|
US341393A
(en)
|
|
1886-05-04 |
|
Steam-pump |
|
US3773319A
(en)
|
1971-12-16 |
1973-11-20 |
Fabcor Ind Inc |
Corrugated sheet inverting machine
|
|
IE52535B1
(en)
|
1981-02-16 |
1987-12-09 |
Ici Plc |
Continuous release pharmaceutical compositions
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
EP0154316B1
(en)
|
1984-03-06 |
1989-09-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified lymphokine and production thereof
|
|
NZ212207A
(en)
|
1984-05-31 |
1991-07-26 |
Genentech Inc |
Recombinant lymphotoxin
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
GB8529014D0
(en)
|
1985-11-25 |
1986-01-02 |
Biogen Nv |
Enhanced secretion of heterologous proteins
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
ATE67415T1
(de)
|
1988-02-16 |
1991-10-15 |
Vetter & Co Apotheker |
Spritze fuer medizinische zwecke.
|
|
JP2989002B2
(ja)
|
1988-12-22 |
1999-12-13 |
キリン―アムジエン・インコーポレーテツド |
化学修飾顆粒球コロニー刺激因子
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
US5395760A
(en)
|
1989-09-05 |
1995-03-07 |
Immunex Corporation |
DNA encoding tumor necrosis factor-α and -β receptors
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
DK0440846T3
(da)
|
1990-02-07 |
1993-07-12 |
Vetter & Co Apotheker |
Dobbeltkammersprøjte og anvendelsesfremgangsmåde
|
|
US5795964A
(en)
|
1990-06-27 |
1998-08-18 |
Biogen, Inc. |
Lymphotoxin-beta and lymphotoxin-beta complexes
|
|
US7030080B2
(en)
|
1990-06-27 |
2006-04-18 |
Biogen, Inc. |
Lymphotoxin-β, lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof
|
|
ATE201879T1
(de)
|
1990-06-27 |
2001-06-15 |
Biogen Inc |
Oberflächenkomplexbildung von lymphotoxin
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
US5874082A
(en)
|
1992-07-09 |
1999-02-23 |
Chiron Corporation |
Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation
|
|
US5397703A
(en)
|
1992-07-09 |
1995-03-14 |
Cetus Oncology Corporation |
Method for generation of antibodies to cell surface molecules
|
|
EP0672143B1
(en)
|
1992-12-04 |
2008-06-04 |
Biogen Idec MA Inc. |
Lymphotoxin-beta, lymphotoxin-beta complexes, pharmaceutical preparations and therapeutic uses thereof
|
|
IL108776A
(en)
*
|
1993-03-11 |
1999-11-30 |
Genentech Inc |
A method of dissolving a cell or inhibiting cell growth, a bispecific molecule that binds FNT-1R and an SAF antibody, a medical preparation that contains it and its use
|
|
FI961285L
(fi)
|
1993-10-01 |
1996-03-20 |
Immunex Corp |
CD40:n vasta-aineita
|
|
KR960704938A
(ko)
|
1993-10-14 |
1996-10-09 |
그리스토퍼 엘. 와이트 |
Fas 길항제 및 그의 용도(Fas Antagonists and Uses Thereof)
|
|
US5985547A
(en)
|
1994-03-04 |
1999-11-16 |
Children's Hospital Of Philadelphia |
Detection of a mutation in the HLA-DMβ gene in an immunocompromised patient
|
|
DK0809510T3
(da)
|
1995-01-26 |
2004-10-04 |
Biogen Inc |
Lymphotoxin-alfa/beta-komplekser og antilymphotoxin-beta-receptorantistoffer som antitumormidler
|
|
US6312691B1
(en)
|
1996-01-26 |
2001-11-06 |
Jeffrey L. Browning |
Lymphotoxin-α/β complexes and anti-lympotoxin-β receptor antibodies as anti-tumor agents
|
|
US6284236B1
(en)
|
1995-06-29 |
2001-09-04 |
Immunex Corporation |
Cytokine that induces apoptosis
|
|
ES2253753T3
(es)
|
1995-06-29 |
2006-06-01 |
Immunex Corporation |
Citocina que induce apoptosis.
