒂克斯公司 | 可溶性受体br43×2和应用方法 |
MXPA01008936A (es) | 1999-03-04 | 2003-07-21 | Human Genome Sciences Inc | Receptores 6 alfa y 6 beta del factor de necrosis tumoral. |
CA2367315A1 (en) | 1999-03-11 | 2000-09-14 | Human Genome Sciences, Inc. | Apoptosis inducing molecule ii and methods of use |
DE19963859A1 (de) | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
US7262005B1 (en) | 2000-02-04 | 2007-08-28 | Aurora Biosciences Corporation | Methods of protein destabilization and uses thereof |
SI2857516T1 (sl) | 2000-04-11 | 2017-09-29 | Genentech, Inc. | Multivalentna protitelesa in njihove uporabe |
TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
US7094875B2 (en) | 2000-06-23 | 2006-08-22 | Maxygen, Inc. | Co-stimulatory polypeptides |
IL153853A0 (en) | 2000-07-10 | 2003-07-31 | Novartis Ag | Bifunctional molecules and vectors complexed therewith for targeted gene delivery |
WO2002102303A2 (en) | 2001-05-01 | 2002-12-27 | Medimmune, Inc. | Crystals and structure of synagis fab |
KR100932577B1 (ko) * | 2001-05-18 | 2009-12-17 | 기린 홀딩스 가부시키가이샤 | 항 trail-r 항체 |
US20050214210A1 (en) * | 2001-05-25 | 2005-09-29 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
CA2448362A1 (en) | 2001-05-25 | 2002-12-05 | Amgen, Inc. | B7 related protein-2 molecules and uses thereof |
WO2002102323A2 (en) | 2001-06-14 | 2002-12-27 | Bristol-Myers Squibb Company | Novel human histone deacetylases |
US20030180296A1 (en) | 2001-12-20 | 2003-09-25 | Theodora Salcedo | Antibodies that immunospecifically bind to trail receptors |
CN101537180B (zh) | 2002-07-18 | 2016-02-10 | 莫鲁斯有限公司 | 抗体混合物的重组生产 |
GB0220205D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Neisseria toxin |
DE60334247D1 (de) | 2002-11-27 | 2010-10-28 | Irm Llc | Verfahren und zusammensetzungen zur apoptoseinduktion in krebszellen |
AU2003303889A1 (en) | 2003-01-07 | 2004-08-30 | Biomerieux | Polypeptides f' of the hepatitis c virus, epitopes, and the diagnostic and therapeutic applications thereof |
AU2004256354B2 (en) | 2003-07-15 | 2011-07-07 | Chugai Seiyaku Kabushiki Kaisha | IgM production by transformed cells and methods for quantifying said IgM production |
CA2534374A1 (en) | 2003-08-01 | 2005-02-10 | Enhan Technology Holdings International Co., Ltd. | Effects of sporoderm-broken germination activated ganoderma spores on treatment of spinal cord injury and proliferation and/or differentiation of neural stem cells in injured spinal cord |
CN100427505C (zh) | 2004-08-19 | 2008-10-22 | 中国医学科学院基础医学研究所 | 抗人肿瘤坏死因子相关凋亡诱导配体的受体dr5单克隆抗体(ad5-10)及其制法与用途 |
CN101098889A (zh) | 2004-11-05 | 2008-01-02 | 盘林京有限公司 | 抗体导致的细胞膜损伤 |
WO2006063067A2 (en) | 2004-12-09 | 2006-06-15 | La Jolla Institute For Allergy And Immunology | Novel tnf receptor regulatory domain |
AU2006206234B2 (en) | 2005-01-21 | 2012-01-12 | Epitopix, Llc | Yersinia spp. polypeptides and methods of use |
US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
US20060269556A1 (en) | 2005-04-18 | 2006-11-30 | Karl Nocka | Mast cell activation using siglec 6 antibodies |
