JP2019513370A5 - - Google Patents

Download PDF

Info

Publication number
JP2019513370A5
JP2019513370A5 JP2018551953A JP2018551953A JP2019513370A5 JP 2019513370 A5 JP2019513370 A5 JP 2019513370A5 JP 2018551953 A JP2018551953 A JP 2018551953A JP 2018551953 A JP2018551953 A JP 2018551953A JP 2019513370 A5 JP2019513370 A5 JP 2019513370A5
Authority
JP
Japan
Prior art keywords
seq
region
amino acid
acid sequence
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018551953A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019513370A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/025573 external-priority patent/WO2017173384A1/en
Publication of JP2019513370A publication Critical patent/JP2019513370A/ja
Publication of JP2019513370A5 publication Critical patent/JP2019513370A5/ja
Pending legal-status Critical Current

Links

JP2018551953A 2016-04-01 2017-03-31 キメラ受容体及びその使用方法 Pending JP2019513370A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662317068P 2016-04-01 2016-04-01
US62/317,068 2016-04-01
PCT/US2017/025573 WO2017173384A1 (en) 2016-04-01 2017-03-31 Chimeric receptors and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020152515A Division JP7134204B2 (ja) 2016-04-01 2020-09-11 キメラ受容体及びその使用方法

Publications (2)

Publication Number Publication Date
JP2019513370A JP2019513370A (ja) 2019-05-30
JP2019513370A5 true JP2019513370A5 (enExample) 2019-10-24

Family

ID=59960746

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2018551953A Pending JP2019513370A (ja) 2016-04-01 2017-03-31 キメラ受容体及びその使用方法
JP2020152515A Active JP7134204B2 (ja) 2016-04-01 2020-09-11 キメラ受容体及びその使用方法
JP2022136417A Active JP7451627B2 (ja) 2016-04-01 2022-08-30 キメラ受容体及びその使用方法
JP2024033511A Active JP7673272B2 (ja) 2016-04-01 2024-03-06 キメラ受容体及びその使用方法
JP2025071243A Pending JP2025111619A (ja) 2016-04-01 2025-04-23 キメラ受容体及びその使用方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2020152515A Active JP7134204B2 (ja) 2016-04-01 2020-09-11 キメラ受容体及びその使用方法
JP2022136417A Active JP7451627B2 (ja) 2016-04-01 2022-08-30 キメラ受容体及びその使用方法
JP2024033511A Active JP7673272B2 (ja) 2016-04-01 2024-03-06 キメラ受容体及びその使用方法
JP2025071243A Pending JP2025111619A (ja) 2016-04-01 2025-04-23 キメラ受容体及びその使用方法

Country Status (33)