|
|
US5925351A
(en)
|
1995-07-21 |
1999-07-20 |
Biogen, Inc. |
Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
|
|
US6340459B1
(en)
|
1995-12-01 |
2002-01-22 |
The Trustees Of Columbia University In The City Of New York |
Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients
|
|
WO1997029110A1
(en)
|
1996-02-07 |
1997-08-14 |
Janssen Pharmaceutica N.V. |
Thiophenopyrimidines
|
|
US6462176B1
(en)
|
1996-09-23 |
2002-10-08 |
Genentech, Inc. |
Apo-3 polypeptide
|
|
HUP9904697A3
(en)
|
1996-10-11 |
2001-06-28 |
Bristol Myers Squibb Company P |
Methods and compositions for immunomodulation
|
|
US7255854B1
(en)
|
1996-10-25 |
2007-08-14 |
Biogen, Inc. |
Use of lymphotoxin-β receptor blocking agents for the treatment of antibody mediated immunological diseases
|
|
EP2003203A1
(en)
|
1996-12-23 |
2008-12-17 |
Immunex Corporation |
Ligand for receptor activator of nf-kappa b, ligand is member of TNF superfamily
|
|
US6271349B1
(en)
|
1996-12-23 |
2001-08-07 |
Immunex Corporation |
Receptor activator of NF-κB
|
|
US6072047A
(en)
|
1997-02-13 |
2000-06-06 |
Immunex Corporation |
Receptor that binds trail
|
|
US20050233958A1
(en)
|
1997-03-17 |
2005-10-20 |
Human Genome Sciences, Inc. |
Death domain containing receptor 5
|
|
ES2281126T3
(es)
|
1997-03-17 |
2007-09-16 |
Human Genome Sciences, Inc. |
Receptor 5 que contiene un dominio de muerte.
|
|
US20040136951A1
(en)
|
1997-03-17 |
2004-07-15 |
Human Genome Sciences, Inc. |
Death domain containing receptor 5
|
|
US6872568B1
(en)
|
1997-03-17 |
2005-03-29 |
Human Genome Sciences, Inc. |
Death domain containing receptor 5 antibodies
|
|
US6342369B1
(en)
|
1997-05-15 |
2002-01-29 |
Genentech, Inc. |
Apo-2-receptor
|
|
ATE516354T1
(de)
|
1997-05-15 |
2011-07-15 |
Genentech Inc |
Apo-2-rezeptor
|
|
AU8400398A
(en)
|
1997-07-11 |
1999-02-08 |
Trustees Of The University Of Pennsylvania, The |
Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use
|
|
US6417328B2
(en)
|
1997-08-15 |
2002-07-09 |
Thomas Jefferson Univeristy |
Trail receptors, nucleic acids encoding the same, and methods of use thereof
|
|
ES2286856T3
(es)
|
1997-09-12 |
2007-12-01 |
Biogen Idec Ma Inc. |
Receptores train ricos en cisteina.
|
|
DK1051187T3
(da)
|
1998-01-30 |
2004-03-08 |
Univ New York |
Behandling af follikulære lymfomer ved anvendelse af inhibitorer af lymfotoxin(LT)-syntesevejen
|
|
US7060667B1
(en)
|
1998-01-30 |
2006-06-13 |
Biogen Idec Ma, Inc. |
Treatment of follicular lymphomas using inhibitors of the LT pathway
|
|
US6051228A
(en)
|
1998-02-19 |
2000-04-18 |
Bristol-Myers Squibb Co. |
Antibodies against human CD40
|
|
US6437113B1
(en)
|
1998-03-05 |
2002-08-20 |
Tularik Inc. |
Suppressors of death domains
|
|
GB9809839D0
(en)
|
1998-05-09 |
1998-07-08 |
Glaxo Group Ltd |
Antibody
|
|
US6252050B1
(en)
|
1998-06-12 |
2001-06-26 |
Genentech, Inc. |
Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
|
|
WO1999064461A2
(en)
|
1998-06-12 |
1999-12-16 |
Genentech, Inc. |
Monoclonal antibodies, cross-reactive antibodies and method for producing the same
|
|
US6355782B1
(en)
|
1998-07-09 |
2002-03-12 |
Baylor College Of Medicine |