PE20061324A1 (es) | 2005-04-29 | 2007-01-15 | Centocor Inc | Anticuerpos anti-il-6, composiciones, metodos y usos |
US8088908B2 (en) | 2005-05-10 | 2012-01-03 | City Of Hope | Humanized anti-prostate stem cell antigen monoclonal antibody |
US20060269569A1 (en) | 2005-05-16 | 2006-11-30 | Liu Yuen | Universal antioncotic and pain relieving ointment |
US20060269567A1 (en) | 2005-05-16 | 2006-11-30 | Liu Yuen | Universal detoxifying composition |
US20060269560A1 (en) | 2005-05-24 | 2006-11-30 | Savarino Stephen J | Anti-adhesin based passive immunoprophlactic |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
AR056142A1 (es) | 2005-10-21 | 2007-09-19 | Amgen Inc | Metodos para generar el anticuerpo igg monovalente |
TWI461436B (zh) | 2005-11-25 | 2014-11-21 | Kyowa Hakko Kirin Co Ltd | 人類cd134(ox40)之人類單株抗體及其製造及使用方法 |
EP1981912A2 (en) | 2006-01-13 | 2008-10-22 | Irm, Llc | Antibodies against thymic stromal lymphopoietin receptor for treating allergic diseases |
CN101074261A (zh) | 2006-04-30 | 2007-11-21 | 北京同为时代生物技术有限公司 | Trail受体1和/或trail受体2特异性抗体及其应用 |
WO2007134384A2 (en) | 2006-05-19 | 2007-11-29 | Children Youth And Women's Health Service | Selective modulation of receptor signalling |
MX2008015524A (es) | 2006-06-12 | 2009-01-13 | Trubion Pharmaceuticals Inc | Proteinas de union multivalentes monocatenarias con funcion efectora. |
KR100847010B1 (ko) | 2006-07-05 | 2008-07-17 | 아주대학교산학협력단 | 세포사멸 수용체 5 (dr5)에 특이적으로 결합하는 항체 및이를 포함하는 암 예방 또는 치료용 조성물 |
EP1894940A1 (en) | 2006-08-28 | 2008-03-05 | Apogenix GmbH | TNF superfamily fusion proteins |
EP3339445B1 (en) | 2006-09-08 | 2020-07-15 | AbbVie Bahamas Ltd. | Interleukin -13 binding proteins |
GB0620894D0 (en) | 2006-10-20 | 2006-11-29 | Univ Southampton | Human immune therapies using a CD27 agonist alone or in combination with other immune modulators |
SG176476A1 (en) | 2006-11-02 | 2011-12-29 | Daniel J Capon | Hybrid immunoglobulins with moving parts |
WO2009030285A1 (en) | 2007-09-07 | 2009-03-12 | Ablynx N.V. | Binding molecules with multiple binding sites, compositions comprising the same and uses thereof |
EP2219458B1 (en) | 2007-11-08 | 2015-07-15 | Cytimmune Sciences, Inc. | Compositions and methods for generating antibodies |
WO2009106073A2 (en) | 2008-02-28 | 2009-09-03 | Dako Denmark A/S | Mhc multimers in borrelia diagnostics and disease |
EP2322220B1 (en) | 2008-08-01 | 2014-01-01 | Axis, Inc. | Therapeutic agent or preventive agent for osteoarthritis |
US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
EP3112382A1 (en) | 2009-12-29 | 2017-01-04 | Emergent Product Development Seattle, LLC | Heterodimer binding proteins and uses thereof |
WO2011116387A1 (en) | 2010-03-19 | 2011-09-22 | Tetragenetics, Inc. | Production of aglycosylated monoclonal antibodies in ciliates |
SG184473A1 (en) | 2010-04-07 | 2012-11-29 | Abbvie Inc | Tnf-alpha binding proteins |
RU2551963C2 (ru) | 2010-09-09 | 2015-06-10 | Пфайзер Инк. | Молекулы, связывающиеся с 4-1вв |
JP5918143B2 (ja) | 2010-10-29 | 2016-05-18 | 第一三共株式会社 | 新規抗dr5抗体 |
WO2012088290A2 (en) | 2010-12-22 | 2012-06-28 | Abbott Laboratories | Tri-variable domain binding proteins and uses thereof |