Country Link
US (3) US10597456B2 (enExample)
EP (2) EP3436030B1 (enExample)
JP (5) JP2019513370A (enExample)
KR (7) KR20200068750A (enExample)
CN (3) CN109641008B (enExample)
AR (1) AR108066A1 (enExample)
AU (3) AU2017240788B2 (enExample)
BR (1) BR112018070260A2 (enExample)
CA (2) CA3019650C (enExample)
CL (5) CL2018002797A1 (enExample)
CO (1) CO2018010547A2 (enExample)
CR (2) CR20210084A (enExample)
DK (1) DK3436030T3 (enExample)
EA (1) EA201891992A1 (enExample)
ES (1) ES2930058T3 (enExample)
HR (1) HRP20221348T1 (enExample)
HU (1) HUE060645T2 (enExample)
IL (2) IL316403A (enExample)
LT (1) LT3436030T (enExample)
MA (1) MA43603A1 (enExample)
MX (2) MX2018012019A (enExample)
MY (1) MY197669A (enExample)
PE (3) PE20211418A1 (enExample)
PH (1) PH12018502113A1 (enExample)
PL (1) PL3436030T3 (enExample)
PT (1) PT3436030T (enExample)
RS (1) RS63735B1 (enExample)
SG (2) SG10201912519VA (enExample)
SI (1) SI3436030T1 (enExample)
SM (1) SMT202200444T1 (enExample)
TW (4) TW201803896A (enExample)
UA (2) UA128781C2 (enExample)
WO (1) WO2017173384A1 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
SG11201808138YA (en) 2016-03-31 2018-10-30 Janssen Pharmaceuticals Inc Substituted indole derivatives as dengue viral replication inhibitors
US10913716B2 (en) 2016-03-31 2021-02-09 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
UA128781C2 (uk) 2016-04-01 2024-10-23 Кайт Фарма, Інк. Т-клітина, спосіб її отримання та застосування
CR20180494A (es) 2016-04-01 2019-01-29 Janssen Pharmaceuticals Inc Derivados de compuestos de indol sustituidos como inhibidores de la replicación vírica del dengue
SG11201808411RA (en) * 2016-04-01 2018-10-30 Kite Pharma Inc Chimeric antigen and t cell receptors and methods of use
KR102397674B1 (ko) 2016-04-01 2022-05-18 카이트 파마 인코포레이티드 Bcma 결합 분자 및 그의 사용 방법
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
EA039702B1 (ru) 2017-05-22 2022-03-01 Янссен Фармасьютикалз, Инк. Замещенные производные индолина в качестве ингибиторов репликации вирусов денге
KR102625988B1 (ko) 2017-05-22 2024-01-16 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체
EP3710471A1 (en) * 2017-11-16 2020-09-23 Kite Pharma, Inc. Modified chimeric antigen receptors and methods of use
KR20220066413A (ko) 2017-12-14 2022-05-24 프로디자인 소닉스, 인크. 음향 트랜스듀서 구동기 및 제어기
CN109609533B (zh) * 2017-12-27 2020-07-10 赛德特生物科技开发有限公司 基于人源化cd276抗体的car慢病毒表达载体构建及其应用
JP7273421B2 (ja) 2018-02-21 2023-05-15 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用
KR20210046006A (ko) * 2018-08-10 2021-04-27 상가모 테라퓨틱스 프랑스 Tnfr2 도메인을 포함하는 신규한 car 작제물
EP3875484A4 (en) * 2018-10-26 2022-07-20 CRAGE medical Co., Limited Cll1-targeting antibody and application thereof
MX2021010441A (es) 2019-03-01 2021-09-21 Allogene Therapeutics Inc Receptores antigenicos quimericos y agentes de union dirigidos a dll3.
EP3966236A4 (en) * 2019-05-07 2023-05-10 The Board of Trustees of the Leland Stanford Junior University Enhancement of polypeptides and chimeric antigen receptors via hinge domains
BR112021026832A2 (pt) 2019-07-02 2022-05-10 Hutchinson Fred Cancer Res Vetores ad35 recombinantes e aprimoramentos da terapia gênica relacionada
CN112500492B (zh) * 2019-09-13 2023-08-04 中国科学院分子细胞科学卓越创新中心 一种嵌合抗原受体及其用途
AU2020346887A1 (en) * 2019-09-13 2022-04-07 Memorial Hospital For Cancer And Allied Diseases Antigen recognizing receptors targeting CD371 and uses thereof
CN113045658B (zh) 2020-12-11 2021-12-24 广州百暨基因科技有限公司 抗cll1抗体及其应用
CN113234169B (zh) 2020-12-11 2022-11-01 广州百暨基因科技有限公司 靶向cll1嵌合抗原受体及其应用
CN113234162B (zh) * 2020-12-24 2022-05-13 四川大学华西医院 一种靶向cd133的嵌合抗原受体t细胞
CN113416713A (zh) * 2021-05-11 2021-09-21 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) 一种重组腺病毒的构建及其应用
CN115521917A (zh) * 2021-06-25 2022-12-27 南京北恒生物科技有限公司 工程化免疫细胞及其用途
EP4469478A1 (en) 2022-01-26 2024-12-04 Mabswitch Inc. Bispecific molecule with tunable affinity to a targetted antigen
TW202340457A (zh) * 2022-02-28 2023-10-16 美商凱特製藥公司 同種異體治療細胞
WO2024044670A1 (en) 2022-08-26 2024-02-29 Kite Pharma, Inc. Improving immune cell function
GB202214132D0 (en) 2022-09-27 2022-11-09 Coding Bio Ltd CLL1 binding molecules
GB202301949D0 (en) 2023-02-10 2023-03-29 Coding Bio Ltd CLL1 and/or CD33 binding molecules
US20240293462A1 (en) * 2023-03-03 2024-09-05 Trustees Of Boston University Immune Cell Fusion (ICF) and Uses Thereof
WO2024218688A1 (en) * 2023-04-18 2024-10-24 Board Of Regents, The University Of Texas System Bcma chimeric antigen receptors and uses thereof
WO2025194098A1 (en) 2024-03-14 2025-09-18 Dana-Farber Cancer Institute, Inc. Engineered immune cells expressing chimeric antigen receptors targeting trop2, and methods of using the same
WO2025231376A1 (en) * 2024-05-03 2025-11-06 Kite Pharma, Inc. Chimeric receptors binding to cll-1 and methods of use thereof