Hypohidrotic ectodermal dyplasia genes and proteins
|
|
WO2000021558A1
(en)
|
1998-10-09 |
2000-04-20 |
Biogen, Inc. |
Reversal of viral-induced systemic shock and respiratory distress by blockade of the lymphotoxin beta pathway
|
|
AU2021800A
(en)
|
1998-12-04 |
2000-06-26 |
Schering Corporation |
Mammalian genes; related reagents
|
|
JP2002543151A
(ja)
|
1999-05-04 |
2002-12-17 |
ヒューマン ジノーム サイエンシーズ, インコーポレイテッド |
死ドメイン含有レセプター5
|
|
US20030118588A1
(en)
|
1999-05-22 |
2003-06-26 |
Linda Diehl |
Induction of anti-tumor CTL immunity through in vivo triggering of 4-1BB and/or CD40
|
|
PT1192185E
(pt)
|
1999-06-09 |
2006-11-30 |
Genentech Inc |
Sinergismo de agonista do receptor de apo-2l e cpt-11
|
|
AU7494300A
(en)
|
1999-09-15 |
2001-04-17 |
Genentech Inc. |
Apo-2 receptor antibodies
|
|
US6727225B2
(en)
|
1999-12-20 |
2004-04-27 |
Immunex Corporation |
TWEAK receptor
|
|
ES2637801T3
(es)
|
2000-04-11 |
2017-10-17 |
Genentech, Inc. |
Anticuerpos multivalentes y usos de los mismos
|
|
US20030059427A1
(en)
|
2000-04-28 |
2003-03-27 |
Force Walker R. |
Isolation and characterization of highly active anti-CD40 antibody
|
|
US7279160B2
(en)
|
2000-05-02 |
2007-10-09 |
The Uab Research Foundation |
Combinations of DR5 antibodies and other therapeutic agents
|
|
US7476383B2
(en)
|
2000-05-02 |
2009-01-13 |
The Uab Research Foundation |
Antibody selective for DR4 and uses thereof
|
|
TWI318983B
(en)
|
2000-05-02 |
2010-01-01 |
Uab Research Foundation |
An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
|
|
DE10034607A1
(de)
*
|
2000-07-20 |
2002-02-07 |
Gundram Jung |
Multispezifisches Reagenz zur selektiven Stimulierung von Zelloberflächenrezeptoren
|
|
WO2002009755A2
(en)
|
2000-07-27 |
2002-02-07 |
Genentech, Inc. |
Apo-2l receptor agonist and cpt-11 synergism
|
|
US20040005314A1
(en)
|
2001-07-27 |
2004-01-08 |
Enrique Escandon |
Apo-2l receptor agonist and cpt-11 synergism
|
|
JP2004508415A
(ja)
|
2000-09-14 |
2004-03-18 |
バイオジェン インコーポレイテッド |
抗脈管形成因子としてのtweakレセプターアゴニスト
|
|
EE200300179A
(et)
|
2000-10-13 |
2003-08-15 |
Biogen, Inc. |
Humaniseeritud LT-ß-R-i vastased antikehad
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
WO2002066516A2
(en)
*
|
2001-02-20 |
2002-08-29 |
Zymogenetics, Inc. |
Antibodies that bind both bcma and taci
|
|
US20020155109A1
(en)
*
|
2001-04-20 |
2002-10-24 |
Lynch David H. |
Bispecific antibodies that bind TRAIL-R1 and TRAIL-R2
|
|
US7115717B2
(en)
|
2001-05-18 |
2006-10-03 |
Kirin Beer Kabushiki Kaisha |
Anti-TRAIL-R antibodies
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
US7662374B2
(en)
*
|
2001-08-03 |
2010-02-16 |
The Trustees Of The University Of Pennsylvania |
Monoclonal antibodies to activated erbB family members and methods of use thereof
|
|
CA2461292A1
(en)
|
2001-10-02 |
2003-04-10 |
Genentech, Inc. |
Apo-2 ligand variants and uses thereof
|
|
CA2461665A1
(en)
|
2001-10-19 |
2003-05-01 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of inflammatory bowel disorders
|
|
ES2357225T3
(es)
|
2001-11-01 |
2011-04-20 |
Uab Research Foundation |
Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos.