MA35035B1 (fr) | 2011-04-21 | 2014-04-03 | Bristol Myers Squibb Co | Anticorps polypeptidiques qui antagonisent les cd40 |
GB201115280D0 (en) | 2011-09-05 | 2011-10-19 | Alligator Bioscience Ab | Antibodies, uses and methods |
GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
US8952134B2 (en) | 2011-09-26 | 2015-02-10 | Jn Biosciences Llc | Hybrid constant regions |
US9382319B2 (en) * | 2011-09-26 | 2016-07-05 | Jn Biosciences Llc | Hybrid constant regions |
AU2012328917B2 (en) | 2011-10-24 | 2017-05-25 | Abbvie Inc. | Bispecific immunobinders directed against TNF and IL-17 |
MX363819B (es) | 2012-02-08 | 2019-04-03 | Igm Biosciences Inc | Uniones a cdim y sus usos. |
EP2684896A1 (en) | 2012-07-09 | 2014-01-15 | International-Drug-Development-Biotech | Anti-DR5 family antibodies, bispecific or multivalent anti-DR5 family antibodies and methods of use thereof |
WO2014022592A1 (en) | 2012-08-02 | 2014-02-06 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece |
US9725517B2 (en) | 2012-10-26 | 2017-08-08 | Institute Of Basic Medical Sciences, Chinese Academy Of Medical Sciences | Humanized monoclonal antibodies against the extracellular domain of human death receptor 5 |
US9487773B2 (en) | 2013-03-01 | 2016-11-08 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Cell-based methods for coupling protein interactions and binding molecule selection |
UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
CN105377893A (zh) | 2013-05-07 | 2016-03-02 | 豪夫迈·罗氏有限公司 | 三聚体抗原结合分子 |
US20150038682A1 (en) | 2013-08-02 | 2015-02-05 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via homomultimerizing peptide |
WO2015053887A1 (en) | 2013-09-05 | 2015-04-16 | Igm Biosciences, Inc. | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
WO2015037000A1 (en) | 2013-09-11 | 2015-03-19 | Compugen Ltd | Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases |
KR102056963B1 (ko) | 2013-12-30 | 2019-12-17 | 에피맙 바이오테라퓨틱스 인코포레이티드 | Fabs-인-탠덤 면역글로불린 및 이의 용도 |
CA2936877C (en) | 2014-01-16 | 2023-03-28 | Mario Umberto Francesco MONDELLI | Neutralizing human monoclonal antibodies against hepatitis b virus surface antigen |
BR112016018313A8 (pt) | 2014-02-10 | 2018-06-12 | Igm Biosciences Inc | Moléculas de ligação multiespecíficas iga |
US11059898B2 (en) | 2014-03-24 | 2021-07-13 | Cancer Research Technology Limited | Modified antibodies containing modified IGG2 domains which elicit agonist or antagonistic properties and use thereof |
PL3560954T3 (pl) | 2014-04-03 | 2021-12-13 | Igm Biosciences, Inc. | Zmodyfikowany łańcuch J |
SG11201702805TA (en) | 2014-10-08 | 2017-05-30 | Hoffmann La Roche | Combination therapy of bispecific antibodies specific for fap and dr5 and chemotherapeutic agents |
SG11201705116SA (en) | 2015-01-20 | 2017-08-30 | Igm Biosciences Inc | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
KR20170105622A (ko) | 2015-01-26 | 2017-09-19 | 마크로제닉스, 인크. | Dr5-결합 도메인을 포함하는 다가 분자 |
ES2874558T3 (es) | 2015-03-04 | 2021-11-05 | Igm Biosciences Inc | Moléculas de unión a CD20 y usos de las mismas |