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988001649A1 (en) 1986-09-02 1988-03-10 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5728388A (en) 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
US6319494B1 (en) 1990-12-14 2001-11-20 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
US5830462A (en) 1993-02-12 1998-11-03 President & Fellows Of Harvard College Regulated transcription of targeted genes and other biological events
US5834266A (en) 1993-02-12 1998-11-10 President & Fellows Of Harvard College Regulated apoptosis
US5869337A (en) 1993-02-12 1999-02-09 President And Fellows Of Harvard College Regulated transcription of targeted genes and other biological events
US20030036654A1 (en) 1994-08-18 2003-02-20 Holt Dennis A. Synthetic multimerizing agents
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US6892139B2 (en) 1999-01-29 2005-05-10 The Regents Of The University Of California Determining the functions and interactions of proteins by comparative analysis
US6406699B1 (en) 1999-10-05 2002-06-18 Gary W. Wood Composition and method of cancer antigen immunotherapy
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
CA2406864A1 (en) 2000-02-24 2001-08-30 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
EP2298809A3 (en) 2001-07-12 2012-02-15 FOOTE, Jefferson Super humanized antibodies
US20040014194A1 (en) 2002-03-27 2004-01-22 Schering Corporation Beta-secretase crystals and methods for preparing and using the same
US7446190B2 (en) * 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
US7393531B2 (en) 2003-01-21 2008-07-01 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of MCSP
CA2526284C (en) * 2003-06-25 2014-11-18 Crucell Holland B.V. Binding molecules for the treatment of myeloid cell malignancies
US20130266551A1 (en) 2003-11-05 2013-10-10 St. Jude Children's Research Hospital, Inc. Chimeric receptors with 4-1bb stimulatory signaling domain
JP4917035B2 (ja) 2004-09-03 2012-04-18 ゼネラル・モーターズ・コーポレーション 燃料電池スタック内の繰返しおよび非繰返しユニットの位置合せ方法
WO2007137300A2 (en) 2006-05-23 2007-11-29 Bellicum Pharmaceuticals, Inc. Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
GB0700058D0 (en) 2007-01-03 2007-02-07 Scancell Aps Anti-tumor vaccine based on normal cells
WO2009051974A1 (en) 2007-10-17 2009-04-23 Nuvelo, Inc. Antibodes to cll-1
AU2009317161B2 (en) 2008-11-24 2014-09-11 Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt Gmbh High affinity T cell receptor and use thereof
DK2406284T5 (en) 2009-03-10 2017-06-12 Biogen Ma Inc ANTI-BCMA ANTIBODIES
US8465743B2 (en) 2009-10-01 2013-06-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer
EP2501816A4 (en) 2009-11-17 2013-07-03 Basf Plant Science Co Gmbh PLANTS WITH INCREASED PERFORMANCE
WO2011138423A1 (en) 2010-05-05 2011-11-10 Addex Pharma Sa Chimeric receptors and methods for identifying agents exhibiting an activity on type 1 single pass transmembrane receptors
US9089520B2 (en) 2010-05-21 2015-07-28 Baylor College Of Medicine Methods for inducing selective apoptosis
US9493740B2 (en) 2010-09-08 2016-11-15 Baylor College Of Medicine Immunotherapy of cancer using genetically engineered GD2-specific T cells
EP2614077B1 (en) 2010-09-08 2016-08-17 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Chimeric antigen receptors with an optimized hinge region
US9845362B2 (en) 2010-10-08 2017-12-19 The University Of North Carolina At Charlotte Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
MX2013008376A (es) 2011-01-18 2013-08-12 Univ Pennsylvania Composiciones y metodos para el tratamiento de cancer.
US9024028B2 (en) 2011-01-26 2015-05-05 Ariad Pharmaceuticals, Inc. Methods and compositions for the synthesis of multimerizing agents
JP6203705B2 (ja) 2011-03-23 2017-09-27 フレッド ハッチンソン キャンサー リサーチ センター 細胞免疫療法のための方法および組成物