|
|
AR039067A1
(es)
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
Anticuerpos para cd40
|
|
CA2467242A1
(en)
|
2001-11-20 |
2003-05-30 |
Seattle Genetics, Inc. |
Treatment of immunological disorders using anti-cd30 antibodies
|
|
WO2003080671A1
(en)
|
2002-03-21 |
2003-10-02 |
Komed Co., Ltd. |
Anti-rank monoclonal antibodies and pharmaceutical composition containing the same
|
|
WO2004000238A2
(en)
|
2002-03-22 |
2003-12-31 |
Tittle Thomas V |
Utilization of mhc class ii binding motifs in immunization to produce immune serum, monoclonal antibodies and vaccines
|
|
CA2482938A1
(en)
|
2002-04-12 |
2003-10-23 |
Human Genome Sciences, Inc. |
Antibodies that specifically bind to tr2
|
|
US20040101915A1
(en)
|
2002-06-18 |
2004-05-27 |
Irm Llc, A Delaware Limited Liability Company |
Diagnosis and treatment of chemoresistant tumors
|
|
JP4574350B2
(ja)
|
2002-06-24 |
2010-11-04 |
ジェネンテック, インコーポレイテッド |
Apo−2リガンド/trail変異体とその使用法
|
|
US6889341B2
(en)
|
2002-06-28 |
2005-05-03 |
Hewlett-Packard Development Company, L.P. |
Method and apparatus for maintaining data integrity using a system management processor
|
|
CA2491480A1
(en)
|
2002-07-01 |
2004-01-08 |
Biogen, Inc. |
Humanized anti-lymphotoxin beta receptor antibodies
|
|
BR0316737A
(pt)
|
2002-11-27 |
2005-12-13 |
Irm Llc |
Métodos e composições para induzir apoptose em células cancerosas
|
|
WO2004058191A2
(en)
|
2002-12-20 |
2004-07-15 |
Biogen Idec Ma Inc. |
Multivalent lymphotoxin beta receptor agonists and therapeutic uses thereof
|
|
CN1753692A
(zh)
|
2002-12-20 |
2006-03-29 |
比奥根艾迪克Ma公司 |
淋巴毒素β受体药剂与化疗剂的联合用药
|
|
EP1754713B1
(en)
|
2003-05-09 |
2009-02-25 |
Genentech, Inc. |
Apo2L (Trail) receptor binding peptides and uses thereof
|
|
EP2216342B1
(en)
|
2003-07-31 |
2015-04-22 |
Immunomedics, Inc. |
Anti-CD19 antibodies
|
|
WO2005014618A2
(en)
|
2003-08-08 |
2005-02-17 |
Immunomedics, Inc. |
Bispecific antibodies for inducing apoptosis of tumor and diseased cells
|
|
SG151294A1
(en)
|
2004-03-23 |
2009-04-30 |
Biogen Idec Inc |
Receptor coupling agents and therapeutic uses thereof
|
|
JP4829780B2
(ja)
|
2004-03-26 |
2011-12-07 |
武田薬品工業株式会社 |
呼吸器疾患の予防・治療剤
|
|
KR20070010046A
(ko)
|
2004-04-06 |
2007-01-19 |
제넨테크, 인크. |
Dr5 항체 및 그의 용도
|
|
WO2005123141A2
(en)
|
2004-06-11 |
2005-12-29 |
Board Of Regents, The University Of Texas System |
Combination treatment of cancer with elicitor of gene product expression and gene-product targeting agent
|
|
EP1786456A1
(en)
|
2004-06-18 |
2007-05-23 |
Genentech, Inc. |
Use of apo2l receptor agonists and nk cells or nk cell activators
|
|
CA2575152A1
(en)
|
2004-08-06 |
2006-02-16 |
Genentech, Inc. |
Method for predicting sensitivity of mammalian cells to apo2l/trail comprising deletion of biomarker expression
|
|
RU2410438C2
(ru)
|
2004-08-06 |
2011-01-27 |
Дженентек, Инк. |
Анализы и способы, использующие биомаркеры
|
|
CN100427505C
(zh)
|
2004-08-19 |
2008-10-22 |
中国医学科学院基础医学研究所 |
抗人肿瘤坏死因子相关凋亡诱导配体的受体dr5单克隆抗体(ad5-10)及其制法与用途
|
|
RU2007112929A
(ru)
|
2004-09-08 |
2008-10-20 |
Дженентек, Инк. (Us) |
Способы применения лигандов рецептора смерти и антител к cd20
|
|
CN101048428A
(zh)
|
2004-09-08 |
2007-10-03 |
健泰科生物技术公司 |
利用死亡受体配体和cd20抗体的方法
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
US8029783B2
(en)
|
2005-02-02 |
2011-10-04 |
Genentech, Inc. |
DR5 antibodies and articles of manufacture containing same
|
|
US20060188498A1
(en)
|
2005-02-18 |
2006-08-24 |
Genentech, Inc. |
Methods of using death receptor agonists and EGFR inhibitors
|
|
IT1395574B1
(it)
|
2009-09-14 |
2012-10-16 |
Guala Dispensing Spa |
Dispositivo di erogazione
|