JP6882184B2 (ja) | 2015-03-25 | 2021-06-02 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多価b型肝炎ウイルス抗原結合分子およびその使用 |
AU2016249404B2 (en) | 2015-04-17 | 2021-01-21 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
EA201890171A1 (ru) | 2015-06-30 | 2018-08-31 | Сэнфорд-Бернхем Медикал Рисерч Инститьют | Слитые белки btla агонисты и их применение |
NZ739830A (en) | 2015-07-12 | 2021-12-24 | Hangzhou Dac Biotech Co Ltd | Bridge linkers for conjugation of cell-binding molecules |
DK3356401T3 (da) | 2015-09-30 | 2020-09-07 | Igm Biosciences Inc | Bindingsmolekyler med modificeret j-kæde |
CA2999284C (en) | 2015-09-30 | 2023-06-13 | Igm Biosciences A/S | Binding molecules with modified j-chain |
IL262295B2 (en) | 2016-05-09 | 2023-09-01 | Igm Biosciences Inc | Antibodies against pd–l1 |
JP2019528683A (ja) | 2016-07-20 | 2019-10-17 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多量体gitr結合分子及びその使用 |
EP3496536A4 (en) | 2016-07-20 | 2020-02-12 | IGM Biosciences, Inc. | MULTIMERIC MOLECULES ATTACHING CD40 AND USES THEREOF |
AU2017298483A1 (en) | 2016-07-20 | 2019-02-07 | Igm Biosciences, Inc. | Multimeric OX40 binding molecules and uses thereof |
EP3487298A4 (en) | 2016-07-20 | 2020-03-11 | IGM Biosciences, Inc. | MOLECULES FIXING PDK137 / 4 AND USES THEREOF |
NZ751956A (en) | 2016-09-23 | 2022-01-28 | Merus Nv | Binding molecules that modulate a biological activity expressed by a cell |
JP2020512820A (ja) | 2017-04-07 | 2020-04-30 | アイジーエム バイオサイエンシズ インコーポレイテッド | 補体依存性細胞溶解のエフェクター機能の調節のための修飾されたヒトIgM定常領域 |
US20200392239A1 (en) | 2018-02-26 | 2020-12-17 | Igm Biosciences, Inc. | Use of a multimeric anti-dr5 binding molecule in combination with a chemotherapeutic agent for treating cancer |
CA3091144A1 (en) | 2018-03-01 | 2019-09-06 | Igm Biosciences, Inc. | Igm fc and j-chain mutations that affect igm serum half-life |
CA3113268A1 (en) | 2018-10-23 | 2020-04-30 | Igm Biosciences, Inc. | Multivalent igm- and iga-fc-based binding molecules |
US20220106398A1 (en) | 2019-02-08 | 2022-04-07 | Igm Biosciences, Inc. | Anti-gitr antigen-binding domains and uses thereof |
KR20220045019A (ko) | 2019-08-15 | 2022-04-12 | 아이쥐엠 바이오사이언스 인코포레이티드 | 면역자극성 다량체 결합 분자 |
CA3147767A1 (en) | 2019-08-17 | 2021-02-25 | Igm Biosciences, Inc. | Multimeric bispecific anti-cd123 binding molecules and uses thereof |
KR20220050166A (ko) | 2019-08-23 | 2022-04-22 | 아이쥐엠 바이오사이언스 인코포레이티드 | Igm 글리코변이체 |
WO2021055765A2 (en) | 2019-09-19 | 2021-03-25 | Igm Biosciences, Inc. | Multimeric antibodies with enhanced selectivity for cells with high target density |
IL293739A (en) | 2020-01-06 | 2022-08-01 | Igm Biosciences Inc | Highly sialic acid-modified multimeric binding compounds |
JP2023522962A (ja) | 2020-04-22 | 2023-06-01 | アイジーエム バイオサイエンシズ インコーポレイテッド | Pd-1アゴニスト多量体結合分子 |
JP2023526224A (ja) | 2020-05-12 | 2023-06-21 | アイジーエム バイオサイエンシズ インコーポレイテッド | がんを治療するための、がん治療薬との組合せでの多量体抗dr5結合分子の使用 |
CA3187008A1 (en) | 2020-07-27 | 2022-02-03 | Paul R. Hinton | Multimeric coronavirus binding molecules and uses thereof |