EA201790330A1 (ru) 2011-05-27 2018-02-28 Глаксо Груп Лимитед Белки, связывающиеся с bcma (cd269/tnfrsf17)
EP2532740A1 (en) 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
CA2848410A1 (en) 2011-09-16 2013-03-21 The Trustees Of The University Of Pennsylvania Rna engineered t cells for the treatment of cancer
DE102012204596A1 (de) 2012-03-22 2013-09-26 Ford Global Technologies, Llc Verfahren und Vorrichtung zum Regeln der Geschwindigkeit eines Kraftfahrzeugs
EP3421489B1 (en) 2012-03-23 2021-05-05 The United States of America, as represented by The Secretary, Department of Health and Human Services Anti-mesothelin chimeric antigen receptors
JP6189415B2 (ja) 2012-04-02 2017-08-30 モデルナティエックス インコーポレイテッドModernaTX,Inc. 細胞質および細胞骨格タンパク質の産生のための修飾ポリヌクレオチド
HK1203393A1 (en) 2012-04-11 2015-10-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptors targeting b-cell maturation antigen
US9163090B2 (en) * 2012-05-07 2015-10-20 Cellerant Therapeutics, Inc. Antibodies specific for CLL-1
WO2014055771A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Human alpha-folate receptor chimeric antigen receptor
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
JP2016507523A (ja) 2013-02-05 2016-03-10 エンクマフ アーゲー CD3εおよびBCMAに対する二重特異的抗体
ES2748398T3 (es) 2013-02-06 2020-03-16 Celgene Corp Linfocitos T modificados con especificidad mejorada
SI3613439T1 (sl) 2013-02-15 2021-11-30 The Regents Of The University Of California Himerni antigenski receptor in postopki njegove uporabe
JP6541639B2 (ja) 2013-03-14 2019-07-10 ベリカム ファーマシューティカルズ, インコーポレイテッド T細胞増殖をコントロールするための方法
CN112795594B (zh) 2013-05-14 2025-09-19 得克萨斯州大学系统董事会 工程化嵌合抗原受体(car)t细胞的人应用
AU2014296626B2 (en) 2013-07-29 2019-03-07 Regeneron Pharmaceuticals, Inc. Multipartite signaling proteins and uses thereof
US10246505B2 (en) 2013-11-25 2019-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptors to control HIV infection
WO2015080981A1 (en) 2013-11-27 2015-06-04 Baylor College Of Medicine Csgp4-specific chimeric antigen receptor for cancer
EP4420663A3 (en) 2013-12-20 2024-10-30 Novartis AG Regulatable chimeric antigen receptor
CN120536374A (zh) 2014-02-04 2025-08-26 凯德药业公司 用于治疗b细胞恶性肿瘤和其它癌症的自体t细胞的生产方法及其组合物
US10934346B2 (en) 2014-02-14 2021-03-02 Bellicum Pharmaceuticals, Inc. Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12
CN106163547A (zh) * 2014-03-15 2016-11-23 诺华股份有限公司 使用嵌合抗原受体治疗癌症
AU2015248956B2 (en) 2014-04-14 2020-06-25 Cellectis BCMA (CD269) specific chimeric antigen receptors for cancer immunotherapy
MX2017001011A (es) 2014-07-21 2018-05-28 Novartis Ag Tratamiento de cancer de usando un receptor quimerico de antigeno anti-bcma.
KR20170037625A (ko) * 2014-07-21 2017-04-04 노파르티스 아게 Cll-1 키메라 항원 수용체를 사용한 암의 치료
SG11201700492SA (en) 2014-07-24 2017-02-27 Bluebird Bio Inc Bcma chimeric antigen receptors
BR112017005631A2 (pt) 2014-09-19 2018-06-26 City Of Hope células t com receptor de antígeno coestimulador quimérico direcionadas à il13ra2
MX2017003640A (es) 2014-09-19 2017-10-31 Regeneron Pharma Receptores antigenicos quimericos.
EP4219530A1 (en) 2014-12-05 2023-08-02 City of Hope Cs1 targeted chimeric antigen receptor-modified t cells
WO2016094304A2 (en) 2014-12-12 2016-06-16 Bluebird Bio, Inc. Bcma chimeric antigen receptors
PH12023550222A1 (en) 2015-04-13 2024-03-11 Pfizer Therapeutic antibodies and their uses
KR102349475B1 (ko) 2015-04-13 2022-01-11 화이자 인코포레이티드 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체
UA128781C2 (uk) 2016-04-01 2024-10-23 Кайт Фарма, Інк. Т-клітина, спосіб її отримання та застосування
WO2017173410A1 (en) 2016-04-01 2017-10-05 Amgen Inc. Chimeric receptors to flt3 and methods of use thereof
KR102397674B1 (ko) 2016-04-01 2022-05-18 카이트 파마 인코포레이티드 Bcma 결합 분자 및 그의 사용 방법
SG11201808411RA (en) 2016-04-01 2018-10-30 Kite Pharma Inc Chimeric antigen and t cell receptors and methods of use

