MA45941A - Anticorps de membres de la superfamille anti-tnfr modifiés par fc ayant une activité agoniste améliorée et leurs procédés d'utilisation - Google Patents

Anticorps de membres de la superfamille anti-tnfr modifiés par fc ayant une activité agoniste améliorée et leurs procédés d'utilisation

Info

Publication number
MA45941A
MA45941A MA045941A MA45941A MA45941A MA 45941 A MA45941 A MA 45941A MA 045941 A MA045941 A MA 045941A MA 45941 A MA45941 A MA 45941A MA 45941 A MA45941 A MA 45941A
Authority
MA
Morocco
Prior art keywords
agonist activity
modified anti
tnfr superfamily
use procedures
improved agonist
Prior art date
Application number
MA045941A
Other languages
English (en)
Inventor
Mark Chiu
Di Zhang
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of MA45941A publication Critical patent/MA45941A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA045941A 2016-08-12 2017-08-04 Anticorps de membres de la superfamille anti-tnfr modifiés par fc ayant une activité agoniste améliorée et leurs procédés d'utilisation MA45941A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662374347P 2016-08-12 2016-08-12

Publications (1)

Publication Number Publication Date
MA45941A true MA45941A (fr) 2019-06-19

Family

ID=61158615

Family Applications (1)

Application Number Title Priority Date Filing Date
MA045941A MA45941A (fr) 2016-08-12 2017-08-04 Anticorps de membres de la superfamille anti-tnfr modifiés par fc ayant une activité agoniste améliorée et leurs procédés d'utilisation

Country Status (11)

Country Link
US (2) US20180044430A1 (fr)
EP (1) EP3497126A4 (fr)
JP (2) JP7009448B2 (fr)
KR (1) KR102554331B1 (fr)
CN (1) CN109843916B (fr)
AU (1) AU2017308734A1 (fr)
CA (1) CA3033665A1 (fr)
IL (1) IL264515A (fr)
MA (1) MA45941A (fr)
SG (1) SG11201900744SA (fr)
WO (1) WO2018031400A1 (fr)

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Also Published As

Publication number Publication date
EP3497126A1 (fr) 2019-06-19
US11359029B2 (en) 2022-06-14
US20180044430A1 (en) 2018-02-15
AU2017308734A1 (en) 2019-02-14
JP2022033769A (ja) 2022-03-02
EP3497126A4 (fr) 2020-04-08
CN109843916A (zh) 2019-06-04
CN109843916B (zh) 2023-10-31
US20200231693A1 (en) 2020-07-23
KR20190038629A (ko) 2019-04-08
JP2019532025A (ja) 2019-11-07
WO2018031400A1 (fr) 2018-02-15
KR102554331B1 (ko) 2023-07-10
IL264515A (en) 2019-02-28
SG11201900744SA (en) 2019-02-27
JP7009448B2 (ja) 2022-02-10
CA3033665A1 (fr) 2018-02-15

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