US20240002526A1 (en) | 2020-11-17 | 2024-01-04 | Igm Biosciences, Inc. | Uses of effector cell engaging molecules with moieties of differing potencies |
WO2022177870A1 (en) | 2021-02-17 | 2022-08-25 | The Board Of Regents Of The University Of Texas System | Multimeric sars-cov-2 binding molecules and uses thereof |
JP2024508709A (ja) | 2021-02-17 | 2024-02-28 | アイジーエム バイオサイエンシズ インコーポレイテッド | 抗cd123結合分子及びその使用法 |
-
2016
- 2016-01-20 SG SG11201705116SA patent/SG11201705116SA/en unknown
- 2016-01-20 PT PT167406867T patent/PT3247728T/pt unknown
- 2016-01-20 HU HUE16740686A patent/HUE051013T2/hu unknown
- 2016-01-20 JP JP2017556795A patent/JP7179464B2/ja active Active
- 2016-01-20 CN CN201680006321.XA patent/CN107207601A/zh active Pending
- 2016-01-20 EP EP20168740.7A patent/EP3750918A1/en active Pending
- 2016-01-20 KR KR1020177022773A patent/KR102435324B1/ko active IP Right Grant
- 2016-01-20 WO PCT/US2016/014153 patent/WO2016118641A1/en active Application Filing
- 2016-01-20 IL IL284430A patent/IL284430B2/en unknown
- 2016-01-20 IL IL308212A patent/IL308212A/en unknown
- 2016-01-20 SI SI201630842T patent/SI3247728T1/sl unknown
- 2016-01-20 NZ NZ732922A patent/NZ732922A/en unknown
- 2016-01-20 ES ES16740686T patent/ES2806500T3/es active Active
- 2016-01-20 CA CA2972990A patent/CA2972990A1/en active Pending
- 2016-01-20 AU AU2016209324A patent/AU2016209324B2/en active Active
- 2016-01-20 EP EP16740686.7A patent/EP3247728B1/en active Active
- 2016-01-20 US US15/544,873 patent/US10689449B2/en active Active
- 2016-01-20 SG SG10202001779UA patent/SG10202001779UA/en unknown
- 2016-01-20 DK DK16740686.7T patent/DK3247728T3/da active
- 2016-01-20 PL PL16740686T patent/PL3247728T3/pl unknown
-
2017
- 2017-06-21 IL IL253054A patent/IL253054B/en unknown
- 2017-06-30 US US15/638,748 patent/US9938347B2/en active Active
-
2020
- 2020-02-24 AU AU2020201323A patent/AU2020201323B2/en active Active
- 2020-04-28 US US16/861,102 patent/US11578131B2/en active Active
- 2020-09-23 JP JP2020158581A patent/JP2021006044A/ja active Pending
-
2022
- 2022-09-07 JP JP2022142258A patent/JP2022177090A/ja active Pending
- 2022-11-14 US US18/055,340 patent/US20230203173A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL284430A (en) | Tumor necrosis factor-α receptor binding molecules and their uses | |
IL259399A (en) | Antibodies against glucocorticoid-induced tumor necrosis factor receptors (gitr) and their uses | |
HK1252957A1 (zh) | TGF-β超家族I型和II型受體異多聚體及其用途 | |
ZA201704797B (en) | Agonistic tnf receptor binding agents | |
IL263799A (en) | Multimeric ox40 binding molecules and uses thereof | |
IL254223A (en) | CD20 binding compounds and their uses | |
GB201519761D0 (en) | Binding molecules specific for CD73 and uses thereof | |
SI3151921T1 (sl) | Protitelesa proti z glukortikoidom induciranim receptorjem za faktor nekroze tumorja(GITR) in njihova uporaba | |
SG11201705583XA (en) | Cxcr4 binding molecules | |
GB201811410D0 (en) | OX40 Binding molecules | |
EP3315513A4 (en) | Cd154 binding polypeptide and use thereof | |
IL259883A (en) | Antibody molecules that bind tnf alpha | |
IL272798A (en) | TNF receptor binding agonists |