Similar Documents

Publication Publication Date Title
JP2019513370A5 (enExample)
CN111018986B (zh) 抗磷脂酰肌醇蛋白多糖-3的抗体及其应用
AU2019243665B2 (en) Multivalent antibody
JP7701911B2 (ja) Ceacam5およびcd3に対する二特異性抗体
JP2022550832A (ja) Cd3を標的とする抗体、二重特異性抗体及びその使用
CA3116294C (en) Anti-l1cam antibody or antigen-binding fragment thereof and chimeric antigen receptor comprising same
WO2018108106A1 (zh) 抗cd19的人源化抗体以及靶向cd19的免疫效应细胞
FI4063397T3 (fi) Yksidomeenivasta-aineisiin perustuvia antigeenireseptoreita ja menetelmiä niiden käyttämiseksi
JP2020508655A5 (enExample)
CN112028996A (zh) 靶向bcma的单域抗体及其用途
JP2016536322A5 (enExample)
JP2018522888A5 (enExample)
RU2018104703A (ru) Опухолеспецифичное антитело против egfr и его применение
CN109796532B (zh) 靶向成纤维激活蛋白α的结合单元及其应用
JP2018528786A5 (enExample)
KR20230143177A (ko) 신규한 항-cd24 항체
JP2024001073A5 (enExample)
AU2020400801B2 (en) Anti-BCMA/anti-4-1BB bispecific antibodies and uses thereof
IL316226A (en) Anti-ror1 antibody and ror1-targeting engineered cells
JP7496093B2 (ja) CARライブラリおよびscFvの製造方法
JPWO2022111633A5 (enExample)
KR20210046725A (ko) 신규 암 면역요법 항체 조성물
CN119894930A (zh) 一种双特异性抗体及其应用
JPWO2019219064A5 (enExample)
KR102811084B1 (ko) 뮤신 1에 특이적인 폴리펩티드 및 이의 이용