JP2007530588A5 - - Google Patents
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- JP2007530588A5 JP2007530588A5 JP2007505213A JP2007505213A JP2007530588A5 JP 2007530588 A5 JP2007530588 A5 JP 2007530588A5 JP 2007505213 A JP2007505213 A JP 2007505213A JP 2007505213 A JP2007505213 A JP 2007505213A JP 2007530588 A5 JP2007530588 A5 JP 2007530588A5
- Authority
- JP
- Japan
- Prior art keywords
- receptor
- coupling agent
- antibody
- binding specificity
- receptor coupling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000005962 receptors Human genes 0.000 claims 78
- 108020003175 receptors Proteins 0.000 claims 78
- 239000007822 coupling agent Substances 0.000 claims 41
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 12
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 12
- 102000010170 Death domains Human genes 0.000 claims 9
- 108050001718 Death domains Proteins 0.000 claims 9
- 101000679857 Homo sapiens Tumor necrosis factor receptor superfamily member 3 Proteins 0.000 claims 8
- 102100022156 Tumor necrosis factor receptor superfamily member 3 Human genes 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- 230000015572 biosynthetic process Effects 0.000 claims 6
- 230000011664 signaling Effects 0.000 claims 5
- 101000679907 Homo sapiens Tumor necrosis factor receptor superfamily member 27 Proteins 0.000 claims 4
- 101100046559 Mus musculus Tnfrsf12a gene Proteins 0.000 claims 4
- 102100022202 Tumor necrosis factor receptor superfamily member 27 Human genes 0.000 claims 4
- 101000610605 Homo sapiens Tumor necrosis factor receptor superfamily member 10A Proteins 0.000 claims 3
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 claims 3
- 101000920026 Homo sapiens Tumor necrosis factor receptor superfamily member EDAR Proteins 0.000 claims 3
- 102100040113 Tumor necrosis factor receptor superfamily member 10A Human genes 0.000 claims 3
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 claims 3
- 102100030810 Tumor necrosis factor receptor superfamily member EDAR Human genes 0.000 claims 3
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000000170 cell membrane Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 101100425751 Mus musculus Tnfrsf19 gene Proteins 0.000 claims 1
- 108010052562 RELT Proteins 0.000 claims 1
- 102000018795 RELT Human genes 0.000 claims 1
- 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 claims 1
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 1
- 101710178300 Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 1
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims 1
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims 1
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims 1
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000005229 liver cell Anatomy 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55580504P | 2004-03-23 | 2004-03-23 | |
| PCT/US2005/009967 WO2005092927A1 (en) | 2004-03-23 | 2005-03-23 | Receptor coupling agents and therapeutic uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007530588A JP2007530588A (ja) | 2007-11-01 |
| JP2007530588A5 true JP2007530588A5 (enExample) | 2008-05-08 |
Family
ID=34968432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007505213A Pending JP2007530588A (ja) | 2004-03-23 | 2005-03-23 | レセプターカップリング剤およびその治療用途 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7799902B2 (enExample) |
| EP (2) | EP1756162A1 (enExample) |
| JP (1) | JP2007530588A (enExample) |
| KR (1) | KR20060132006A (enExample) |
| CN (1) | CN1980957A (enExample) |
| AU (1) | AU2005227322A1 (enExample) |
| BR (1) | BRPI0509201A (enExample) |
| CA (1) | CA2560742A1 (enExample) |
| IL (1) | IL178254A0 (enExample) |
| NZ (1) | NZ550518A (enExample) |
| SG (1) | SG151294A1 (enExample) |
| WO (1) | WO2005092927A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6312691B1 (en) * | 1996-01-26 | 2001-11-06 | Jeffrey L. Browning | Lymphotoxin-α/β complexes and anti-lympotoxin-β receptor antibodies as anti-tumor agents |
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| EP4190149A1 (en) | 2009-12-25 | 2023-06-07 | Chugai Seiyaku Kabushiki Kaisha | Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein |
| US11124773B2 (en) | 2010-10-06 | 2021-09-21 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell population and method for production thereof |
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| EP2749641B1 (en) | 2011-09-07 | 2021-06-02 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell isolation |
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| EP2772268B8 (en) * | 2011-10-28 | 2020-01-08 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell-specific molecule |
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| US9914785B2 (en) | 2012-11-28 | 2018-03-13 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
| UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
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| US11505605B2 (en) | 2014-05-13 | 2022-11-22 | Chugai Seiyaku Kabushiki Kaisha | T cell-redirected antigen-binding molecule for cells having immunosuppression function |
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| EP3378488A4 (en) | 2015-11-18 | 2019-10-30 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR IMPROVING THE HUMORAL IMMUNE REACTION |
| JP6931329B2 (ja) | 2015-11-18 | 2021-09-01 | 中外製薬株式会社 | 免疫抑制機能を有する細胞に対するｔ細胞リダイレクト抗原結合分子を用いた併用療法 |
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-
2005
- 2005-03-23 EP EP05744495A patent/EP1756162A1/en not_active Withdrawn
- 2005-03-23 KR KR1020067021701A patent/KR20060132006A/ko not_active Ceased
- 2005-03-23 NZ NZ550518A patent/NZ550518A/en unknown
- 2005-03-23 JP JP2007505213A patent/JP2007530588A/ja active Pending
- 2005-03-23 WO PCT/US2005/009967 patent/WO2005092927A1/en not_active Ceased
- 2005-03-23 AU AU2005227322A patent/AU2005227322A1/en not_active Abandoned
- 2005-03-23 CA CA002560742A patent/CA2560742A1/en not_active Abandoned
- 2005-03-23 CN CNA2005800165978A patent/CN1980957A/zh active Pending
- 2005-03-23 BR BRPI0509201-9A patent/BRPI0509201A/pt not_active IP Right Cessation
- 2005-03-23 SG SG200901965-4A patent/SG151294A1/en unknown
- 2005-03-23 EP EP10186088A patent/EP2332992A1/en not_active Withdrawn
-
2006
- 2006-09-21 IL IL178254A patent/IL178254A0/en unknown
- 2006-09-21 US US11/524,786 patent/US7799902B2/en active Active
-
2010
- 2010-01-26 US US12/694,092 patent/US7947271B2/en not_active Expired - Lifetime
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